| Name: | 5-[(3S,8R,9S,10R,13R,14S,17R)-14-hydroxy-10,13-dimethyl-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy-1,2,3,6,7,8,9,11,12,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]pyran-2-one |
| CAS Number: | 466-06-8 |  3D/inchi
|
| Other(deleted CASRN): | 12041-88-2 |
| ECHA EINECS - REACH Pre-Reg: | 207-370-4 |
| FDA UNII: | KC6BL281EN |
| MDL: | MFCD00214065 |
| XlogP3-AA: | 1.90 (est) |
| Molecular Weight: | 530.65834000 |
| Formula: | C30 H42 O8 |
| BioActivity Summary: | listing |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) |
Category:pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 80.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 221.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 716.70 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 451.00 °F. TCC ( 232.60 °C. ) (est)
|
| logP (o/w): | 2.480 |
| Soluble in: |
| | water, 58.8 mg/L @ 20 °C (exp) | | | water, 3.465 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-cat LD50 111 ug/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1, 1970.
oral-cat LD50 377 ug/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1, 1970.
parenteral-cat LDLo 1 mg/kg
Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 34, Pg. 431, 1977.
intravenous-guinea pig LD50 280 ug/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1, 1970.
oral-guinea pig LD50 6810 ug/kg
United States Patent Document. Vol. #4230702
intravenous-mouse LD50 4700 ug/kg
Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 411, 1968.
oral-mouse LD50 30500 ug/kg
Drugs in Japan Vol. 6, Pg. 723, 1982.
intravenous-rat LD50 9 mg/kg
BEHAVIORAL: ATAXIA
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toxicology and Applied Pharmacology. Vol. 20, Pg. 599, 1971.
oral-rat LD50 56 mg/kg
BEHAVIORAL: ATAXIA
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toxicology and Applied Pharmacology. Vol. 20, Pg. 599, 1971.
|
| Dermal Toxicity: |
subcutaneous-rat LD50 > 1000 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 411, 1968.
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | pharmaceuticals / chemical synthisis |
| Recommendation for proscillaridin usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for proscillaridin flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :222154 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| 5-[(3S,8R,9S,10R,13R,14S,17R)-14-hydroxy-10,13-dimethyl-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy-1,2,3,6,7,8,9,11,12,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]pyran-2-one |
| Chemidplus:0000466068 |
| RTECS:UK6650000 for cas# 466-06-8 |
References:
| | 5-[(3S,8R,9S,10R,13R,14S,17R)-14-hydroxy-10,13-dimethyl-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy-1,2,3,6,7,8,9,11,12,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]pyran-2-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 222154 |
| Pubchem (sid): | 135269945 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | caradrin | | | caradrine | | | cardion | | | cardiovite | | | carmazon | | | coratol | | ((6- | deoxy-alpha-L-mannopyranosyl)oxy)-14-hydroxybufa-4,20,22-trienolide | | | desgluco-transvaalin | | 3-beta,14-beta- | dihydroxybufa-4,20,22-trienolide 3-rhamnoside | | | herzo proscillan | | 5-[(3S,8R,9S,10R,13R,14S,17R)-14- | hydroxy-10,13-dimethyl-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy-1,2,3,6,7,8,9,11,12,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]pyran-2-one | | 14- | hydroxy-3beta-(rhamnosyloxy)bufa-4,20,22-trienolide | | | procardin | | | procilan | | | proscillaridin A | | | proscillaridine | | | proscillaridinum | | | proslladin | | | prostosin | | | proszin | | | protasin | | | purosin-TC | | | rhamnopyranoside, scillarenin-3, alpha-L- | | 3-beta- | rhamnosido-14-beta-hydroxy-delta(sup 4,20,22)-bufatrienolide | | | sandoscill | | | scillacrist | | | scillarenin 3beta-rhamnoside | | | scillarenin-rhamnose | | | scillarenin, 3alpha-L-rhamnopyranoside | | | simeon | | | solestril | | | stellarid | | | talucard | | | talusin | | | tradenal | | | transvaalin, degluco- | | | urgilan | | | wirnesin
|
Articles:
| PubMed:Convallatoxin: A new P-glycoprotein substrate. |
| PubMed:Interaction of digitalis-like compounds with liver uptake transporters NTCP, OATP1B1, and OATP1B3. |
| PubMed:The traditional medical uses and cytotoxic activities of sixty-one Egyptian plants: discovery of an active cardiac glycoside from Urginea maritima. |
| PubMed:Interaction of digitalis-like compounds with p-glycoprotein. |
| PubMed:Inhibition of DNA topoisomerases I and II by G3 PAMAM-NH2 dendrimer-modified digoxin and proscillaridin A conjugates in a cell free system. |
| PubMed:Synthesis and cytotoxic activity of G3 PAMAM-NH(2) dendrimer-modified digoxin and proscillaridin A conjugates in breast cancer cells. |
| PubMed:Dual effects of ouabain, digoxin and proscillaridin A on the regulation of apoptosis in human fibroblasts. |
| PubMed:Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs. |
| PubMed:Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. |
| PubMed:Antiproliferative activity of derivatives of ouabain, digoxin and proscillaridin A in human MCF-7 and MDA-MB-231 breast cancer cells. |
| PubMed:Apoptosis-mediated cytotoxicity of ouabain, digoxin and proscillaridin A in the estrogen independent MDA-MB-231 breast cancer cells. |
| PubMed:Inhibition of DNA topoisomerases I and II, and growth inhibition of breast cancer MCF-7 cells by ouabain, digoxin and proscillaridin A. |
| PubMed:A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure. |
| PubMed:Ouabain binding to Na+,K+-ATPase relaxes cell attachment and sends a specific signal (NACos) to the nucleus. |
| PubMed:[Separation and purification of an endogenous inhibitor of sodium pump from chansu by thin-layer chromatography and reversed-phase high performance liquid chromatography]. |
| PubMed:[An elderly case of idiopathic dilatation of the right atrium in which right-sided heart failure was exacerbated by drug-induced bradyarrhythmia]. |
| PubMed:Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells. |
| PubMed:The T-cell suppressive effect of bufadienolides: structural requirements for their immunoregulatory activity. |
| PubMed:Exquisitely small amounts of nonglucocorticoid natural steroids suppress the human allogeneic T-cell response. |
| PubMed:Sanguinarine induces K+ outflow from yeast cells expressing mammalian sodium pumps. |
| PubMed:Selective inhibition of human erythrocyte Na+/K+ ATPase by cardiac glycosides and by a mammalian digitalis like factor. |
| PubMed:Scilla maderensis, TLC screening and positive inotropic effect of bulb extracts. |
| PubMed:[A case of proscillaridin poisoning]. |
| PubMed:Proscillaridin A immunoreactivity: its purification, transport in blood by a specific binding protein and its correlation with blood pressure. |
| PubMed:A specific binding protein for cardiac glycosides exists in bovine serum. |
| PubMed:Bovine adrenals and hypothalamus are a major source of proscillaridin A- and ouabain-immunoreactivities. |
| PubMed:Bovine adrenals contain, in addition to ouabain, a second inhibitor of the sodium pump. |
| PubMed:Proscillaridin A immunoreactivity: a new endogenous cardiac glycoside? |
| PubMed:Pulse pressure correlates in humans with a proscillaridin A immunoreactive compound. |
| PubMed:Role of endogenous cardiac glycosides in the spontaneously hypertensive rat--antagonism by active immunization. |
| PubMed:Uptake and sequestration of ouabain and other cardiac glycosides inDanaus plexippus (Lepidoptera: Danaidae): Evidence for a carrier-mediated process. |
| PubMed:About the bufadienolide complex of "red" squill. |
| PubMed:Cardiac glycoside-induced elevation of intracellular Na+ ion concentration in human erythrocytes studied by 23Na NMR spectroscopy: relationship between inotropy speed and elevation rate of intracellular Na+ ion concentration. |
| PubMed:[Preparation of phenylpropylsilica and its application to high performance liquid chromatographic analysis of proscillaridin]. |
| PubMed:[Studies on cardiac ingredients of plants. X. Preparation of nitrates of tetrahydroproscillaridin and their pharmacological activities]. |
| PubMed:[Effects of bufadienolides and some kinds of cardiotonics on guinea pig hearts]. |
| PubMed:Studies on cardiac ingredients of plants. IX. Chemical transformation of proscillaridin by utilizing its 1,4-cycloadducts as key compounds and biological activities of their derivatives. |
| PubMed:Bufadienolides from Urginea maritima sensu strictu. |
| PubMed:Studies on cardiac ingredients of plants. VII: Chemical transformation of proscillaridin by means of the Diels-Alder reaction and biological activities of its derivatives. |
| PubMed:[Studies on cardiac ingredients of plants. VIII. Preparation of nitrates of proscillaridin and their pharmacological activities]. |
| PubMed:Cardiotonic drugs inhibit purified mammalian acetylcholinesterase. |
| PubMed:Specific anti-digoxin Fab fragments: an available antidote for proscillaridin and scilliroside poisoning? |
| PubMed:The bioavailability of methylepoxyproscillaridin (P35): a new semisynthetic cardiac glycoside. |
| PubMed:Hemodynamic effect of methylepoxyproscillaridin (P35) in patients with congestive myocardiopathy. |
| PubMed:Studies on cardiac ingredients of plants. V. Chemical transformation of proscillaridin and biological activities of derivatives. |
| PubMed:Binding of [3H]ouabain to endothelial cells derived from various vascular beds. |
| PubMed:[Studies on cardiac ingredients of plants (IV). Effect of reduced proscillaridins on guinea-pig hearts]. |
| PubMed:Studies on cardiac ingredients of plants. III. Structural confirmation and biological activity of reduced proscillaridins. |
| PubMed:Determination of proscillaridin in plasma by radioimmunoassay. |
| PubMed:[Potential radiopharmaceutical for adrenal gland scintigraphy. 1. Radioiodination of tyramine derivatives of some derivatives of digitoxigenin and scillarenin]. |
| PubMed:[Use of a cardiotonic agent in the ventricular pre-excitation syndrome. Report of a case]. |
| PubMed:A comparative dose-effect study with cardiac glycosides assessing cardiac and extracardiac responses in normal subjects. |
| PubMed:[Effect of plant glycosides on resistance and capacitance vessels]. |
| PubMed:Electrophysiological studies of some semisynthetic cardiac glycoside derivatives in isolated papillary muscle of the guinea-pig. |
| PubMed:Quantitation of Principal Bufadienolides in Different Cytotypes of Urginea indica. |
| PubMed:[Plasma concentration and elimination behavior of the cardiac glycoside meproscillarin in patients with liver cirrhosis]. |
| PubMed:Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention--III. Profile of action of sodium 2-mercaptoethane sulfonate (mesna). |
| PubMed:Pharmacokinetic review of digitalis glycosides. |
| PubMed:[Therapy of chronic cardiac insufficiency with cardiac glycosides]. |
| PubMed:[Evaluation of the practical use of mathematical methods and computer technics for the control of treatment with selected digitalis glycosides]. |
| PubMed:[Use of mathematical methods and computer technics for monitoring the concentration of digitalis glycosides in the body of patients with symptoms of overdigitalization]. |
| PubMed:[Problems of glycoside therapy in kidney insufficiency and uremia]. |
| PubMed:[Threshold of action of meproscillarin following intravenous administration]. |
| PubMed:[Determination of individual sensitivity threshold to digitalis glycosides in chronic circulatory insufficiency]. |
| PubMed:[Densitometric determination of proscillaridin A, scillaren A and scilliroside]. |
| PubMed:[Construction of tables facilitating daily control of treatment with proscillaridin A]. |
| PubMed:[Meproscillarin in patients with renal failure and concomitant heart failure (author's transl)]. |
| PubMed:Disposition rate of proscillaridin A in man after multiple oral doses. |
| PubMed:[14,15-beta-oxido analog of proscillaridin (HOE 040). A new cardiac glycoside with low arrhythmic activity and greater absorption ratio]. |
| PubMed:[Effect of proscillaridin on adenosine triphosphatase in kidney tissue in the rat. Electron microscopy demonstration and significance for calcium metabolism]. |
| PubMed:[Effect of proscillaridin on specific adenosine triphosphatases in heart muscle of rats. Electron optical demonstration and significance for calcium metabolism]. |
| PubMed:[Modern cardiac glycoside therapy]. |
| PubMed:[Studies on the disposition of meproscillarin in rat and dog (author's transl)]. |
| PubMed:[Studies on extracardiac effects of the cardiac glycoside meproscillarin in animal experiments (author's transl)]. |
| PubMed:[Meproscillarin, a new semisynthetic cardiac glycoside/chemistry and physical properties (author's transl)]. |
| PubMed:[Cardiac glycoside receptor affinity and (Na++K+)-ATPase inhibition of digitoxin, digoxin, methyldigoxin, strophanthin, proscillaridin, and meproscillarin. Measurements on isolated human cardiac cell membranes]. |
| PubMed:Contribution to the biochemical characterization of cardiac glycosides concerning their influence on ATP-ases. |
| PubMed:[Effect of proscillaridin-4'-methylether on pressure rise velocity in the left ventricle of patients with coronary heart disease (author's transl)]. |
| PubMed:Proscillaridin activity in portal and peripheral venous blood after oral administration to man. |
| PubMed:Biliary excretion and enterochepatic recycling of proscillaridin A after oral adminstration to man. |
| PubMed:Stability in vitro of methylproscillaridin. |
| PubMed:Activities of proscillaridin A in thoracic duct lymph after single oral doses in man. |
| PubMed:[Echocardiography during the therapy of cardiovascular diseases]. |
| PubMed:[Comparative studies of action in cats of intraintestinally administered digoxin, proscillardin and K- strophantoside]. |
| PubMed:[Influence of high intravenous doses of D-penicillamine on toxic actions of cardiac glycosides in the guinea pig. Short communication (author's transl)]. |
| PubMed:On the absorption of proscillaridin A after single oral doses to normal and achlorhydric subjects. |
| PubMed:Proscillaridin A yield from squill bulbs. |
| PubMed:[Trial of a combination of proscillaridin A, thioridazine and Cori ester in the ambulatory treatment of some cardiopathies, especially senile types]. |
| PubMed:[Echocardiographic evaluation of left ventricular function during therapy with cardiovascularly effective drugs]. |
| PubMed:Pharmacokinetics and pharmacodynamics of methyl proscillaridin in healthy man. |
| PubMed:[Enteral availability and therapeutic activity of proscillaridin-4'-methyl ether (author's transl)]. |
| PubMed:Plasma concentrations during repeated intravenous and oral methyl-proscillaridin application in man. |
| PubMed:[Investigations on the Stability of Proscillaridine, Proscillaridine-3'-methylether and Proscillaridine-4'-methylether in Artificial Gastric and Intestinal Fluids (author's transl)]. |
| PubMed:Excretion of methylproscillaridin in patients with a biliary fistula. |
| PubMed:[Standardized prescription glycoside: results of prescription analysis and clinical observations (glycoside intoxication)]. |
| PubMed:Multiclinical open studies on the effect of beta-methyldigoxin on congestive heart failure with atrial fibrillation. |
| PubMed:Metabolism and excretion of methylproscillaridin by man. |
| PubMed:On the pharmacokinetics of proscillaridin A in man. |
| PubMed:[Relationship between binding to the myocardium and effects of proscillaridin on isolated perfused heart of the guinea pig]. |
| PubMed:In vitro stability of proscillaridin A. |
| PubMed:[Enteral availability and suggested dosages for methyl proscillaridin in decompensated heart patients]. |
| PubMed:Studies on cardioactive steroids. III. Characterization of different cardiac glycosides by their effects on contractility and rhythmicity at different extracellular potassium concentrations. |
| PubMed:[Effect and plasma level of methylproscillaridin and beta-acetyldigitoxin following long term administration in man]. |
| PubMed:Effect of oral charcoal on plasma levels of intravenous methyl proscillaridin. |
| PubMed:[Plasma concentrations and elimination of methyl proscillaridin in renal failure (author's transl)]. |
| PubMed:[Plasma levels, elimination and cumulation of proscillaridin in renal failure (author's transl)]. |
| PubMed:A study on timed intracellular localization and distribution of tritiated digitoxin and proscillaridin A in the myocardial cells by electron microscopic autoradiography. |
| PubMed:[Studies on direct effects of proscillaridin A on the electrolyte excretion and transport ATPase in dog kidneys (author's transl)]. |
| PubMed:The reactivation of the proscillaridin-inhibited membrane ATPase by specific antibodies. |
| PubMed:[Effect of proscillaridin on active cation transport across human red cell membrane (author's transl)]. |
| PubMed:Proceedings: Studies on pharmacokinetics of proscillaridin-4'-methyl ether in man. |
| PubMed:[Plasma levels and electrocardiogram after intravenous administration of proscillaridin and digoxin]. |
| PubMed:Plasma levels after a single oral dose of proscillaridin. |
| PubMed:Characterization and specificity of proscillaridin antibodies. |
| PubMed:A comparison of the cardiovascular effects of proscillaridin and ouabain in anaesthetised dogs. |
| PubMed:[Cardiotonic effects of proscillaridin A]. |
| PubMed:A quantitative comparison of the cardiac actions of peruvoside with those of G-strophanthin and proscillaridin. |
| PubMed:Species and ionic influences on the accumulation of digitalis glycosides by isolated perfused hearts. |
| PubMed:[Combination of proscillaridin A and secobarbital. Clinical report]. |
| PubMed:[Practical aspects of treatment of senile cardiopathies with a combination of proscillaridin A, thioridazine and Cori ester]. |
| PubMed:The hemodynamic response to digoxin and proscillaridin during rest and exercise in patients with a fixed rate artificial pacemaker. |
| PubMed:Protection by catatoxic steroids and related compounds against proscillaridin intoxication. |
| PubMed:[Talusin (proscillaridin)--once more]. |
| PubMed:Pharmacological and electrophysiological actions of proscillaridin A. The mechanism of bigeminal rhythm induced by its toxic dosage studied by the change of the transmembrane action potential. |
| PubMed:[Effects of proscillaridin A on the dynamic values of cardiac revolution, measured with the polygraphic method in patients with myocardial infarct in the acute phase]. |
| PubMed:[Conformation of rhamnose in proscillaridin]. |
| PubMed:[Cardiovascular effect of a cardiac glycoside, proscillaridin A]. |
| PubMed:[Proscillaridin carbonates]. |
| PubMed:[Clinical trial of proscillaridin A]. |
| PubMed:[Methyl ether of proscillaridin]. |
| PubMed:[Study of the activity of a cardioactive glucoside, proscillaridin A, in ambulatory patients]. |
| PubMed:[Behavior of gastric secretion after administration of a single dose of Proscillaridin A. Statistical and clinical findings]. |
| PubMed:[Effect of cardiac glycosides on the duration of systole. A comparison between proscillaridin and strophanthin]. |
| PubMed:[Acetates of proscillaridin]. |
| PubMed:[Clinical experience in the use of proscillaridin A in cardiac patients with tubercular bronchopneumopathy]. |
| PubMed:[Therapeutic trial of an association of theophylline and proscillaridin A in the treatment of cor pulmonale and of some decompensated heart diseases]. |
| PubMed:Clinical studies on proscillaridin a new squill glycoside. |
| PubMed:[Acyl and alkyl derivatives of proscillaridin]. |
| PubMed:[On some aspects of occupational pathology in workers engaged in the manufacture of proscillaridin A]. |
| PubMed:[Clinical evaluation of the association of proscillaridin and beta-hydroxy-ethyl-theophylline in the treatment of cardiac insufficiency]. |
| PubMed:[Clinical and physiopathological observations on the treatment of chronic cor pulmonale with an association of theophylline and proscillaridin A]. |
| PubMed:[Clinical and experimental studies on the effect of proscillaridin A]. |
| PubMed:[Pharmacology of isopropylidene-proscillaridin]. |
| PubMed:Comparative cardiovascular effects and metabolism of proscillaridin A and of digoxin. |
| PubMed:[Metabolic turnover and effect of cardiac glycosides. I. Determination of blood levels and of the ventricular ejection index and of R-I time derivated from apex cardiogram after intravenous injection of acetyl-digitoxin or proscillaridin A-H3 in normal subjects]. |
| PubMed:[Influencing the cardiotonic effect of proscillaridin by verapamil]. |
| PubMed:[Dynamics of the total left ventricular systole under the influence of cardiac glycosides with particular reference to proscillaridin A]. |
| PubMed:Effect of spironolactone and norbolethone on the toxicity of digitalis compounds in the rat. |
| PubMed:Comparative effects of digoxin and proscillaridin in the heart-lung preparation. |
| PubMed:[Contribution to the quantitative and qual-itative study on the glycoside proscillaridin]. |
| PubMed:[Experiences with the clinical use of proscillaridin A]. |
| PubMed:The uptake and release of proscillaridin-3H by several tissues of the guinea pig after oral administration. |
| PubMed:[Proscillaridin A in the therapy of decompensated heart diseases]. |
| PubMed:[Clinical observations on the use of a combination of proscillaridin and theophylline in the treatment of the senile heart and chronic cor pulmonale]. |
| PubMed:[Intravenous proscillaridin A in cardiotonic therapy of the senile heart]. |
| PubMed:Effects of dimethyl sulfoxide (DMSO) on cardiovascular responses to ouabain, proscillaridin and digitoxin. |
| PubMed:[Clinical evaluation of Proscillaridin A, a glycoside of Scilla maritima]. |
| PubMed:[Clinical experimental studies with the heart glycoside, proscillaridin, with special reference to its enteral resorption rate]. |
| PubMed:Assessment of contractility following proscillaridin A in dog hearts both normal and pretreated with propranolol. |
| PubMed:[Therapeutic experiences with proscillaridin A in decompensated heart diseases]. |
| PubMed:[Clinical experiences with a squill preparation (proscillaridin A) in oral administration]. |
| PubMed:[Some clinical observations on the use of a cardiokinetic extract of squill: proscillaridin A. Differences from other more commonly used glycosides]. |
| PubMed:[Clinical action of a new cardioactive glycoside: proscillaridin A]. |
| PubMed:[On the effectiveness of proscillaridin A as deduced from the study of cardiac output in patients with myocardiosclerosis]. |
| PubMed:[The clinical use of a new cardioactive glycoside: proscillaridin A]. |
| PubMed:[Clinical use of a new cardioactive glycoside: proscillaridin A. Case studies]. |
| PubMed:[Therapeutic examination of proscillaridin A]. |
| PubMed:[The use of proscillaridin A in the therapy of cardiac insufficiency in the aged]. |
| PubMed:[On the question of standardization of German bulbus Scillae standard and proscillaridin A in guinea pigs]. |
| PubMed:[On the clinical use of proscillaridin A (Sandoscill)]. |
| PubMed:[Experiences with the cardiac glycoside Proscillaridin A (Sandoscill)]. |
| PubMed:[Observations on the use of proscillaridin A in some disorders of cardiac rhythm]. |
| PubMed:[A year of clinical experience with a new cardio-active glycoside, proscillaridin]. |
| PubMed:[The use of a new cardioactive glucoside: Proscillaridin A, in the treatment of cardiopathy in the aged]. |
| PubMed:[Comparative studies on the diuretic effect and acute toxicity of g-strophanthin, scillaren and proscillaridin in dogs]. |
| PubMed:[Clinical analysis with proscillaridin]. |
| PubMed:[Comparative hemodynamic effect of proscillaridin A and strophanthin]. |
| PubMed:Comparative blood pressure and electrocardiographic changes induced by proscillaridin and ouabain. |
| PubMed:[Changes of the electrocardiograms of heart disease patients caused by the administration of proscillaridin A]. |
| PubMed:[Value of the clinical use of proscillaridin A]. |
| PubMed:[Contribution to the konwledge of some effects of proscillaridin on the cardiovascular system. Electrocardiographic and radiocardiographic research]. |
| PubMed:[Data on the hospital treatment of heart disease patients with proscillaridin A]. |
| PubMed:[Clinical experience with a new cardioactive glycoside: Proscillaridin A]. |
| PubMed:Treatment of chronic right-heart lesions. Proscillaridin for cor pulmonale and the senile heart. |
| PubMed:[Clinical use of a new cardioactive glycoside: proscillaridin A]. |
| PubMed:[Clinical notes on the effect of a new cardiokinetic drug (proscillaridin A)]. |
| PubMed:[Research on a new cardioactive glycoside in clinical practice: proscillaridin A]. |
| PubMed:[Clinical observations on the use of a new cardioactive glycoside: proscillaridin A]. |
| PubMed:[Proscillaridin A in some senile heart diseases. Preliminary clinico-therapeutic observations]. |
| PubMed:[Study of the therapeutic effect of a cardioactive glycoside extracted from scilla (proscillaridin A), by means of polygraphic investigations]. |
| PubMed:[Evaluation by the polygraphic method of the cardiokinetic action of a new glycoside isolated from scilla (proscillaridin A)]. |
| PubMed:[On the therapy of heart insufficiency with the pure glycoside Proscillaridin A]. |
| PubMed:[Experience with proscillaridin A in cardiac insufficiency]. |
| PubMed:[Clinical experimentation with a new cardioactive glycoside derived from Scilla: proscillaridin]. |
| PubMed:[Clinical studies on the cardiotonic effects of proscillaridin A]. |
| PubMed:[Action of oral proscillaridin treatment in various forms of heart insufficiency]. |
| PubMed:[Effects of proscillaridin A on the duration of phases of ventricular systole and on normal heart rate]. |
| PubMed:[Therapeutic experiences with a new cardiac glycoside: proscillaridin A]. |
| PubMed:[STUDIES ON THE EFFECTIVENESS OF PROSCILLARIDIN A]. |
| PubMed:[ON PHARMACOLOGY AND THE THERAPEUTIC USE OF PROSCILLARIDIN A]. |
|
