EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

tectochrysin
flavone, 5-hydroxy-7-methoxy- (8CI)

Supplier Sponsors

Name:5-hydroxy-7-methoxy-2-phenylchromen-4-one
CAS Number: 520-28-5Picture of molecule3D/inchi
FDA UNII: 9UBO28W2AK
Nikkaji Web:J61.252I
MDL:MFCD00016945
XlogP3:2.40 (est)
Molecular Weight:268.26844000
Formula:C16 H12 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 487.40 °C. @ 760.00 mm Hg (est)
Flash Point: 368.00 °F. TCC ( 186.80 °C. ) (est)
logP (o/w): 3.130 (est)
Soluble in:
 water, 34.13 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Techtochrysin 98%
BOC Sciences
For experimental / research use only.
Tectochrysin 0.99
Odor: characteristic
Use: Tectochrysin isolated from the heartwood of Pinus strobus L. It leads to apoptotic cell death in NSCLC cells through activating of DR3 and Fas expression antioxidant;
Carbosynth
For experimental / research use only.
Tectochrysin
ExtraSynthese
For experimental / research use only.
Tectochrysin (HPLC) ≥90%
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for tectochrysin usage levels up to:
 not for fragrance use.
 
Recommendation for tectochrysin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5281954
National Institute of Allergy and Infectious Diseases:Data
5-hydroxy-7-methoxy-2-phenylchromen-4-one
Chemidplus:0000520285
 
References:
 5-hydroxy-7-methoxy-2-phenylchromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5281954
Pubchem (sid):135025512
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C11621
HMDB (The Human Metabolome Database):Search
FooDB:FDB015536
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 cherry sour cherry plant
Search Trop Picture
 cherry sweet cherry
Search Trop Picture
 pinus spp.
Search Trop Picture
 prunus spp
Search Trop Picture
 
Synonyms:
4H-1-benzopyran-4-one, 5-hydroxy-7-methoxy-2-phenyl- (9CI)
 flavone, 5-hydroxy-7-methoxy- (8CI)
5-hydroxy-7-methoxy-2-phenylchromen-4-one
5-hydroxy-7-methoxyflavone
 methyl chrysin
 

Articles:

PubMed:Modulation of (-)-epicatechin Metabolism by Co-administration with other Polyphenols in Caco-2 Cell Model.
PubMed:Anti-cancer effect of tectochrysin in NSCLC cells through overexpression of death receptor and inactivation of STAT3.
PubMed:[Chemical constituents of leaves of Psidium guajava].
PubMed:Identification of known chemicals and their metabolites from Alpinia oxyphylla fruit extract in rat plasma using liquid chromatography/tandem mass spectrometry (LC-MS/MS) with selected reaction monitoring.
PubMed:Different accumulation profiles of multiple components between pericarp and seed of Alpinia oxyphylla capsular fruit as determined by UFLC-MS/MS.
PubMed:Two new antioxidant diarylheptanoids from the fruits of Alpinia oxyphylla.
PubMed:Anti-diarrheal constituents of Alpinia oxyphylla.
PubMed:Nocapyrones H-J, 3,6-disubstituted α-pyrones from the marine actinomycete Nocardiopsis sp. KMF-001.
PubMed:Two new natural products from the fruits of Alpinia oxyphylla with inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophage cells.
PubMed:Antitumor constituents from the leaves of Carya cathayensis.
PubMed:Polyphenolic fraction of Algerian propolis protects rat kidney against acute oxidative stress induced by doxorubicin.
PubMed:Aryl hydrocarbon receptor ligand activity of commercial health foods.
PubMed:Chemical composition of the ethanolic propolis extracts and its effect on HeLa cells.
PubMed:Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids.
PubMed:[Chemical constituents from seeds of Alpinia katsumadai, inhibition on NF-kappaB activation and anti-tumor effect].
PubMed:[Chemical constituents of roots of Saposhnikovia divaricata].
PubMed:Study on the constituents of Mexican propolis and their cytotoxic activity against PANC-1 human pancreatic cancer cells.
PubMed:Bioactivity of flavonoids isolated from Lychnophora markgravii against Leishmania amazonensis amastigotes.
PubMed:[Studies on chemical constituents in fruit of Alpinia oxyphylla].
PubMed:Simultaneous quantification of eight major bioactive phenolic compounds in Chinese propolis by high-performance liquid chromatography.
PubMed:Main flavonoids, DPPH activity, and metal content allow determination of the geographical origin of propolis from the Province of San Juan (Argentina).
PubMed:[Studies on ethyl acetate soluble constituents of Huanglian Jiedutang].
PubMed:Modulation of glucose uptake in a human choriocarcinoma cell line (BeWo) by dietary bioactive compounds and drugs of abuse.
PubMed:Hexaquacobalt(II) bis(5-hydroxy-7-methoxy-4-oxo-2-phenyl-4H-chromene-6-sulfonate) tetrahydrate.
PubMed:Influence of some bioflavonoids on the transport of nitrendipine.
PubMed:Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones.
PubMed:Gateways to clinical trials.
PubMed:Aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha in MCF-7 breast cancer cells.
PubMed:Effect of different flavonoids on collagen synthesis in human fibroblasts.
PubMed:Biflavonoids from Lonicera japonica.
PubMed:Evaluation of the main contact allergens in propolis (1995 to 2005).
PubMed:Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2.
PubMed:Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures.
PubMed:Effects of the dietary flavonoid chrysin in isolated rat mesenteric vascular bed.
PubMed:Chrysin and its phosphate ester inhibit cell proliferation and induce apoptosis in Hela cells.
PubMed:Identification of metabolites in plasma and urine of Uruguayan propolis-treated rats.
PubMed:Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta.
PubMed:Trypanocidal activity of Lychnophora staavioides Mart. (Vernonieae, Asteraceae).
PubMed:Quantification of 6-deoxy-6-demethyl-4-dedimethylaminotetracycline (COL-3) in human plasma using liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
PubMed:Effect of chrysin, a flavonoid compound, on the mutagenic activity of 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) and benzo(a)pyrene (B(a)P) in bacterial and human hepatoma (HepG2) cells.
PubMed:In vivo anti-oxidant activities of tectochrysin.
PubMed:[Flavonoids from Beijing propolis].
PubMed:Induction of human UDP-glucuronosyltransferase UGT1A1 by flavonoids-structural requirements.
PubMed:Vasorelaxant effects of the bioflavonoid chrysin in isolated rat aorta.
PubMed:Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in Caco-2 cells--potential role in carcinogen bioinactivation.
PubMed:Identification of kaempferol as a monoamine oxidase inhibitor and potential Neuroprotectant in extracts of Ginkgo biloba leaves.
PubMed:Differential effects of dietary flavonoids on drug metabolizing and antioxidant enzymes in female rat.
PubMed:Separation of structurally related flavonoids by GC/MS technique and determination of their polarographic parameters and potential carcinogenicity.
PubMed:A novel 2-hydroxyflavanone from collinsonia canadensis
PubMed:Methyl 4-hydroxy-3-(3'-methyl-2'-butenyl)benzoate, major insecticidal principle from Piper guanacastensis.
PubMed:Redox intermediates of flavonoids and caffeic acid esters from propolis: an EPR spectroscopy and cyclic voltammetry study.
PubMed:Antimutagenic effect of plant flavonoids in the Salmonella assay system.
PubMed:Flavonoid inhibition of aromatase enzyme activity in human preadipocytes.
PubMed:Isolation of potential cancer chemopreventive agents from Eriodictyon californicum.
PubMed:Leaf Gland Flavonoids in Comptonia peregrina and Myrica pensylvanica (Myricaceae).
PubMed:Metabolism of apigenin and related compounds in the rat. Metabolite formation in vivo and by the intestinal microflora in vitro.
 
Notes:
None found
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