EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

eupafolin
nepetin

Supplier Sponsors

Name:2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one
CAS Number: 520-11-6Picture of molecule3D/inchi
FDA UNII: I3O7LF3GED
Nikkaji Web:J11.589D
XlogP3:1.40 (est)
Molecular Weight:316.26604000
Formula:C16 H12 O7
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 505.9 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Nepetin 98%
BOC Sciences
For experimental / research use only.
6-Methoxyluteolin 95%
ExtraSynthese
For experimental / research use only.
6-Methoxyluteolin (HPLC) ≥95%
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for eupafolin usage levels up to:
 not for fragrance use.
 
Recommendation for eupafolin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5317284
National Institute of Allergy and Infectious Diseases:Data
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one
Chemidplus:0000520116
 
References:
 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5317284
Pubchem (sid):135053570
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
FooDB:FDB002422
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 rosemary plant
Search Trop Picture
 sage plant
Search Trop Picture
 sesame leaf
Search Trop Picture
 
Synonyms:
4H-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxy- (9CI)
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one
 flavone, 3',4',5,7-tetrahydroxy-6-methoxy- (8CI)
6-methoxyluteolin
 nepetin
 

Articles:

PubMed:HPLC-fingerprints and antioxidant constituents of Phyla nodiflora.
PubMed:Eupafolin inhibits PGE2 production and COX2 expression in LPS-stimulated human dermal fibroblasts by blocking JNK/AP-1 and Nox2/p47(phox) pathway.
PubMed:Separation of nine compounds from Salvia plebeia R.Br. using two-step high-speed counter-current chromatography with different elution modes.
PubMed:Characterisation of polyphenolic compounds in Clerodendrum petasites S. Moore and their potential for topical delivery through the skin.
PubMed:Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling.
PubMed:Further characterization of foliar flavonoids in Crossostephium chinense and their geographic variation.
PubMed:One-Step Separation of Four Flavonoids from Herba Salviae Plbeiae by HSCCC.
PubMed:Phytochemical and antitrypanosomal investigation of the fractions and compounds isolated from Artemisia elegantissima.
PubMed:Eupafolin, a skin whitening flavonoid isolated from Phyla nodiflora, downregulated melanogenesis: Role of MAPK and Akt pathways.
PubMed:Eupafolin and Ethyl Acetate Fraction of Kalanchoe gracilis Stem Extract Show Potent Antiviral Activities against Enterovirus 71 and Coxsackievirus A16.
PubMed:Flavonoids from the Japanese monotypic genus, Nipponanthemum.
PubMed:[Chemical constituents of Eupatorium lindleyanum].
PubMed:Antiproliferative, antimicrobial and apoptosis inducing effects of compounds isolated from Inula viscosa.
PubMed:Sesquiterpenes and other constituents from Dendranthema zawadskii var. latilobum.
PubMed:Antioxidant, anti-inflammatory and antiproliferative activities of Kalanchoe gracilis (L.) DC stem.
PubMed:Eupatorium perfoliatum L.: phytochemistry, traditional use and current applications.
PubMed:Cytotoxic compounds from the leaves of Gaillardia aristata Pursh. growing in Egypt.
PubMed:Anti-inflammatory activity of Eupatorium perfoliatum L. extracts, eupafolin, and dimeric guaianolide via iNOS inhibitory activity and modulation of inflammation-related cytokines and chemokines.
PubMed:An unusual dimeric guaianolide with antiprotozoal activity and further sesquiterpene lactones from Eupatoriumperfoliatum.
PubMed:Eupafolin, a flavonoid isolated from Artemisia princeps, induced apoptosis in human cervical adenocarcinoma HeLa cells.
PubMed:Chemical fingerprint and quantitative analysis of Salvia plebeia R.Br. by high-performance liquid chromatography.
PubMed:Eupafolin: Effect on mitochondrial energetic metabolism.
PubMed:A novel daucosterol derivative and antibacterial activity of compounds from Arctotis arctotoides.
PubMed:Anti-inflammatory activity of flavonoids from Eupatorium arnottianum.
PubMed:Hispidulin: antioxidant properties and effect on mitochondrial energy metabolism.
PubMed:Topical anti-inflammatory activity of flavonoids and a new xanthone from Santolina insularis.
PubMed:[Studies on chemical constituents in bud of Artemisia scoparia (II)].
PubMed:Cytotoxic activity of nepetin, a flavonoid from Eupatorium ballotaefolium HBK.
PubMed:Iridoids from Globularia dumulosa.
PubMed:Eudesmanolides from Dimerostemma vestitum.
PubMed:Antiproliferative constituents in plants 9. Aerial parts of Lippia dulcis and Lippia canescens.
PubMed:Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship.
PubMed:Flavonoids of Inula britannica protect cultured cortical cells from necrotic cell death induced by glutamate.
PubMed:Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method.
PubMed:Anti-phospholipase A2 and anti-inflammatory activity of Santolina chamaecyparissus.
PubMed:Analysis of vervain flavonoids by HPLC/Diode array detector method. Its application to quality control.
PubMed:Mono- and sesquiterpenes and antifungal constituents from Artemisia species.
PubMed:Decreased helenalin-induced cytotoxicity by flavonoids from Arnica as studied in a human lung carcinoma cell line.
PubMed:Influence of a series of natural flavonoids on free radical generating systems and oxidative stress.
PubMed:New Flavonoid Glycosides from Arnicae Flos DAB 91.
PubMed:Flavones and flavonol glycosides from Eupatorium cannabinum L.
PubMed:Screening of the influence of flavonoids on lipoxygenase and cyclooxygenase activity, as well as on nonenzymic lipid oxidation.
PubMed:Some pharmacological, toxicological and phytochemical investigations on Centaurea phyllocephala.
 
Notes:
None found
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