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sennidin A
dihydroxydianthrone

Supplier Sponsors

Name:(9R)-9-[(9R)-2-carboxy-4,5-dihydroxy-10-oxo-9H-anthracen-9-yl]-4,5-dihydroxy-10-oxo-9H-anthracene-2-carboxylic acid
CAS Number: 641-12-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:211-371-5
FDA UNII: O8793FIM31
Nikkaji Web:J562.021J
MDL:MFCD00017368
XlogP3-AA:4.80 (est)
Molecular Weight:538.46546000
Formula:C30 H18 O10
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 801.80 °C. @ 760.00 mm Hg (est)
Flash Point: 847.00 °F. TCC ( 452.60 °C. ) (est)
logP (o/w): 8.240 (est)
Soluble in:
 water, 0.0007279 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Sennidine A 98%
BOC Sciences
For experimental / research use only.
SENNIDINE A >98%
Odor: characteristic
Use: Sennidin A-stimulated glucose incorporation was completely inhibited by wortmannin. Sennidin A did not induce tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate-1 (IRS-1), but induced phosphorylation of Akt and glucose trans Laxative
Carbosynth
For experimental / research use only.
Sennidin A
ExtraSynthese
For experimental / research use only.
Sennidin A (HPLC) ≥90%
Sigma-Aldrich
For experimental / research use only.
Sennidin A phyproof® Reference Substance
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for sennidin A usage levels up to:
 not for fragrance use.
 
Recommendation for sennidin A flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :92826
National Institute of Allergy and Infectious Diseases:Data
(9R)-9-[(9R)-2-carboxy-4,5-dihydroxy-10-oxo-9H-anthracen-9-yl]-4,5-dihydroxy-10-oxo-9H-anthracene-2-carboxylic acid
Chemidplus:0000641123
 
References:
 (9R)-9-[(9R)-2-carboxy-4,5-dihydroxy-10-oxo-9H-anthracen-9-yl]-4,5-dihydroxy-10-oxo-9H-anthracene-2-carboxylic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):92826
Pubchem (sid):135050553
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
(9,9'-bianthracene)-2,2'-dicarboxylic acid, 9,9',10,10'-tetrahydro-4,4',5,5'-tetrahydroxy-10,10'-dioxo-, (R*,R*)-(+)-
(9R)-9-[(9R)-2-carboxy-4,5-dihydroxy-10-oxo-9H-anthracen-9-yl]-4,5-dihydroxy-10-oxo-9H-anthracene-2-carboxylic acid
 dihydroxydianthrone
(R*,R*)-(+)-9,9',10,10'-tetrahydro-4,4',5,5'-tetrahydroxy-10,10'-dioxo(9,9'-bianthracene)-2,2'-dicarboxylic acid
 

Articles:

PubMed:Necrosis targeted combinational theragnostic approach using radioiodinated Sennidin A in rodent tumor models.
PubMed:Sennidin stimulates glucose incorporation in rat adipocytes.
PubMed:The influence of the sennosides on absorption of glycyrrhetic acid in rats.
PubMed:A sennoside-hydrolyzing beta-glucosidase from Bifidobacterium sp. strain SEN is inducible.
PubMed:Isolation of a human intestinal anaerobe, Bifidobacterium sp. strain SEN, capable of hydrolyzing sennosides to sennidins.
PubMed:The senna drug and its chemistry.
 
Notes:
aglycone of senna glycosides.
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