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quercetin 3-methyl ether
4H-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-methoxy-

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Name:2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-methoxychromen-4-one
CAS Number: 1486-70-0Picture of molecule3D/inchi
FDA UNII: 7J92C373RH
Nikkaji Web:J876A
Beilstein Number:0324509
MDL:MFCD00210588
XlogP3-AA:2.50 (est)
Molecular Weight:316.26604000
Formula:C16 H12 O7
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 643.00 °C. @ 760.00 mm Hg (est)
Flash Point: 472.00 °F. TCC ( 244.70 °C. ) (est)
logP (o/w): 2.020 (est)
Soluble in:
 water, 1446 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
3-O-Methylquercetin 98%
BOC Sciences
For experimental / research use only.
3-O-Methylquercetin 0.985
Odor: characteristic
Use: 3-O-Methylquercetin isolated from the herbs of Croton cascarilloides. It is a selective and competitive PDE3/PDE4 inhibitor, inhibiting PDE3 than PDE4 with a low K(m) value. anti-inflammatory effect;
Carbosynth
For experimental / research use only.
3-O-Methyl quercetin
ExtraSynthese
For experimental / research use only.
3',4',5,7-Tetrahydroxy-3-methoxyflavone (HPLC) ≥90%
Santa Cruz Biotechnology
For experimental / research use only.
Quercetin 3-methyl Ether
Sigma-Aldrich: Sigma
For experimental / research use only.
3-O-Methylquercetin ≥97% (HPLC)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for quercetin 3-methyl ether usage levels up to:
 not for fragrance use.
 
Recommendation for quercetin 3-methyl ether flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5280681
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-methoxychromen-4-one
Chemidplus:0001486700
 
References:
 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-methoxychromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5280681
Pubchem (sid):135055920
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C04443
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
4H-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-methoxy-
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-methoxy-4H-1-benzopyran-4-one
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-methoxychromen-4-one
 flavone, 3',4',5,7-tetrahydroxy-3-methoxy-
 quercetin-3-methylether
3',4',5,7-tetrahydroxy-3-methoxyflavone
 

Articles:

PubMed:Further characterization of foliar flavonoids in Crossostephium chinense and their geographic variation.
PubMed:New thiophene and flavonoid from Tagetes minuta leaves growing in Saudi Arabia.
PubMed:A fraction rich in phenyl propanoids from L. divaricata aqueous extract is capable of inducing apoptosis, in relation to H₂O₂ modulation, on a murine lymphoma cell line.
PubMed:Flavonoids from the Japanese monotypic genus, Nipponanthemum.
PubMed:Quercetin-3-methyl ether suppresses proliferation of mouse epidermal JB6 P+ cells by targeting ERKs.
PubMed:Quercetin-3-methyl ether inhibits lapatinib-sensitive and -resistant breast cancer cell growth by inducing G(2)/M arrest and apoptosis.
PubMed:Acetyl derivative of quercetin 3-methyl ether-induced cell death in human leukemia cells is amplified by the inhibition of ERK.
PubMed:Complement-Inhibiting Constituents of Bridelia ferruginea Stem Bark.
PubMed:Constituents of Psiadia terebinthina A.J. Scott, an endemic Asteraceae from Mauritius.
PubMed:Flavonoids with anti-Helicobacter pylori activity from Cistus laurifolius leaves.
PubMed:Effect of Cistus laurifolius L. leaf extracts and flavonoids on acetaminophen-induced hepatotoxicity in mice.
PubMed:Flavonoids from Achyrocline satureioides with relaxant effects on the smooth muscle of Guinea pig corpus cavernosum.
PubMed:Constituents of the stems and fruits of Opuntia ficus-indica var. saboten.
PubMed:Trypanocidal activity of Lychnophora staavioides Mart. (Vernonieae, Asteraceae).
PubMed:Influence of ethyl acetate extract and quercetin-3-methyl ether from Polygonum amphibium on activation lymphocytes from peripheral blood of healthy donor in vitro.
PubMed:Phenolic compounds on the pod-surface of pigeonpea, Cajanus cajan, mediate feeding behavior of Helicoverpa armigera larvae.
PubMed:Sesquiterpene lactones from Anthemis altissima and their anti-Helicobacter pylori activity.
PubMed:Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten.
PubMed:Comparative study on the free flavonoid aglycones in herbs of different species of Polygonum L.
PubMed:Relaxant effects of quercetin methyl ether derivatives in isolated guinea pig trachea and their structure-activity relationships.
PubMed:Flavonol and chalcone ester glycosides from Bidens andicola.
PubMed:A flavonoid diglycoside from Lepisorus ussuriensis.
PubMed:Chemical and biological investigation of the root bark of Clerodendrum mandarinorum.
PubMed:Pharmacological investigations on Achyrocline satureioides (LAM.) DC., Compositae.
 
Notes:
None found
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