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wogonin
4H-1-benzopyran-4-one, 5,7-dihydroxy-8-methoxy-2-phenyl-

Supplier Sponsors

Name:5,7-dihydroxy-8-methoxy-2-phenylchromen-4-one
CAS Number: 632-85-9Picture of molecule3D/inchi
FDA UNII: POK93PO28W
Nikkaji Web:J12.474E
Beilstein Number:0287152
MDL:MFCD12828871
XlogP3-AA:3.00 (est)
Molecular Weight:284.26764000
Formula:C16 H12 O5
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 518.80 °C. @ 760.00 mm Hg (est)
Flash Point: 389.00 °F. TCC ( 198.40 °C. ) (est)
logP (o/w): 2.140 (est)
Soluble in:
 water, 30.94 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Wogonin 98%
BOC Sciences
For experimental / research use only.
Wogonin >98%
Odor: characteristic
Use: Wogonin is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties.
Carbosynth
For experimental / research use only.
Wogonin
EMD Millipore
For experimental / research use only.
Wogonin, S. baicalensis
ExtraSynthese
For experimental / research use only.
Wogonin (HPLC) ≥99%
Glentham Life Sciences
Wogonin
M.C.Biotec
Wogonin
Santa Cruz Biotechnology
For experimental / research use only.
Wogonin, S. baicalensis >98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Wogonin hydrate ≥98% (HPLC), solid
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for wogonin usage levels up to:
 not for fragrance use.
 
Recommendation for wogonin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5281703
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
5,7-dihydroxy-8-methoxy-2-phenylchromen-4-one
Chemidplus:0000632859
RTECS:LK8331000 for cas# 632-85-9
 
References:
 5,7-dihydroxy-8-methoxy-2-phenylchromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5281703
Pubchem (sid):134977323
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C10197
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
4H-1-benzopyran-4-one, 5,7-dihydroxy-8-methoxy-2-phenyl-
5,7-dihydroxy-8-methoxy-2-phenylchromen-4-one
5,7-dihydroxy-8-methoxyflavone
 flavone, 5,7-dihydroxy-8-methoxy-
 vogonin
 

Articles:

PubMed:[Feasibility study of QAMS for quantitative analysis of multiple structural types of ingredients in Zhizi Jinhua pill].
PubMed:Potential therapeutic effects of baicalein, baicalin, and wogonin in ocular disorders.
PubMed:Wogonin Reverses Multi-Drug Resistance of Human myelogenous leukemia K562/A02 cells via Downregulation of MRP1 Expression by Inhibiting Nrf2/ARE Signaling Pathway.
PubMed:Extraction and Bioactivity Analysis of Major Flavones Compounds from Scutellaria baicalensis Using In Vitro Assay and Online Screening HPLC-ABTS System.
PubMed:Anti-inflammatory Effects of Baicalin, Baicalein, and Wogonin In Vitro and In Vivo.
PubMed:Effect of light, methyl jasmonate and cyclodextrin on production of phenolic compounds in hairy root cultures of Scutellaria lateriflora.
PubMed:A Chinese Medicine Formula Gegen Qinlian Decoction Suppresses Expansion of Human Renal Carcinoma With Inhibition of Matrix Metalloproteinase-2.
PubMed:Vascular barrier protective effects of baicalin, baicalein and wogonin in vitro and in vivo.
PubMed:Wogonin suppresses melanoma cell B16-F10 invasion and migration by inhibiting Ras-medicated pathways.
PubMed:Effect of TGFβ on Na(+)/K(+) ATPase activity in megakaryocytes.
PubMed:Wogonin induces cell cycle arrest and erythroid differentiation in imatinib-resistant K562 cells and primary CML cells.
PubMed:LC-MS/MS analysis of Gegen Qinlian Decoction and its pharmacokinetics after oral administration to rats.
PubMed:Overexpression of cinnamate 4-hydroxylase and 4-coumaroyl CoA ligase prompted flavone accumulation in Scutellaria baicalensis hairy roots.
PubMed:Determination of chrysotoxine in rat plasma by liquid chromatography-tandem mass spectrometry and its application to a rat pharmacokinetic study.
PubMed:[Experimental study on inhibitory effect of wogonin on proliferation and invasion of breast cancer cells].
PubMed:The role of wogonin in controlling SOCS3 expression in neuronal cells.
PubMed:Antithrombotic activities of wogonin and wogonoside via inhibiting platelet aggregation.
PubMed:A new antioxidant flavone glycoside from Scutellaria baicalensis Georgi.
PubMed:Wogonin suppresses human alveolar adenocarcinoma cell A549 migration in inflammatory microenvironment by modulating the IL-6/STAT3 signaling pathway.
PubMed:Wogonin attenuates ovalbumin antigen-induced neutrophilic airway inflammation by inhibiting th17 differentiation.
PubMed:NMDA receptor-mediated neuroprotective effect of the Scutellaria baicalensis Georgi extract on the excitotoxic neuronal cell death in primary rat cortical cell cultures.
PubMed:The effects of wine-processing on ascending and descending: The distribution of flavonoids in rat tissues after oral administration of crude and wine-processed Radix scutellariae.
PubMed:NF-κB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis.
PubMed:Targeting CDK9 by wogonin and related natural flavones potentiates the anti-cancer efficacy of the Bcl-2 family inhibitor ABT-263.
PubMed:Wogonin inhibits LPS-induced tumor angiogenesis via suppressing PI3K/Akt/NF-κB signaling.
PubMed:Development of a SPE-LC/MS/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and oroxyloside in rats and its application to brain uptake and plasma pharmacokinetic studies.
PubMed:[Optimization of Scutellaria baicalensis extraction process by orthogonal experiment combined with pharmacodynamic index].
PubMed:Pharmacokinetics, tissue distribution, excretion and plasma protein binding studies of wogonin in rats.
PubMed:Wogonin prevents lipopolysaccharide-induced acute lung injury and inflammation in mice via peroxisome proliferator-activated receptor gamma-mediated attenuation of the nuclear factor-kappaB pathway.
PubMed:Simultaneous Quantitative and Qualitative Analysis of Flavonoids from Ultraviolet-B Radiation in Leaves and Roots of Scutellaria baicalensis Georgi Using LC-UV-ESI-Q/TOF/MS.
PubMed:[Network pharmacology study on major active compounds of siwu decoction analogous formulae for treating primary dysmenorrhea of gynecology blood stasis syndrome].
PubMed:Scutellaria baicalensis in stroke management: nature's blessing in traditional Eastern medicine.
PubMed:Apigenin and Wogonin Regulate Epidermal Growth Factor Receptor Signaling Pathway Involved in MUC5AC Mucin Gene Expression and Production from Cultured Airway Epithelial Cells.
PubMed:Simultaneous Determination of 12 Index Components and Compatibility Changes in Longchai Decoction by Liquid Chromatography-Mass Spectrometry.
PubMed:Ambient mass spectrometry imaging: plasma assisted laser desorption ionization mass spectrometry imaging and its applications.
PubMed:Wogonin-enhanced reactive oxygen species-induced apoptosis and potentiated cytotoxic effects of chemotherapeutic agents by suppression Nrf2-mediated signaling in HepG2 cells.
PubMed:Flavonoid components in Scutellaria baicalensis inhibit nicotine-induced proliferation, metastasis and lung cancer-associated inflammation in vitro.
PubMed:Skullcap (Scutellaria baicalensis) extract and its active compound, wogonin, inhibit ovalbumin-induced Th2-mediated response.
PubMed:Wogonin inhibits H2O2-induced angiogenesis via suppressing PI3K/Akt/NF-κB signaling pathway.
PubMed:Multitargeted effects of hangeshashinto for treatment of chemotherapy-induced oral mucositis on inducible prostaglandin E2 production in human oral keratinocytes.
PubMed:[Recombinant soluble CD40 ligand enhances Wogonin-induced antitumor activity].
PubMed:Pharmacokinetics difference of multiple active constituents from decoction and maceration of Fuzi Xiexin Tang after oral administration in rat by UPLC-MS/MS.
PubMed:Scutellaria extract decreases the proportion of side population cells in a myeloma cell line by down-regulating the expression of ABCG2 protein.
PubMed:Antidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stress.
PubMed:Traditional Chinese medicine and related active compounds: a review of their role on hepatitis B virus infection.
PubMed:Simulated gastrointestinal tract metabolism and pharmacological activities of water extract of Scutellaria baicalensis roots.
PubMed:Screening of osteoanagenesis-active compounds from Scutellaria baicalensis Georgi by hPDLC/CMC-online-HPLC/MS.
PubMed:Wogonin, a natural and biologically-active flavonoid, influences a murine WEHI-3 leukemia model in vivo through enhancing populations of T- and B-cells.
PubMed:Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung.
PubMed:Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549.
PubMed:Synergistic inhibitory effect of wogonin and low-dose paclitaxel on gastric cancer cells and tumor xenografts.
PubMed:Comparative pharmacokinetics of baicalin, wogonoside, baicalein and wogonin in plasma after oral administration of pure baicalin, radix scutellariae and scutellariae-paeoniae couple extracts in normal and ulcerative colitis rats.
PubMed:Probe substrate and enzyme source-dependent inhibition of UDP-glucuronosyltransferase (UGT) 1A9 by wogonin.
PubMed:A wogonin-loaded glycyrrhetinic acid-modified liposome for hepatic targeting with anti-tumor effects.
PubMed:Differences in pharmacokinetics and anti-inflammatory effects between decoction and maceration of Sanhuang Xiexin Tang in rats and mice.
PubMed:Species difference in the inhibitory potentials of non-steroidal anti-inflammatory drugs on the hepatic sulfation and glucuronidation of bioactive flavonoids: differential observations among common inhibition parameters.
PubMed:Comparative analysis of flavonoids and polar metabolites from hairy roots of Scutellaria baicalensis and Scutellaria lateriflora.
PubMed:Wogonin influences vascular permeability via Wnt/β-catenin pathway.
PubMed:Influence of mefenamic acid on the intestinal absorption and metabolism of three bioactive flavones in Radix Scutellariae and potential pharmacological impact.
PubMed:Flavonoids from the leaves of Carya cathayensis Sarg. inhibit vascular endothelial growth factor-induced angiogenesis.
PubMed:Depletion of high-abundance flavonoids by metal complexation and identification of low-abundance flavonoids in Scutellaria baicalensis Georgi.
PubMed:Scutellariae radix suppresses LPS-induced liver endothelial cell activation and inhibits hepatic stellate cell migration.
PubMed:Pretreatment of baicalin and wogonoside with glycoside hydrolase: a promising approach to enhance anticancer potential.
PubMed:The inhibitory effects of the bioactive components isolated from Scutellaria baicalensis on the cellular uptake mediated by the essential solute carrier transporters.
PubMed:Anticancer properties of the flavone wogonin.
PubMed:[LC-MS quantification and pharmacokinetics of the multi-constituents of Huangqin Tang in rat plasma after different single oral doses].
PubMed:Wogonin induces apoptosis by suppressing E6 and E7 expressions and activating intrinsic signaling pathways in HPV-16 cervical cancer cells.
PubMed:Chemical constituents from leaves of Evodia lepta.
PubMed:Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells.
PubMed:Exploring insights for virulent gene inhibition of multidrug resistant Salmonella typhi, Vibrio cholerae, and Staphylococcus areus by potential phytoligands via in silico screening.
PubMed:GSK3β/β-catenin signaling is correlated with the differentiation of glioma cells induced by wogonin.
PubMed:Wogonin attenuates etoposide-induced oxidative DNA damage and apoptosis via suppression of oxidative DNA stress and modulation of OGG1 expression.
PubMed:Employing bifunctional enzymes for enhanced extraction of bioactives from plants: flavonoids as an example.
PubMed:HPLC and chemometrics for the quality consistency evaluation of Shuanghuanglian injection.
PubMed:Enhanced 5-fluorouracil cytotoxicity in high COX-2 expressing hepatocellular carcinoma cells by wogonin via the PI3K/Akt pathway.
PubMed:Bioconversion of flavones during fermentation in milk containing Scutellaria baicalensis extract by Lactobacillus brevis.
PubMed:V8, a newly synthetic flavonoid, induces apoptosis through ROS-mediated ER stress pathway in hepatocellular carcinoma.
PubMed:Assessment of dermal safety of Scutellaria baicalensis aqueous extract topical application on skin hypersensitivity.
PubMed:Inhibitory Effects of Hwangryunhaedok-Tang in 3T3-L1 Adipogenesis by Regulation of Raf/MEK1/ERK1/2 Pathway and PDK1/Akt Phosphorylation.
PubMed:Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway.
PubMed:Different extraction pretreatments significantly change the flavonoid contents of Scutellaria baicalensis.
PubMed:Anti-HBV effect of individual traditional Chinese herbal medicine in vitro and in vivo: an analytic review.
PubMed:Wogonin inhibits tumor angiogenesis via degradation of HIF-1α protein.
PubMed:UPLC-ESI/MS determination of 17 active constituents in two categorized formulas of traditional Chinese medicine, Sanhuang Xiexin Tang and Fuzi Xiexin Tang: application in comparing the differences in decoctions and macerations.
PubMed:Wogonin ameliorates hyperglycemia and dyslipidemia via PPARα activation in db/db mice.
PubMed:Relationships between pharmacokinetics and efficacy of Xie-xin decoction in rats with experimental ulcerative colitis.
PubMed:Simultaneous determination of flavonoid analogs in Scutellariae Barbatae Herba by β-cyclodextrin and acetonitrile modified capillary zone electrophoresis.
PubMed:Protective effect of wogonin on proinflammatory cytokine generation via Jak1/3-STAT1/3 pathway in lipopolysaccharide stimulated BV2 microglial cells.
PubMed:Inhibition of TNF-α-induced MUC5AC mucin gene expression and production by wogonin through the inactivation of NF-κB signaling in airway epithelial cells.
PubMed:Quantitative assessment of traditional Oriental herbal formulation Samhwangsasim-tang using UPLC technique.
PubMed:[Effects of plant growth regulator mepiquat chloride on content of active compounds in Scutellaria baicalensis].
PubMed:Wogonin enhances antitumor activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo through ROS-mediated downregulation of cFLIPL and IAP proteins.
PubMed:Wogonin attenuates endotoxin-induced prostaglandin E2 and nitric oxide production via Src-ERK1/2-NFκB pathway in BV-2 microglial cells.
PubMed:Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway.
PubMed:Wogonin induced cytotoxicity in human hepatocellular carcinoma cells by activation of unfolded protein response and inactivation of AKT.
PubMed:Pharmacokinetics and Relative Bioavailability of Flavonoids between Two Dosage Forms of Gegen-Qinlian-Tang in Rats.
PubMed:Wogonin induced calreticulin/annexin A1 exposure dictates the immunogenicity of cancer cells in a PERK/AKT dependent manner.
PubMed:Anti-inflammatory effect of Sosihotang via inhibition of nuclear factor-κB and mitogen-activated protein kinases signaling pathways in lipopolysaccharide-stimulated RAW 264.7 macrophage cells.
PubMed:Wogonin inhibits H2O2-induced vascular permeability through suppressing the phosphorylation of caveolin-1.
PubMed:Infiltrating macrophages are key to the development of seizures following virus infection.
PubMed:Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis.
PubMed:Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity--a role of immunomodulation in chemoprevention.
PubMed:Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway.
PubMed:[Preparation of flavonoid reference standards from Scutellariae Radix under the guidance of high performance liquid chromatography-mass spectrometry analysis].
PubMed:Wogonin induces apoptosis in RPMI 8226, a human myeloma cell line, by downregulating phospho-Akt and overexpressing Bax.
PubMed:Natural inhibitors of indoleamine 3,5-dioxygenase induced by interferon-gamma in human neural stem cells.
PubMed:A novel local recycling mechanism that enhances enteric bioavailability of flavonoids and prolongs their residence time in the gut.
PubMed:Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells.
PubMed:Scutellaria baicalensis Extracts and Flavonoids Protect Rat L6 Cells from Antimycin A-Induced Mitochondrial Dysfunction.
PubMed:Wogonin induces reactive oxygen species production and cell apoptosis in human glioma cancer cells.
PubMed:Pharmacokinetic interactions among major bioactive components in Radix Scutellariae via metabolic competition.
PubMed:Traditional Japanese herbal (kampo) medicines and treatment of ocular diseases: a review.
PubMed:A novel process related impurity and forced degradation study of synthetic wogonin: development of a liquid chromatographic method for purity control.
PubMed:A new strategy for quality control and qualitative analysis of Yinhuang preparations by HPLC-DAD-MS/MS.
PubMed:Simultaneous determination of active flavonoids and alkaloids of Tang-Min-Ling-Pill in rat plasma by liquid chromatography tandem mass spectrometry.
PubMed:Development of simultaneous analysis for marker constituents in Hwangryunhaedok-tang () and its application in commercial herbal formulas.
PubMed:Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells.
PubMed:[Non-alkaloid chemical constituents from Coptis chinensis].
PubMed:Effect of magnetic nanoparticles of Fe3O4 and wogonin on the reversal of multidrug resistance in K562/A02 cell line.
PubMed:Quantitative analysis of anti-inflammatory activity of orengedokuto: importance of combination of flavonoids in inhibition of PGE2 production in mouse macrophage-like cell line J774.1.
PubMed:Simultaneous determination of baicalin, wogonoside, baicalein, wogonin, oroxylin A and chrysin of Radix scutellariae extract in rat plasma by liquid chromatography tandem mass spectrometry.
PubMed:Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells.
PubMed:[Research on relationship between commercial specifications of Scutellariae Radix and chemical composition and drug quality].
PubMed:Wogonin potentiates cisplatin-induced cancer cell apoptosis through accumulation of intracellular reactive oxygen species.
PubMed:Enhanced accumulation of secondary metabolites in hairy root cultures of Scutellaria lateriflora following elicitation.
PubMed:Scutellaria baicalensis alleviates cantharidin-induced rat hemorrhagic cystitis through inhibition of cyclooxygenase-2 overexpression.
PubMed:Drug resistance associates with activation of Nrf2 in MCF-7/DOX cells, and wogonin reverses it by down-regulating Nrf2-mediated cellular defense response.
PubMed:Chemical constituents of the aerial parts of Scutellaria lateriflora and their alpha-glucosidase inhibitory activities.
PubMed:[Study on ingredients of Scutellaria Radix extract penetrable through placental barrier of pregnant rat].
PubMed:Anti-atherosclerotic action of Ger-Gen-Chyn-Lian-Tang and AMPK-dependent lipid lowering effect in hepatocytes.
PubMed:Comparative study of the effect of baicalin and its natural analogs on neurons with oxygen and glucose deprivation involving innate immune reaction of TLR2/TNFα.
PubMed:[Wogonin inhibits IGF-1-stimulated cell growth and estrogen receptor α expression in breast adenocarcinoma cell and angiogenesis of chick chorioallantoic membrane].
PubMed:[Simultaneous determination of five main index components and specific chromatograms analysis in Xiaochaihu granules].
PubMed:Relaxant effect induced by wogonin from Scutellaria baicalensis on rat isolated uterine smooth muscle.
PubMed:6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection.
PubMed:Functional role of wogonin in anti-angiogenesis.
PubMed:Phorbol ester or epidermal growth-factor-induced MUC5AC mucin gene expression and production from airway epithelial cells are inhibited by apigenin and wogonin.
PubMed:Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production.
PubMed:Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells.
PubMed:A simple isocratic HPLC method for the simultaneous determination of bioactive components of Scutellariae radix extract.
PubMed:Advances in the treatment of ovarian cancer: a potential role of antiinflammatory phytochemicals.
PubMed:Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κB signaling after experimental traumatic brain injury.
PubMed:Screening active compounds acting on the epidermal growth factor receptor from Radix scutellariae via cell membrane chromatography online coupled with HPLC/MS.
PubMed:The molecular basis for the inhibition of human cytochrome P450 1A2 by oroxylin and wogonin.
PubMed:Studying on inclusion complexes of Wogonin with β-cyclodextrin and hydroxypropyl-cyclodextrin.
PubMed:Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway.
PubMed:Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae.
PubMed:Detection of baicalin metabolites baicalein and oroxylin-a in mouse pancreas and pancreatic xenografts.
PubMed:Transcription factor NF-κB regulates expression of pore-forming Ca2+ channel unit, Orai1, and its activator, STIM1, to control Ca2+ entry and affect cellular functions.
PubMed:Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression.
PubMed:Polyphenols and neuroprotection against ischemia and neurodegeneration.
PubMed:[Comparision of adsorption-desorption dynamics of huanglian jiedu decoction using different macroporous resins combinations].
PubMed:Scutellaria extract and wogonin inhibit tumor-mediated induction of T(reg) cells via inhibition of TGF-β1 activity.
PubMed:[Comparative and correlational studies on contents of flavonoids in axial root and lateral root of Scutellaria baicalensis].
PubMed:Antitumor constituents from the leaves of Carya cathayensis.
PubMed:Wogonin ameliorates lipotoxicity-induced apoptosis of cultured vascular smooth muscle cells via interfering with DAG-PKC pathway.
PubMed:Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones.
PubMed:Comparative chemical and statistical analysis of cultivated and wild Radix Scutellariae.
PubMed:Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspin.
PubMed:[Study on transportation of Xiaochaihu Tang in Caco-2 cell model].
PubMed:Anti-cancer natural products isolated from chinese medicinal herbs.
PubMed:Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1.
PubMed:Development of a novel method combining HPLC fingerprint and multi-ingredients quantitative analysis for quality evaluation of traditional Chinese medicine preparation.
PubMed:Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes.
PubMed:Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1β-treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos/AP-1 and JAK/STAT signaling pathways.
PubMed:Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells.
PubMed:Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways.
PubMed:Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice.
PubMed:Enhancement of flavone levels through overexpression of chalcone isomerase in hairy root cultures of Scutellaria baicalensis.
PubMed:Simultaneous determination of five flavonoids from Scutellaria Barbata extract in rat plasma by LC-MS/MS and its application to pharmacokinetic study.
PubMed:The inhibitory activities of the components of Huang-Lian-Jie-Du-Tang (HLJDT) on eicosanoid generation via lipoxygenase pathway.
PubMed:Developmental toxicity and genotoxicity studies of wogonin.
PubMed:The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells.
PubMed:Wogonin induces apoptosis by activation of ERK and p38 MAPKs signaling pathways and generation of reactive oxygen species in human breast cancer cells.
PubMed:[Bio-activity evaluation of Qinlian Siwu decoction on inhibiting mice uterine contraction in vitro and its components analysis].
PubMed:Wogonin suppresses arrhythmias, inflammatory responses, and apoptosis induced by myocardial ischemia/reperfusion in rats.
PubMed:Baicalein and wogonin are activators of rat TREK-2 two-pore domain K+ channel.
PubMed:Inhibitory effects of wogonin on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9.
PubMed:Catalase suppression-mediated H(2)O(2) accumulation in cancer cells by wogonin effectively blocks tumor necrosis factor-induced NF-κB activation and sensitizes apoptosis.
PubMed:Structure-metabolism relationships for the glucuronidation of flavonoids by UGT1A3 and UGT1A9.
PubMed:Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration?
PubMed:Wogonin induced apoptosis in human nasopharyngeal carcinoma cells by targeting GSK-3β and ΔNp63.
PubMed:Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages.
PubMed:Characterization of the multiple absorbed constituents in rats after oral administration of Chai-Huang decoction by liquid chromatography coupled with electrospray-ionization mass spectrometry.
PubMed:Simultaneous quantification of twelve active components in Yiqing granule by ultra-performance liquid chromatography: application to quality control study.
PubMed:Different apoptotic effects of wogonin via induction of H(2)O(2) generation and Ca(2+) overload in malignant hepatoma and normal hepatic cells.
PubMed:Identification and quantification of baicalein, wogonin, oroxylin A and their major glucuronide conjugated metabolites in rat plasma after oral administration of Radix scutellariae product.
PubMed:Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats.
PubMed:Wogonin induces differentiation and neurite outgrowth of neural precursor cells.
PubMed:Simultaneous quantification of multiple active components from Xiexin decoction in rat plasma by LC-ESI-MS/MS: application in pharmacokinetics.
PubMed:Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicals.
PubMed:Molecular cloning and characterization of phenylalanine ammonia-lyase, cinnamate 4-hydroxylase and genes involved in flavone biosynthesis in Scutellaria baicalensis.
PubMed:Targeting apoptosis pathways in cancer by Chinese medicine.
PubMed:Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects.
PubMed:Plant Natural compounds with antibacterial activity towards common pathogens of pond-cultured channel catfish (Ictalurus punctatus).
PubMed:Wogonin potentiates the antitumor effects of low dose 5-fluorouracil against gastric cancer through induction of apoptosis by down-regulation of NF-kappaB and regulation of its metabolism.
PubMed:[Simultaneous determination of 7 active ingredients in Scutellaria barbata D. Don by capillary micellar electrokinetic chromatography].
PubMed:[Simultaneous determination of five active constitutents in Xiaochaihu Tang by HPLC].
PubMed:Delayed growth of glioma by Scutellaria flavonoids involve inhibition of Akt, GSK-3 and NF-κB signaling.
PubMed:12-O-tetradecanoylphorbol-13-acetate-induced invasion/migration of glioblastoma cells through activating PKCalpha/ERK/NF-kappaB-dependent MMP-9 expression.
PubMed:Secondary metabolite mapping identifies Scutellaria inhibitors of human lung cancer cells.
PubMed:Traditional Chinese medicine and related active compounds against hepatitis B virus infection.
PubMed:Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography-tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria-coptis herb couple.
PubMed:Baicalein and Wogonin inhibit collagen deposition in SHR and WKY cardiac fibroblast cultures.
PubMed:Use of isoform-specific UGT metabolism to determine and describe rates and profiles of glucuronidation of wogonin and oroxylin A by human liver and intestinal microsomes.
PubMed:[A quantitative method for simultaneous assay of four flavones with one marker in Radix Scutellariae].
PubMed:[Analysis of main flavonoids contents of Scutellaria baicalensis].
PubMed:Spectrometric study of the interaction between alpinetin and bovine serum albumin using chemometrics approaches.
PubMed:Combinative method using HPLC fingerprint and quantitative analyses for quality consistency evaluation of an herbal medicinal preparation produced by different manufacturers.
PubMed:On-line continuous flow ultrasonic extraction coupled with high performance liquid chromatographic separation for determination of the flavonoids from root of Scutellaria baicalensis Georgi.
PubMed:Inhibition of prostaglandin E2 production by flavone and its related compounds.
PubMed:Inhibition of prostaglandin E2 production by synthetic wogonin analogs.
PubMed:Cloning and expression of beta-glucuronidase from Lactobacillus brevis in E. coli and application in the bioconversion of baicalin and wogonoside.
PubMed:Wogonin inhibits osteoclast formation induced by lipopolysaccharide.
PubMed:Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21Cip1 in human cervical carcinoma HeLa cells.
PubMed:Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells.
PubMed:Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells.
PubMed:[Flavonoids from Scutellaria baicalensis and their bioactivities].
PubMed:Qualitative and quantitative analysis of traditional Chinese medicine Niu Huang Jie Du Pill using ultra performance liquid chromatography coupled with tunable UV detector and rapid resolution liquid chromatography coupled with time-of-flight tandem mass spectrometry.
PubMed:Metabolism and pharmacokinetics of san-huang-xie-xin-tang, a polyphenol-rich chinese medicine formula, in rats and ex-vivo antioxidant activity.
PubMed:Inhibition of P-glycoprotein by wogonin is involved with the potentiation of etoposide-induced apoptosis in cancer cells.
PubMed:Influence of coptis Chinensis on pharmacokinetics of flavonoids after oral administration of radix Scutellariae in rats.
PubMed:[A new flavonoid glucoside from Huanglianjiedutang decoction].
PubMed:Molecular crosstalk between TRAIL and natural antioxidants in the treatment of cancer.
PubMed:[Analysis of the 4th generation Scutellaria baicalensis Georgi with space mutagenesis via FTIR spectroscopy].
PubMed:Arsenic accumulation in Scutellaria baicalensis Georgi and its effects on plant growth and pharmaceutical components.
PubMed:Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells.
PubMed:In vitro anti-leukemic activity of the ethno-pharmacological plant Scutellaria orientalis ssp. carica endemic to western Turkey.
PubMed:Effects of Japanese herbal medicine, Kampo, on human UGT1A1 activity.
PubMed:Effect of Scutellariae radix ingredients on prostaglandin E(2) production and COX-2 expression by LPS-activated macrophage.
PubMed:Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora.
PubMed:Simple and reliable methods for the determination of sixteen marker components for quality control of Daochi pill by HPLC coupled with diode array detection.
PubMed:Contents of major bioactive flavones in proprietary traditional Chinese medicine products and reference herb of radix Scutellariae.
PubMed:Reactive oxygen species up-regulate p53 and Puma; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin.
PubMed:Subchronic toxicity and plasma pharmacokinetic studies on wogonin, a natural flavonoid, in Beagle dogs.
PubMed:Simultaneous determination of 11 active components in two well-known traditional Chinese medicines by HPLC coupled with diode array detection for quality control.
PubMed:[Studies on ethyl acetate soluble constituents of Huanglian Jiedutang].
PubMed:Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography.
PubMed:Mechanism of CYP2C9 inhibition by flavones and flavonols.
PubMed:Natural products as promising drug candidates for the treatment of hepatitis B and C.
PubMed:In vitro antitumor mechanisms of various Scutellaria extracts and constituent flavonoids.
PubMed:New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin.
PubMed:Toxicological studies of wogonin in experimental animals.
PubMed:[Comparative study on chemcial composition between cultivated and wild Scutellariae radix].
PubMed:Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling.
PubMed:Production of cytokines and stimulation of resistance to viral infection in human leukocytes by Scutellaria baicalensis flavones.
PubMed:Wogonin inhibits microglial cell migration via suppression of nuclear factor-kappa B activity.
PubMed:Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu- tang across human intestinal Caco-2 cell monolayers.
PubMed:Genetic characterization and phytochemical analysis of wild and cultivated populations of Scutellaria baicalensis.
PubMed:Wogonin induced differentiation and G1 phase arrest of human U-937 leukemia cells via PKCdelta phosphorylation.
PubMed:Enhanced electrochemiluminescence of Ru(bpy)3(2+) by flavone compounds.
PubMed:Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cells.
PubMed:Comparisons of Scutellaria baicalensis, Scutellaria lateriflora and Scutellaria racemosa: genome size, antioxidant potential and phytochemistry.
PubMed:Blockade of the dioxin pathway by herbal medicine Formula Bupleuri Minor: identification of active entities for suppression of AhR activation.
PubMed:Validation of a HPLC method for flavonoid biomarkers in skullcap (Scutellaria) and its use to illustrate wide variability in the quality of commercial tinctures.
PubMed:Comparison of the major flavonoid content of S. baicalensis, S. lateriflora, and their commercial products.
PubMed:Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2.
PubMed:Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells.
PubMed:Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression.
PubMed:Assessment of luteolin (3',4',5,7-tetrahydroxyflavone) neuropharmacological activity.
PubMed:Two new alkaloids from Capparis himalayensis.
PubMed:Down-regulation of androgen-receptor and PSA by phytochemicals.
PubMed:Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis.
PubMed:[Effects of processing and extracting methods on active components in Radix Scutellariae by HPLC analysis].
PubMed:[HPLC fingerprint of flavonoids of Kushen Tang and its correlation to Scutellaria baicalensis and Sophora flavescens].
PubMed:Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron.
PubMed:[Antiatherosclerotic properties of flavones from the roots of Scutellaria baicalensis Georgi].
PubMed:Anticancer effects of wogonin in both estrogen receptor-positive and -negative human breast cancer cell lines in vitro and in nude mice xenografts.
PubMed:Differential apoptotic effect of wogonin and nor-wogonin via stimulation of ROS production in human leukemia cells.
PubMed:[Enzymatic extraction of baicalein and wogonin from radix scutellariae].
PubMed:Inhibition of mammalian collagenase, matrix metalloproteinase-1, by naturally-occurring flavonoids.
PubMed:[Pharmacokinetics of flavonoids from xiexin decoction in rats].
PubMed:Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis.
PubMed:Wogonin prevents glucocorticoid-induced thymocyte apoptosis without diminishing its anti-inflammatory action.
PubMed:Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents.
PubMed:Effects of baicalin and wogonin on mucin release from cultured airway epithelial cells.
PubMed:Wogonin but not Nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophages.
PubMed:Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytes.
PubMed:Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells.
PubMed:Wogonin prevents immunosuppressive action but not anti-inflammatory effect induced by glucocorticoid.
PubMed:Pharmacokinetics of baicalein, baicalin and wogonin after oral administration of a standardized extract of Scutellaria baicalensis, PF-2405 in rats.
PubMed:Wogonin suppresses TARC expression induced by mite antigen via heme oxygenase 1 in human keratinocytes. Suppressive effect of wogonin on mite antigen-induced TARC expression.
PubMed:Changes in mitochondrial membrane potential and reactive oxygen species during wogonin-induced cell death in human hepatoma cells.
PubMed:Anti-hepatitis B virus activity of wogonin in vitro and in vivo.
PubMed:Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin.
PubMed:Studies on the constituents of roots of Scutellaria planipes.
PubMed:Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity.
PubMed:Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells.
PubMed:Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI.
PubMed:Wogonin inhibits IL-6-induced angiogenesis via down-regulation of VEGF and VEGFR-1, not VEGFR-2.
PubMed:Quantitative analysis and chromatographic fingerprinting for the quality evaluation of Scutellaria baicalensis Georgi using capillary electrophoresis.
PubMed:Protective role of wogonin against lipopolysaccharide-induced angiogenesis via VEGFR-2, not VEGFR-1.
PubMed:Analysis of baicalein, baicalin and wogonin in Scutellariae radix and its preparation by microemulsion electrokinetic chromatography with 1-butyl-3-methylimizolium tetrafluoborate ionic liquid as additive.
PubMed:Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice.
PubMed:Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis.
PubMed:Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721.
PubMed:Effects of wogonin on the levels of cytokines and functions of leukocytes associated with NF-kappa B expression in Sprague-Dawley rats.
PubMed:Liquid chromatography with tandem mass spectrometry for the simultaneous determination of baicalein, baicalin, oroxylin A and wogonin in rat plasma.
PubMed:[Qualitative and quantitative determination of the main components of huanglianjiedu decoction by HPLC-UV/MS].
PubMed:Simultaneous determination of eight active components in Chinese medicine 'YIQING' capsule using high-performance liquid chromatography.
PubMed:[Simultaneous determination of three kinds of components in sanhuang tablets by high-performance liquid chromatography].
PubMed:The anticancer activities of wogonin in murine sarcoma S180 both in vitro and in vivo.
PubMed:Cardioprotective effects of grape seed proanthocyanidins, baicalin and wogonin: comparison between acute and chronic treatments.
PubMed:Studies on the constituents of Scutellaria species (XXII). Constituents of the roots of Scutellaria amabilis HARA.
PubMed:Lipopolysaccharide plus 12-o-tetradecanoylphorbol 13-acetate induction of migration and invasion of glioma cells in vitro and in vivo: Differential inhibitory effects of flavonoids.
PubMed:Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin-nitrite-H2O2 induced liver injury.
PubMed:[Determination of contents of the effective ingredients in root of Scutellaria baicalensis by HPLC-ECD].
PubMed:Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell.
PubMed:Application of LC/MS and ICP/MS for establishing the fingerprint spectrum of the traditional Chinese medicinal preparation Gan-Lu-Yin.
PubMed:[Studies on chemical constituents in bark of dictamnus dasycarpus].
PubMed:Retention behavior of silica-bonded and novel polymeric reversed-phase sorbents in studies on flavones as chemotaxonomic markers of Scutellaria L. genus.
PubMed:Micellar electrokinetic chromatography for separation of a mixture of coptis alkaloids, scute flavonoids, and rhubarb anthraquinones and bianthrones.
PubMed:Binding of wogonin to human gammaglobulin.
PubMed:Inhibitory effects of a chemically standardized extract from Scutellaria barbata in human colon cancer cell lines, LoVo.
PubMed:Skullcapflavone I from Scutellaria baicalensis induces apoptosis in activated rat hepatic stellate cells.
PubMed:Structure and antiinflammatory activity relationships of wogonin derivatives.
PubMed:Inhibition of prostaglandin production by a structurally-optimized flavonoid derivative, 2',4',7-trimethoxyflavone and cellular action mechanism.
PubMed:Synthesis and iNOS inhibitory activities of thioflavones.
PubMed:Therapeutic potential of wogonin: a naturally occurring flavonoid.
PubMed:Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives.
PubMed:Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography.
PubMed:Enhancing effects of Scutellaria baicalensis and some of its constituents on TGF-beta1 gene expression in RAW 264.7 murine macrophage cell line.
PubMed:Interaction of wogonin with bovine serum albumin.
PubMed:Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma.
PubMed:Wogonin inhibits N-acetyltransferase activity and gene expression in human leukemia HL-60 cells.
PubMed:Synthetic wogonin derivatives suppress lipopolysaccharide-induced nitric oxide production and hydrogen peroxide-induced cytotoxicity.
PubMed:The herbal medicine Sho-saiko-to selectively inhibits CD8+ T-cell proliferation.
PubMed:Non-aqueous capillary electrophoresis for simultaneous separation and determination of three major active components in traditional medicinal preparations.
PubMed:Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells.
PubMed:Efficacy of wogonin in the production of immunoglobulins and cytokines by mesenteric lymph node lymphocytes in mouse colitis induced with dextran sulfate sodium.
PubMed:Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix.
PubMed:[Isolation and elucidation of antioxidant constituents from acetone extract in root of Scutellaria rehderiana].
PubMed:Separation methods used for Scutellaria baicalensis active components.
PubMed:Separation and isolation methods for analysis of the active principles of Sho-saiko-to (SST) oriental medicine.
PubMed:Neuroprotective effect of wogonin: potential roles of inflammatory cytokines.
PubMed:Proteomic analysis of mouse liver for the evaluation of effects of Scutellariae radix by liquid chromatography with tandem mass spectrometry.
PubMed:Wogonin inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion.
PubMed:A metabolomic analysis of medicinal diversity in Huang-qin (Scutellaria baicalensis Georgi) genotypes: discovery of novel compounds.
PubMed:Neuroprotective effect of wogonin in hippocampal slice culture exposed to oxygen and glucose deprivation.
PubMed:Inhibition of contact dermatitis in animal models and suppression of proinflammatory gene expression by topically applied flavonoid, wogonin.
PubMed:Preventive effect of the flavonoid, wogonin, against ethanol-induced gastric mucosal damage in rats.
PubMed:Synthesis and biological activities of 8-arylflavones.
PubMed:Antimutagenic and antiradical properties of flavones from the roots of Scutellaria baicalensis georgi.
PubMed:Binding of wogonin to human serum albumin: a common binding site of wogonin in subdomain IIA.
PubMed:Cytotoxic activities of flavonoids from two Scutellaria plants in Chinese medicine.
PubMed:Phytotoxic and antimicrobial constituents of Bacopa monnieri and Holmskioldia sanguinea.
PubMed:Wogonin inhibits excitotoxic and oxidative neuronal damage in primary cultured rat cortical cells.
PubMed:Lipopolysaccharide enhancement of 12-o-tetradecanoylphorbol 13-acetate-mediated transformation in rat glioma C6, accompanied by induction of inducible nitric oxide synthase.
PubMed:Antifungal activity of wogonin.
PubMed:Wogonin suppresses cellular proliferation and expression of monocyte chemoattractant protein 1 in Peyronie's plaque-derived cells.
PubMed:Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression.
PubMed:Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and glucose deprivation-induced neuronal death.
PubMed:[Effects of wogonin on inducing apoptosis of human ovarian cancer A2780 cells and telomerase activity].
PubMed:Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia.
PubMed:Effects of baicalin, baicalein, and wogonin on interleukin-6 and interleukin-8 expression, and nuclear factor-kappab binding activities induced by interleukin-1beta in human retinal pigment epithelial cell line.
PubMed:Pharmacokinetic study on the multi-constituents of Huangqin-Tang decoction in rats.
PubMed:Effect of the flavonoid components obtained from Scutellaria radix on the histamine, immunoglobulin E and lipid peroxidation of spleen lymphocytes of Sprague-Dawley rats.
PubMed:Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties.
PubMed:Effects of topical instillation of traditional herbal medicines, herbal extracts, and their components on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits.
PubMed:[Studies on chemical constituents of Sorbaria sorbifolia].
PubMed:[A novel approach to quality evaluation of root of Scutellaria baicalensis by DPPH free radical scavenging].
PubMed:[Determination of flavone for Scutellaria baicalensis from different areas by HPLC].
PubMed:Degradation of flavonoid aglycones by rabbit, rat and human fecal flora.
PubMed:Novel synthesis of flavonoids of Scutellaria baicalensis Georgi.
PubMed:[Determination of wogonin in rat plasma by liquid chromatography-tandem mass spectrometry].
PubMed:Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans.
PubMed:Effects of wogonin, wogonoside, and 3,5,7,2',6'-pentahydroxyflavone on chemical mediator production in peritoneal exduate cells and immunoglobulin E of rat mesenteric lymph node lymphocytes.
PubMed:Tumor necrosis factor-producing activity of wogonin in RAW 264.7 murine macrophage cell line.
PubMed:Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi.
PubMed:Evaluation of variation of acteoside and three major flavonoids in wild and cultivated Scutellaria baicalensis roots by micellar electrokinetic chromatography.
PubMed:Quantitation of the flavonoid wogonin and its major metabolite wogonin-7 beta-D-glucuronide in rat plasma by liquid chromatography-tandem mass spectrometry.
PubMed:Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1.
PubMed:In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production.
PubMed:Metabolism of constituents in Huangqin-Tang, a prescription in traditional Chinese medicine, by human intestinal flora.
PubMed:[Antibacterial constituents against Helicobacter pylori of Brazilian medicinal plant, Pariparoba].
PubMed:Evaluation of the anti-inflammatory effect of baicalein on dextran sulfate sodium-induced colitis in mice.
PubMed:Different effects of baicalein, baicalin and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines.
PubMed:Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease.
PubMed:Induction of apoptosis in human lung fibroblasts and peripheral lymphocytes in vitro by Shosaiko-to derived phenolic metabolites.
PubMed:Antiviral Chinese medicinal herbs against respiratory syncytial virus.
PubMed:Protective effect of wogonin on endotoxin-induced lethal shock in D-galactosamine-sensitized mice.
PubMed:Protective effects of baicalein and wogonin against benzo[a]pyrene- and aflatoxin B(1)-induced genotoxicities.
PubMed:Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells.
PubMed:Inhibition of TPA-induced cyclooxygenase-2 expression and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix.
PubMed:The plant flavonoid wogonin suppresses death of activated C6 rat glial cells by inhibiting nitric oxide production.
PubMed:Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes.
PubMed:Determination of 14 chemical constituents in the traditional Chinese medicinal preparation Huangqin-Tang by high performance liquid chromatography.
PubMed:Effects of scutellariae radix extract and its components (baicalein, baicalin, and wogonin) on the experimental elevation of aqueous flare in pigmented rabbits.
PubMed:Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide.
PubMed:Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells.
PubMed:Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells.
PubMed:Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis.
PubMed:Pharmacological effects of urinary products obtained after treatment with saiboku-to, a herbal medicine for bronchial asthma, on type IV allergic reaction.
PubMed:Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin.
PubMed:Effects of baicalein and wogonin on drug-metabolizing enzymes in C57BL/6J mice.
PubMed:Wogonin inhibits inducible prostaglandin E(2) production in macrophages.
PubMed:Cloning and expression of UDP-glucose: flavonoid 7-O-glucosyltransferase from hairy root cultures of Scutellaria baicalensis.
PubMed:Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines.
PubMed:Study of major flavonoids in crude Scutellariae Radix by micellar electrokinetic capillary chromatography.
PubMed:Purification and characterization of UDP-glucuronate: baicalein 7-O-glucuronosyltransferase from Scutellaria baicalensis Georgi. cell suspension cultures.
PubMed:Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site.
PubMed:Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi.
PubMed:Simultaneous determination of baicalin, wogonoside, baicalein, wogonin, berberine, coptisine, palmatine, jateorrhizine and glycyrrhizin in Kampo medicines by ion-pair high-performance liquid chromatography.
PubMed:The nitric oxide-producing activities of Scutellaria baicalensis.
PubMed:Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships.
PubMed:Inhibitory effects of baicalein and wogonin on lipopolysaccharide-induced nitric oxide production in macrophages.
PubMed:Inhibition of cyclooxygenase/lipoxygenase from human platelets by polyhydroxylated/methoxylated flavonoids isolated from medicinal plants.
PubMed:Induction of quinone reductase by a methanol extract of Scutellaria baicalensis and its flavonoids in murine Hepa 1c1c7 cells.
PubMed:Characteristics of delayed excretion of flavonoids in human urine after administration of Shosaiko-to, a herbal medicine.
PubMed:Analysis of inhibitory effects of scutellariae radix and baicalein on prostaglandin E2 production in rat C6 glioma cells.
PubMed:Stereochemistry and putative origins of flavanones found in post-administration urine of the traditional Chinese remedies shosaiko-to and daisaiko-to.
PubMed:Comparative study of Scutellaria planipes and Scutellaria baicalensis.
PubMed:Antioxidant activity of flavones from Scutellaria baicalensis in lecithin liposomes.
PubMed:Study on baths with crude drug. III. The effect of ligustici chuanxiong rhizoma extract on the percutaneous absorption of some natural compounds.
PubMed:Effects of flavonoids isolated from scutellariae radix on fibrinolytic system induced by trypsin in human umbilical vein endothelial cells.
PubMed:Systematic analysis of post-administrative saiboku-to urine by liquid chromatography to determine pharmacokinetics of traditional Chinese medicine.
PubMed:Determination of wogonin in rat plasma by liquid chromatography and its pharmacokinetic application.
PubMed:Determination of gentiopicroside, mangiferin, palmatine, berberine, baicalin, wogonin and glycyrrhizin in the traditional Chinese medicinal preparation sann-joong-kuey-jian-tang by high-performance liquid chromatography.
PubMed:The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, baicalin, baicalein and wogonin.
PubMed:Effects of nine active ingredients in Chinese herbal medicine sho-saiko-to on 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide mutagenicity.
PubMed:Purification and properties of a plant beta-D-glucuronidase form Scutellaria root.
PubMed:Two flavone 2'-glucosides from Scutellaria baicalensis.
PubMed:Pharmacological effects of methanolic extract from the root of Scutellaria baicalensis and its flavonoids on human gingival fibroblast.
PubMed:Cytotoxic effect of herbal medicine sho-saiko-to on human lung-cancer cell-lines in-vitro.
PubMed:Effects of baicalein and esculetin on transduction signals and growth factors expression in T-lymphoid leukemia cells.
PubMed:The herbal medicine sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase.
PubMed:Antiproliferative effect of baicalein, a flavonoid from a Chinese herb, on vascular smooth muscle cell.
PubMed:Inhibitory effects of flavonoids on xanthine oxidase.
PubMed:Identification and production of flavonoids in a cell suspension culture of Scutellaria baicalensis G.
PubMed:Effect of some alkaloids, flavonoids and triterpenoids, contents of Japanese-Chinese traditional herbal medicines, on the lipogenesis of sebaceous glands.
PubMed:Mechanism of antioxidant action of pueraria glycoside (PG)-1 (an isoflavonoid) and mangiferin (a xanthonoid).
PubMed:Inhibition of rat liver NAD(P)H:quinone acceptor oxidoreductase (DT-diaphorase) by flavonoids isolated from the Chinese herb scutellariae radix (Huang Qin).
PubMed:Inhibition of mouse liver sialidase by the root of Scutellaria baicalensis.
PubMed:Mutagenicities of 61 flavonoids and 11 related compounds.
PubMed:[Studies on the constituents of Anodendron affine Durce. I. Isolation of wogonin, dambonitol, sucrose and some other components from stems].
PubMed:[Synthesis of 2,3-dihydro-wogonin-7-mono-beta-D-glucoside, a new glycoside from Prunus cerasus L].
 
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