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Category:herbicides / pesticides
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 182.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 504.40 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 555.00 °F. TCC ( 290.40 °C. ) (est)
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| logP (o/w): | 3.100 |
| Soluble in: |
| | water, 1 mg/L @ 25 °C (exp) | | | water, 26.5 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Clofentezine 98%
Odor: characteristic Use: Clofentezine is an active substance of plant protection product used as pesticide, acaricide. It belongs to the chemical family of quinoxalines. It is used in agriculture for the protection of ornamentals, food and non-food crops in the field.
Clofentezine is used as a pesticide, acaricide. It is used in agriculture for the protection of ornamentals, |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Clofentezine
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| Sigma-Aldrich |
| For experimental / research use only. |
| Clofentezine PESTANAL®, analytical standard
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Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-duck LD50 > 3000 mg/kg
Proceedings-British Crop Protection Conference-Pests and Diseases. Vol. -, Pg. 67, 1981.
unreported-duck LD50 > 3000 mg/kg
Defense des Vegetaux. Vol. 39(231), Pg. 11, 1985.
oral-mouse LD50 > 3200 mg/kg
Proceedings-British Crop Protection Conference-Pests and Diseases. Vol. -, Pg. 67, 1981.
oral-quail LD50 > 750 mg/kg
Proceedings-British Crop Protection Conference-Pests and Diseases. Vol. -, Pg. 67, 1981.
oral-rat LD50 > 3200 mg/kg
Proceedings-British Crop Protection Conference-Pests and Diseases. Vol. -, Pg. 67, 1981.
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| Dermal Toxicity: |
skin-rat LD50 > 1332 mg/kg
"Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A543, Pg. 1984
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| Inhalation Toxicity: |
inhalation-rat LC50 > 9000 mg/m3/4H
Pesticide Manual. Vol. 9, Pg. 177, 1991.
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Safety in Use Information:
| Category: | | herbicides / pesticides |
| Recommendation for clofentezine usage levels up to: | | | not for fragrance use.
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| Recommendation for clofentezine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
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Reasoned opinion on the modification of the existing MRLs for clofentezine in cherries, cucurbits with edible peel, tomatoes and aubergines
View page or View pdf
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Retrospective analysis of the immunotoxic effects of plant protection products as reported in the Draft Assessment Reports for their peer review at EU level
View page or View pdf
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Outcome of the consultation with Member States, the applicant and EFSA on the pesticide risk assessment for clofentezine in light of confirmatory data
View page or View pdf
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Peer review of the pesticide risk assessment of the active substance clofentezine
View page or View pdf
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| EPI System: View |
| EPA-Iris:IRIS |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :73670 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| 3,6-bis(2-chlorophenyl)-1,2,4,5-tetrazine |
| Chemidplus:0074115245 |
| RTECS:XF6860000 for cas# 74115-24-5 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | acaristop | | | apollo 50W | | | bisclofentazin | | | bisclofentazine | | 3,6-bis(2- | chlorophenyl)-1,2,4,5-tetrazine | | | panatac | | 1,2,4,5- | tetrazine, 3,6-bis(2-chlorophenyl)- |
Articles:
| PubMed:Evaluation of etoxazole against insects and acari in vegetables in China. |
| PubMed:Determination of pesticides in sunflower seeds by high-performance liquid chromatography coupled with a diode array detector. |
| PubMed:High resolution genetic mapping uncovers chitin synthase-1 as the target-site of the structurally diverse mite growth inhibitors clofentezine, hexythiazox and etoxazole in Tetranychus urticae. |
| PubMed:Abamectin is metabolized by CYP392A16, a cytochrome P450 associated with high levels of acaricide resistance in Tetranychus urticae. |
| PubMed:Dispersive micro-solid phase extraction based on self-assembling, ionic liquid-coated magnetic particles for the determination of clofentezine and chlorfenapyr in environmental water samples. |
| PubMed:Pesticide compatibility with natural enemies for pest management in greenhouse gerbera daisies. |
| PubMed:Determination of the inheritance, cross-resistance and detoxifying enzyme levels of a laboratory-selected, spiromesifen-resistant population of the predatory mite Neoseiulus californicus (Acari: Phytoseiidae). |
| PubMed:[Population-related peculiarities of molecular stress-responsive systems of bivalve mollusk under the effect of tetrazine pesticide]. |
| PubMed:Resistance to acaricides in Italian strains of Tetranychus urticae: toxicological and enzymatic assays. |
| PubMed:Determination of clofentezine in medical herb extracts by chromatographic methods combined with diode array scanning densitometry. |
| PubMed:Development, validation and application of a methodology based on solid-phase micro extraction followed by gas chromatography coupled to mass spectrometry (SPME/GC-MS) for the determination of pesticide residues in mangoes. |
| PubMed:Determination of pesticides in water samples from the Wieprz-krzna Canal in the Leczyńsko-Włodawskie Lake District of southeastern Poland by thin-layer chromatography with diode array scanning and high-performance column liquid chromatography with diode array detection. |
| PubMed:Efficacy of five selected acaricides against Tetranychus urticae (Acari: Tetranychidae) and their side effects on relevant natural enemies occurring in citrus orchards. |
| PubMed:Effects of acaricides, pyrethroids and predator distributions on populations of Tetranychus urticae in apple orchards. |
| PubMed:Assessment of sublethal effects of clofentezine on life-table parameters in Hawthorn spider mite (Tetranychus viennensis). |
| PubMed:Baseline susceptibility and cross resistances of some new acaricides in the European red mite, Panonychus ulmi. |
| PubMed:Comparative acaricide susceptibility and detoxifying enzyme activities in field-collected resistant and susceptible strains of Tetranychus urticae. |
| PubMed:Toxicity of pesticides to predatory mites and insects in apple-tree site under field conditions. |
| PubMed:Genetic analysis and cross-resistance spectrum of a laboratory-selected chlorfenapyr resistant strain of two-spotted spider mite (Acari: Tetranychidae). |
| PubMed:Determination of fluquinconazole, pyrimethanil, and clofentezine residues in fruits by liquid chromatography with ultraviolet detection. |
| PubMed:The effects of clofentezine on life-table parameters in two-spotted spider mite Tetranychus urticae. |
| PubMed:An index for selective toxicity of miticides to phytophagous mites and their predators based on orchard trials. |
| PubMed:Characterization of resistance to clofentezine in populations of European red mite from orchards in Ontario. |
| PubMed:[Method-performance studies of notified analytical method for clofentezine]. |
| PubMed:Acaricide toxicity and resistance in larvae of different strains of Tetranychus urticae and Panonychus ulmi (Acari: Tetranychidae). |
| PubMed:Multiresidue determination of pesticides in plants by high-performance liquid chromatography following gel permeation chromatographic clean-up. |
| PubMed:Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents. |
| PubMed:Determination of the pesticides diflubenzuron and clofentezine in plums, strawberries and blackcurrant-based fruit drinks by high performance liquid chromatographic/atmospheric pressure chemical ionization-mass spectrometry. |
| PubMed:Relevance of kinetic and metabolic data to the interpretation of toxicological findings. |
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3D/inchi