EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

tetrahydroalstonine
alstonine, 3,4,5,6-tetrahydro- (8CI)

Supplier Sponsors

CAS Number: 6474-90-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:229-331-0
FDA UNII: Search
Nikkaji Web:J109.490D
Beilstein Number:0097270
MDL:MFCD00083501
XlogP3-AA:2.70 (est)
Molecular Weight:352.43388000
Formula:C21 H24 N2 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 524.00 °C. @ 760.00 mm Hg (est)
Flash Point: 519.00 °F. TCC ( 270.70 °C. ) (est)
logP (o/w): 2.880 (est)
Soluble in:
 water, 755.9 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Tetrahydroalstonine 98%
BOC Sciences
For experimental / research use only.
Tetrahydroalstonine
ExtraSynthese
For experimental / research use only.
Tetrahydroalstonine
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD > 3000 mg/kg
United States Patent Document. Vol. #3969521

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for tetrahydroalstonine usage levels up to:
 not for fragrance use.
 
Recommendation for tetrahydroalstonine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :72340
National Institute of Allergy and Infectious Diseases:Data
Chemidplus:0006474904
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):72340
Pubchem (sid):135029298
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
KEGG (GenomeNet):C11682
HMDB (The Human Metabolome Database):Search
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 alstonine, 3,4,5,6-tetrahydro- (8CI)
 alstonine, 3,4,5,6-tetrahydro-, (3alpha)-
 methyl (19alpha,20alpha)-16,17-didehydro-19-methyloxayohimban-16-carboxylate
 oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methyl ester, (19-alpha,20-alpha)-
 

Articles:

PubMed:[Alkaloids of Vinca rosea L. introduced to Western Georgia].
PubMed:A new monoterpenoid oxindole alkaloid from Hamelia patens micropropagated plantlets.
PubMed:HPTLC method for the simultaneous determination of four indole alkaloids in Rauwolfia tetraphylla: a study of organic/green solvent and continuous/pulse sonication.
PubMed:Construction and expression of a dual vector for chemo-enzymatic synthesis of plant indole alkaloids in Escherichia coli.
PubMed:Improved accumulation of ajmalicine and tetrahydroalstonine in Catharanthus cells expressing an ABC transporter.
PubMed:New Indole Alkaloids from Amsonia sinensis.
PubMed:Tetrahydroalstonine from Ophiorrhiza discolor.
PubMed:Structure of a key intermediate in the synthesis of (-)-5-carboxytetrahydroalstonine and (-)-tetrahydroalstonine.
PubMed:Alkaloids from Rauwolfia cubana Stem Bark.
PubMed:Selectivity of raubasine stereoisomers for alpha 1- and alpha 2-adrenoceptors in the rat.
PubMed:[Differential inhibition of raubasine and tetrahydroalstonine on the vasopressor response to sympathetic nervous stimulation and intravenous noradrenaline in the pithed rat].
PubMed:Partial purification and characterization of a NADPH dependent tetrahydroalstonine synthase from Catharanthus roseus cell suspension cultures.
PubMed:Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine.
PubMed:Effects of raubasine stereoisomers on pre- and postsynaptic alpha-adrenoceptors in the rat vas deferens.
PubMed:Tetrahydroalstonine from Fruits of Rhazya stricta.
PubMed:[Monomeric Indole Alkaloids from Kopsia officinalis.].
PubMed:Alkaloids from Tabernaemontana psorocarpa.
PubMed:[Evaluation of antimicrobial activity of indol alkaloids].
PubMed:[Fungal activity of various alkaloids isolated from Catharanthus roseus G. Don].
PubMed:Catharanthus alkaloids XXXI: isolation of ajmalicine, pericalline, tetrahydroalstonine, vindolinine, and ursolic acid from Catharanthus trichophyllus roots.
PubMed:Effects of certain nonsteroid anti-inflammatory drugs, tolbutamide, and tetrahydroalstonine on blood glucose and carrageen in-induced pedal edema in rats.
PubMed:Catharanthus lanceus VII. Isolation of tetrahydroalstonine, lochnerinine, and periformyline.
 
Notes:
None found
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