EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

alpha-solanine
beta-d-galactopyranoside, (3beta)-solanid-5-en-3-yl o-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-(beta-D-glucopyranosyl-(1-3))

Supplier Sponsors

CAS Number: 20562-02-1Picture of molecule3D/inchi
Other(deleted CASRN):11017-45-1
ECHA EINECS - REACH Pre-Reg:243-879-8
FDA UNII: 15XXN7Q45T
Beilstein Number:0077607
MDL:MFCD00077873
XlogP3-AA:1.80 (est)
Molecular Weight:868.07181000
Formula:C45 H73 N O15
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 285.00 °C. @ 760.00 mm Hg
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): 5.670 (est)
Soluble in:
 water, 0.5159 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
a-Solanine
ExtraSynthese
For experimental / research use only.
alpha-Solanine (HPLC) ≥98%
Glentham Life Sciences
a-Solanine
Santa Cruz Biotechnology
For experimental / research use only.
a-Solanine >95%
Sigma-Aldrich: Aldrich
For experimental / research use only.
a-Solanine from potato sprouts, ≥95%
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-human TDLo 2800 ug/kg
BEHAVIORAL: HEADACHE GASTROINTESTINAL: GASTRITIS
Veterinary and Human Toxicology. Vol. 25, Pg. 13, 1983.

unreported-man LDLo 2941 ug/kg
"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.

intraperitoneal-mouse LD50 32 mg/kg
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Food and Cosmetics Toxicology. Vol. 10, Pg. 395, 1972.

intraperitoneal-rabbit LDLo 20 mg/kg
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Toxicology and Applied Pharmacology. Vol. 19, Pg. 81, 1971.

intravenous-rabbit LDLo 10 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Toxicology and Applied Pharmacology. Vol. 19, Pg. 81, 1971.

intraperitoneal-rat LD50 67 mg/kg
Toxicology and Applied Pharmacology. Vol. 36, Pg. 227, 1976.

oral-rat LD50 590 mg/kg
Teratology, The International Journal of Abnormal Development. Vol. 8, Pg. 349, 1973.

Dermal Toxicity:
subcutaneous-rabbit LDLo 5 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1398, 1935.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for alpha-solanine usage levels up to:
 not for fragrance use.
 
Recommendation for alpha-solanine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :30185
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0020562021
RTECS:WF0250000 for cas# 20562-02-1
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):30185
Pubchem (sid):134995801
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
KEGG (GenomeNet):C10820
HMDB (The Human Metabolome Database):HMDB34202
FooDB:FDB012500
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 potato flower
Search Trop Picture
 potato leaf
Search Trop Picture
 potato shoot
Search Trop Picture
 potato sprout
Search Trop Picture
 potato tuber
Search Trop Picture
 tomato
Search Trop Picture
 
Synonyms:
beta-d-galactopyranoside, (3beta)-solanid-5-en-3-yl o-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-(beta-D-glucopyranosyl-(1-3))
 solanid-5-ene, 3-beta-((O-6-deoxy-alpha-L-mannopyranosyl)-O-(beta-d-glucopyranosyl-beta-d-galactopyranosyl)oxy)-
 solanin
 solatunine
 

Articles:

PubMed:[Determination of alpha-solanine, alpha-chaconine and solanidine in plasma and urine by ultra-performance liquid chromatography-triple quadrupole mass spectrometry].
PubMed:Sterol side chain reductase 2 is a key enzyme in the biosynthesis of cholesterol, the common precursor of toxic steroidal glycoalkaloids in potato.
PubMed:Comparative Metabolite Profiling of Solanum tuberosum against Six Wild Solanum Species with Colorado Potato Beetle Resistance.
PubMed:α-Solanine inhibits invasion of human prostate cancer cell by suppressing epithelial-mesenchymal transition and MMPs expression.
PubMed:Potato leaf extract and its component, α-solanine, exert similar impacts on development and oxidative stress in Galleria mellonella L.
PubMed:Solanine induces mitochondria-mediated apoptosis in human pancreatic cancer cells.
PubMed:Detection of glycoalkaloids using disposable biosensors based on genetically modified enzymes.
PubMed:Effect of genotype and environment on the glycoalkaloid content of rare, heritage, and commercial potato varieties.
PubMed:Ultrasonic extraction of steroidal alkaloids from potato peel waste.
PubMed:Antitumor efficacy of α-solanine against pancreatic cancer in vitro and in vivo.
PubMed:Identification of differently expressed genes and small molecule drugs for Tetralogy of Fallot by bioinformatics strategy.
PubMed:Conversion of exogenous cholesterol into glycoalkaloids in potato shoots, using two methods for sterol solubilisation.
PubMed:Electrochemical determination of glycoalkaloids using a carbon nanotubes-phenylboronic acid modified glassy carbon electrode.
PubMed:Allelic variation in genes contributing to glycoalkaloid biosynthesis in a diploid interspecific population of potato.
PubMed:The protective and therapeutic effects of alpha-solanine on mice breast cancer.
PubMed:Structural effects of the Solanum steroids solasodine, diosgenin and solanine on human erythrocytes and molecular models of eukaryotic membranes.
PubMed:Synergistic cytotoxicity induced by α-solanine and α-chaconine.
PubMed:Biosynthesis of antinutritional alkaloids in solanaceous crops is mediated by clustered genes.
PubMed:Glycoalkaloid and calystegine levels in table potato cultivars subjected to wounding, light, and heat treatments.
PubMed:Solanidine isolation from Solanum tuberosum by centrifugal partition chromatography.
PubMed:Review of the inhibition of biological activities of food-related selected toxins by natural compounds.
PubMed:Screening test for rapid food safety evaluation by menadione-catalysed chemiluminescent assay.
PubMed:The influence of dietary α-solanine on the waxmoth Galleria mellonella L.
PubMed:Biosynthesis of steroidal alkaloids in Solanaceae plants: involvement of an aldehyde intermediate during C-26 amination.
PubMed:Anti-inflammatory properties of potato glycoalkaloids in stimulated Jurkat and Raw 264.7 mouse macrophages.
PubMed:Effect of peeling and three cooking methods on the content of selected phytochemicals in potato tubers with various colour of flesh.
PubMed:Guatemalan potato moth Tecia solanivora distinguish odour profiles from qualitatively different potatoes Solanum tuberosum L.
PubMed:Preparative separation of glycoalkaloids α-solanine and α-chaconine by centrifugal partition chromatography.
PubMed:Polyphenol and glycoalkaloid contents in potato cultivars grown in Luxembourg.
PubMed:Compositional and toxicological analysis of a GM potato line with reduced α-solanine content--a 90-day feeding study in the Syrian Golden hamster.
PubMed:Simple and reliable methods for the determination of three steroidal glycosides in the eight species of Solanum by reversed-phase HPLC coupled with diode array detection.
PubMed:Glycoalkaloids (α-chaconine and α-solanine) contents of selected Pakistani potato cultivars and their dietary intake assessment.
PubMed:Induction of potato steroidal glycoalkaloid biosynthetic pathway by overexpression of cDNA encoding primary metabolism HMG-CoA reductase and squalene synthase.
PubMed:The chloroform fraction of Solanum nigrum suppresses nitric oxide and tumor necrosis factor-α in LPS-stimulated mouse peritoneal macrophages through inhibition of p38, JNK and ERK1/2.
PubMed:Effects of auxins on the production of steroidal alkaloids in rapidly proliferating tissue and cell cultures of Solanum lyratum.
PubMed:Four potato (Solanum tuberosum) ABCG transporters and their expression in response to abiotic factors and Phytophthora infestans infection.
PubMed:Development of a liquid chromatography-tandem mass spectrometric method for the simultaneous determination of tropane alkaloids and glycoalkaloids in crops.
PubMed:[Inhibitory effect of solanine on prostate cancer cell line PC-3 in vitro].
PubMed:Glycoalkaloid content in pet food by UPLC-tandem mass spectrometry.
PubMed:α-Solanine inhibits human melanoma cell migration and invasion by reducing matrix metalloproteinase-2/9 activities.
PubMed:In vivo antimalarial activities of glycoalkaloids isolated from Solanaceae plants.
PubMed:Elucidation of the mass fragmentation pathways of potato glycoalkaloids and aglycons using Orbitrap mass spectrometry.
PubMed:Effects of glycoalkaloids from Solanum plants on cucumber root growth.
PubMed:The bioactive compounds alpha-chaconine and gallic acid in potato extracts decrease survival and induce apoptosis in LNCaP and PC3 prostate cancer cells.
PubMed:alpha-Chaconine inhibits angiogenesis in vitro by reducing matrix metalloproteinase-2.
PubMed:Naturally occurring glycoalkaloids in potatoes aggravate intestinal inflammation in two mouse models of inflammatory bowel disease.
PubMed:Composition of phenolic compounds and glycoalkaloids alpha-solanine and alpha-chaconine during commercial potato processing.
PubMed:Degradation of the potato glycoalkaloid alpha-solanine in three agricultural soils.
PubMed:Potatoes, tomatoes, and solanine toxicity (Solanum tuberosum L., Solanum lycopersicum L.).
PubMed:Biological activity of alkaloids from Solanum dulcamara L.
PubMed:Glycoalkaloids as biomarkers for recognition of cultivated, wild, and somatic hybrids of potato.
PubMed:Degradation of the potato glycoalkaloids--alpha-solanine and alpha-chaconine in groundwater.
PubMed:Probabilistic modelling of exposure doses and implications for health risk characterization: glycoalkaloids from potatoes.
PubMed:Fate of toxic potato glycoalkaloids in a potato field.
PubMed:A 28-day repeat dose toxicity study of steroidal glycoalkaloids, alpha-solanine and alpha-chaconine in the Syrian Golden hamster.
PubMed:Modification of the health-promoting value of potato tubers field grown under drought stress: emphasis on dietary antioxidant and glycoalkaloid contents in five native andean cultivars (Solanum tuberosum L.).
PubMed:Distribution of glycoalkaloids in potato tubers of 59 accessions of two wild and five cultivated Solanum species.
PubMed:PI3K/AKT, JNK, and ERK pathways are not crucial for the induction of cholesterol biosynthesis gene transcription in intestinal epithelial cells following treatment with the potato glycoalkaloid alpha-chaconine.
PubMed:Acute toxicity of high doses of the glycoalkaloids, alpha-solanine and alpha-chaconine, in the Syrian Golden hamster.
PubMed:A human dietary risk assessment associated with glycoalkaloid responses of potato to Colorado potato beetle defoliation.
PubMed:A major QTL and an SSR marker associated with glycoalkaloid content in potato tubers from Solanum tuberosum x S. sparsipilum located on chromosome I.
PubMed:Central diabetes insipidus following digestion Solanum indicum L. concentrated solution.
PubMed:Potato glycoalkaloids in soil-optimising liquid chromatography-time-of-flight mass spectrometry for quantitative studies.
PubMed:Alpha-chaconine-reduced metastasis involves a PI3K/Akt signaling pathway with downregulation of NF-kappaB in human lung adenocarcinoma A549 cells.
PubMed:Induction of apoptosis in HepG2 cells by solanine and Bcl-2 protein.
PubMed:Differential gene expression in intestinal epithelial cells induced by single and mixtures of potato glycoalkaloids.
PubMed:Potato steroidal glycoalkaloid levels and the expression of key isoprenoid metabolic genes.
PubMed:[Survey of glycoalkaloids content in the various potatoes].
PubMed:Induction of the cholesterol biosynthesis pathway in differentiated Caco-2 cells by the potato glycoalkaloid alpha-chaconine.
PubMed:Effect of carbohydrates on the production of thaxtomin A by Streptomyces acidiscabies.
PubMed:[Study of the interaction of main potato glycoalkaloids in inhibition of immobilized butyryl cholinesterase].
PubMed:Potato glycosterol rhamnosyltransferase, the terminal step in triose side-chain biosynthesis.
PubMed:The Solanaceae: foods and poisons.
PubMed:[Kinetic properties of butyrylcholinesterases immobilised on pH-sensitive field-effect transistor surface and inhibitory action of steroidal glycoalkaloids on these enzymes].
PubMed:Potato glycoalkaloids and metabolites: roles in the plant and in the diet.
PubMed:Compartmentalization of oxidative stress and antioxidant defense in the larval gut of Spodoptera littoralis.
PubMed:CHIH-DFT determination of the molecular structure and infrared and ultraviolet spectra of gamma-solanine.
PubMed:Rapid screening of ascorbic acid, glycoalkaloids, and phenolics in potato using high-performance liquid chromatography.
PubMed:Effect of solanine on the membrane potential of mitochondria in HepG2 cells and [Ca2+]i in the cells.
PubMed:Alpha-chaconine, a potato glycoalkaloid, induces apoptosis of HT-29 human colon cancer cells through caspase-3 activation and inhibition of ERK 1/2 phosphorylation.
PubMed:The primary in vivo steroidal alkaloid glucosyltransferase from potato.
PubMed:The effect of selected allelochemicals on germination of conidia and blastospores and mycelial growth of the entomopathogenic fungus, Paecilomyces fumosoroseus (Deuteromycotina: Hyphomycetes).
PubMed:Hydrolysis of the potato glycoalkaloid alpha-chaconine by filamentous fungi.
PubMed:Simple and sensitive method for determination of glycoalkaloids in potato tubers by high-performance liquid chromatography with chemiluminescence detection.
PubMed:Anticarcinogenic effects of glycoalkaloids from potatoes against human cervical, liver, lymphoma, and stomach cancer cells.
PubMed:[Contents and its change during storage of alpha-solanine and alpha-chaconine in potatoes].
PubMed:Potato glycoalkaloids and adverse effects in humans: an ascending dose study.
PubMed:Molecular mechanisms of toxicity of important food-borne phytotoxins.
PubMed:Comparison of rapid liquid chromatography-electrospray ionization-tandem mass spectrometry methods for determination of glycoalkaloids in transgenic field-grown potatoes.
PubMed:Effects of steroidal glycoalkaloids from potatoes (Solanum tuberosum) on in vitro bovine embryo development.
PubMed:Analysis of biologically active compounds in potatoes (Solanum tuberosum), tomatoes (Lycopersicon esculentum), and jimson weed (Datura stramonium) seeds.
PubMed:Effect of selenate supplementation on glycoalkaloid content of potato (Solanum tuberosum L.).
PubMed:Enrichment of the glycoalkaloids alpha-solanine and alpha-chaconine from potato juice by adsorptive bubble separation using a pH gradient.
PubMed:Colorado potato beetle toxins revisited: evidence the beetle does not sequester host plant glycoalkaloids.
PubMed:Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells.
PubMed:Determination of potato glycoalkaloids using high-pressure liquid chromatography-electrospray ionisation/mass spectrometry.
PubMed:Potato glycoalkaloids: true safety or false sense of security?
PubMed:Development and optimisation of biosensors based on pH-sensitive field effect transistors and cholinesterases for sensitive detection of solanaceous glycoalkaloids.
PubMed:Glycoalkaloid and calystegine contents of eight potato cultivars.
PubMed:Evaluation of glycoalkaloids in tubers of genetically modified virus Y-resistant potato plants (var. Désirée) by non-aqueous capillary electrophoresis coupled with electrospray ionization mass spectrometry (NACE-ESI-MS).
PubMed:[Glycoalkaloids in potatoes].
PubMed:Monitoring changes in anthocyanin and steroid alkaloid glycoside content in lines of transgenic potato plants using liquid chromatography/mass spectrometry.
PubMed:ADP ribosylation factor regulates metabolism and antioxidant capacity of transgenic potato tubers.
PubMed:Potato glycoalkaloids adversely affect intestinal permeability and aggravate inflammatory bowel disease.
PubMed:Effect of feeding solanidine, solasodine and tomatidine to non-pregnant and pregnant mice.
PubMed:Determination of glycoalkaloids and relative aglycones by nonaqueous capillary electrophoresis coupled with electrospray ionization-ion trap mass spectrometry.
PubMed:Glycoalkaloid content and chemical composition of potatoes improved with nonconventional breeding approaches.
PubMed:A novel enzyme biosensor for steroidal glycoalkaloids detection based on pH-sensitive field effect transistors.
PubMed:Comparative Responses of Globodera rostochiensis and G. pallida to Hatching Chemicals.
PubMed:Practical and highly regio- and stereoselective synthesis of 2-substituted dihydropyridines and piperidines: application to the synthesis of (-)-coniine.
PubMed:Effect of light exposure on the glycoalkaloid content of Solanum phureja tubers.
PubMed:Glycoalkaloids in potato tubers grown under controlled environments.
PubMed:Synthesis of peracetylated chacotriose.
PubMed:Differential neurosensory responses of adult Colorado potato beetle, Leptinotarsa decemlineata, to glycoalkaloids.
PubMed:Synergism between the potato glycoalkaloids alpha-chaconine and alpha-solanine in inhibition of snail feeding.
PubMed:cAMP and calcium ionophore induce outgrowth of neuronal processes in PC12 mutant cells in which nerve growth factor-induced outgrowth of neuronal processes is impaired.
PubMed:Membrane disruption and enzyme inhibition by naturally-occurring and modified chacotriose-containing Solanum steroidal glycoalkaloids.
PubMed:Immunoaffinity sample purification and MALDI-TOF MS analysis of alpha-Solanine and alpha-chaconine in serum.
PubMed:Tracer studies on the incorporation of [2-14C]-DL-mevalonate into chlorophylls a and b, alpha-chaconine, and alpha-solanine of potato sprouts.
PubMed:High-performance thin-layer chromatographic determination of potato glycoalkaloids.
PubMed:Determination of alpha-solanine and alpha-chaconine in potatoes by high-performance thin-layer chromatography/densitometry.
PubMed:The folic acid analogue methotrexate protects frog embryo cell membranes against damage by the potato glycoalkaloid alpha-chaconine.
PubMed:Cholinesterase inhibition by potato glycoalkaloids slows mivacurium metabolism.
PubMed:High-performance liquid chromatographic determination of the glycoalkaloids alpha-solanine and alpha-chaconine in 12 commercial varieties of Mexican potato.
PubMed:Substantial equivalence of antinutrients and inherent plant toxins in genetically modified novel foods.
PubMed:Determination of potato glycoalkaloids using a liposome immunomigration, liquid-phase competition immunoassay.
PubMed:Sampling leaves of young potato (Solanum tuberosum) plants for glycoalkaloid analysis.
PubMed:Photo-induced synthesis of tomatidenol-based glycoalkaloids in Solanum phureja tubers.
PubMed:Comparison of commercial solid-phase extraction sorbents for the sample preparation of potato glycoalkaloids.
PubMed:Inheritance of morphological characters and glycoalkaloids in potatoes of somatic hybrids between dihaploid Solanum acauleand tetraploid Solanum tuberosum.
PubMed:Glycoalkaloid concentration in Alberta potatoes determined by matrix-assisted laser desorption/ionization mass spectrometry.
PubMed:[Solanine and chaconine: occurrence, properties, methods for determination].
PubMed:Amelioration by glucose-6-phosphate and NADP of potato glycoalkaloid inhibition in cell, enzyme and liposome assays.
PubMed:Induction of rat hepatic cytochromes P450 by toxic ingredients in plants: lack of correlation between toxicity and inductive activity.
PubMed:Steroidal alkaloid glycosides from Solanum orbignianum.
PubMed:Inhibition of Trypanosoma cruzi growth in vitro by Solanum alkaloids: a comparison with ketoconazole.
PubMed:Normal and atypical butyrylcholinesterases in placental development, function, and malfunction.
PubMed:Liquid chromatographic determination of the glycoalkaloids alpha-solanine and alpha-chaconine in potato tubers: NMKL Interlaboratory Study. Nordic Committee on Food Analysis.
PubMed:Synthesis of gamma-chaconine and gamma-solanine are catalyzed in potato by two separate glycosyltransferases: UDP-glucose:solanidine glucosyltransferase and UDP-galactose:solanidine galactosyltransferase.
PubMed:Anticholinergic toxicity from nightshade berry poisoning responsive to physostigmine.
PubMed:Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis.
PubMed:Inhibition of human plasma and serum butyrylcholinesterase (EC 3.1.1.8) by alpha-chaconine and alpha-solanine.
PubMed:A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitness in Colorado Potato Beetle
PubMed:A study of the toxic hazard that might be associated with the consumption of green potato tops.
PubMed:Effects of saponins and glycoalkaloids on the permeability and viability of mammalian intestinal cells and on the integrity of tissue preparations in vitro.
PubMed:Feeding of potato, tomato and eggplant alkaloids affects food consumption and body and liver weights in mice.
PubMed:Glycoalkaloids selectively permeabilize cholesterol containing biomembranes.
PubMed:Induction of terata in hamsters by solanidane alkaloids derived from Solanum tuberosum.
PubMed:Comparison of high- and low-energy collision-induced dissociation tandem mass spectrometry in the analysis of glycoalkaloids and their aglycons.
PubMed:Steroidal glycoalkaloids in Andean potatoes.
PubMed:Molecular basis of glycoalkaloid induced membrane disruption.
PubMed:Protective effects of glucose-6-phosphate and NADP against alpha-chaconine-induced developmental toxicity in Xenopus embryos.
PubMed:Synergistic interaction of glycoalkaloids alpha-chaconine and alpha-solanine on developmental toxicity in Xenopus embryos.
PubMed:The glycoalkaloids: naturally of interest (but a hot potato?).
PubMed:A preliminary assessment of the toxic and mutagenic potential of steroidal alkaloids in transgenic mice.
PubMed:Tissue distribution of human acetylcholinesterase and butyrylcholinesterase messenger RNA.
PubMed:The mysterious potato.
PubMed:Analysis of glycoalkaloids from potato shoots and tomatoes by four-sector tandem mass spectrometry with scanning-array detection: comparison of positive ion and negative ion methods.
PubMed:Bioavailability and disposition of 3H-solanine in rat and hamster.
PubMed:Steroidal alkaloid toxicity to fish embryos.
PubMed:[Teratogenic effect of potato glycoalkaloids].
PubMed:Dual specificity of sterol-mediated glycoalkaloid induced membrane disruption.
PubMed:Absence of genotoxicity of potato alkaloids alpha-chaconine, alpha-solanine and solanidine in the Ames Salmonella and adult and foetal erythrocyte micronucleus assays.
PubMed:Studies of embryotoxicity and the incidence of external malformations after continuous intravenous infusion of alpha-chaconine in pregnant rats.
PubMed:Glycoalkaloid and nitrate content of potatoes as affected by method of selenium application.
PubMed:Determination of potato glycoalkaloids and their aglycone in blood serum by high-performance liquid chromatography. Application to pharmacokinetic studies in humans.
PubMed:Inhibition of insect acetylcholinesterase by the potato glycoalkaloid alpha-chaconine.
PubMed:Developmental toxicology of potato alkaloids in the frog embryo teratogenesis assay--Xenopus (FETAX).
PubMed:Hepatic ornithine decarboxylase induction by potato glycoalkaloids in rats.
PubMed:Comparison of solanaceous glycoalkaloids-evoked Ca(2+) influx in different types of cultured cells.
PubMed:Solanine (glycoalkaloids) in potatoes: toxicological evaluation.
PubMed:[The hygienic evaluation of potato treated with the preparation Polikar made from the byproducts of soda manufacture].
PubMed:Natural pesticides and bioactive components in foods.
PubMed:Toxicity of nightshade berries (Solanum dulcamara) in mice.
PubMed:Extending the detection limit of the TDx fluorescence polarization immunoassay for benzoylecgonine in urine.
PubMed:Sensitivity ofBeauveria bassiana to solanine and tomatine : Plant defensive chemicals inhibit an insect pathogen.
PubMed:Bioassays of segregating plants : A strategy for studying chemical defenses.
PubMed:Synergistic interaction between potato glycoalkaloidsα-solanine andα-chaconine in relation to destabilization of cell membranes: Ecological implications.
PubMed:Host-plant acceptance by geographic populations of the colorado potato beetle,Leptinotarsa decemlineata : Role of solanaceous alkaloids as sensory deterrents.
PubMed:Mechanism of death in Syrian hamsters gavaged potato sprout material.
PubMed:Interactions of alkaloids with galeal chemosensory cells of colorado potato beetle.
PubMed:Production of Microbial Biomass Protein from Potato Processing Wastes by Cephalosporium eichhorniae.
PubMed:Utilization of potatoes in bioregenerative life support systems.
PubMed:Lesions of potato sprout and extracted potato sprout alkaloid toxicity in Syrian hamsters.
PubMed:[Chemical contaminants in food].
PubMed:Food additives and contaminants. An update.
PubMed:Laser desorption/Fourier transform mass spectra of glycoalkaloids and steroid glycosides.
PubMed:The inactivation of herpes simplex virus by some Solanaceae glycoalkaloids.
PubMed:Steroidal glycoalkaloid content of potato, tomato and their somatic hybrids.
PubMed:Comparative assessment of the effect of solanine administered orally and intraperitoneally on hepatic dysfunction in male rats.
PubMed:The effect of alpha-solanine on the active calcium transport in rat intestine.
PubMed:Neural-tube defects produced in Syrian hamsters by potato glycoalkaloids.
PubMed:[Chemical studies on active principles of Veratrum stenophyllum. III. Studies on the structure of beta 1-chaconine and the partial structures of stenophylline C and stenophylline D].
PubMed:Alpha-solanine tested for mutagenicity with Ames test.
PubMed:[Determination of the solanine content of potato tubers].
PubMed:Toxicology of solanine: an overview.
PubMed:Subcellular distribution of alpha-chaconine in mouse hepatocytes.
PubMed:Toxic alkaloids and their interaction with microsomal cytochrome P-450 in vitro.
PubMed:High-performance liquid chromatographic separation of potato glycoalkaloids using a radially compressed amino column.
PubMed:Naturally occurring toxic alkaloids in foods.
PubMed:[Effect of solanine on synaptic transmission].
PubMed:Analysis of potato glycoalkaloids by gas-liquid chromatography of alkaloid components.
PubMed:Aging, arthritis and food allergies: a research opportunity revisited.
PubMed:Toxic effect of the glycoalkaloids solanine and tomatine on cultured neonatal rat heart cells.
PubMed:Potato glycoalkaloids.
PubMed:[Nature and mechanism of action of the solanidine glycosides solanine and chaconine on biological objects].
PubMed:Solanine poisoning.
PubMed:Potato poisoning.
PubMed:Excretion of alpha-chaconine-3H, a steroidal glycoalkaloid from Solanum tuberosum L. and its metabolites in hamsters.
PubMed:An outbreak of suspected solanine poisoning in schoolboys: Examinations of criteria of solanine poisoning.
PubMed:[Study of therapeutic effect of solanine suspension in various eye diseases].
PubMed:[Effect of solanine hydrochloride on experimental sensitization of the body of guinea pigs].
PubMed:[On the determination of the solanum alkaloide solanine and chaconine (author's transl)].
PubMed:An evaluation of the embryotoxic effects of blighted potatoes on chicken embryos.
PubMed:[Determination of the solanine-chaconine ratio in potato sprouts and tubers (author's transl)].
PubMed:Positive inotropic action of Solanaceae glycoalkaloids.
PubMed:A novel pathway for the synthesis of solanidine in the isolated chloroplast from greening potatoes.
PubMed:Antibiotic action of Solanum incanum Linnaeus.
PubMed:Teratological and toxicological studies of alkaloidal and phenolic compounds from Solanum tuberosum L.
PubMed:[Laryngeal paralysis and associated tracheobronchial lesions of unusual toxic origin].
PubMed:Excretion, distribution and metabolic fate of 3H-alpha-chaconine.
PubMed:Embryotoxicity of solanine and aspirin in mice.
PubMed:Pharmacology and toxicology of chaconine and tomatine.
PubMed:Separation of potato glycoalkaloids by gas chromatography.
PubMed:Teratogenic effects in early chick embryos of solanine and glycoalkaloids from potatoes infected with late-blight, Phytophthora infestans.
PubMed:Changes in the mitotic cycle induced by alpha-solanine.
PubMed:Formation and control of chlorophyll and glycoalkaloids in tubers of Solanum tuberosum L. and evaluation of glycoalkaloid toxicity.
PubMed:Steroid alkaloid and sapogenin constituents of Solanum laciniatum.
PubMed:Toxicants occurring naturally in foods.
PubMed:Potatoes and spina bifida.
PubMed:Nonteratogenicity in rats of blighted potatoes and compounds contained in them.
PubMed:The influence of stage of maturity, level of nitrogen fertilization and storage on the concentration of solanine in tubers of three potato cultivars.
PubMed:[The quality of potatoes during transport and storage in relation to various packaging materials. Part 2. The effect of various packaging materials on solanine formation].
PubMed:[The quality of potatoes during transport and storage in relation to various packaging materials. Part 1. The effect of packaging methods on the storage characteristics of potatoes].
PubMed:Metabolites accumulating in potato tubers following infection and stress.
PubMed:Are potatoes teratogenic for experimental animals?
PubMed:Potatoes and birth defects: summary.
PubMed:Possible mechanisms of human teratogenesis by imperfect potato.
PubMed:[Biosynthesis of steroid glycoalkaloids in wilting leaves of the laciniate nightshade Solanum laciniatum].
PubMed:The steroidal constituents of Solanum arundo.
PubMed:The case against the blighted potato.
PubMed:Seasonal changes in glyco-alkaloid and carbohydrate contents in leaves of Solanum laciniatum Ait. plants.
PubMed:Seasonal changes in glyco-alkaloid and carbohydrate contents in fruits of Solanum laciniatum Ait.
PubMed:Evaluation of solanine toxicity.
PubMed:Hypothesis: anencephaly and spina bifida are usually preventable by avoidance of a specific but unidentified substance present in certain potato tubers.
PubMed:Synthesis of 2-O- -L-rhamnopyranosyl-D-galactose, a reported partial hydrolysis product of -solanine, and some taste-eliciting flavonoid 2-O- -L-rhamnopyranosyl- -D-galactopyranosides.
PubMed:[Occurrence of the adaptation syndrome, stress, at the cellular level and its role in the reaction of cells to radiation].
PubMed:[Determination of solanidine by the extraction-photometric method].
PubMed:Pharmacology of solanine.
PubMed:On the "glucocorticoid-like" effects of solanum alkaloids.
PubMed:[Experimental hormonal therapy of skin allergic reactions in sensitized guinea pigs].
PubMed:[Solanum alkaloids. LXXXIX. Synthesis of the steroid alkaloid leptinidin and other 23 beta-hydroxy-solanidans].
PubMed:[Pharmacognostic study of the sprouts of potato Solanum tuberosum L. as the source for solanine].
PubMed:Separation and identification of alkaloids by paper electrophoresis and its application in medico-legal cases.
PubMed:Synthetic studies in steroidal alkaloids and sapogenins. VII. Synthesis of solanidine.
PubMed:Glycemic effects of solanine in rats.
PubMed:[Effect of the new anticholinergic tridihextyl chlorhydrate on the gastric secretion in duodenal ulcer].
PubMed:[Solanum alkaloids. 83. Analytical and preparative thin layer chromatographic separation of 5alpha-saturated and respectively delta5-unsaturated steroid alkaloids and -sapogenins in silver nitrate rich absorption plates].
PubMed:[Experimental studies on the acid production of the stomach under stimulation by solamine solution].
PubMed:[Kinetic study of the inhibition of horse serum cholinesterase by certain steroid alkaloids of Solanum].
PubMed:The microbial hydroxylation of solanidine and the mass spectrometric studies of some hydroxylated solanidines.
PubMed:[Experiences in the diagnosis of food allergy and it's treatment with solanine].
PubMed:Detection of cholinesterase-inhibiting insecticide chemicals and pharmaceutical alkaloids on thin-layer chromatograms.
PubMed:[A paper chromatographic method to determine solanine in potatoes and potato products].
PubMed:[Comparative action of solasodine and cortisone on the vascular permeability].
PubMed:[Determination of steroid glycoalkaloids in Solanum laciniatum].
PubMed:MEASUREMENT OF HYDROLYSIS OF ACETYLTHIOCHOLINE WITH THE SILVER THIOL ELECTRODE. ITS USE IN THE STUDY OF SERUM PSEUDOCHOLINESTERASE INHIBITION.
PubMed:DETECTION OF NATURALLY OCCURRING CHLOINESTERASE INHIBITORS IN SEVERAL CROPS BY PAPER CHROMATOGRAPHY.
PubMed:[EFFECT OF GLYCOALCALOIDS OF THE POTATO ON THE GROWTH OF CORYNEBACTERIUM SEPEDONICUM (SPIECK. AND KOTT.) SKAPT. AND BURKH].
PubMed:[SEPARATION OF SOLANINE, CHACONINE AND SOLANIDINE BY THIN LAYER CHROMATOGRAPHY].
PubMed:Differential inhibition of the serum cholinesterase phenotypes by solanine and solanidine.
PubMed:Toxic effects of potato sprouts and of solanine fed to pregnant rats.
PubMed:[On the preparation and determination of solanine by ion exchange].
PubMed:[Utilization of acetate for the biosynthesis of chaconine and solanine in potato sprouts].
PubMed:A small outbreak of solanine poisoning.
PubMed:Factors affecting the toxicity of solanine and related alkaloids to Fusarium caeruleum.
PubMed:[Mass poisoning with solanine].
PubMed:Identification of solanine.
PubMed:[Paper chromatographic separation and identification of alkaloid-glycosides from Solanum aviculare].
PubMed:[Contribution to the electrophotometric method of determination of solanine].
PubMed:Solanine poisoning.
PubMed:[Studies on potato flour].
PubMed:[Two cases of nightshade poisoning].
PubMed:[Method of quantitative determination of glucoalkaloids in Solanum].
PubMed:[Solanin in potatoes].
PubMed:[Improved method for extraction and quantitative determination of solanine-t, the glycoalkaloid of the potato plant].
PubMed:[Solanine poisoning after eating potato soup].
PubMed:A fatal case of solanine poisoning.
PubMed:Estimation and physiological role of solanine in the potato.
PubMed:[Not available].
PubMed:EFFECT OF LIGHT ON SOLANINE SYNTHESIS IN THE POTATO TUBER.
 
Notes:
a mixture of alpha-chaconine and alpha-solanine, found in solanaceae plants. Alkaloid from potato (Solanum tuberosum) and very many other Solanum spp. (Solanaceae). Responsible for the teratogenicity of sprouting potatoes
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