| Name: | (3S,5S,8R,9S,10S,13R,14S)-5,14-dihydroxy-3-[(2R,4S,5R,6R)-4-methoxy-6-methyl-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydro |
| CAS Number: | 33279-57-1 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 251-439-1 |
| FDA UNII: | 8141H9654J |
| MDL: | MFCD00167450 |
| XlogP3: | -2.90 (est) |
| Molecular Weight: | 872.95688000 |
| Formula: | C42 H64 O19 |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) |
Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 1027.20 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 579.00 °F. TCC ( 304.00 °C. ) (est)
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| logP (o/w): | -1.600 (est) |
| Soluble in: |
| | water, 3.391e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-cat LD50 130 ug/kg
"Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963Vol. -, Pg. 194, 1963.
oral-cat LDLo 5 mg/kg
Farmacognosia. Vol. 13, Pg. 375, 1953.
parenteral-cat LDLo 1900 ug/kg
Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 34, Pg. 431, 1977.
unreported-cat LDLo 187 ug/kg
"Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963Vol. -, Pg. 124, 1963.
intraperitoneal-mammal (species unspecified) LDLo 550 ug/kg
Acta Pharmaceutica Jugoslavica. Vol. 24, Pg. 179, 1974.
intravenous-mammal (species unspecified) LDLo 240 ug/kg
Acta Pharmaceutica Jugoslavica. Vol. 24, Pg. 179, 1974.
intravenous-mouse LD50 8161 ug/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 908, 1961.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
|
Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for k-strophanthoside usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for k-strophanthoside flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :36398 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| (3S,5S,8R,9S,10S,13R,14S)-5,14-dihydroxy-3-[(2R,4S,5R,6R)-4-methoxy-6-methyl-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydro |
| Chemidplus:0033279571 |
References:
| | (3S,5S,8R,9S,10S,13R,14S)-5,14-dihydroxy-3-[(2R,4S,5R,6R)-4-methoxy-6-methyl-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydro |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 36398 |
| Pubchem (sid): | 134999525 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | strophanthidin + cymarose + beta-glucose + alpha-glucose | | k- | strophanthidin-gamma | | | strophanthoside-K | | k- | strophantosid | | k- | strophantoside |
Articles:
| PubMed:LC-ESI-MS/MS characterization of strophanthin-K. |
| PubMed:Interactions of cationic drugs and cardiac glycosides at the hepatic uptake level: studies in the rat in vivo, isolated perfused rat liver, isolated rat hepatocytes and oocytes expressing oatp2. |
| PubMed:Cardenolides as oviposition deterrents to twoPieris species: Structure-activity relationships. |
| PubMed:Biodistribution of two 99mTc-cardiac glycosides with end glucose unit: effect of lipophilicity on their relative myocardial accumulation. |
| PubMed:The action of prostaglandins on ureter smooth muscle of guinea-pig. |
| PubMed:Changes in autorhythmic heart frequency elicited by redox agents. |
| PubMed:Experimental investigation of the effect of cardiac glycosides on the ischemic coronary circulation. |
| PubMed:Absorption, metabolism and elimination of strophanthus glycosides in man. |
| PubMed:Activatory effect of two cardioglycosides on Cavia cobaya kidney Na+/K+-ATPase activity. |
| PubMed:Energy transport at the toxic damaged heart muscle cells. |
| PubMed:Effect of cardiac glycosides on the coronaries: physiologic and morphologic studies in the dog heart. |
| PubMed:Impact of neonatal treatment with cardioactive glycosides (digoxin, ouabain) on receptor binding capacity, blood level and cardiac function in the adult rat. Extension of the imprinting theory. |
| PubMed:Relationship between the tissue redox state potential and dak/dt changes of [K+]0 activity during k-strophantoside or acetylcholine induced contractures. |
| PubMed:[Effects of glucosides on a spontaneously active vascular smooth muscle in vitro (author's transl)]. |
| PubMed:Nifedipine for digitalis-induced arrhythmias. |
| PubMed:Cardiomechanical effect of k-strophanthoside administered to healthy volunteers by the rectal route. |
| PubMed:Choleresis and hepatic transport mechanisms. III. Binding of ouabain and K-strophanthoside to biliary micelles and influence of choleresis on their biliary excretion. |
| PubMed:Bilary and urinary excretion of five cardiac glycosides and its correlation with their physical and chemical properties. |
| PubMed:Positive inotropic action of Solanaceae glycoalkaloids. |
| PubMed:Plasma turnover and excretion of K-strophanthoside-3H in human volunteers after parenteral administration. |
| PubMed:[Plasma levels and urinary elimination of k-strophanthoside in intravenous administration in patients with renal insufficiency]. |
| PubMed:[Plasma levels and urinary elimination of k-strophanthoside in venous and muscular administration in cardiac disease patients]. |
| PubMed:Subcellular distribution of K-strophanthoside (3H) in isolated guinea-pig hearts. |
| PubMed:The absorption, distribution and excretion of K-strophanthoside-3H in guinea pigs after parenteral administration. |
| PubMed:[Plasma concentration and biliary and urinary excretion of K-strophanthoside in subjects with biliary fistula (author's transl)]. |
| PubMed:Plasma levels and urinary excretion of K-strophanthoside (3H) administered rectally to human subjects. |
| PubMed:Absorption, distribution and excretion of K-strophanthoside(3H) administered rectally to guinea-pigs. |
| PubMed:[Subcellular distribution of K-strophanthoside in the isolated guinea-pig heart]. |
| PubMed:[Biliary and urinary elimination and intrahepatic circulation of K-strophanthoside-(H3) in humans and guinea pigs]. |
| PubMed:[Plasmatic levels and urinary elimination of K-strophanthoside after intravenous administration in normal humans]. |
| PubMed:[Absorption of K strophanthoside-H 3 through the rectal mucosa of the guinea pig]. |
| PubMed:[Metoclopramide and electrocardiographic changes caused by KC1, BaC12, CaC12, MgC12, aconitine, k-strophanthoside, vasopressin and by asphyxia]. |
| PubMed:Adenosine triphosphatase activity in the membranes of the squid nerve fiber. |
| PubMed:Nature of the Schwann cell electrical potential. Effects of the external ionic concentrations and a cardiac glycoside. |
| PubMed:5-Hydroxytryptamine and the toxicity of k-strophanthoside. |
| PubMed:[Therapeutic and hemodynamic effects of a lyophilized preparation with a base of K-strophanthoside]. |
| PubMed:[Action of k-strophanthoside on erythrocyte-plasma exchange of the potassium ion in human heparinized blood: study in vitro and in vivo]. |
| PubMed:[Behavior of various enzymes from rat myocardium during acute K-strophanthoside poisoning]. |
| PubMed:Depolarizing action of K-strophantine and K-strophanthoside on isolated frog skin. |
| PubMed:[Effects of k-strophanthoside and adrenal cortical steroids on sodium transport through isolated frog skin]. |
| PubMed:[Behavior of several enzymatic activities of the rabbit heart treated with cardiac glycosides. I. Variations in the succinic dehydrogenase and cytochrome oxidase activity of the rabbit heart after a single dose and after prolonged administration of K-strophanthoside]. |
| PubMed:Unipolar electrocardiograms of isolated rabbit's hearts treated with k-strophanthoside (strophoside). |
| PubMed:[Allergy to k-strophanthoside and other cardiokinetic glucosides; considerations on the dangers of intolerance of allergic types to drugs in general]. |
| PubMed:Influence of nitrate ion upon the synergistic effects of glucose and k-strophanthoside. |
| PubMed:Dibucaine hydrochloride in the control of K-strophanthoside-induced ventricular tachycardia and other toxic manifestations. |
| PubMed:Treatment of cardiac emergencies with K-strophanthoside and lanatoside C. |
| PubMed:Influence of striated muscle activity on the lethal dose of k-strophanthoside. |
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