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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 838.10 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 566.00 °F. TCC ( 296.80 °C. ) (est)
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| logP (o/w): | -0.090 (est) |
| Soluble in: |
| | water, 2888 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for luteolin-7-glucoside usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for luteolin-7-glucoside flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :5280637 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| 2-(3,4-dihydroxyphenyl)-5-hydroxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one |
| Chemidplus:0005373115 |
| RTECS:DJ3009400 for cas# 5373-11-5 |
References:
| | 2-(3,4-dihydroxyphenyl)-5-hydroxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 5373-11-5 |
| Pubchem (cid): | 5280637 |
| Pubchem (sid): | 135047751 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H-1- | benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-7-(beta-D-glucopyranosyloxy)-5-hydroxy- | | | cynaroside | | 2-(3,4- | dihydroxyphenyl)-5-hydroxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one | | 2-(3,4- | dihydroxyphenyl)-7-(beta-D-glucopyranosyloxy)-5-hydroxy-4H-1-benzopyran-4-one | | 7- | glucosylluteolin | | | luteolin 7-O-glucopyranoside |
Articles:
| PubMed:Ursolic acid and luteolin-7-glucoside improve lipid profiles and increase liver glycogen content through glycogen synthase kinase-3. |
| PubMed:Antioxidant and enzyme inhibitory activities of Plebeian herba (Salvia plebeia R. Br.) under different cultivation conditions. |
| PubMed:Functional and antiischemic effects of luteolin-7-glucoside in isolated rabbit hearts. |
| PubMed:Protective effects of luteolin-7-glucoside against liver injury caused by carbon tetrachloride in rats. |
| PubMed:The inhibitory effect and mechanism of luteolin 7-glucoside on rat aortic vascular smooth muscle cell proliferation. |
| PubMed:Taraxacum mongolicum extract exhibits a protective effect on hepatocytes and an antiviral effect against hepatitis B virus in animal and human cells. |
| PubMed:Luteolin and luteolin-7-O-glucoside strengthen antioxidative potential through the modulation of Nrf2/MAPK mediated HO-1 signaling cascade in RAW 264.7 cells. |
| PubMed:Comprehensive assessment of phenolics and antiradical potential of Rumex hastatus D. Don. roots. |
| PubMed:The flavonoid constitunts of Leucaena leucocephala. Growing in Egypt, and their biological activity. |
| PubMed:Ethanol extract of the Prunus mume fruits stimulates glucose uptake by regulating PPAR-γ in C2C12 myotubes and ameliorates glucose intolerance and fat accumulation in mice fed a high-fat diet. |
| PubMed:The aqueous extract of Lycopus lucidus Turcz ameliorates streptozotocin-induced diabetic renal damage via inhibiting TGF-β1 signaling pathway. |
| PubMed:Boehmeria nivea attenuates LPS-induced inflammatory markers by inhibiting p38 and JNK phosphorylations in RAW264.7 macrophages. |
| PubMed:In vitro anthelmintic effect of Vicia pannonica var. purpurascens on trichostrongylosis in sheep. |
| PubMed:Luteolin-7-glucoside as a characteristic component of the plant genera Juncus and Luzula (family Juncaceae). |
| PubMed:Anti-Inflammatory Effect of Supercritical-Carbon Dioxide Fluid Extract from Flowers and Buds of Chrysanthemum indicum Linnén. |
| PubMed:Chemical fingerprint and quantitative analysis of Salvia plebeia R.Br. by high-performance liquid chromatography. |
| PubMed:Chemical and biological evaluation of nephrocizin in protecting nerve growth factor-differentiated PC12 cells by 6-hydroxydopamine-induced neurotoxicity. |
| PubMed:Solid-liquid transfer of biophenols from olive leaves for the enrichment of edible oils by a dynamic ultrasound-assisted approach. |
| PubMed:Phenolic compounds in fresh and dried figs from Cilento (Italy), by considering breba crop and full crop, in comparison to Turkish and Greek dried figs. |
| PubMed:Efficacy of Daphne oleoides subsp. kurdica used for wound healing: identification of active compounds through bioassay guided isolation technique. |
| PubMed:[The influence of different processing on the content of flavones of Dendranthema morifolium]. |
| PubMed:Ethnopharmacological evaluation of some Scorzonera species: in vivo anti-inflammatory and antinociceptive effects. |
| PubMed:Bioactivity-guided fractionation of the triglyceride-lowering component and in vivo and in vitro evaluation of hypolipidemic effects of Calyx seu Fructus Physalis. |
| PubMed:[Simultaneous determination of isoorientin, scutellarin and cynaroside in rat plasma and pharmacokinetics by UPLC-MS/MS]. |
| PubMed:Polyphenol compounds in artichoke plant tissues and varieties. |
| PubMed:Flavonoids in Scutellaria immaculata and S. ramosissima (Lamiaceae) and their biological activity. |
| PubMed:Effects of flavonoids on prostaglandin E2 production and on COX-2 and mPGES-1 expressions in activated macrophages. |
| PubMed:Protective effects of cynaroside against H₂O₂-induced apoptosis in H9c2 cardiomyoblasts. |
| PubMed:[Simultaneous determination of 6 active components in Chrysanthemum morifolium by HPLC]. |
| PubMed:Antioxidant activity of Glossogyne tenuifolia. |
| PubMed:Antioxidant activity, cytotoxicity, and DNA information of Glossogyne tenuifolia. |
| PubMed:Immunomodulatory effect of Glossogyne tenuifolia in murine peritoneal macrophages and splenocytes. |
| PubMed:Polyphenolic compounds from Salvia species protect cellular DNA from oxidation and stimulate DNA repair in cultured human cells. |
| PubMed:Stress-induced biosynthesis of dicaffeoylquinic acids in globe artichoke. |
| PubMed:Glossogyne tenuifolia acts to inhibit inflammatory mediator production in a macrophage cell line by downregulating LPS-induced NF-kappa B. |
| PubMed:On the influence of the sugar moiety on the antigonadotropic activity of luteoline glycosides. |
| PubMed:Phenolic compounds from Achillea millefolium L. and their bioactivity. |
| PubMed:Superheated liquid extraction of oleuropein and related biophenols from olive leaves. |
| PubMed:Comparative antioxidant activity and HPLC profiles of some selected Korean thistles. |
| PubMed:[Studies on flavones from Flos Chrysanthemi Indici]. |
| PubMed:Antioxidant activities of aqueous extract from Agrimonia pilosa Ledeb and its fractions. |
| PubMed:Antiasthmatic activity of luteolin-7-O-glucoside from Ailanthus altissima through the downregulation of T helper 2 cytokine expression and inhibition of prostaglandin E2 production in an ovalbumin-induced asthma model. |
| PubMed:Identification of compounds in wine by HPLC-tandem mass spectrometry. |
| PubMed:Myocardial effects of flavonoids from Crataegus species. |
| PubMed:Antioxidant, prooxidant, and cytotoxic activities of solvent-fractionated dandelion (Taraxacum officinale) flower extracts in vitro. |
| PubMed:Effect of six flavonoid compounds from Ixeris sonchifolia on stimulus-induced superoxide generation and tyrosyl phosphorylation in human neutrophils. |
| PubMed:[Separation and identification of flavonoid glucosides from Elsholtzia blanda (Benth.) Benth]. |
| PubMed:[Chemical constituents from Neo-Taraxacum siphonathum]. |
| PubMed:Simultaneous determination of flavonoids and phenylethanoids in the flowers of Verbascum densiflorum and V. phlomoides by high-performance liquid chromatography. |
| PubMed:Allergy-preventive effects of the flowers of Impatiens textori. |
| PubMed:Antimutagenic activity and radical scavenging activity of water infusions and phenolics from ligustrum plants leaves. |
| PubMed:Antinociceptive activity of Buddleja globosa (matico) in several models of pain. |
| PubMed:[Studies on chemical constituents from Pteris multifida]. |
| PubMed:Liquid-liquid extraction for the enrichment of edible oils with phenols from olive leaf extracts. |
| PubMed:Phenolic metabolites in leaves of the invasive shrub, Lonicera maackii, and their potential phytotoxic and anti-herbivore effects. |
| PubMed:Evaluation of proinflammatory cytokine pathway inhibitors for p38 MAPK inhibitory potential. |
| PubMed:[Studies on the chemical constituents of Phlomis younghusbandii]. |
| PubMed:Achillea millefolium L. s.l. -- is the anti-inflammatory activity mediated by protease inhibition? |
| PubMed:[Studies on flavones in of Lavandula augustifolia]. |
| PubMed:Dysfunctionality of the xylem in Olea europaea L. Plants associated with the infection process by Verticillium dahliae Kleb. Role of phenolic compounds in plant defense mechanism. |
| PubMed:Effect of different extracting methods on quality of Chrysanthemum Morifolium Ramat. Infusion. |
| PubMed:Simultaneous quantification of seven bioactive components in Caulis Lonicerae Japonicae by high performance liquid chromatography. |
| PubMed:Water and methanolic extracts of Salvia officinalis protect HepG2 cells from t-BHP induced oxidative damage. |
| PubMed:Pathway engineering for healthy phytochemicals leading to the production of novel flavonoids in tomato fruit. |
| PubMed:Phenolic compounds protect HepG2 cells from oxidative damage: relevance of glutathione levels. |
| PubMed:Antiviral activities of purified compounds from Youngia japonica (L.) DC (Asteraceae, Compositae). |
| PubMed:Dynamic ultrasound-assisted extraction of oleuropein and related biophenols from olive leaves. |
| PubMed:[Chemical constituents from Elsholtzia blanda]. |
| PubMed:Effects of Chamomilla recutita flavonoids on age-related liver sphingolipid turnover in rats. |
| PubMed:Anti-inflammatory and antiviral effects of Glossogyne tenuifolia. |
| PubMed:[Studies on the chemical constituents from Chrysanthemum morifolium Ramat]. |
| PubMed:[Isolation of resisting thrombus and arteriosclerosis compounds in leaves of Salix matsudana]. |
| PubMed:Inhibition of cholesterol biosynthesis in HepG2 cells by artichoke extracts is reinforced by glucosidase pretreatment. |
| PubMed:Effects of extract from Angelica keiskei and its component, cynaroside, on the hepatic bromobenzene-metabolizing enzyme system in rats. |
| PubMed:Polyphenol increases in safflower and cucumber seedlings exposed to strong visible light with limited water. |
| PubMed:[Constituents of the leaves of Holodiscus discolor (Pursh) Maxim]. |
| PubMed:Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid. |
| PubMed:Anaerobic degradation of flavonoids by Eubacterium ramulus. |
| PubMed:Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans. |
| PubMed:Analysis of the components of Lycopus europaeus L. in body fluids during metabolism studies. Comparison of capillary electrophoresis and high-performance liquid chromatography. |
| PubMed:Hepatoprotective activity of polyphenolic compounds from Cynara scolymus against CCl4 toxicity in isolated rat hepatocytes. |
| PubMed:[Studies on chemical constituents of Artemisia rupestris (II)]. |
| PubMed:[Determination of main flavone glycosides in Flos Chrysanthemi and observation of factors influenced contents]. |
| PubMed:The effect of luteolin-7-O-beta-D-glucuronopyranoside on gastritis and esophagitis in rats. |
| PubMed:Phenylalkylamine alkaloids from Stapelia hirsuta L. |
| PubMed:Influence of biotransformation of luteolin, luteolin 7-O-glucoside, 3',4'-dihydroxyflavone and apigenin by cultured rat hepatocytes on antioxidative capacity and inhibition of EGF receptor tyrosine kinase activity. |
| PubMed:Effects of compounds in leaves of Salix matsudana on arachidonic acid metabolism. |
| PubMed:[Studying the mechanism of antioxidant effect of vitamins and flavonoids]. |
| PubMed:Luteolin and luteolin-7-O-glucoside from dandelion flower suppress iNOS and COX-2 in RAW264.7 cells. |
| PubMed:The inhibitory effect of luteolin-7-O-glucoside on the formation of pentyl and 7-carboxyheptyl radicals from 13-hydroperoxy-9,11-octadecadienoic acid in the presence of iron(II) ions. |
| PubMed:Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships. |
| PubMed:Investigation of the membrane localization and distribution of flavonoids by high-resolution magic angle spinning NMR spectroscopy. |
| PubMed:[Determination of luteolin and luteolin-7-beta-D-glucoside in Chrysanthemum morfolium Ramat. from different collection time by RP-HPLC]. |
| PubMed:Free radical scavenging abilities of flavonoids as mechanism of protection against mutagenicity induced by tert-butyl hydroperoxide or cumene hydroperoxide in Salmonella typhimurium TA102. |
| PubMed:Cytotoxic effect of Plantago spp. on cancer cell lines. |
| PubMed:Developmental transition of the flavonoid contents in safflower leaves during stress-loaded cultivation. |
| PubMed:[Chemical constituents from Salix oritrepha Schneid]. |
| PubMed:[Studies on the chemical constituents from Aquilegia ecalcarata Maxim]. |
| PubMed:[Studies on the chemical constituents of Carduus crispus L]. |
| PubMed:[Studies on chemical constituents of leaves of Salix matsudana Koidz and their influence on lipolysis]. |
| PubMed:Polyphenolic compounds from Plantago lagopus L. |
| PubMed:Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages. |
| PubMed:Luteolin-rich artichoke extract protects low density lipoprotein from oxidation in vitro. |
| PubMed:Quantification of contact oviposition stimulants for black swallowtail butterfly,Papilio polyxenes, on the leaf surfaces of wild carrot,Daucus carota. |
| PubMed:Flavonoids of Cynara scolymus L. cultivated in Egypt. |
| PubMed:Antimutagenic effects of flavonoids, chalcones and structurally related compounds on the activity of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and other heterocyclic amine mutagens from cooked food. |
| PubMed:Induction of sister-chromatid exchanges (SCE), polyploidy, and micronuclei by plant flavonoids in human lymphocyte cultures. A comparative study of 19 flavonoids. |
| PubMed:[Chemical constituents of the flower of Ligustrum lucidum Ait]. |
| PubMed:The role of lipophilic and polar flavonoids in the classification of temperate members of the Anthemideae. |
| PubMed:Evaluation of antioxidant and prooxidant activities of bamboo Phyllostachys nigra var. Henonis leaf extract in vitro. |
| PubMed:[Isolation and identification of flavon(ol)-O-glycosides in caraway (Carum carvi L.), fennel (Foeniculum vulgare Mill.), anise (Pimpinella anisum L.), and coriander (Coriandrum sativum L.), and of flavon-C-glycosides in anise. I. Phenolics of spices (author's transl)]. |
| PubMed:Flavonoids, cinnamic acids and coumarins from the different tissues and medicinal preparations of Taraxacum officinale. |
| PubMed:Effects of different inotropes with antioxidant properties on acute regional myocardial ischemia in isolated rabbit hearts. |
| PubMed:A biologically active lipophilic flavonol from Tanacetum parthenium. |
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Constit. of the leaves of Capsicum annuum (red pepper)
Cynaroside is a flavone, a flavonoid-like chemical compound. It is a 7-O-glucoside of luteolin and can be found in dandelion coffee, in Ferula varia and F. foetida in Campanula persicifolia and C. rotundifolia and in Cynara scolymus (artichoke).
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3D/inchi