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phyllanthin
benzene, 1,1'-(2,3-bis(methoxymethyl)-1,4-butanediyl)bis(3,4-dimethoxy-, (S-(R*,R*))-

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Name:4-[3-[(3,4-dimethoxyphenyl)methyl]-4-methoxy-2-(methoxymethyl)butyl]-1,2-dimethoxybenzene
CAS Number: 10351-88-9Picture of molecule3D/inchi
FDA UNII: 75O1TFF47Z
Beilstein Number:2066503
MDL:MFCD17166965
XlogP3-AA:4.20 (est)
Molecular Weight:418.53018000
Formula:C24 H34 O6
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 530.60 °C. @ 760.00 mm Hg (est)
Flash Point: 405.00 °F. TCC ( 207.30 °C. ) (est)
logP (o/w): 4.110 (est)
Soluble in:
 water, 0.4845 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Phyllanthin >98%
Odor: characteristic
Use: Phyllanthin, one of the most common species of Indian origin, is a natural lignan which is found in the herb of Phyllanthus niruri L. Phyllanthin inhibits the activity of hepatoprotective and antigenotoxic. anti-genotoxic
Carbosynth
For experimental / research use only.
Phyllanthin
ExtraSynthese
For experimental / research use only.
Phyllantin (HPLC) ≥90%
Sigma-Aldrich
For experimental / research use only.
Phyllanthin
analytical standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for phyllanthin usage levels up to:
 not for fragrance use.
 
Recommendation for phyllanthin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :101522
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
4-[3-[(3,4-dimethoxyphenyl)methyl]-4-methoxy-2-(methoxymethyl)butyl]-1,2-dimethoxybenzene
Chemidplus:0010351889
 
References:
 4-[3-[(3,4-dimethoxyphenyl)methyl]-4-methoxy-2-(methoxymethyl)butyl]-1,2-dimethoxybenzene
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):101522
Pubchem (sid):135058205
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
 benzene, 1,1'-(2,3-bis(methoxymethyl)-1,4-butanediyl)bis(3,4-dimethoxy-, (S-(R*,R*))-
4-[3-[(3,4-dimethoxyphenyl)methyl]-4-methoxy-2-(methoxymethyl)butyl]-1,2-dimethoxybenzene
1,1'-[2,3-bis(methoxymethyl)-1,4-butanediyl]bis(3,4-dimethoxybenzene)
 

Articles:

PubMed:Phyllanthin inhibits CCl4-mediated oxidative stress and hepatic fibrosis by down-regulating TNF-α/ NF-κB and pro-fibrotic factor TGF-β1 mediated inflammatory signaling.
PubMed:Phyllanthus amarus does not affect hypernociception in experimental autoimmune encephalomyelitis.
PubMed:Development of phyllanthin-loaded self-microemulsifying drug delivery system for oral bioavailability enhancement.
PubMed:Optimization of process variables for phyllanthin extraction from Phyllanthus amarus leaves by supercritical fluid using a Box-Behnken experimental design followed by HPLC identification.
PubMed:Inhibitory Effects of Standardized Extracts of Phyllanthus amarus and Phyllanthus urinaria and Their Marker Compounds on Phagocytic Activity of Human Neutrophils.
PubMed:Physicochemical characterization of phyllanthin from Phyllanthus amarus Schum. et Thonn.
PubMed:Phyllanthin and hypophyllanthin inhibit function of P-gp but not MRP2 in Caco-2 cells.
PubMed:Growth inhibition of human gynecologic and colon cancer cells by Phyllanthus watsonii through apoptosis induction.
PubMed:Hepatoprotective activity of Indian Phyllanthus.
PubMed:Development of hydrocortisone succinic acid/and 5-fluorouracil/chitosan microcapsules for oral and topical drug deliveries.
PubMed:Enhancing hepatoprotective bioactives of phyllanthus amarus through immobilization by growth promoters and media changes.
PubMed:Clonal propagation of Phyllanthus amarus: A hepatoprotector.
PubMed:Development of phyllanthin containing microcapsules and their improved biological activity towards skin cells and Staphylococcus aureus.
PubMed:Hepatoprotective activity of the Phyllanthus species on tert-butyl hydroperoxide (t-BH)-induced cytotoxicity in HepG2 cells.
PubMed:Endothelium-independent effects of phyllanthin and hypophyllanthin on vascular tension.
PubMed:Phytochemical analysis, antioxidant and anti-inflammatory activities of Phyllanthus simplex.
PubMed:Recent advances in herbal medicine for treatment of liver diseases.
PubMed:Inhibitory effects of Phyllanthus amarus and its major lignans on human microsomal cytochrome P450 activities: evidence for CYP3A4 mechanism-based inhibition.
PubMed:Protective activity of phyllanthin in ethanol-treated primary culture of rat hepatocytes.
PubMed:Isolation, characterization and antioxidative effect of phyllanthin against CCl4-induced toxicity in HepG2 cell line.
PubMed:Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents.
PubMed:Drug development for liver diseases: focus on picroliv, ellagic acid and curcumin.
PubMed:Synergistic effect of silymarin and standardized extract of Phyllanthus amarus against CCl4-induced hepatotoxicity in Rattus norvegicus.
PubMed:Chromium-induced changes in ultramorphology and secondary metabolites of Phyllanthus amarus Schum & Thonn. - an hepatoprotective plant.
PubMed:Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria.
PubMed:Separation and quantification of lignans in Phyllanthus species by a simple chiral densitometric method.
PubMed:Recent advances in plant hepatoprotectives: a chemical and biological profile of some important leads.
PubMed:Determination of four lignans in Phyllanthus niruri L. by a simple high-performance liquid chromatography method with fluorescence detection.
PubMed:Analysis of lignans from Phyllanthus niruri L. in plasma using a simple HPLC method with fluorescence detection and its application in a pharmacokinetic study.
PubMed:Quantitative determination of phyllanthin and hypophyllanthin in Phyllanthus species by high-performance thin layer chromatography.
PubMed:The cytotoxic effect and the multidrug resistance reversing action of lignans from Phyllanthus amarus.
PubMed:Antihyperuricemic lignans from the leaves of Phyllanthus niruri.
PubMed:High-performance thin-layer chromatography densitometric method for simultaneous quantitation of phyllanthin, hypophyllanthin, gallic acid, and ellagic acid in Phyllanthus amarus.
PubMed:Antimicrobial potentiality of Phyllanthus amarus against drug resistant pathogens.
PubMed:Comparative pharmacognostic studies of three Phyllanthus species.
PubMed:Anti-inflammatory properties of extracts, fractions and lignans isolated from Phyllanthus amarus.
PubMed:Effect of cadmium on growth, ultramorphology of leaf and secondary metabolites of Phyllanthus amarus Schum. and Thonn.
PubMed:Preparation and anti-HIV activities of retrojusticidin B analogs and azalignans.
PubMed:In vivo studies of a crude extract of Phyllanthus amarus L. in modifying the genotoxicity induced in Vicia faba L. by tannery effluents.
PubMed:1H- and 13C-nmr assignments of phyllanthin and hypophyllanthin: lignans that enhance cytotoxic responses with cultured multidrug-resistant cells.
PubMed:Antihepatotoxic principles of Phyllanthus niruri herbs.
 
Notes:
None found
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