EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

linarin
acacetin-7-O-rutinoside

Supplier Sponsors

Name:5-hydroxy-2-(4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
CAS Number: 480-36-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:207-547-6
FDA UNII: HBH2I685IU
Nikkaji Web:J6.164F
MDL:MFCD00151178
XlogP3-AA:-0.50 (est)
Molecular Weight:592.55184000
Formula:C28 H32 O14
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 415.9 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Linarin;Buddleoside 98%
BOC Sciences
For experimental / research use only.
Diosmin Impurity E (Linarin)
Carbosynth
For experimental / research use only.
Linarin
ExtraSynthese
For experimental / research use only.
Linarin (HPLC) ≥98.5%
Glentham Life Sciences
Linarin
Santa Cruz Biotechnology
For experimental / research use only.
Linarin
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for linarin usage levels up to:
 not for fragrance use.
 
Recommendation for linarin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5317025
National Institute of Allergy and Infectious Diseases:Data
5-hydroxy-2-(4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
Chemidplus:0000480364
 
References:
 5-hydroxy-2-(4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5317025
Pubchem (sid):135227076
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
FooDB:FDB002767
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 basswood leaf
Search Trop Picture
 horsemint plant
Search Trop Picture
 linaria japonica leaf
Search Trop Picture
 water mint plant
Search Trop Picture
 
Synonyms:
 acacetin 7-O-rutinoside
 acacetin-7-O-rutinoside
 acacetin-7-rutinoside
 acaciin
7-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(4-methoxyphenyl)-4H-benzopyran-4-one
5,7-dihydroxy-4'-methoxyflavone-D-glucosido-L-rhamnoside
5-hydroxy-2-(4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
 

Articles:

PubMed:Protective effect of linarin against d-galactosamine and lipopolysaccharide-induced fulminant hepatic failure.
PubMed:Effects of piperine on the intestinal permeability and pharmacokinetics of linarin in rats.
PubMed:[Optimization of hydrolysis process of linarin using response surface methodology and research about ARI activity of glycosylation-acacetin].
PubMed:Simultaneous determination of linarin, naringenin and formononetin in rat plasma by LC-MS/MS and its application to a pharmacokinetic study after oral administration of Bushen Guchi Pill.
PubMed:Determination and pharmacokinetics of linarin in rat plasma after intramuscular administration of linarin solution and Yejuhua injection by HPLC.
PubMed:Rapid LC-MS/MS determination and pharmacokinetic application of linarin in rat plasma.
PubMed:Phytochemical linarin enriched in the flower of Chrysanthemum indicum inhibits proliferation of A549 human alveolar basal epithelial cells through suppression of the Akt-dependent signaling pathway.
PubMed:Virtual screening studies reveal linarin as a potential natural inhibitor targeting CDK4 in retinoblastoma.
PubMed:Neuroprotective effects of linarin through activation of the PI3K/Akt pathway in amyloid-β-induced neuronal cell death.
PubMed:Linarin isolated from Buddleja officinalis prevents hydrogen peroxide-induced dysfunction in osteoblastic MC3T3-E1 cells.
PubMed:[Determination of chlorogenic acid, caffeic acid and linarin in Flos Chrysanthemi Indici from different places by RP-hPLC].
PubMed:[Simultaneous determination of chlorogenic acid, cryptochlorogenic acid, caffeic acid, naringin, hesperidin and linarin in xiao'erjinning oral liquid by an HPLC method].
PubMed:Identification and quantification of the sedative and anticonvulsant flavone glycoside from Chrysanthemum boreale.
PubMed:The effect of linarin on LPS-induced cytokine production and nitric oxide inhibition in murine macrophages cell line RAW264.7.
PubMed:Analgesic and antipyretic activities of an aqueous extract and of the flavone linarin of Buddleia cordata.
PubMed:Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate.
PubMed:[Determination of linarin in Yuye Jiedu granule by RP-HPLC].
PubMed:A comparative study of the analgesic and anti-inflammatory activities of pectolinarin isolated from Cirsium subcoriaceum and linarin isolated from Buddleia cordata.
PubMed:A gradient HPLC method for the quality control of chlorogenic acid, linarin and luteolin in Flos Chrysanthemi Indici suppository.
PubMed:Determination of the flavonoids/antioxidant levels in Cirsium oleraceum and Cirsium rivulare extracts with cerium(IV)-rhodamine 6G chemiluminescence detection.
PubMed:Semisynthesis of linarin, acacetin, and 6-iodoapigenin derivatives from diosmin.
PubMed:Linarin, a selective acetylcholinesterase inhibitor from Mentha arvensis.
PubMed:Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis.
PubMed:Telemetry as a tool to measure sedative effects of a valerian root extract and its single constituents in mice.
PubMed:Corn mint (Mentha arvensis) extract diminishes acute Chlamydia pneumoniae infection in vitro and in vivo.
PubMed:Development of a rapid resolution liquid chromatography-diode array detector method for the determination of three compounds in Ziziphora clinopodioides Lam from different origins of Xinjiang.
PubMed:[Linarin-isovalerianate, a currently unknown flavonoid from Valeriana wallichii D.C. 6. Report on the active substances of Valeriana].
PubMed:[Investigations on the glycosides of acacetin. II. Note on the identity of acaciin from Robinia pseudoacacia L. with linarin from Linaria vulgaris Mill].
PubMed:[On the additional occurrence of pectolinarin and linarin in the plant kingdom. I. On the Compositae and Papilionaceae flavones].
PubMed:[Simultaneous determination of eight active components in Chrysanthemum indicum by HPLC].
PubMed:Comprehensive analysis of Cirsium spinosissimum Scop., a wild alpine food plant.
PubMed:Shensong Yangxin Capsule prevents diabetic myocardial fibrosis by inhibiting TGF-β1/Smad signaling.
PubMed:Photoprotection of Buddleja cordata extract against UVB-induced skin damage in SKH-1 hairless mice.
PubMed:Luteolin mediates the antidepressant-like effects of Cirsium japonicum in mice, possibly through modulation of the GABAA receptor.
PubMed:Combined antihypertensive effect of luteolin and buddleoside enriched extracts in spontaneously hypertensive rats.
PubMed:[Flavonoid glycosides from leaves of Turpinia arguta and their anti-inflammatory activity].
PubMed:Potent α-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris.
PubMed:[Study on chemical components of Aconitum flavum and their inflammatory and analgesic effects].
PubMed:Simultaneous quantification and validation of caffeoylquinic acids and flavonoids in Hemistepta lyrata and peroxynitrite-scavenging activity.
PubMed:Anti-Inflammatory Effect of Supercritical-Carbon Dioxide Fluid Extract from Flowers and Buds of Chrysanthemum indicum Linnén.
PubMed:[Chemical constituents and activities of total flavonoids from Yushen Tang].
PubMed:Simultaneous analysis of 11 main active components in Cirsium setosum based on HPLC-ESI-MS/MS and combined with statistical methods.
PubMed:Chemical fingerprinting by RP-RRLC-DAD and principal component analysis of Ziziphora clinopodioides from different locations.
PubMed:Photoprotective activity of Buddleja scordioides.
PubMed:Protective effect of Calamintha officinalis Moench leaves against alcohol-induced gastric mucosa injury in rats. Macroscopic, histologic and phytochemical analysis.
PubMed:Inhibitory activity of coumarins from Artemisia capillaris against advanced glycation endproduct formation.
PubMed:[Chemical constituents from n-butanol extract of aerial part of Polygala sibirica].
PubMed:Targeting structural motifs of flavonoid diglycosides using collision-induced dissociation experiments on flavonoid/Pb2+ complexes.
PubMed:In vitro evaluation of the amebicidal activity of Buddleia cordata (Loganiaceae, H.B.K.) on several strains of Acanthamoeba.
PubMed:Phytochemical investigation and biological studies of Bombax malabaricum flowers.
PubMed:[Studies on the chemical constituents from Lobelia chinensis].
PubMed:Differentiation of Cirsium japonicum and C. setosum by TLC and HPLC-MS.
PubMed:[Studies on chemical components of Lobelia chinensis].
PubMed:Alpha-glucosidase inhibitory constituents of Linaria kurdica subsp. eriocalyx.
PubMed:Pro-cognitive effects of Cirsium rivulare extracts in rats.
PubMed:Different flavonoids present in the micronized purified flavonoid fraction (Daflon 500 mg) contribute to its anti-hyperpermeability effect in the hamster cheek pouch microcirculation.
PubMed:Two-dimensional liquid chromatography coupled with mass spectrometry for the analysis of Lobelia chinensis Lour. using an ESI/APCI multimode ion source.
PubMed:Total peroxynitrite scavenging capacity of phenylethanoid and flavonoid glycosides from the flowers of Buddleja officinalis.
PubMed:[Studies on antiviral flavonoids in yinqiaosan powder].
PubMed:[Simultaneous determination of six flavonoids in Flos Chrysanthemi Indici by RP-HPLC].
PubMed:[Studies on chemical constituents in Huangjuhua (flowers of Chrysanthemum morifolium)].
PubMed:Central nervous system depressant action of flavonoid glycosides.
PubMed:Separation and purification of rutin and acaciin from the chinese medicinal herb Herba Cirsii by combination of macroporous absorption resin and high-speed counter-current chromatography.
PubMed:[Studies on involatile constituents of Mentha haplocalyx].
PubMed:Chemical fingerprinting of valeriana species: simultaneous determination of valerenic acids, flavonoids, and phenylpropanoids using liquid chromatography with ultraviolet detection.
PubMed:[Studies on constituents in herb of Senecio scandens].
PubMed:Antihepatotoxic activity and chemical constituents of Buddleja asiatica Lour.
PubMed:A new ferulic acid ester and other constituents from Dracocephalum peregrinum.
PubMed:[Separation and identification of the flavonoids from Buddleia officinalis Maxim].
PubMed:Assessing the antioxidative properties and chemical composition of Linaria vulgaris infusion.
PubMed:[Studies on chemical constituents from flowers of Chrysanthemum indicum].
PubMed:[Relative adscriptions of components in the effective fractions of Yinqiao decoction and its composing individual herbs].
PubMed:[Studies on the chemical constituents of Cirsium japonicum DC].
PubMed:[Studies on the flavonoids from Dendranthema lavandulifolium].
PubMed:[Chemical constituents from Cirsium pendulum Fisch. ex DC].
PubMed:[Study on the active components of Nardostachys chinensis].
PubMed:[Studies on chemical constituents of Paederia scandense].
PubMed:Flavonoid compounds from the flowers of Cirsium rivulare (Jacq.) All.
PubMed:[Coulometric titration of acaciin in Chrysanthemum indicum].
 
Notes:
flavone glycoside isolated from leaves of linaria japonica miq.
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