EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

hydroxytyrosol
1,2-benzenediol, 4-(2-hydroxyethyl)-

Supplier Sponsors

Name:4-(2-hydroxyethyl)benzene-1,2-diol
CAS Number: 10597-60-1Picture of molecule3D/inchi
FDA UNII: QEU0NE4O90
Nikkaji Web:J246.008D
Beilstein Number:2208118
MDL:MFCD01320529
XlogP3:-0.70 (est)
Molecular Weight:154.16530000
Formula:C8 H10 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic ingredient for skin conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 600 Hydroxytyrosol View - notice PDF
GRN 726 Phenolic preparation from olive fruit View - notice PDF
GRN 837 Hydroxytyrosol View - notice PDF
GRN 876 Hydroxytyrosol View - notice PDF
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 355.40 °C. @ 760.00 mm Hg (est)
Flash Point: 361.00 °F. TCC ( 182.60 °C. ) (est)
logP (o/w): 0.020 (est)
Soluble in:
 water, 2.716e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Hydroxytyrosol 98%
BOC Sciences
For experimental / research use only.
2-(3,4-Dihydroxyphenyl)ethanol 0.98
Odor: characteristic
Use: 3,4-Dihydroxyphenyl ethanol is a phenolic component of olive oil that inhibits both 12- and 5-LO. The IC50 values for the inhibition of rat platelet 12-LO and rat neutrophil 5-LO are 4.2 and 13 ?M, respectively. It does not inhibit,
Carbosynth
For experimental / research use only.
2-(3,4-Dihydroxyphenyl)ethanol
ExtraSynthese
For experimental / research use only.
Hydroxytyrosol (HPLC) ≥98%
Glentham Life Sciences
3-Hydroxytyrosol
Jiangyin Healthway
Hydroxytyrosol
New functional food ingredients
Layn Natural ingredients
Olive Extract Hydroxytyrosol 5% - 85%
Santa Cruz Biotechnology
For experimental / research use only.
3,4-Dihydroxyphenyl Ethanol ≥98%
Shaanxi Y-Herb Biotechnology
Olive Leaf Extract Natural Cosmetic Ingredients Hydroxytyrosol Oleuropein Powder
Sigma-Aldrich
For experimental / research use only.
3-Hydroxytyrosol analytical standard
Sigma-Aldrich: Sigma
For experimental / research use only.
3-Hydroxytyrosol ≥98% (HPLC)
sds
TCI AMERICA
For experimental / research use only.
2-(3,4-Dihydroxyphenyl)ethyl Alcohol >98.0%(GC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic ingredient for skin conditioning
Recommendation for hydroxytyrosol usage levels up to:
 not for fragrance use.
 
Recommendation for hydroxytyrosol flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Safety of hydroxytyrosol as a novel food pursuant to Regulation (EC) No 258/97
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :82755
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
4-(2-hydroxyethyl)benzene-1,2-diol
Chemidplus:0010597601
 
References:
 4-(2-hydroxyethyl)benzene-1,2-diol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:10597-60-1
Pubchem (cid):82755
Pubchem (sid):135041334
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB05784
FooDB:FDB008754
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 clove leaf
Search Trop Picture
 olive fruit
Search Trop Picture
 
Synonyms:
1,2-benzenediol, 4-(2-hydroxyethyl)-
2-(3,4-dihydroxyphenyl)ethanol
3,4-dihydroxyphenylethanol
beta-3,4-dihydroxyphenylethyl alcohol
 dopet
4-(2-hydroxyethyl)benzene-1,2-diol
 

Articles:

PubMed:Modulating oxidoreductase activity modifies the phenolic content of virgin olive oil.
PubMed:Preparative isolation of oleocanthal, tyrosol, and hydroxytyrosol from olive oil by HPCCC.
PubMed:Antioxidants in the prevention of UVB-induced keratynocyte apoptosis.
PubMed:Bioactivity and phenolic composition from natural fermented table olives.
PubMed:Synthesis and Antioxidant Activity of Nitrohydroxytyrosol and Its Acyl Derivatives.
PubMed:Phosphatidyl derivative of hydroxytyrosol. In vitro intestinal digestion, bioaccessibility, and its effect on antioxidant activity.
PubMed:Quantitative analysis of pungent and anti-inflammatory phenolic compounds in olive oil by capillary electrophoresis.
PubMed:Recovering bioactive compounds from olive oil filter cake by advanced extraction techniques.
PubMed:Cell wall bound anionic peroxidases from asparagus byproducts.
PubMed:Effects of functional olive oil enriched with its own phenolic compounds on endothelial function in hypertensive patients. A randomised controlled trial.
PubMed:Comparison of food antioxidants and iron chelators in two cellular free radical assays: strong protection by luteolin.
PubMed:Secoiridoid type of antiallergic substances in olive waste materials of three Japanese varieties of Olea europaea.
PubMed:In vivo and in vitro addition of dried olive extract in poultry.
PubMed:Faecal microbial metabolism of olive oil phenolic compounds: in vitro and in vivo approaches.
PubMed:Chronic hydroxytyrosol feeding modulates glutathione-mediated oxido-reduction pathways in adipose tissue: a nutrigenomic study.
PubMed:Hydroxytyrosol induces apoptosis in human colon cancer cells through ROS generation.
PubMed:Estimation of the intake of phenol compounds from virgin olive oil of a population from southern Spain.
PubMed:Phenolic compounds and antioxidant capacity of virgin olive oil.
PubMed:Optimisation and validation of analytical methods for the simultaneous extraction of antioxidants: application to the analysis of tomato sauces.
PubMed:Biomimetic synthesis and antioxidant evaluation of 3,4-DHPEA-EDA [2-(3,4-hydroxyphenyl) ethyl (3S,4E)-4-formyl-3-(2-oxoethyl)hex-4-enoate].
PubMed:Comparative evaluation of the metabolic effects of hydroxytyrosol and its lipophilic derivatives (hydroxytyrosyl acetate and ethyl hydroxytyrosyl ether) in hypercholesterolemic rats.
PubMed:Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer.
PubMed:Influence of olive-derived hydroxytyrosol on the toll-like receptor 4-dependent inflammatory response of mouse peritoneal macrophages.
PubMed:Ortho-diphenol profile and antioxidant activity of Algerian black olive cultivars: effect of dry salting process.
PubMed:Targeting mitochondrial alterations to prevent type 2 diabetes-Evidence from studies of dietary redox-active compounds.
PubMed:High-resolution mass spectrometry to evaluate the influence of cross-breeding segregating populations on the phenolic profile of virgin olive oils.
PubMed:Addressing analytical requirements to support health claims on "olive oil polyphenols" (EC Regulation 432/2012).
PubMed:Characterization of poly(ε-caprolactone)-based nanocomposites containing hydroxytyrosol for active food packaging.
PubMed:Inhibition of human neutrophils NEP activity, CD11b/CD18 expression and elastase release by 3,4-dihydroxyphenylethanol-elenolic acid dialdehyde, oleacein.
PubMed:Degradation of caffeic acid in subcritical water and online HPLC-DPPH assay of degradation products.
PubMed:Hydroxytyrosol and its potential therapeutic effects.
PubMed:Directed evolution of nitrobenzene dioxygenase for the synthesis of the antioxidant hydroxytyrosol.
PubMed:Antioxidant role of hydroxytyrosol on oxidative stress in cadmium-intoxicated rats: different effect in spleen and testes.
PubMed:Isolation of megaritolactones and other bioactive metabolites from 'megaritiki' table olives and debittering water.
PubMed:Antioxidant capacity of individual and combined virgin olive oil minor compounds evaluated at mild temperature (25 and 40°C) as compared to accelerated and antiradical assays.
PubMed:Ultrasound-assisted emulsification-microextraction for the determination of phenolic compounds in olive oils.
PubMed:Hydroxytyrosol attenuates tunicamycin-induced endoplasmic reticulum stress in human hepatocarcinoma cells.
PubMed:Radical-scavenging compounds from olive tree (Olea europaea L.) wood.
PubMed:Effect of the co-occurring olive oil and thyme extracts on the phenolic bioaccessibility and bioavailability assessed by in vitro digestion and cell models.
PubMed:Bioavailability of phenolics from an oleuropein-rich olive (Olea europaea) leaf extract and its acute effect on plasma antioxidant status: comparison between pre- and postmenopausal women.
PubMed:Application of dried spot cards as a rapid sample treatment method for determining hydroxytyrosol metabolites in human urine samples. Comparison with microelution solid-phase extraction.
PubMed:Nutrition and healthy ageing: calorie restriction or polyphenol-rich "MediterrAsian" diet?
PubMed:Olive leaf extracts are a natural source of advanced glycation end product inhibitors.
PubMed:Oleuropein and hydroxytyrosol activate GPER/ GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells.
PubMed:A novel multi-commutated method for the determination of hydroxytyrosol in enriched foods using mercaptopropionic acid-capped CdTe quantum dots.
PubMed:Protective activity of hydroxytyrosol metabolites on erythrocyte oxidative-induced hemolysis.
PubMed:Hydroxytyrosol is not genotoxic in vitro.
PubMed:Human absorption and metabolism of oleuropein and hydroxytyrosol ingested as olive (Olea europaea L.) leaf extract.
PubMed:The impact of fruit maturation on bioactive microconstituents, inhibition of serum oxidation and inflammatory markers in stimulated PBMCs and sensory characteristics of Koroneiki virgin olive oils from Messenia, Greece.
PubMed:Kinetic study of hydroxytyrosol oxidation and its related compounds by Red Globe grape polyphenol oxidase.
PubMed:Protective effects of hydroxytyrosol on liver ischemia/reperfusion injury in mice.
PubMed:Hydroxytyrosyl alkyl ether derivatives inhibit platelet activation after oral administration to rats.
PubMed:Genotoxic effects induced by zearalenone in a human embryonic kidney cell line.
PubMed:Selective cytotoxic activity of new lipophilic hydroxytyrosol alkyl ether derivatives.
PubMed:A new process for obtaining hydroxytyrosol using transformed Escherichia coli whole cells with phenol hydroxylase gene from Geobacillus thermoglucosidasius.
PubMed:Olive fermentation brine: biotechnological potentialities and valorization.
PubMed:Antioxidant activity of phenolic fractions in olive mill wastewater.
PubMed:Neuroprotective effect of alkyl hydroxytyrosyl ethers in rat brain slices subjected to a hypoxia-reoxygenation model.
PubMed:Validation of micellar LC-based methods applied to analyze foodstuffs.
PubMed:A validated method for the determination of selected phenolics in olive oil using high-performance liquid chromatography with coulometric electrochemical detection and a fused-core column.
PubMed:Characterization of 3,4-DHPEA-EDA oxidation products in virgin olive oil by high performance liquid chromatography coupled with mass spectrometry.
PubMed:Hydroxytyrosyl ethyl ether exhibits stronger intestinal anticarcinogenic potency and effects on transcript profiles compared to hydroxytyrosol.
PubMed:Toxicological evaluation of pure hydroxytyrosol.
PubMed:Isolation and identification of phenolic glucosides from thermally treated olive oil byproducts.
PubMed:Anti-apoptotic activity of hydroxytyrosol and hydroxytyrosyl laurate.
PubMed:Synthesis and bioactivity profile of 5-s-lipoylhydroxytyrosol-based multidefense antioxidants with a sizeable (poly)sulfide chain.
PubMed:Naturally occurring hydroxytyrosol: synthesis and anticancer potential.
PubMed:A new hydroxytyrosol metabolite identified in human plasma: hydroxytyrosol acetate sulphate.
PubMed:Novel, biocatalytically produced hydroxytyrosol dimer protects against ultraviolet-induced cell death in human immortalized keratinocytes.
PubMed:Comprehensive analysis of polyphenols in 55 extra virgin olive oils by HPLC-ECD and their correlation with antioxidant activities.
PubMed:Phenolics profiles of olive fruits (Olea europaea L.) and oils from Ayvalık, Domat and Gemlik varieties at different ripening stages.
PubMed:Microchip electrophoresis with amperometric detection for a novel determination of phenolic compounds in olive oil.
PubMed:Impact of olive oil phenolic concentration on human plasmatic phenolic metabolites.
PubMed:Influence of harvest year, cultivar and geographical origin on Greek extra virgin olive oils composition: a study by NMR spectroscopy and biometric analysis.
PubMed:Assay of tyrosol and hydroxytyrosol in olive oil by tandem mass spectrometry and isotope dilution method.
PubMed:Recovery of hydroxytyrosol rich extract from two-phase Chemlali olive pomace by chemical treatment.
PubMed:Analysis of total contents of hydroxytyrosol and tyrosol in olive oils.
PubMed:Cytoprotective effect of hydroxytyrosyl alkyl ether derivatives after oral administration to rats in a model of glucose-oxygen deprivation in brain slices.
PubMed:Synthesis and structure/antioxidant activity relationship of novel catecholic antioxidant structural analogues to hydroxytyrosol and its lipophilic esters.
PubMed:Reuse of drinking water treatment sludge for olive oil mill wastewater treatment.
PubMed:Distribution of hydroxytyrosol and hydroxytyrosol acetate in olive oil emulsions and their antioxidant efficiency.
PubMed:Factors influencing phenolic compounds in table olives (Olea europaea).
PubMed:Alperujo extract, hydroxytyrosol, and 3,4-dihydroxyphenylglycol are bioavailable and have antioxidant properties in vitamin E-deficient rats--a proteomics and network analysis approach.
PubMed:Squalene ameliorates atherosclerotic lesions through the reduction of CD36 scavenger receptor expression in macrophages.
PubMed:Characterization of refined edible oils enriched with phenolic extracts from olive leaves and pomace.
PubMed:Hydroxytyrosol attenuates peripheral neuropathy in streptozotocin-induced diabetes in rats.
PubMed:Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans.
PubMed:The olive compound 4-hydroxytyrosol inactivates Staphylococcus aureus bacteria and Staphylococcal Enterotoxin A (SEA).
PubMed:Retraction. Does white wine qualify for French paradox? Comparison of the cardioprotective effects of red and white wines and their constituents: resveratrol, tyrosol, and hydroxytyrosol.
PubMed:The protective effects of hydroxytyrosol against ortho-phenylphenol-induced DNA damage in HepG2 cells.
PubMed:Digestive stability of hydroxytyrosol, hydroxytyrosyl acetate and alkyl hydroxytyrosyl ethers.
PubMed:A diet rich in olive oil phenolics reduces oxidative stress in the heart of SAMP8 mice by induction of Nrf2-dependent gene expression.
PubMed:Unsaturated fatty alcohol derivatives of olive oil phenolic compounds with potential low-density lipoprotein (LDL) antioxidant and antiobesity properties.
PubMed:Distribution of olive oil phenolic compounds in rat tissues after administration of a phenolic extract from olive cake.
PubMed:Antioxidant phenolic profile from ethyl acetate fraction of Fructus Ligustri Lucidi with protection against hydrogen peroxide-induced oxidative damage in SH-SY5Y cells.
PubMed:Preparation and antioxidant activity of tyrosyl and homovanillyl ethers.
PubMed:Oleuropein ameliorates acute colitis in mice.
PubMed:Enzymatic routes for the production of mono- and di-glucosylated derivatives of hydroxytyrosol.
PubMed:Changes in the content of bioactive polyphenolic compounds of olive mill wastewater by the action of exogenous enzymes.
PubMed:Ultrasonic extraction of phenols from olive mill wastewater: comparison with conventional methods.
PubMed:Direct liquid chromatography method for the simultaneous quantification of hydroxytyrosol and tyrosol in red wines.
PubMed:Wastes generated during the storage of extra virgin olive oil as a natural source of phenolic compounds.
PubMed:Comment on hydroxytyrosol induces proliferation and cytoprotection against oxidative injury in vascular endothelial cells: role of Nrf2 activation and HO-1 induction.
PubMed:Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model.
PubMed:Enzymatic hydrolysis of olive wastewater for hydroxytyrosol enrichment.
PubMed:Bioavailability of phenols from a phenol-enriched olive oil.
PubMed:Structure and function of the oxidation products of polyphenols and identification of potent lipoxygenase inhibitors from Fe-catalyzed oxidation of resveratrol.
PubMed:Influence of cultivar and concentration of selected phenolic constituents on the in vitro chemiopreventive potential of olive oil extracts.
PubMed:Determination of 3,4-dihydroxyphenylglycol, hydroxytyrosol and tyrosol purified from olive oil by-products with HPLC in animal plasma and tissues.
PubMed:Antimicrobial activity of olive solutions from stored Alpeorujo against plant pathogenic microorganisms.
PubMed:Tyrosol and hydroxytyrosol, two main components of olive oil, protect N2a cells against amyloid-β-induced toxicity. Involvement of the NF-κB signaling.
PubMed:New possibilities for the valorization of olive oil by-products.
PubMed:Alkyl hydroxytyrosyl ethers show protective effects against oxidative stress in HepG2 cells.
PubMed:Functional milk beverage fortified with phenolic compounds extracted from olive vegetation water, and fermented with functional lactic acid bacteria.
PubMed:Hydroxytyrosol induces proliferation and cytoprotection against oxidative injury in vascular endothelial cells: role of Nrf2 activation and HO-1 induction.
PubMed:Oleuropein and derivatives from olives as Tau aggregation inhibitors.
PubMed:High-throughput assay of oleopentanedialdheydes in extra virgin olive oil by the UHPLC-ESI-MS/MS and isotope dilution methods.
PubMed:Chemical and cellular antioxidant activity of phytochemicals purified from olive mill waste waters.
PubMed:Influence of Eriophyid mites (Aculus olearius Castagnoli and Aceria oleae (Nalepa) (Acarina: Eriophyidae)) on some physical and chemical characteristics of Ayvalık variety olive fruit.
PubMed:Use of multivariate statistical techniques to optimize the simultaneous separation of 13 phenolic compounds from extra-virgin olive oil by capillary electrophoresis.
PubMed:Possible involvement of oxidative stress in potassium bromate-induced genotoxicity in human HepG2 cells.
PubMed:Effects of conventional heating on the stability of major olive oil phenolic compounds by tandem mass spectrometry and isotope dilution assay.
PubMed:Hydroxytyrosol inhibits growth and cell proliferation and promotes high expression of sfrp4 in rat mammary tumours.
PubMed:Phenol metabolism in the leaves of the olive tree (Olea europaea L.) cv. Picual, Verdial, Arbequina, and Frantoio during ripening.
PubMed:β-cyclodextrin and caffeine complexes with natural polyphenols from olive and olive oils: NMR, thermodynamic, and molecular modeling studies.
PubMed:Hydroxytyrosol rich extract from olive leaves modulates cell cycle progression in MCF-7 human breast cancer cells.
PubMed:Characterization of antioxidant olive oil biophenols by spectroscopic methods.
PubMed:Transepithelial transport and metabolism of new lipophilic ether derivatives of hydroxytyrosol by enterocyte-like Caco-2/TC7 cells.
PubMed:Hydroxytyrosol acyl esters: biosynthesis and activities.
PubMed:Sensory quality of functional beverages: bitterness perception and bitter masking of olive leaf extract fortified fruit smoothies.
PubMed:Improving biocatalyst performance by integrating statistical methods into protein engineering.
PubMed:Protective effect of simple phenols from extravirgin olive oil against lipid peroxidation in intestinal Caco-2 cells.
PubMed:Antioxidant activity of resveratrol in several fish lipid matrices: effect of acylation and glucosylation.
PubMed:Biological activity of high molecular weight phenolics from olive mill wastewater.
PubMed:Recent patents in olive oil industry: New technologies for the recovery of phenols compounds from olive oil, olive oil industrial by-products and waste waters.
PubMed:HPLC analysis of oleuropein, hydroxytyrosol, and tyrosol in stems and roots of Olea europaea L. cv. Picual during ripening.
PubMed:Recovery and concentration of polyphenols from olive mill wastewaters by integrated membrane system.
PubMed:Oil content, phenolic profiling and antioxidant potential of Tunisian olive drupes.
PubMed:Surface-active properties of lipophilic antioxidants tyrosol and hydroxytyrosol fatty acid esters: a potential explanation for the nonlinear hypothesis of the antioxidant activity in oil-in-water emulsions.
PubMed:Hydroxytyrosol: from laboratory investigations to future clinical trials.
PubMed:Fatty acid hydroxytyrosyl esters: structure/antioxidant activity relationship by ABTS and in cell-culture DCF assays.
PubMed:Effect of olive ripeness on chemical properties and phenolic composition of Chétoui virgin olive oil.
PubMed:Hydroxytyrosol induces antioxidant/detoxificant enzymes and Nrf2 translocation via extracellular regulated kinases and phosphatidylinositol-3-kinase/protein kinase B pathways in HepG2 cells.
PubMed:Elevated circulating LDL phenol levels in men who consumed virgin rather than refined olive oil are associated with less oxidation of plasma LDL.
PubMed:Uptake and metabolism of new synthetic lipophilic derivatives, hydroxytyrosyl ethers, by human hepatoma HepG2 cells.
PubMed:Involvement of ERK, Akt and JNK signalling in H2O2-induced cell injury and protection by hydroxytyrosol and its metabolite homovanillic alcohol.
PubMed:Oleuropein and hydroxytyrosol inhibit MCF-7 breast cancer cell proliferation interfering with ERK1/2 activation.
PubMed:Bactericidal activity of glutaraldehyde-like compounds from olive products.
PubMed:Identification of Throuba Thassos, a traditional Greek table olive variety, as a nutritional rich source of oleuropein.
PubMed:Powerful protective role of 3,4-dihydroxyphenylethanol-elenolic acid dialdehyde against erythrocyte oxidative-induced hemolysis.
PubMed:Improved method for identifying and quantifying olive oil phenolic compounds and their metabolites in human plasma by microelution solid-phase extraction plate and liquid chromatography-tandem mass spectrometry.
PubMed:Synthesis, biological evaluation, and molecular modeling of oleuropein and its semisynthetic derivatives as cyclooxygenase inhibitors.
PubMed:Tentative characterization of novel phenolic compounds in extra virgin olive oils by rapid-resolution liquid chromatography coupled with mass spectrometry.
PubMed:Phenylalanine ammonia-lyase, polyphenol oxidase, and phenol concentration in fruits of Olea europaea L. cv. Picual, Verdial, Arbequina, and Frantoio during ripening.
PubMed:Effect of lipophilization of hydroxytyrosol on its antioxidant activity in fish oils and fish oil-in-water emulsions.
PubMed:Alcohol consumption is associated with high concentrations of urinary hydroxytyrosol.
PubMed:Antidiabetic and antioxidant effects of hydroxytyrosol and oleuropein from olive leaves in alloxan-diabetic rats.
PubMed:Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1.
PubMed:Gingival vascular damage in atherosclerotic rabbits: hydroxytyrosol and squalene benefits.
PubMed:3,4-Dihydroxyphenylglycol (DHPG): an important phenolic compound present in natural table olives.
PubMed:Production of hydrogen peroxide is responsible for the induction of apoptosis by hydroxytyrosol on HL60 cells.
PubMed:Enhanced bactericidal activity of enterocin AS-48 in combination with essential oils, natural bioactive compounds and chemical preservatives against Listeria monocytogenes in ready-to-eat salad.
PubMed:Mechanism of the antiviral effect of hydroxytyrosol on influenza virus appears to involve morphological change of the virus.
PubMed:Olive oil phenolic compounds inhibit homocysteine-induced endothelial cell adhesion regardless of their different antioxidant activity.
PubMed:Effects of olive oil polyphenols on erythrocyte oxidative damage.
PubMed:Effect of malaxation conditions on phenol and volatile profiles in olive paste and the corresponding virgin olive oils (Olea europaea L. Cv. Cornicabra).
PubMed:Phenolic composition, sugar contents and antioxidant activity of Tunisian sweet olive cultivar with regard to fruit ripening.
PubMed:Saline water irrigation effects on fruit development, quality, and phenolic composition of virgin olive oils, cv. Chemlali.
PubMed:Impact of sampling parameters on the radical scavenging potential of olive (Olea europaea L.) leaves.
PubMed:Methods for preparing phenolic extracts from olive cake for potential application as food antioxidants.
PubMed:New lipophilic tyrosyl esters. Comparative antioxidant evaluation with hydroxytyrosyl esters.
PubMed:Does white wine qualify for French paradox? Comparison of the cardioprotective effects of red and white wines and their constituents: resveratrol, tyrosol, and hydroxytyrosol.
PubMed:Bioavailability of olive oil phenolic compounds in humans.
PubMed:Major phenolic compounds in olive oil modulate bone loss in an ovariectomy/inflammation experimental model.
PubMed:Nutritional benefit of olive oil: the biological effects of hydroxytyrosol and its arylating quinone adducts.
PubMed:Convenient synthesis of hydroxytyrosol and its lipophilic derivatives from tyrosol or homovanillyl alcohol.
PubMed:Effects of hydroxytyrosol and hydroxytyrosol acetate administration to rats on platelet function compared to acetylsalicylic acid.
PubMed:Protective effect of hydroxytyrosol and its metabolite homovanillic alcohol on H(2)O(2) induced lipid peroxidation in renal tubular epithelial cells.
PubMed:Isolation and characterization of a new hydroxytyrosol derivative from olive (Olea europaea) leaves.
PubMed:Correlations of the phenolic compounds and the phenolic content in some Spanish and French olive oils.
PubMed:Tunisian table olive phenolic compounds and their antioxidant capacity.
PubMed:Hydroxytyrosol prevents oxidative deterioration in foodstuffs rich in fish lipids.
PubMed:Lipid-lowering and antioxidant effects of hydroxytyrosol and its triacetylated derivative recovered from olive tree leaves in cholesterol-fed rats.
PubMed:Effect of the maturation process on the phenolic fractions, fatty acids, and antioxidant activity of the Chétoui olive fruit cultivar.
PubMed:Oxidative transformation of natural and synthetic phenolic mixtures by Trametes versicolor laccase.
PubMed:Main antimicrobial compounds in table olives.
PubMed:Chemical screening of olive biophenol extracts by hyphenated liquid chromatography.
PubMed:Phenolic molecules in virgin olive oils: a survey of their sensory properties, health effects, antioxidant activity and analytical methods. An overview of the last decade.
PubMed:Inhibitory effects of olive oil phenolics on invasion in human colon adenocarcinoma cells in vitro.
PubMed:Bioconversion of tyrosol into hydroxytyrosol and 3,4-dihydroxyphenylacetic acid under hypersaline conditions by the new Halomonas sp. strain HTB24.
PubMed:How heating affects extra virgin olive oil quality indexes and chemical composition.
PubMed:Inhibition of p38/CREB phosphorylation and COX-2 expression by olive oil polyphenols underlies their anti-proliferative effects.
PubMed:New insights into controversies on the antioxidant potential of the olive oil antioxidant hydroxytyrosol.
PubMed:Hydroxytyrosol-rich olive mill wastewater extract protects brain cells in vitro and ex vivo.
PubMed:Evaluation of the influence of thermal oxidation on the phenolic composition and on the antioxidant activity of extra-virgin olive oils.
PubMed:Mild photochemical synthesis of the antioxidant hydroxytyrosol via conversion of tyrosol.
PubMed:Small branches of olive tree: a source of biophenols complementary to olive leaves.
PubMed:Static-dynamic superheated liquid extraction of hydroxytyrosol and other biophenols from alperujo (a semisolid residue of the olive oil industry).
PubMed:High-yielding preparation of a stable precursor of hydroxytyrosol by total synthesis and from the natural glycoside oleuropein.
PubMed:Presence of virgin olive oil phenolic metabolites in human low density lipoprotein fraction: determination by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.
PubMed:Novel secoiridoids with antioxidant activity from Australian olive mill waste.
PubMed:A new process for the management of olive oil mill waste water and recovery of natural antioxidants.
PubMed:Bioscreening of Australian olive mill waste extracts: biophenol content, antioxidant, antimicrobial and molluscicidal activities.
PubMed:Hypocholesterolemic effects of phenolic extracts and purified hydroxytyrosol recovered from olive mill wastewater in rats fed a cholesterol-rich diet.
PubMed:Comparison of analytical methodologies based on 1h and 31p NMR spectroscopy with conventional methods of analysis for the determination of some olive oil constituents.
PubMed:Effect of steam treatment of alperujo on the composition, enzymatic saccharification, and in vitro digestibility of alperujo.
PubMed:Production of high hydroxytyrosol yields via tyrosol conversion by Pseudomonas aeruginosa immobilized resting cells.
PubMed:Production of triacetylhydroxytyrosol from olive mill waste waters for use as stabilized bioantioxidant.
PubMed:Table olives from Portugal: phenolic compounds, antioxidant potential, and antimicrobial activity.
PubMed:Phenolic and volatile compounds of extra virgin olive oil (Olea europaea L. Cv. Cornicabra) with regard to fruit ripening and irrigation management.
PubMed:Tyrosol, the major extra virgin olive oil compound, restored intracellular antioxidant defences in spite of its weak antioxidative effectiveness.
PubMed:Effects of olive oil and its minor constituents on serum lipids, oxidative stress, and energy metabolism in cardiac muscle.
PubMed:Comparison of the concentrations of phenolic compounds in olive oils and other plant oils: correlation with antimicrobial activity.
PubMed:Inhibition of hemoglobin- and iron-promoted oxidation in fish microsomes by natural phenolics.
PubMed:The fate of olive oil polyphenols in the gastrointestinal tract: implications of gastric and colonic microflora-dependent biotransformation.
PubMed:The use of Lactobacillus pentosus 1MO to shorten the debittering process time of black table olives (Cv. Itrana and Leccino): a pilot-scale application.
PubMed:Lipophilic hydroxytyrosyl esters. Antioxidant activity in lipid matrices and biological systems.
PubMed:Effects of copper on the antioxidant activity of olive polyphenols in bulk oil and oil-in-water emulsions.
PubMed:Minor components of olive oil modulate proatherogenic adhesion molecules involved in endothelial activation.
PubMed:Antioxidant effect of two virgin olive oils depends on the concentration and composition of minor polar compounds.
PubMed:Daily consumption of a high-phenol extra-virgin olive oil reduces oxidative DNA damage in postmenopausal women.
PubMed:Storage of olives (Olea europaea L.) under CO2 atmosphere: liquid chromatography-mass spectrometry characterization of indices related to changes in polyphenolic metabolism.
PubMed:Safety assessment of aqueous olive pulp extract as an antioxidant or antimicrobial agent in foods.
PubMed:Physicochemical properties of natural phenolics from grapes and olive oil byproducts and their antioxidant activity in frozen horse mackerel fillets.
PubMed:Investigation of Australian olive mill waste for recovery of biophenols.
PubMed:Metabolism of the olive oil phenols hydroxytyrosol, tyrosol, and hydroxytyrosyl acetate by human hepatoma HepG2 cells.
PubMed:Protective effects of synthetic hydroxytyrosol acetyl derivatives against oxidative stress in human cells.
PubMed:Colorimetric evaluation of phenolic content and GC-MS characterization of phenolic composition of alimentary and cosmetic argan oil and press cake.
PubMed:Model study on the effect of 15 phenolic olive mill wastewater constituents on seed germination and Vibrio fischeri metabolism.
PubMed:Synthesis of hydroxytyrosol, 2-hydroxyphenylacetic acid, and 3-hydroxyphenylacetic acid by differential conversion of tyrosol isomers using Serratia marcescens strain.
PubMed:Development of a sensitive and specific solid phase extraction--gas chromatography-tandem mass spectrometry method for the determination of elenolic acid, hydroxytyrosol, and tyrosol in rat urine.
PubMed:Relationships between oxidative stability, triacylglycerol composition, and antioxidant content in olive oil matrices.
PubMed:Kinetic study of the physicochemical and microbiological changes in "seasoned" olives during the shelf-life period.
PubMed:Effect of the conservation procedure on the contents of phenolic compounds and organic acids in chanterelle (Cantharellus cibarius) mushroom.
PubMed:Separation and identification of phenolic compounds in olive oil by coupling high-performance liquid chromatography with postcolumn solid-phase extraction to nuclear magnetic resonance spectroscopy (LC-SPE-NMR).
PubMed:Alpha-tocopherol oxidation in fish muscle during chilling and frozen storage.
PubMed:Antioxidant and anti-atherogenic activities of olive oil phenolics.
PubMed:Interactions of ferric ions with olive oil phenolic compounds.
PubMed:Antioxidant activity of olive pulp and olive oil phenolic compounds of the arbequina cultivar.
PubMed:Secoiridoids, tocopherols, and antioxidant activity of monovarietal extra virgin olive oils extracted from destoned fruits.
PubMed:Characterization of a new tyrosinase from Pycnoporus species with high potential for food technological applications.
PubMed:Radical scavenging potential of phenolic compounds encountered in O. europaea products as indicated by calculation of bond dissociation enthalpy and ionization potential values.
PubMed:Identification and antioxidant potential of flavonoids and low molecular weight phenols in olive cultivar chemlali growing in Tunisia.
PubMed:Phenolic compounds in olive oils intended for refining: formation of 4-ethylphenol during olive paste storage.
PubMed:Qualitative and semiquantitative analysis of phenolic compounds in extra virgin olive oils as a function of the ripening degree of olive fruits by different analytical techniques.
PubMed:Total recovery of the waste of two-phase olive oil processing: isolation of added-value compounds.
PubMed:Comparative study on phenolic content and antioxidant activity during maturation of the olive cultivar Chemlali from Tunisia.
PubMed:Removal of monomeric phenols in dry mill olive residue by saprobic fungi.
PubMed:Polyphenol changes during fermentation of naturally black olives.
PubMed:Effect of cultivar and processing method on the contents of polyphenols in table olives.
PubMed:Toward a high yield recovery of antioxidants and purified hydroxytyrosol from olive mill wastewaters.
PubMed:Biogenic amine formation and "zapatera" spoilage of fermented green olives: effect of storage temperature and debittering process.
PubMed:Antioxidant effect of phenolic compounds, alpha-tocopherol, and other minor components in virgin olive oil.
PubMed:Hydroxytyrosol excretion differs between rats and humans and depends on the vehicle of administration.
PubMed:Quantitative changes in phenolic content during physiological development of the olive (Olea europaea) cultivar Hardy's Mammoth.
PubMed:Isolation, structure elucidation and antioxidant potential of the major phenolic and flavonoid compounds in brined olive drupes.
PubMed:Environmental effects caused by olive mill wastewaters: toxicity comparison of low-molecular-weight phenol components.
PubMed:Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer.
PubMed:Changes in phenolic composition and antioxidant activity of virgin olive oil during frying.
PubMed:Radioprotective effects in vivo of phenolics extracted from Olea europaea L. leaves against X-ray-induced chromosomal damage: comparative study versus several flavonoids and sulfur-containing compounds.
PubMed:Comparison of the antioxidant activities of extra virgin olive oils.
PubMed:Phenolic compounds profile of cornicabra virgin olive oil.
PubMed:Production in large quantities of highly purified hydroxytyrosol from liquid-solid waste of two-phase olive oil processing or "Alperujo".
PubMed:Influence of thermal treatments simulating cooking processes on the polyphenol content in virgin olive oil.
PubMed:Olive oil phenolics: effects on DNA oxidation and redox enzyme mRNA in prostate cells.
PubMed:Olea europaea L. leaf extract and derivatives: antioxidant properties.
PubMed:Deterioration of natural antioxidant species of vegetable edible oils during the domestic deep-frying and pan-frying of potatoes.
PubMed:Hydroxytyrosol 4-beta-D-glucoside, an important phenolic compound in olive fruits and derived products.
PubMed:Biophenols in table olives.
PubMed:Biological properties of olive oil phytochemicals.
PubMed:Partition behavior of virgin olive oil phenolic compounds in oil-brine mixtures during thermal processing for fish canning.
PubMed:Comparison of radical scavenging effect, inhibition of microsomal oxygen free radical generation, and serum lipoprotein oxidation of several natural antioxidants.
PubMed:Structural characterization of the metabolites of hydroxytyrosol, the principal phenolic component in olive oil, in rats.
PubMed:Supplementation of plasma with olive oil phenols and extracts: influence on LDL oxidation.
PubMed:Changes occurring in phenolic compounds and alpha-tocopherol of virgin olive oil during storage.
PubMed:Bioactive derivatives from oleuropein by a biotransformation on Olea europaea leaf extracts.
PubMed:Acid hydrolysis of secoiridoid aglycons during storage of virgin olive oil.
PubMed:Changes in the phenolic composition of virgin olive oil from young trees (Olea europaea L. cv. Arbequina) grown under linear irrigation strategies.
PubMed:Reduction of oil bitterness by heating of olive (Olea europaea) fruits.
PubMed:Inactivation of cytochrome P450 by the food-derived complex phenol oleuropein.
PubMed:Antioxidant activity of the main bioactive derivatives from oleuropein hydrolysis by hyperthermophilic beta-glycosidase.
PubMed:Antioxidant activity of hydroxytyrosol acetate compared with that of other olive oil polyphenols.
PubMed:Effect of enzyme treatment during mechanical extraction of olive oil on phenolic compounds and polysaccharides.
PubMed:Synthesis of the antioxidant hydroxytyrosol using tyrosinase as biocatalyst.
PubMed:Hydroxytyrosol, as a component of olive mill waste water, is dose- dependently absorbed and increases the antioxidant capacity of rat plasma.
PubMed:Phenolic Compounds in Different Olive Varieties.
PubMed:Synthesis of tritium-labeled hydroxytyrosol, a phenolic compound found in olive Oil.
PubMed:Phenolic compounds and squalene in olive oils: the concentration and antioxidant potential of total phenols, simple phenols, secoiridoids, lignansand squalene.
PubMed:Oleuropein site selective hydrolysis by technomimetic nuclear magnetic resonance experiments.
PubMed:Predictive study on Tuscan extra virgin olive oil stability under several commercial conditions.
PubMed:Rapid evaluation of phenolic component profile and analysis of oleuropein aglycon in olive oil by atmospheric pressure chemical ionization-mass spectrometry (APCI-MS).
PubMed:Phenolic compounds in Spanish olive oils.
PubMed:A highly convenient synthesis of hydroxytyrosol and its recovery from agricultural waste waters.
PubMed:Analytical evaluation of virgin olive oil of first and second extraction.
PubMed:On the in-vitro antimicrobial activity of oleuropein and hydroxytyrosol.
PubMed:Dietary non-tocopherol antioxidants present in extra virgin olive oil increase the resistance of low density lipoproteins to oxidation in rabbits.
PubMed:Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol.
PubMed:Gas chromatographic/mass spectrometric methodology for simultaneous assay of salsolinol, dopamine, norepinephrine, dihydroxyphenylacetic acid and dihydroxyphenylethanol.
PubMed:Comparison of high-performance liquid chromatography with electrochemical detection and gas chromatography-mass fragmentography for the assay of salsolinol, dopamine and dopamine metabolites in food and beverage samples.
 
Notes:
serotonin metabolite. Indicator of maturity in olives which increases as the fruit ripens [DFC]
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