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Name:(2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
CAS Number: 4350-09-8Picture of molecule3D/inchi
Other(deleted CASRN):1228817-95-5
ECHA EINECS - REACH Pre-Reg:224-411-1
Nikkaji Web:J4.572A
Beilstein Number:0088200
XlogP3:-1.20 (est)
Molecular Weight:220.22824000
Formula:C11 H12 N2 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Appearance:colorless to pale pink crystals (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 520.60 °C. @ 760.00 mm Hg (est)
Flash Point: 516.00 °F. TCC ( 268.70 °C. ) (est)
logP (o/w): -0.140 (est)
Soluble in:
 water, 3.15e+004 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
None found
Alfa Biotechnology
For experimental / research use only.
5-Hydroxy-L-tryptophan 98%
BOC Sciences
For experimental / research use only.
L-5-Hydroxytryptophan >95%
Odor: characteristic
Use: L-5-Hydroxytryptophan is an intermediate in the biosynthesis of serotonin from tryptophan. An intermediate
Charkit Chemical
EMD Millipore
For experimental / research use only.
5-Hydroxy-L-tryptophan, Dihydrate
For experimental / research use only.
5-Hydroxy-L-Tryptophan (HPLC) ≥98%
Glentham Life Sciences
Indis NV
For experimental / research use only.
5-HTP (5-Hydroxy-L-Tryptophane)
Shaanxi Y-Herb Biotechnology
5-HTP Monomer Powder Griffonia Simplicifolia Seed Extract 98% 99% 5-Hydroxytryptophan
Sigma-Aldrich: Sigma
For experimental / research use only.
5-Hydroxy-L-tryptophan powder
For experimental / research use only.
5-Hydroxy-L-tryptophan >98.0%(HPLC)(T)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
natural substances and extractives
Recommendation for laevo-oxitriptan usage levels up to:
 not for fragrance use.
Recommendation for laevo-oxitriptan flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):4350-09-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :439280
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
EPA/NOAA CAMEO:hazardous materials
RTECS:YN7110000 for cas# 4350-09-8
 (2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):439280
Pubchem (sid):134985540
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
Golm Metabolome Database:Search
Metabolomics Database:Search
KEGG (GenomeNet):C00643
HMDB (The Human Metabolome Database):HMDB00472
Export Tariff Code:2933.99.8210
VCF-Online:VCF Volatile Compounds in Food
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 banana plant
Search Trop Picture
(2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
5-hydroxytryptophan L-form
L-tryptophan, 5-hydroxy-
 tryptophan, 5-hydroxy-, L-


PubMed:Peripheral Serotonin Regulates Maternal Calcium Trafficking in Mammary Epithelial Cells during Lactation in Mice.
PubMed:Serotonin regulates calcium homeostasis in lactation by epigenetic activation of hedgehog signaling.
PubMed:Molecular docking of bacosides with tryptophan hydroxylase: a model to understand the bacosides mechanism.
PubMed:Investigation of estrogen receptor (ESR1) for breast cancer from traditional Chinese medicine.
PubMed:Lead screening for CXCR4 of the human HIV infection receptor inhibited by traditional Chinese medicine.
PubMed:In Silico Identification of Potent PPAR-γ Agonists from Traditional Chinese Medicine: A Bioactivity Prediction, Virtual Screening, and Molecular Dynamics Study.
PubMed:Lead Screening for HIV of C-C Chemokine Receptor Type 5 Receptor Inhibited by Traditional Chinese Medicine.
PubMed:The murine serotonin syndrome - Evaluation of responses to 5-HT-enhancing drugs in NMRI mice.
PubMed:5-HT1A/1B receptors as targets for optimizing pigmentary responses in C57BL/6 mouse skin to stress.
PubMed:Quantitative imaging of serotonergic biosynthesis and degradation in the endocrine pancreas.
PubMed:Detection of metastatic insulinoma by positron emission tomography with [(68)ga]exendin-4-a case report.
PubMed:Combination of cross-sectional and molecular imaging studies in the localization of gastroenteropancreatic neuroendocrine tumors.
PubMed:Antidepressant-like effects of a water-soluble extract from the culture medium of Ganoderma lucidum mycelia in rats.
PubMed:Neuroendocrine tumours: the role of imaging for diagnosis and therapy.
PubMed:Enhanced synthesis of 5-hydroxy-l-tryptophan through tetrahydropterin regeneration.
PubMed:Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: evidence for direct 5-HT receptor modulation.
PubMed:Emitting state of 5-hydroxyindole, 5-hydroxytryptophan, and 5-hydroxytryptophan incorporated in proteins.
PubMed:The absorptive flux of the anti-epileptic drug substance vigabatrin is carrier-mediated across Caco-2 cell monolayers.
PubMed:Animal models of the serotonin syndrome: a systematic review.
PubMed:Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis.
PubMed:Radiosynthesis and biological evaluation of 5-(3-[18F]fluoropropyloxy)-L-tryptophan for tumor PET imaging.
PubMed:Mood disorders and complementary and alternative medicine: a literature review.
PubMed:Feeding 5-hydroxy-l-tryptophan during the transition from pregnancy to lactation increases calcium mobilization from bone in rats.
PubMed:Eukaryotic-type aromatic amino acid decarboxylase from the root colonizer Pseudomonas putida is highly specific for 3,4-dihydroxyphenyl-L-alanine, an allelochemical in the rhizosphere.
PubMed:Risperidone attenuates the increase of extracellular nitric oxide and glutamate levels in serotonin syndrome animal models.
PubMed:Mutations in monoamine oxidase (MAO) genes in mice lead to hypersensitivity to serotonin-enhancing drugs: implications for drug side effects in humans.
PubMed:Role of endothelial AADC in cardiac synthesis of serotonin and nitrates accumulation.
PubMed:5-(2-18F-fluoroethoxy)-L-tryptophan as a substrate of system L transport for tumor imaging by PET.
PubMed:5-hydroxy-L-tryptophan Suppressed Food Intake in Rats Despite an Increase in the Arcuate NPY Expression.
PubMed:Identification and expression analysis of the genes involved in serotonin biosynthesis and transduction in the field cricket Gryllus bimaculatus.
PubMed:The effects of the perinatal treatment with 5-hydroxytryptophan or tranylcypromine on the peripheral and central serotonin homeostasis in adult rats.
PubMed:Gastroprotective and antidepressant effects of a new zinc(II)-curcumin complex in rodent models of gastric ulcer and depression induced by stresses.
PubMed:Anxiolytic-like effect of Griffonia simplicifolia Baill. seed extract in rats.
PubMed:Serotonin (5-HT) precursor loading with 5-hydroxy-l-tryptophan (5-HTP) reduces locomotor activation produced by (+)-amphetamine in the rat.
PubMed:Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a ß-arrestin2/Src/Akt signaling complex in vivo.
PubMed:The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics.
PubMed:Non-coplanar polychlorinated biphenyl (PCB)-induced immunotoxicity is coincident with alterations in the serotonergic system.
PubMed:Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2).
PubMed:Liquid chromatography on a monolithic column microfluidic chip coupled with "three-T" sample injection mode and amperometric detection.
PubMed:Involvement of 5-HT2A receptors in the serotonin (5-HT) syndrome caused by excessive 5-HT efflux in rat brain.
PubMed:Griffonia simplicifolia negatively affects sexual behavior in female rats.
PubMed:Delta-aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1).
PubMed:5-Hydroxy-L-tryptophan alters gaboxadol pharmacokinetics in rats: involvement of PAT1 and rOat1 in gaboxadol absorption and elimination.
PubMed:Filmy channel microchip with amperometric detection.
PubMed:Enhancement of L-tryptophan 5-hydroxylation activity by structure-based modification of L-phenylalanine 4-hydroxylase from Chromobacterium violaceum.
PubMed:Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice.
PubMed:Direct and decarboxylation-dependent effects of neurotransmitter precursors on firing of isolated monoaminergic neurons.
PubMed:Production and Peripheral Roles of 5-HTP, a Precursor of Serotonin.
PubMed:Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice.
PubMed:Characterization of serotonin-toxicity syndrome (toxidrome) elicited by 5-hydroxy-l-tryptophan in clorgyline-pretreated rats.
PubMed:Role of a serotonin precursor in development of gut microvilli.
PubMed:Delta 9-tetrahydrocannabinol-induced catalepsy-like immobilization is mediated by decreased 5-HT neurotransmission in the nucleus accumbens due to the action of glutamate-containing neurons.
PubMed:Antidepressant-like effect of Cordyceps sinensis in the mouse tail suspension test.
PubMed:Receptor mediation of exaggerated responses to serotonin-enhancing drugs in serotonin transporter (SERT)-deficient mice.
PubMed:Effects of increased endogenous serotonin on the in vivo binding of [11C]DASB to serotonin transporters in conscious monkey brain.
PubMed:Nuclear imaging of neuroendocrine tumours.
PubMed:Anxiolytic effect of serotonin depletion in the novelty-induced hypophagia test.
PubMed:A new application of pre-normalized principal component analysis for improvement of image quality and clinical diagnosis in human brain PET studies--clinical brain studies using [11C]-GR205171, [11C]-L-deuterium-deprenyl, [11C]-5-Hydroxy-L-Tryptophan, [11C]-L-DOPA and Pittsburgh Compound-B.
PubMed:Alterations in alcohol consumption, withdrawal seizures, and monoamine transmission in rats treated with phentermine and 5-hydroxy-L-tryptophan.
PubMed:Serotonin, L-tryptophan, and tryptamine are effective inhibitors of the amino acid transport system PAT1.
PubMed:Neuroendocrine tumors of the gastrointestinal tract: recent advances in molecular genetics, diagnosis, and treatment.
PubMed:Indirect fluorescence detection of amino sugars with the use of copper complexes of tryptophan and its analogues following high-performance liquid chromatographic separation.
PubMed:Separation and determination of L-tryptophan and its metabolites by capillary micellar electrokinetic chromatography with amperometric detection.
PubMed:[Determination of the antioxidant activity of potential scavengers of nitric oxide].
PubMed:Depletion and restoration of endogenous monoamines affects beta-CIT binding to serotonin but not dopamine transporters in non-human primates.
PubMed:Extracellular serotonin, dopamine and glutamate levels are elevated in the hypothalamus in a serotonin syndrome animal model induced by tranylcypromine and fluoxetine.
PubMed:Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells.
PubMed:PET in the diagnosis of neuroendocrine tumors.
PubMed:Safety of 5-hydroxy-L-tryptophan.
PubMed:Memantine, an NMDA antagonist, prevents the development of hyperthermia in an animal model for serotonin syndrome.
PubMed:5-Hydroxy-L-tryptophan suppresses food intake in food-deprived and stressed rats.
PubMed:Systemic 5-hydroxy-L-tryptophan down-regulates the arcuate CART mRNA level in rats.
PubMed:Effects of gabaergic and serotoninergic systems on hypothalamic content of catecholamines during sexual development in female rats.
PubMed:Determination of ppb levels of tryptophan derivatives by capillary electrophoresis with homogeneous liquid-liquid extraction and sweeping method.
PubMed:Diazepam and chlormethiazole attenuate the development of hyperthermia in an animal model of the serotonin syndrome.
PubMed:Kinetic compartment modeling of [11C]-5-hydroxy-L-tryptophan for positron emission tomography assessment of serotonin synthesis in human brain.
PubMed:Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin.
PubMed:Suppressive effect of nantenine, isolated from Nandina domestica Thunberg, on the 5-hydroxy-L-tryptophan plus clorgyline-induced head-twitch response in mice.
PubMed:Involvement of 5-hydroxytryptamine neuronal system in Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory.
PubMed:[Physicochemical and pharmacological characteristic and clinical efficacy of an anti-irritable bowel syndrome agent, polycarbophil calcium (Polyful)].
PubMed:Depletion of 5-HT disrupts prepulse inhibition in rats: dependence on the magnitude of depletion, and reversal by a 5-HT precursor.
PubMed:Studies on the binding mechanism of fluoroquinolones to melanin.
PubMed:Pharmacological studies of geissoschizine methyl ether, isolated from Uncaria sinensis Oliv., in the central nervous system.
PubMed:Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome.
PubMed:Effects of naltrexone on the accumulation of L-3, 4-dihydroxyphenylalanine and 5-hydroxy-L-tryptophan and on the firing rate induced by acute ethanol administration.
PubMed:Tryptophan hydroxylase and 5-hydroxytryptamine in carcinoids of the gastrointestinal tract.
PubMed:Regulation of central corticosteroid receptors following short-term activation of serotonin transmission by 5-hydroxy-L-tryptophan or fluoxetine.
PubMed:Effects of dopamine, NMDA, opiate, and serotonin-related agents on acute methamphetamine-induced self-injurious behavior in mice.
PubMed:Risperidone counteracts lethality in an animal model of the serotonin syndrome.
PubMed:Expression and purification of recombinant human indoleamine 2, 3-dioxygenase.
PubMed:Demonstration of [11C] 5-hydroxy-L-tryptophan uptake and decarboxylation in carcinoid tumors by specific positioning labeling in positron emission tomography.
PubMed:Eosinophilia-myalgia syndrome case-associated contaminants in commercially available 5-hydroxytryptophan.
PubMed:Presence of peak X and related compounds: the reported contaminant in case related 5-hydroxy-L-tryptophan associated with eosinophilia-myalgia syndrome.
PubMed:N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline studies on the role of 5-HT1A and 5-HT2 receptors in mediating foot-shock-induced ultrasonic vocalisation in adult rats.
PubMed:Problems with over-the-counter 5-hydroxy-L-tryptophan.
PubMed:Determination of 5-hydroxy-L-[beta-11C]tryptophan and its in vivo-formed radiolabeled metabolites in brain tissue using high performance liquid chromatography: a study supporting radiotracer kinetics obtained with positron emission tomography.
PubMed:Effects of dopaminergic agents on reversal of reserpine-induced impairment in conditioned avoidance response in rats.
PubMed:Neuroendocrine response to 5-hydroxy-L-tryptophan in prepubertal children at high risk of major depressive disorder.
PubMed:Central administration of FMRFamide produces antipsychotic-like effects in rodents.
PubMed:Can we treat respiratory failure in Friedreich ataxia?
PubMed:Role of serotoninergic receptors in gonadotropin secretion in male rats.
PubMed:Serotonergic, noradrenergic, and dopaminergic measures in suicide brains.
PubMed:Melatonin and testicular function: characterization of binding sites for 2-[125I]-iodomelatonin in immature rat testes.
PubMed:Human brainstem serotonin receptors: characterization and implications for subcortical myoclonus.
PubMed:gamma-L-glutamyl-5-hydroxy-L-tryptophan, but not gamma-L-glutamyl-L-tryptophan, causes sodium retention in normal man.
PubMed:On the in-vivo modulation of neostriatal dopamine release by fluoxetine and 5-hydroxy-L-tryptophan in conscious rats.
PubMed:Renal metabolism and effects of the glutamyl derivatives of L-dopa and 5-hydroxytryptophan in man.
PubMed:A controlled trial of 5-hydroxy-L-tryptophan for ataxia in progressive myoclonus epilepsy.
PubMed:Involvement of pituitary adenylate cyclase-activating polypeptide in growth hormone secretion induced by serotoninergic mechanisms in the rat.
PubMed:Regional distribution of the 5-HT innervation in the brain of normal and lurcher mice as revealed by [3H]citalopram quantitative autoradiography.
PubMed:Brain monoaminergic and neuropeptidergic variations in human aging.
PubMed:Modulation of swimming in the lamprey, Petromyzon marinus, by serotonergic and dopaminergic drugs.
PubMed:Chemical features of monoaminergic and non-monoaminergic neurons in the brain of laboratory shrew (Suncus murinus) are changed by systemic administration of monoamine precursors.
PubMed:Protein-protein interactions in colicin E9 DNase-immunity protein complexes. 1. Diffusion-controlled association and femtomolar binding for the cognate complex.
PubMed:Neuropharmacology of progressive myoclonus epilepsy: response to 5-hydroxy-L-tryptophan.
PubMed:Blood and urine 5-hydroxytryptophan and 5-hydroxytryptamine levels after administration of two 5-hydroxytryptamine precursors in normal man.
PubMed:Pyridoxine effect on synthesis rate of serotonin in the monkey brain measured with positron emission tomography.
PubMed:Phenotypic changes of AADC-only immunopositive premammillary neurons in the brain of laboratory shrew Suncus murinus by systemic administration of monoamine precursors.
PubMed:The antinatriuretic action of gamma-L-glutamyl-5-hydroxy-L-tryptophan is dependent on its decarboxylation to 5-hydroxytryptamine in normal man.
PubMed:Altered dopamine and serotonin metabolism in the dopamine-denervated and serotonin-hyperinnervated neostriatum of adult rat after neonatal 6-hydroxydopamine.
PubMed:Steady-state and time-resolved phosphorescence of wild-type and modified bacteriophage λcI repressors.
PubMed:Buspirone enhances head twitch behavior in mice.
PubMed:Radioprotective efficiency of a combination of hydroxytryptophan and AET on mouse bone marrow micronuclei.
PubMed:A comparison of the renal and neuroendocrine effects of two 5-hydroxytryptamine renal prodrugs in normal man.
PubMed:Use of hydroxylamine in improving radio protection of a combination of 5-hydroxy L-tryptophan and a thiol compound (AET) in small mammals.
PubMed:A comparison of the effects of two putative 5-hydroxytryptamine renal prodrugs in normal man.
PubMed:The clinical challenge of progressive myoclonus epilepsy.
PubMed:Brainstem serotonin receptors in the guinea pig: implications for myoclonus.
PubMed:Enantiospecific syntheses of alpha-(fluoromethyl)tryptophan analogues: interactions with tryptophan hydroxylase and aromatic L-amino acid decarboxylase.
PubMed:Effect of ascorbic acid on pituitary prolactin secretion in the non-ascorbate synthesizing Osteogenic Disorder Shionogi (ODS) rat.
PubMed:Neuroendocrine control of immunoreactive growth hormone and bioactive prolactin secretion in neonatal rats: ontogeny and interactions between the serotonergic, cholinergic and alpha 2-adrenergic systems.
PubMed:Effects of monoamine precursors on food intake in male rats.
PubMed:Positron emission tomographic studies on aromatic L-amino acid decarboxylase activity in vivo for L-dopa and 5-hydroxy-L-tryptophan in the monkey brain.
PubMed:Spectral enhancement of proteins: biological incorporation and fluorescence characterization of 5-hydroxytryptophan in bacteriophage lambda cI repressor.
PubMed:Thyrotropin-releasing hormone mediates growth hormone release induced by milk and nursing in neonatal rats.
PubMed:Acute ethanol intoxication during pregnancy: postnatal effects on the behavioral response to serotonin agents.
PubMed:Protection to glycolysis by a combination of 5-hydroxy-L-tryptophan and 2-aminoethylisothiuronium bromide hydrobromide in lethally irradiated rats.
PubMed:Radioprotection of spleen by a combination of 5-hydroxy-L-tryptophan and 2-aminoethylisothiuronium bromide hydrobromide in lethally irradiated rats.
PubMed:Differential radioprotection of tissues in C3H/J mice by a combination of 5-hydroxy L-tryptophan with 2-aminoethylisothiuronium bromide hydrobromide.
PubMed:[Mianserin agranulocytosis followed by oxitriptan eosinophilia].
PubMed:Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study.
PubMed:Brain kinetics of 11 C-labelled L-tryptophan and 5-hydroxy-L-tryptophan in the rhesus monkey. A study using positron emission tomography.
PubMed:Effect of 5-hydroxy-L-tryptophan on the release of 5-HT in rat hypothalamus in vivo as measured by microdialysis.
PubMed:Radiation protection of male fertility in mouse and rat by a combination of 5-hydroxy-L-tryptophan and a thiol compound (AET).
PubMed:In vivo effects of serotonergic agents on alpha-melanocyte-stimulating hormone secretion.
PubMed:Purification and properties of thermostable tryptophanase from an obligately symbiotic thermophile, Symbiobacterium thermophilum.
PubMed:Modulation by serotonin of glutamate-induced lethality in mice.
PubMed:Regulation of Basal and nursing-induced secretion of growth hormone in the neonatal rat: the involvement of serotonergic, muscarinic cholinergic, alpha-adrenergic, somatostatin and growth hormone-releasing hormone systems.
PubMed:[3H]paroxetine binding and serotonin content of rat and rabbit cortical areas, hippocampus, neostriatum, ventral mesencephalic tegmentum, and midbrain raphe nuclei region.
PubMed:[The anticonvulsant action of 5-hydroxy-L-tryptophan in various seizure models in the mouse].
PubMed:Inhibition studies on liver arylformamidases of rainbow trout and cattle.
PubMed:Regional central serotonin receptor binding in rats treated chronically with high-dose 5-hydroxy-L-tryptophan.
PubMed:Mediation of ACTH and prolactin responses to 5-HTP by 5-HT2 receptors.
PubMed:The relationships between the cortisol responses to dexamethasone and to L-5-HTP, and the availability of L-tryptophan in depressed females.
PubMed:Circadian regulation of melatonin in the retina of Xenopus laevis: limitation by serotonin availability.
PubMed:Reverse tolerance to amphetamine evokes reverse tolerance to 5-hydroxytryptophan.
PubMed:Clomipramine. An overview of its pharmacological properties and a review of its therapeutic use in obsessive compulsive disorder and panic disorder.
PubMed:Effects of biogenic amine precursors on ovarian steroid-induced LH release in acutely ovariectomized rats.
PubMed:Protection to testicular activity by a combination of 5-hydroxy L-tryptophan with a thiol compound in whole body gamma irradiated rats.
PubMed:Evidence for the involvement of central 5-HT1A receptors in the mediation of lordosis behavior in the female rat.
PubMed:Intracellular metabolism of biogenic amines in paraneurons.
PubMed:Properties of some 1-arylpiperazines as antagonists of stereotyped behaviors mediated by central serotonergic receptors in rodents.
PubMed:[Hydroxytryptophan (oxitriptan) associated with classical antidepressants: an additional therapeutic possibility].
PubMed:Mechanisms of 5-hydroxy-L-tryptophan-induced adrenocorticotropin release: a major role for central noradrenergic drive.
PubMed:Serotonin-induced head shaking behavior in rats does not involve receptors located in the frontal cortex.
PubMed:Paraventricular nucleus mediates prolactin secretory responses to restraint stress, ether stress, and 5-hydroxy-L-tryptophan injection in the rat.
PubMed:The effect of neurotransmitters on cataleptic behavior induced by PG D2 in rats.
PubMed:Radioprotection of peripheral blood cells with a combination of hydroxytryptophan and a thiol compound in mice.
PubMed:The role of the aural head shake reflex in serotonin-mediated head shaking behavior.
PubMed:Prenatal stress increases the behavioral response to serotonin agonists and alters open field behavior in the rat.
PubMed:Involvement of growth hormone (GH)-releasing factor in GH secretion induced by serotoninergic mechanisms in conscious rats.
PubMed:Increased gastric cholinergic activity evoked by 5-hydroxy-L-tryptophan in the rat.
PubMed:Stimulation of aortic smooth muscle cell mitogenesis by serotonin.
PubMed:Effect of indolamines on beta-endorphin release by rat anterior pituitary cells.
PubMed:Effect of passive immunization with antisera to vasoactive intestinal polypeptide and peptide histidine isoleucine amide on 5-hydroxy-L-tryptophan-induced prolactin release in rats.
PubMed:Human indolylamine 2,3-dioxygenase. Its tissue distribution, and characterization of the placental enzyme.
PubMed:An immunohistochemical study of serotoninergic nerves in the colon and rectum of children with Hirschsprung's disease.
PubMed:Effects of 8-OH-DPAT, lisuride and some ergot-related compounds on the acoustic startle response in the rat.
PubMed:Effects of colchicine on the ultrastructure of mouse taste buds.
PubMed:Studies on in vitro effect of serotonin on calcitonin secretion by rat thyroid C cells.
PubMed:Changes in monoamine metabolites measured by simultaneous in vivo differential pulse voltammetry and intracerebral dialysis.
PubMed:Locomotion in the rat after 5-hydroxy-L-tryptophan.
PubMed:Differential actions of serotonin antagonists on two behavioral models of serotonin receptor activation in the rat.
PubMed:Kinetics of the reaction of DOPA decarboxylase with 5-hydroxy-L-tryptophan.
PubMed:The role of central serotoninergic neurotransmission in the morphine abstinence syndrome in rats.
PubMed:The regulation of 5-hydroxytryptamine release from superfused synaptosomes by 5-hydroxytryptamine and its immediate precursors.
PubMed:[Effects of combined administration of DL-3-pyridylalanine and 5-hydroxy-L-tryptophan on brain and peripheral tissue serotonin contents in rats].
PubMed:Fluorimetric determination of biogenic 5-hydroxy- and 5-methoxyindoles by high-performance liquid chromatography using perchloric acid as post-column reagent.
PubMed:Inhibition of ionic transport and ATPase activities by serotonin analogues in the isolated toad lens.
PubMed:Monoamine roles in retention and reversal of delayed response in cats.
PubMed:Serotonin and its precursors as modulators of the immunological responsiveness in mice.
PubMed:Central pharmacological control of corticosterone secretion in the intact rat. Demonstration of cholinergic and serotoninergic facilitatory and alpha-adrenergic inhibitory mechanisms.
PubMed:Biochemical studies on the mechanism of difference in the renal toxicity of 5-hydroxy-L-tryptophan between Sprague Dawley and Wistar rats.
PubMed:Hypothalamic catecholaminergic effects on prolactin release in vitro.
PubMed:Central neurochemical factors related to serotonin metabolism and cardiac ventricular vulnerability for repetitive electrical activity.
PubMed:Clinical evaluation of 5-hydroxy-L-tryptophan as an antidepressant drug.
PubMed:[Differences between human and rat blood towards 3,4-dihydroxy-L-phenylalanine and 5-hydroxy-L-tryptophan in vitro. Biochemical and histochemical data (author's transl)].
PubMed:Tryptophan and the control of plasma glucose concentrations in the rat.
PubMed:Adaptation of the liquid cation exchange method for the assay of 3,4-dihydroxy-L-phenylalanine and 5-hydroxy-L-tryptophan decarboxylases in rat brain.
PubMed:5-Hydroxy-L-tryptophan decarboxylase activity: microassay and distribution in discrete rat brain nuclei.
PubMed:Neurotransmitter regulation of growth hormone and ACTH in the rhesus monkey: effects of biogenic amines.
PubMed:[Pharmacological studides on 5-hydroxy-L-tryptophan (L-5HTP). Interaction between L-5HTP and p-CPA].
PubMed:Purification and characterization of kynurenine--2-oxoglutarate aminotransferase from the liver, brain and small intestine of rats.
PubMed:Brain DOPA-5-HTP decarboxylase activity after the chronic administration of L-dopa or 5-hydroxy-L-tryptophan in normal and lesioned cats.
PubMed:[Pharmacological studies on 5-hydroxy-L-tryptophan (L-5HTP). 1. Influence of L-5HTP on the central nervous system].
PubMed:Activities of 3,4-dihydroxy-L-phenylalanine and 5-hydroxy-L-tryptophan decarboxylases in rat brain: assay characteristics and distribution.
PubMed:Administration of 5-hydroxy-L-tryptophan to individuals with Huntington's chorea.
PubMed:Enzymatic preparation of L-tryptophan and 5-hydroxy-L-tryptophan.
PubMed:Detection of 5-hydroxy-L-tryptophan decarboxylase in nucleated erythrocytes of ducks.
PubMed:Occurrence of 5-hydroxy-L-tryptophan as a free plant amino-acid.
5-Hydroxytryptophan (5-HTP), also known as oxitriptan (INN), is a naturally-occurring amino acid and chemical precursor as well as metabolic intermediate in the biosynthesis of the neurotransmitters serotonin and melatonin from tryptophan. (Wikipedia)
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