EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

astragalin
kaempferol-3-O-glucoside

Supplier Sponsors

Name:5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
CAS Number: 480-10-4Picture of molecule3D/inchi
FDA UNII: APM8UQ3Z9O
Nikkaji Web:J12.462A
MDL:MFCD00075932
XlogP3-AA:0.70 (est)
Molecular Weight:448.38160000
Formula:C21 H20 O11
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 823.20 °C. @ 760.00 mm Hg (est)
Flash Point: 557.00 °F. TCC ( 291.60 °C. ) (est)
logP (o/w): 1.950 (est)
Soluble in:
 water, 1.366e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Astragalin 98%
BOC Sciences
For experimental / research use only.
Astragalin
ExtraSynthese
For experimental / research use only.
Kaempferol-3-O-glucoside (HPLC) ≥99%
Santa Cruz Biotechnology
For experimental / research use only.
Kaempferol-3-glucoside ≥95%
Sigma-Aldrich: Sigma
For experimental / research use only.
Kaempferol 3-β-D-glucopyranoside ≥97.0% (HPLC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for astragalin usage levels up to:
 not for fragrance use.
 
Recommendation for astragalin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5282102
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
Chemidplus:0000480104
RTECS:DJ3080000 for cas# 480-10-4
 
References:
 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5282102
Pubchem (sid):135032677
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C12249
HMDB (The Human Metabolome Database):HMDB37429
FooDB:FDB016478
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 anise star anise plant
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 apricot plant
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 basswood flower
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 bay laurel leaf
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 bean fava bean fruit
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 bilberry fruit
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 bilberry leaf
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 caraway seed
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 carrot root
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 carrot seed
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 chicory leaf
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 chicory plant
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 chive leaf
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 clove fruit
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 corn pollen
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 currant black currant fruit juice
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 currant black currant leaf
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 elder black elder flower
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 elder black elder plant
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 endive leaf
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 fig fruit
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 ginkgo biloba leaf
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 grape fruit
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 grape leaf
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 grape plant
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 hazelnut leaf
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 horseradish leaf
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 leek
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 leek wild leek plant
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 lupine white lupine
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 peach plant
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 pear plant
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 pepper black pepper fruit
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 persimmon
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 pokeweed leaf
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 safflower
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 saffron flower
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 soybean leaf
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 soybean shoot
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 spinach shoot
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 tea leaf
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 wine red wine
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Synonyms:
 astragaline
4H-1-benzopyran-4-one, 3-(beta-D-glucopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-
5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
 kaempferol-3-beta-glucopyranoside
 kaempferol-3-beta-monoglucoside
 kaempferol-3-glucoside
 kaempferol-3-O-glucoside
3,4',5,7-tetrahydroxyflavone-3-glucoside
 

Articles:

PubMed:Changes of major tea polyphenols and production of four new B-ring fission metabolites of catechins from post-fermented Jing-Wei Fu brick tea.
PubMed:Cuscuta chinensis Lam.: A systematic review on ethnopharmacology, phytochemistry and pharmacology of an important traditional herbal medicine.
PubMed:Chemical constituents of Morus alba L. and their inhibitory effect on 3T3-L1 preadipocyte proliferation and differentiation.
PubMed:Astragalin inhibits airway eotaxin-1 induction and epithelial apoptosis through modulating oxidative stress-responsive MAPK signaling.
PubMed:Antioxidant activities and polyphenol content of Morus alba leaf extracts collected from varying regions.
PubMed:Inhibitory effects of astragalin on lipopolysaccharide-induced inflammatory response in mouse mammary epithelial cells.
PubMed:Flavonols and derivatives of gallic acid from young leaves of Toona sinensis (A. Juss.) Roemer and evaluation of their anti-oxidant capacity by chemical methods.
PubMed:Isolation, structural elucidation and anti-inflammatory activity of astragalin, (-)hinokinin, aristolactam I and aristolochic acids (I & II) from Aristolochia indica.
PubMed:Variation of quantitative composition of phenolic compounds in rowan (Sorbus aucuparia L.) leaves during the growth season.
PubMed:Quantitative Changes of Polyphenolic Compounds in Mulberry (Morus alba L.) Leaves in Relation to Varieties, Harvest Period, and Heat Processing.
PubMed:Simultaneous analysis and peroxynitrite-scavenging activity of galloylated flavonoid glycosides and ellagic acid in Euphorbia supina.
PubMed:[Chemical constituents from Psoralea corylifolia and their antioxidant alpha-glucosidase inhibitory and antimicrobial activities].
PubMed:Flavonoids with α-glucosidase inhibitory activities and their contents in the leaves of Morus atropurpurea.
PubMed:Varietal differences in the flavonol content of mulberry (Morus spp.) leaves and genetic analysis of quercetin 3-(6-malonylglucoside) for component breeding.
PubMed:Astragalin suppresses inflammatory responses via down-regulation of NF-κB signaling pathway in lipopolysaccharide-induced mastitis in a murine model.
PubMed:[HPLC-MS/MS for determination of astragalin in rat plasma and its pharmacokinetics].
PubMed:Extracts of Koelreuteria henryi Dummer induce apoptosis and autophagy by inhibiting dihydrodiol dehydrogenase, thus enhancing anticancer effects.
PubMed:A sensitive LC-MS/MS method for simultaneous determination of six flavonoids in rat plasma: application to a pharmacokinetic study of total flavonoids from mulberry leaves.
PubMed:LC-NMR, NMR, and LC-MS identification and LC-DAD quantification of flavonoids and ellagic acid derivatives in Drosera peltata.
PubMed:Simultaneous HPLC quantitative analysis of active compounds in leaves of Moringa oleifera Lam.
PubMed:Flavonoids from Pseudotsuga menziesii.
PubMed:Phenolic antioxidants from Rosa soulieana flowers.
PubMed:[Chemical constituents from leaves of Nelumbo nucifera].
PubMed:Hypoglycemic and anti-hyperglycemic study of Gynura procumbens leaf extracts.
PubMed:Role of gastric mucus secretion, oxinitrergic system and sulfhydryl groups on the gastroprotection elicited by Polygala cyparissias (Polygalaceae) in mice.
PubMed:Regiospecific modifications of naringenin for astragalin production in Escherichia coli.
PubMed:Simultaneous Determination of Crypto-Chlorogenic Acid, Isoquercetin, and Astragalin Contents in Moringa oleifera Leaf Extracts by TLC-Densitometric Method.
PubMed:Determination of major components and fingerprint analysis of Flaveria bidentis (L.) Kuntze.
PubMed:Antioxidant effect of astragalin isolated from the leaves of Morus alba L. against free radical-induced oxidative hemolysis of human red blood cells.
PubMed:Phenolics and antioxidant activity of mulberry leaves depend on cultivar and harvest month in Southern China.
PubMed:Antioxidant changes of leek (Allium ampeloprasum var. porrum) during spontaneous fermentation of the white shaft and green leaves.
PubMed:[Analysis of fingerprint and bioactive components of Bidens biternata by HPLC].
PubMed:The environmental and human effects of ptaquiloside-induced enzootic bovine hematuria: a tumorous disease of cattle.
PubMed:[Study on neuroprotective effects of astragalan in rats with ischemic brain injury and its mechanisms].
PubMed:Novel synthesis of leucoside by enzymatic hydrolysis of tea seed extract.
PubMed:The effect of astragalin on the VEGF production of cultured Müller cells under high glucose conditions.
PubMed:[Study on the chemical constituets in ethyl acetante extraction from semen litchi].
PubMed:Rapid screening and identification of α-glucosidase inhibitors from mulberry leaves using enzyme-immobilized magnetic beads coupled with HPLC/MS and NMR.
PubMed:[Chemical constituents of flavonoids from flowers of Koelreuteria paniculata].
PubMed:[Separation and purification of flavones from Nelumbo nucifera Gaertn. by silica gel chromatography and high-speed counter-current chromatography].
PubMed:Astragalin from Cassia alata Induces DNA Adducts in Vitro and Repairable DNA Damage in the Yeast Saccharomyces cerevisiae.
PubMed:A new norisoprenoid and other compounds from Fuzhuan brick tea.
PubMed:Astragalin attenuates lipopolysaccharide-induced inflammatory responses by down-regulating NF-κB signaling pathway.
PubMed:Theoretical investigation of the effect of sugar substitution on the antioxidant properties of flavonoids.
PubMed:Key role of chemical hardness to compare 2,2-diphenyl-1-picrylhydrazyl radical scavenging power of flavone and flavonol O-glycoside and C-glycoside derivatives.
PubMed:Inhibitory effect of astragalin on expression of lipopolysaccharide-induced inflammatory mediators through NF-κB in macrophages.
PubMed:Determination of astragalin and astragaloside content in Radix Astragali using high-performance liquid chromatography coupled with pulsed amperometric detection.
PubMed:Glucosylation of the flavonoid, astragalin by Leuconostoc mesenteroides B-512FMCM dextransucrase acceptor reactions and characterization of the products.
PubMed:Change of supercooling capability in solutions containing different kinds of ice nucleators by flavonol glycosides from deep supercooling xylem parenchyma cells in trees.
PubMed:[Chemical constituents from Exochorda racemosa].
PubMed:Activity-guided isolation and identification of free radical-scavenging components from various leaf extracts of Sorbus aria (L.) Crantz.
PubMed:[Studies on flavonoids from the leaves of Lindera aggregata].
PubMed:Metabolism of quercetin by Cunninghamella elegans ATCC 9245.
PubMed:Differentiation of Cuscuta chinensis and Cuscuta australis by HPLC-DAD-MS analysis and HPLC-UV quantitation.
PubMed:Astragalin heptaacetate-induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway.
PubMed:Isolation and tyrosinase inhibitory effects of polyphenols from the leaves of persimmon, Diospyros kaki.
PubMed:Isolation and anti-inflammatory effect of astragalin synthesized by enzymatic hydrolysis of tea seed extract.
PubMed:A dimeric triterpenoid glycoside and flavonoid glycosides with free radical-scavenging activity isolated from Rubus rigidus var. camerunensis.
PubMed:Antiosteoporotic compounds from seeds of Cuscuta chinensis.
PubMed:HPLC analysis of kaempherol and quercetin derivatives isolated by different extraction techniques from plant matrix.
PubMed:A new ursane-type triterpenoid glycoside from Centella asiatica leaves modulates the production of nitric oxide and secretion of TNF-α in activated RAW 264.7 cells.
PubMed:Metabolite profiling and antioxidant activity of Prunus padus L. flowers and leaves.
PubMed:Separation of patuletin-3-O-glucoside, astragalin, quercetin, kaempferol and isorhamnetin from Flaveria bidentis (L.) Kuntze by elution-pump-out high-performance counter-current chromatography.
PubMed:[Studies on the chemical constituents from the aerial parts of Gladiolus gandavensis].
PubMed:Ellagitannins from Phyllanthus muellerianus (Kuntze) Exell.: Geraniin and furosin stimulate cellular activity, differentiation and collagen synthesis of human skin keratinocytes and dermal fibroblasts.
PubMed:Comprehensive separation and identification of chemical constituents from Apocynum venetum leaves by high-performance counter-current chromatography and high performance liquid chromatography coupled with mass spectrometry.
PubMed:Phenolic glycosides from Agrimonia pilosa.
PubMed:Solvent gradient elution for comprehensive separation of constituents with wide range of polarity in Apocynum venetum leaves by high-speed counter-current chromatography.
PubMed:The constituents of Urtica cannabina used in Uighur medicine.
PubMed:Separation and identification of flavonoids from fistular onion stalk (Allium fisturosum L. var. Caespitosum Makio).
PubMed:Flavonoids and antioxidant activity of Rosa agrestis leaves.
PubMed:[Spectroscopic investigation on the interaction between astragalin from lotus leaf and DNA].
PubMed:Isolation and characterization of nicotiflorin obtained by enzymatic hydrolysis of two precursors in tea seed extract.
PubMed:SEPARATION OF THE MINOR FLAVONOLS FROM FLOS GOSSYPII BY HIGH-SPEED COUNTERCURRENT CHROMATOGRAPHY.
PubMed:Chemical composition and antimicrobial activity of wild garlic Allium ursinum of Bulgarian origin.
PubMed:Isolation and purification of three flavonoid glycosides from the leaves of Nelumbo nucifera (Lotus) by high-speed counter-current chromatography.
PubMed:A new rearranged abietane diterpene and other constituents from Clerodendrum philipinum.
PubMed:Assessing potential effects of inulin and probiotic bacteria on Fe availability from common beans (Phaseolus vulgaris L.) to Caco-2 cells.
PubMed:Rhusonoside A, a new megastigmane glycoside from Rhus sylvestris, increases the function of osteoblastic MC3T3-E1 cells.
PubMed:A new phenylpropanoid glycoside from Jasminum subtriplinerve Blume.
PubMed:Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells.
PubMed:Calpain inhibitory flavonoids isolated from Orostachys japonicus.
PubMed:[Chemical contrast research on Buyang Huanwu complex ultramicro powder soak and traditional decoction].
PubMed:Identification of hop polyphenolic components which inhibit prostaglandin E2 production by gingival epithelial cells stimulated with periodontal pathogen.
PubMed:Phytochemical investigation of Tiarella polyphylla.
PubMed:Inflammatory responses of gingival epithelial cells stimulated with Porphyromonas gingivalis vesicles are inhibited by hop-associated polyphenols.
PubMed:[Studies on chemical constituentsfrom leaves of Acer truncatum].
PubMed:[Chemical study on aerial parts of Ligusticum chuanxiong].
PubMed:Constituents from the leaves of Nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice.
PubMed:[Studies on chemical constituents from leaves of Sapium sebiferum].
PubMed:Chemical constituents from leaves of Celastrus gemmatus Loes.
PubMed:Flavonoids from Astragalus hamosus.
PubMed:[Flavonoids: efficient protectors of glucose-6-phosphate dehydrogenase from ultrasonic cavitation-induced inactivation].
PubMed:[Isolation and preparation of flavonoids from the leaves of Nelumbo nucifera Gaertn by preparative reversed-phase high performance liquid chromatography].
PubMed:A New Rosmarinic Acid Derivative from Isodon oresbius.
PubMed:SPE-HPLC method for the determination of four flavonols in rat plasma and urine after oral administration of Abelmoschus manihot extract.
PubMed:Kaempferol in red and pinto bean seed (Phaseolus vulgaris L.) coats inhibits iron bioavailability using an in vitro digestion/human Caco-2 cell model.
PubMed:Additional antiprotozoal flavonol glycosides of the aerial parts of Helianthemum glomeratum.
PubMed:Effects of different organic farming methods on the concentration of phenolic compounds in sea buckthorn leaves.
PubMed:[Flavonoids as effective protectors of urease from ultrasonic inactivation in solutions].
PubMed:High-performance liquid chromatographic identification of flavonoid monoglycosides from Prunus serotina ehrh.
PubMed:Structural studies of zoospore attractants from Trachelospermum jasminoides var. pubescens: taxifolin 3-O-glycosides.
PubMed:[HPLC investigation of antioxidant components in Solidago herba].
PubMed:Hepatoprotective effect of flavonol glycosides rich fraction from Egyptian Vicia calcarata Desf. against CCl4-induced liver damage in rats.
PubMed:Dihydrostilbene derivatives from Glycyrrhiza glabra leaves.
PubMed:[Study on flavonoids from leaf of Ipomoea batatas].
PubMed:Characterization of phenolic compounds in the Chinese herbal drug Tu-Si-Zi by liquid chromatography coupled to electrospray ionization mass spectrometry.
PubMed:Caesaldecan, a cassane diterpenoid from the leaves of Caesalpinia decapetala.
PubMed:[Study on the flavonoids of Eupatorium lindleyanum].
PubMed:Four new prenylated isoflavonoids in Tadehagi triquetrum.
PubMed:Flavonol glycosides from the leaves of Eucommia ulmoides O. with glycation inhibitory activity.
PubMed:Flavonol glycosides from the aerial parts of Aceriphyllum rossii and their antioxidant activities.
PubMed:Influences of traditional Chinese medicine on non-specific immunity of Jian Carp (Cyprinus carpio var. Jian).
PubMed:Phytochemical constituents from Diodia teres.
PubMed:[The preliminary studies on antioxidation of three kinds of flavoniods from Litsea coreana].
PubMed:Bioactive phenolics from Carthamus lanatus L.
PubMed:Fisetin, a flavonol, inhibits TH2-type cytokine production by activated human basophils.
PubMed:Effects of Chinese herbal polysaccharides on the immunity and growth performance of young broilers.
PubMed:[Study on chemical constituents of Hemistepta lyrata Bunge].
PubMed:[Studies on flavonoids from leave of Eucommia ulmoides Oliv].
PubMed:Characterisation of new oligoglycosidic compounds in two Chinese medicinal herbs.
PubMed:Oral administration of persimmon leaf extract ameliorates skin symptoms and transepidermal water loss in atopic dermatitis model mice, NC/Nga.
PubMed:Proposed active constituents of Dipladenia martiana.
PubMed:Effect of Astragalin on matrix secretion and beta 1 integrin mRNA expression in human mesangial cells.
PubMed:Phlomisflavosides A and B, new flavonol bisglycosides from Phlomis spinidens.
PubMed:Antiprotozoal activity of the constituents of Conyza filaginoides.
PubMed:Constituents and the antitumor principle of Allium victorialis var. platyphyllum.
PubMed:Studies on the constituents of the leaves of Morus alba L.
PubMed:Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice.
PubMed:Monoterpene and pregnane glucosides from Solenostemma argel.
PubMed:Phenylvaleric acid and flavonoid glycosides from Polygonum salicifolium.
PubMed:Antioxidative flavonoids from the leaves of Morus alba.
PubMed:Anti-complement activity of tiliroside from the flower buds of Magnolia fargesii.
PubMed:Studies on Securigera securidacea (L.) Deg. et Dörfl. (Fabaceae) seeds, an antidiabetic Egyptian folk medicine.
PubMed:Phenolic and antibacterial constituents of Vahlia capensis.
PubMed:Identification and quantitative analysis of phenolic compounds from the dry extract of Hedera helix.
PubMed:Medicinal foodstuffs. V. Moroheiya. (1): Absolute stereostructures of corchoionosides A, B, and C, histamine release inhibitors from the leaves of Vietnamese Corchorus olitorius L. (Tiliaceae).
PubMed:[Flavonoids of Cuscuta australis R. Br].
PubMed:Xanthine oxidase inhibitors from the leaves of Alsophila spinulosa (Hook) Tryon.
PubMed:Isolation of camelliaside C from "tea seed cake" and inhibitory effects of its derivatives on arachidonate 5-lipoxygenase.
PubMed:[A research on the quality of radix Astragali].
PubMed:[Glycosides of phenolic acid and flavonoids from the leaves of Glycyrrhiza uralensis Ficsh].
PubMed:[Content of astraglin A in zhongfeng naomai tong oral liquid].
PubMed:Flavonoids of Ochradenus baccatus.
PubMed:Incorporation of kaempferol 3-O-glucoside into the cell walls of Norway spruce needles.
PubMed:[Glycosides from Mussaenda arcuata Lam. ex Poiret leaves].
PubMed:Flavones and flavonol glycosides from Eupatorium cannabinum L.
PubMed:Inhibitory effects of various flavonoids isolated from leaves of persimmon on angiotensin-converting enzyme activity.
PubMed:Antitumor agents. 49 tricin, kaempferol-3-O-beta-D-glucopyranoside and (+)-nortrachelogenin, antileukemic principles from Wikstroemia indica.
PubMed:Biological and phytochemical investigations of Dianthus barbatus cv. "China Doll" (Caryophyllaceae).
PubMed:[Studies on the constituents of Anodendron affine Durce. IV. Isolation of kaempferol, astragalin and dambonitol from leaves].
PubMed:[Flavoneglycosides in the flowers of Paeonia arborea and P. suffruticosa].
PubMed:[The occurrence of kaempferol and astragalin in inflorescences of Coronilla varia L].
PubMed:[ASTRAGALIN FROM PODOPHYLLUM PELTATUM L. AND P. EMODI WALL].
 
Notes:
Present in red wine. Isol. from many plant spp. Astragalin is a 3-O-glucoside of kaempferol.; Astragalin is a chemical compound. It can be isolated from Phytolacca americana (the American pokeweed).
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