EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

pilocarpine
2(3H)-furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S-cis)-

Supplier Sponsors

Name:(3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one
CAS Number: 92-13-7Picture of molecule3D/inchi
Other(deleted CASRN):91484-73-0
ECHA EINECS - REACH Pre-Reg:202-128-4
FDA UNII: 01MI4Q9DI3
Nikkaji Web:J9.328I
XlogP3-AA:1.10 (est)
Molecular Weight:208.26092000
Formula:C11 H16 N2 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 34.00 °C. @ 760.00 mm Hg
Boiling Point: 431.80 °C. @ 760.00 mm Hg (est)
Flash Point: 419.00 °F. TCC ( 215.00 °C. ) (est)
logP (o/w): 0.120
Soluble in:
 water, 3.133e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Pilocarpine-d3 HCl (deuterated) > 95%
Odor: characteristic
Use: The deuterated labelled form ofPilocarpine which is used as a miotic and in the treatment of glaucoma.
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
unreported-man LDLo 1912 ug/kg
"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.

intraperitoneal-mouse LD50 220 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 192, Pg. 88, 1971.

intravenous-mouse LD50 61900 ug/kg
Drugs in Japan Vol. 6, Pg. APP-16, 1982.

oral-mouse LD50 119 mg/kg
Drugs in Japan Vol. 6, Pg. APP-16, 1982.

intravenous-rabbit LDLo 120 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1386, 1935.

intraperitoneal-rat LD50 166 mg/kg
Drugs in Japan Vol. 6, Pg. APP-16, 1982.

intravenous-rat LD50 88500 ug/kg
Drugs in Japan Vol. 6, Pg. APP-16, 1982.

oral-rat LD50 402 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 1204, 1981.

Dermal Toxicity:
subcutaneous-human LDLo 143 ug/kg
BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: CYANOSIS VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION
Confinia Neurologica. Vol. 10, Pg. 8, 1949.

subcutaneous-mouse LD50 90900 ug/kg
Drugs in Japan Vol. 6, Pg. APP-16, 1982.

subcutaneous-rat LD50 366 mg/kg
Drugs in Japan Vol. 6, Pg. APP-16, 1982.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for pilocarpine usage levels up to:
 not for fragrance use.
 
Recommendation for pilocarpine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA Substance Registry Services (TSCA):92-13-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5910
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one
Chemidplus:0000092137
 
References:
 (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5910
Pubchem (sid):134972029
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C07474
HMDB (The Human Metabolome Database):Search
MedlinePlusSupp:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
(3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one
2(3H)-furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S-cis)-
 imidazole-5-butyric acid, alpha-ethyl-beta-(hydroxymethyl)-1-methyl-, gamma-lactone
 ocusert P 20
 ocusert pilo
 ocusert pilo-20
 ocusert pilo-40
 pilocarpin
 pilocarpol
 pilokarpin
 pilokarpol
 syncarpine
 

Articles:

PubMed:Activation of brain indoleamine 2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy.
PubMed:Speed modulation of hippocampal theta frequency correlates with spatial memory performance.
PubMed:Nucleus accumbens neurotransmission and effort-related choice behavior in food motivation: effects of drugs acting on dopamine, adenosine, and muscarinic acetylcholine receptors.
PubMed:E2f1-deficient NOD/SCID mice have dry mouth due to a change of acinar/duct structure and the down-regulation of AQP5 in the salivary gland.
PubMed:Functional and proteomic analysis of submandibular saliva in rats exposed to chronic stress by immobilization or constant light.
PubMed:Salivary 8-OHdG Induction by Physical Exercise Training Under Food Restriction.
PubMed:Salivary secretions from the honeybee mite, Varroa destructor: effects on insect haemocytes and preliminary biochemical characterization.
PubMed:Metabolic alterations in different developmental stages of Pilocarpus microphyllus.
PubMed:Attenuation of cocaine's reinforcing and discriminative stimulus effects via muscarinic M1 acetylcholine receptor stimulation.
PubMed:Availability of saliva for the assessment of alterations in the autonomic nervous system caused by physical exercise training.
PubMed:The effects of pilocarpine-induced status epilepticus on oxidative stress/damage in developing animals.
PubMed:Insidious weight gain in prepubertal seized rats treated with an atypical neuroleptic: the role of food consumption, fluid consumption, and spontaneous ambulatory activity.
PubMed:[Zinc and insulin level in islet cells under various functional state of insular apparatus].
PubMed:Food for thought: honeybee foraging, memory, and acetylcholine.
PubMed:[Xerostomia in palliative care].
PubMed:Herbal treatment following post-seizure induction in rat by lithium pilocarpine: Scutellaria lateriflora (Skullcap), Gelsemium sempervirens (Gelsemium) and Datura stramonium (Jimson Weed) may prevent development of spontaneous seizures.
PubMed:Effect of food deprivation during early development on cognition and neurogenesis in the rat.
PubMed:M(3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice.
PubMed:Hippocampal N-acetyl aspartate levels do not mirror neuronal cell densities in creatine-supplemented epileptic rats.
PubMed:Neuroendocrine alterations impair enamel mineralization, tooth eruption and saliva in rats.
PubMed:Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice.
PubMed:Increased drinking in mutant mice with truncated M5 muscarinic receptor genes.
PubMed:Seizure onset times for rats receiving systemic lithium and pilocarpine: sources of variability.
PubMed:Weight gain in post-seized rats is facilitated by adding aspirin, glucose, or glucose-taurine-acetaminophen to food mush.
PubMed:Changes of salivary amylase in serum and parotid gland during pharmacological and physiological stimulation.
PubMed:Brief successive temporal observational sampling as a possible indicator of daily overt seizure activity in epileptic rats.
PubMed:Synchronized feeding as a "conditioned stimulus" for overt seizures in chronically (limbic) epileptic rats: a model for "psychogenic seizures" with complex partial epilepsy.
PubMed:Post-radiation severe xerostomia relieved by pilocarpine: a prospective French cooperative study.
PubMed:Update in Sjögren syndrome.
PubMed:Disorder of salivary secretion in inbred polydipsic mouse.
PubMed:Fetal alcohol-exposed rats exhibit differential response to cholinergic drugs on a delay-dependent memory task.
PubMed:Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels.
PubMed:Preemptive pharmacologic intervention in radiation-induced salivary dysfunction.
PubMed:Vascular protein leakage in the rat parotid gland elicited by reflex stimulation, parasympathetic nerve stimulation and administration of neuropeptides.
PubMed:Transient tonic pupils in botulism type B.
PubMed:Detection of visual signals by rats: effects of chlordiazepoxide and cholinergic and adrenergic drugs on sustained attention.
PubMed:Fluoride and pilocarpine reduce the risk of caries produced by chronic clomipramine treatment in rats.
PubMed:Comments on the pathogenesis of muscarinic agonist-induced corneal opacities in rats.
PubMed:Cytotoxicity in chicken alimentary secretions as measured by a derivative of the tumor necrosis factor assay.
PubMed:First effective drug for dry mouth.
PubMed:Oral pilocarpine (Salagen)--a recently approved salivary stimulant.
PubMed:Visoltricin, a novel biologically active compound produced by Fusarium tricinctum.
PubMed:Pharmacological characterization of performance on a concurrent lever pressing/feeding choice procedure: effects of dopamine antagonist, cholinomimetic, sedative and stimulant drugs.
PubMed:Pancreatic B-cell culture after intravitam B-cell selection with nitric pilocarpine and modified B-technique use.
PubMed:Transient blocking of persistent gnawing by haloperidol in rats with seizure-induced multifocal brain damage.
PubMed:Attenuation of scopolamine-induced spatial memory deficits in the rat by cholinomimetic and non-cholinomimetic drugs using a novel task in the 12-arm radial maze.
PubMed:Interactions between scopolamine and muscarinic cholinergic agonists or cholinesterase inhibitors on spatial alternation performance in rats.
PubMed:Functional morphology of accommodation in the raccoon.
PubMed:A study of stimuli operative in the release of antibodies in the rat intestine.
PubMed:Salivatory neurons in the brainstem nucleus parvocellularis of the rat: effects of electrolytic lesions.
PubMed:Discriminative stimulus properties of physostigmine in rats.
PubMed:Discriminative stimulus properties of muscarinic agonists.
PubMed:Deaths of two hospital inpatients poisoned by pilocarpine.
PubMed:Effects of muscarinic receptor antagonism upon two forms of stress-induced analgesia.
PubMed:Cholinergic suppression: a postsynaptic mechanism of long-term associative learning.
PubMed:[Effect of the intake of food and of biologically active substances on the capacity of the blood serum to inhibit proteolytic activity].
PubMed:Pilocarpine and physostigmine attenuate spatial memory impairments produced by lesions of the nucleus basalis magnocellularis.
PubMed:Stability of pilocarpine hydrochloride and pilocarpine nitrate ophthalmic solutions submitted by U.S. hospitals.
PubMed:[Xerostomia. II. Therapeutic possibilities].
PubMed:Disordered drinking in developing spontaneously hypertensive rats.
PubMed:Effect of chronic administration of deoxycorticosterone acetate on salt appetite of captopril-treated rats.
PubMed:Trigger activation of the paradoxical salivatory response to atropine in the parasympathetically denervated human parotid gland.
PubMed:Radioprotection by WR-2721 of gamma-irradiated rat parotid gland: effect on gland weight and secretion at 8-10 days post irradiation.
PubMed:Clinical implications of reported timolol-induced side effects.
PubMed:Growth, appetite, sequence of pathological signs and survival following the induction of rapid, synchronous vitamin A deficiency in the rat.
PubMed:Immediate transformation of the cholinonegative effect of atropine into a cholinopositive one in denervated human salivary gland by reflex stimulations.
PubMed:[Decrease of ACh response in isolated duodenum from SART stressed (repeated cold stressed) mice (author's transl)].
PubMed:Trialwise tracking method for measuring drug-affected sensory threshold changes in animals.
PubMed:Pilocarpine, food deprivation, and induction of mouse killing by cats.
PubMed:Effects of combining pilocarpine, d-amphetamine, and either a free feeding schedule or cyclic food deprivation on mouse killing by rats.
PubMed:Rate of protein synthesis in rat salivary gland cells after pilocarpine or feeding. II. Protein synthesis in vivo in cells of the submandibular and parotid gland after secretion.
PubMed:Rate of protein synthesis in rat salivary gland cells after pilocarpine or feeding. I. Rate of (glyco) protein secretion from cells of mixed salivary glands.
PubMed:Metiamide: an antagonist of histamine-stimulated gastric acid secretion.
PubMed:Effects of fasting and feeding and pilocarpine on paneth cells of the mouse.
PubMed:The effects of secretagogues on the incorporation of (2- 3 H)myoinositol into lipid in cytological fractions in the pancreas of the guinea pig in vivo.
PubMed:Amylase and other protein components of parotid saliva of the baboon, Papio anubis.
PubMed:Renin-like activity of the rat submaxillary gland: characterization and the effect of several drugs and stimuli.
PubMed:[Innervation of the dog submandibular gland].
PubMed:Protein synthesis in the pancreas of the rat after stimulation of secretion.
 
Notes:
a slowly hydrolyzed muscarinic agonist with no nicotinic effects. pilocarpine is used as a miotic and in the treatment of glaucoma.
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2021 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy