neoruscogenin, 17676-33-4

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CODE169949 CODE169949
Product(s):
17676-33-4 neoruscogenin >98%

Name:	7,9,13-trimethyl-5'-methylidenespiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-14,16-diol
CAS Number:	17676-33-4	3D/inchi
Other(deleted CASRN):	514-31-8
ECHA EINECS - REACH Pre-Reg:	241-660-1
FDA UNII:	D4E4KC2TUK
MDL:	MFCD00210534
XlogP3-AA:	4.10 (est)
Molecular Weight:	428.61260000
Formula:	C27 H40 O4
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:cosmetic ingredient for skin conditioning

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Boiling Point:	566.60 °C. @ 760.00 mm Hg (est)
Flash Point:	566.00 °F. TCC ( 296.40 °C. ) (est)
logP (o/w):	4.210 (est)
Soluble in:
	water, 0.07339 mg/L @ 25 °C (est)

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

CosIng:	cosmetic data
Cosmetic Uses:	skin conditioning

Suppliers:

Alfa Biotechnology

For experimental / research use only.

Neoruscogenin 98%

BOC Sciences

For experimental / research use only.

neoruscogenin >98%

Carbosynth

For experimental / research use only.

neoRuscogenin

ExtraSynthese

For experimental / research use only.

neoRuscogenin (HPLC) ≥95%

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
cosmetic ingredient for skin conditioning
Recommendation for neoruscogenin usage levels up to:
	not for fragrance use.

Recommendation for neoruscogenin flavor usage levels up to:
	not for flavor use.

Safety References:

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :86605

National Institute of Allergy and Infectious Diseases:Data

7,9,13-trimethyl-5'-methylidenespiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-14,16-diol

Chemidplus:0017676334

References:

	7,9,13-trimethyl-5'-methylidenespiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-14,16-diol
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	86605
Pubchem (sid):	135042797

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
HMDB (The Human Metabolome Database):	Search
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

found in nature

Synonyms:

	spirosta-5,25(27)-dien-1,3-diol
	spirosta-5,25(27)-diene-1beta,3beta-diol
7,9,13-	trimethyl-5'-methylidenespiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-14,16-diol

Articles:

PubMed:The identification of naturally occurring neoruscogenin as a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (NR1F1).

PubMed:Spirostanol saponins and esculin from Rusci rhizoma reduce the thrombin-induced hyperpermeability of endothelial cells.

PubMed:High-throughput LC/MS/MS analysis of ruscogenin and neoruscogenin in Ruscus aculeatus L.

PubMed:Inhibition of proteoglycan synthesis affects neuronal outgrowth and astrocytic migration in organotypic cultures of fetal ventral mesencephalon.

PubMed:Ruscus aculeatus (butcher's broom). Monograph.

PubMed:Steroidal saponins from Nolina recurvata stems and their inhibitory activity on cyclic AMP phosphodiesterase.

Notes:

None found

neoruscogenin spirosta-5,25(27)-diene-1beta,3beta-diol

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Articles:

neoruscogenin
spirosta-5,25(27)-diene-1beta,3beta-diol