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Category:herbicides / pesticides
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white powder (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 204.50 °C. @ 760.00 mm Hg
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| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est)
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| logP (o/w): | 3.700 |
| Soluble in: |
| | water, 1 mg/L @ 25 °C (exp) | | | water, 3.312 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | herbicides / pesticides |
| Recommendation for methoxyfenozide usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for methoxyfenozide flavor usage levels up to: |
| | not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
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Reasoned opinion on the review of the existing maximum residue levels (MRLs) for methoxyfenozide according to Article 12 of Regulation (EC) No 396/2005
View page or View pdf
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Peer review of the pesticide risk assessment of the active substance methoxyfenozide
View page or View pdf
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Focussed assessment of certain existing MRLs of concern for methoxyfenozide
View page or View pdf
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| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :105010 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:2 |
| N'-tert-butyl-N'-(3,5-dimethylbenzoyl)-3-methoxy-2-methylbenzohydrazide |
| Chemidplus:0161050584 |
References:
| | N'-tert-butyl-N'-(3,5-dimethylbenzoyl)-3-methoxy-2-methylbenzohydrazide |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 105010 |
| Pubchem (sid): | 135238159 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzoic acid, 3-methoxy-2-methyl-, 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl)hydrazide [ACD/Index Name] | | N'-(tert- | butyl )-N'-(3,5-dimethylbenzoyl)-3-methoxy-2-methylbenzohydrazide | | N-tert- | butyl-N'-(3-methoxy-o-toluoyl)-3,5-xylohydrazide | | N'-tert- | butyl-N'-(3,5-dimethylbenzoyl)-3-methoxy-2-methylbenzohydrazid | | N'-tert- | butyl-N'-(3,5-dimethylbenzoyl)-3-methoxy-2-methylbenzohydrazide | | N'-tert- | butyl-N'-[(3,5-dimethylphenyl)carbonyl]-3-methoxy-2-methylbenzohydrazide | | N'-(tert- | butyl)-N'-(3,5-dimethylbenzoyl)-3-methoxy-2-methylbenzohydrazide | | N-[N-(tert- | butyl)(3,5-dimethylphenyl)carbonylamino](3-methoxy-2-methylphenyl)carboxamide | | N'-(3,5- | dimethylbenzoyl)-3-methoxy-2-methyl-N'-(2-methyl-2-propanyl)benzohydrazide | | 3- | methoxy-2-methylbenzoic acid 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl)hydrazide | | | nchembio858-comp2 | | | RH 2485 | | | RH-2485 |
Articles:
| PubMed:Resistance selection, mechanism and stability of Spodoptera litura (Lepidoptera: Noctuidae) to methoxyfenozide. |
| PubMed:Susceptibility in field populations of codling moth, Cydia pomonella (L.) (Lepidoptera: Tortricidae), in Ontario and Quebec apple orchards to a selection of insecticides. |
| PubMed:Relative toxicity and residual activity of insecticides used in blueberry pest management: mortality of natural enemies. |
| PubMed:Survival and growth of foodborne pathogens in pesticide solutions routinely used in leafy green vegetables and tomato production. |
| PubMed:Xenobiotic effects on intestinal stem cell proliferation in adult honey bee (Apis mellifera L) workers. |
| PubMed:The impact of insecticides applied in apple orchards on the predatory mite Kampimodromus aberrans (Acari: Phytoseiidae). |
| PubMed:Foliar persistence and residual activity of methoxyfenozide against beet armyworm (Lepidoptera: Noctuidae). |
| PubMed:The effect of insecticides on the non-target predatory mite Kampimodromus aberrans: laboratory studies. |
| PubMed:Nuclear receptors HR96 and ultraspiracle from the fall armyworm (Spodoptera frugiperda), developmental expression and induction by xenobiotics. |
| PubMed:Safety evaluation of eleven insecticides to Trichogramma nubilale (Hymenoptera: Trichogrammatidae). |
| PubMed:Short and long-term effects of endosulfan, cypermethrin, spinosad, and methoxyfenozide on adults of Chrysoperla externa (Neuroptera: Chrysopidae). |
| PubMed:A new dibenzoylhydrazine with insecticidal activity against Anopheles mosquito larvae. |
| PubMed:Field efficacy and application timing of methoxyfenozide, a reduced-risk treatment for control of navel orangeworm (Lepidoptera: Pyralidae) in almond. |
| PubMed:Adding microencapsulated pear ester to insecticides for control of Cydia pomonella (Lepidoptera: Tortricidae) in apple. |
| PubMed:Selectivity of diacylhydrazine insecticides to the predatory bug Orius laevigatus: in vivo and modelling/docking experiments. |
| PubMed:Insect growth regulators as potential insecticides to control olive fruit fly (Bactrocera oleae Rossi): insect toxicity bioassays and molecular docking approach. |
| PubMed:Effects of a naturally occurring and a synthetic synergist on toxicity of three insecticides and a phytochemical to navel orangeworm (Lepidoptera: Pyralidae). |
| PubMed:Efficacy of insect growth regulators as grain protectants against two stored-product pests in wheat and maize. |
| PubMed:Ecdysteroid receptor docking suggests that dibenzoylhydrazine-based insecticides are devoid of any deleterious effect on the parasitic wasp Psyttalia concolor (Hym. Braconidae). |
| PubMed:Vitellogenin-like proteins in the freshwater amphipod Gammarus fossarum (Koch, 1835): functional characterization throughout reproductive process, potential for use as an indicator of oocyte quality and endocrine disruption biomarker in males. |
| PubMed:Life stage toxicity and residual activity of insecticides to codling moth and oriental fruit moth (Lepidoptera: Tortricidae). |
| PubMed:Determination of 16 insect growth regulators in edible Chinese traditional herbs by liquid chromatography electrospray tandem mass spectrometry. |
| PubMed:Development of a rapid resistance monitoring bioassay for codling moth larvae. |
| PubMed:Induced accumulation of cuticular waxes enhances drought tolerance in Arabidopsis by changes in development of stomata. |
| PubMed:A safe and effective plant gene switch system for tissue-specific induction of gene expression in Arabidopsis thaliana and Brassica juncea. |
| PubMed:Determination of insecticides in water using in situ halide exchange reaction-assisted ionic liquid dispersive liquid-liquid microextraction followed by high-performance liquid chromatography. |
| PubMed:Effects of hormone agonists on Sf9 cells, proliferation and cell cycle arrest. |
| PubMed:Induction of 9-cis-epoxycarotenoid dioxygenase in Arabidopsis thaliana seeds enhances seed dormancy. |
| PubMed:Generating susceptible strain and resistance status of field populations of Spodoptera exigua (Lepidoptera: Noctuidae) against some conventional and new chemistry insecticides in Pakistan. |
| PubMed:Microencapsulated pear ester enhances insecticide efficacy in walnuts for codling moth (Lepidoptera: Tortricidae) and navel orangeworm (Lepidoptera: Pyralidae). |
| PubMed:Long-term effects of methoxyfenozide on the adult reproductive processes and longevity of Spodoptera exigua (Lepidoptera: Noctuidae). |
| PubMed:Determination of sixteen pesticides in peppers using high-performance liquid chromatography/mass spectrometry. |
| PubMed:Residue analysis of four diacylhydrazine insecticides in fruits and vegetables by Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) method using ultra-performance liquid chromatography coupled to tandem mass spectrometry. |
| PubMed:Single solid phase extraction method for the simultaneous analysis of polar and non-polar pesticides in urine samples by gas chromatography and ultra high pressure liquid chromatography coupled to tandem mass spectrometry. |
| PubMed:Field trial measuring the compatibility of methoxyfenozide and flonicamid with Orius laevigatus Fieber (Hemiptera: Anthocoridae) and Amblyseius swirskii (Athias-Henriot) (Acari: Phytoseiidae) in a commercial pepper greenhouse. |
| PubMed:Lethal and sublethal effects of methoxyfenozide on the development, survival and reproduction of the fall armyworm, Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae). |
| PubMed:Control of larval-pupal-adult molt in the moth Sesamia nonagrioides by juvenile hormone and ecdysteroids. |
| PubMed:[Determination of five diacylhydrazine insecticide residues in welsh onion using high performance liquid chromatography-tandem mass spectrometry]. |
| PubMed:Exposure to methoxyfenozide-treated surfaces reduces the responsiveness of adult male codling moth (Lepidoptera: Tortricidae) to codlemone and pear ester lures in a wind tunnel. |
| PubMed:Improvement of ecdysone receptor gene switch for applications in plants: Locusta migratoria retinoid X receptor (LmRXR) mutagenesis and optimization of translation start site. |
| PubMed:Ecdysone signaling and transcript signature in Drosophila cells resistant against methoxyfenozide. |
| PubMed:Effects of six selected orchard insecticides on Neoseiulus fallacis (Acari: Phytoseiidae) in the laboratory. |
| PubMed:[Determination of benzoylurea and bishydrazide pesticide residues in vegetables by ultra performance liquid chromatography-tandem mass spectrometry with matrix solid phase dispersion]. |
| PubMed:Cross-resistance between azinphos-methyl and acetamiprid in populations of codling moth, Cydia pomonella (L.) (Lepidoptera: Tortricidae), from Washington State. |
| PubMed:Toxicity and sublethal effects of methoxyfenozide on Spodoptera exigua (Lepidoptera: Noctuidae). |
| PubMed:Adaptation of an ecdysone-based genetic switch for transgene expression in soybean seeds. |
| PubMed:Influence of azadirachtin and methoxyfenozide on life parameters of Spodoptera littoralis (Lepidoptera: Noctuidae). |
| PubMed:Towards Coleoptera-specific high-throughput screening systems for compounds with ecdysone activity: development of EcR reporter assays using weevil (Anthonomus grandis)-derived cell lines and in silico analysis of ligand binding to A. grandis EcR ligand-binding pocket. |
| PubMed:Properties of ecdysteroid receptors from diverse insect species in a heterologous cell culture system--a basis for screening novel insecticidal candidates. |
| PubMed:Control of grape berry moth (Lepidoptera: Tortricidae) in relation to oviposition phenology. |
| PubMed:Feeding cessation effects of chlorantraniliprole, a new anthranilic diamide insecticide, in comparison with several insecticides in distinct chemical classes and mode-of-action groups. |
| PubMed:Influence of Lobesia botrana field control on black aspergilli rot and ochratoxin A contamination in grapes. |
| PubMed:Biochemical mechanisms of methoxyfenozide resistance in the cotton leafworm Spodoptera littoralis. |
| PubMed:Integrating chemical and biological control of European corn borer in bell pepper. |
| PubMed:Efficacy results of insecticides against Cydia pomonella, the codling moth, in Belgium during the last decade (1998-2007). |
| PubMed:Resistance of Pakistani field populations of spotted bollworm Earias vittella (Lepidoptera: Noctuidae) to pyrethroid, organophosphorus and new chemical insecticides. |
| PubMed:Effects of larval exposure to sublethal concentrations of methoxyfenozide in Spodoptera frugiperda (J.E. Smith). |
| PubMed:Susceptibility of Chrysoperla externa eggs (Neuroptera: Chrisopidae) to conventional and biorational insecticides. |
| PubMed:Effects of classical insect hormones on the expression profiles of a lipase gene from the cotton bollworm (Helicoverpa armigera). |
| PubMed:Ecdysteroid signaling in ecdysteroid-resistant cell lines from the polyphagous noctuid pest Spodoptera exigua. |
| PubMed:Monitoring of beet armyworm resistance to spinosad and methoxyfenozide in Mexico. |
| PubMed:Effect of conventional and biorational insecticides on larvae of Chrysoperla externa. |
| PubMed:Assessment of methoxyfenozide exposure on the sexual attractiveness and responsiveness of adult codling moth, Cydia pomonella L., in small orchard blocks. |
| PubMed:Improvement of a monopartite ecdysone receptor gene switch and demonstration of its utility in regulation of transgene expression in plants. |
| PubMed:Resistance of codling moth, Cydia pomonella (L.) (Lepidoptera: Tortricidae), larvae in Michigan to insecticides with different modes of action and the impact on field residual activity. |
| PubMed:Influence of mixtures of kaolin particle film and synthetic insecticides on mortality of larval obliquebanded leafrollers (Lepidoptera: Tortricidae) from resistant and susceptible populations. |
| PubMed:The ecological impact of four IGR insecticides in adults of Hyposoter didymator (Hym., Ichneumonidae): pharmacokinetics approach. |
| PubMed:Selection for resistance to methoxyfenozide and 20-hydroxyecdysone in cells of the beet armyworm, Spodoptera exigua. |
| PubMed:Laboratory studies to elucidate the residual toxicity of eight insecticides to Anystis baccarum (Acari: Anystidae). |
| PubMed:Lethal and sublethal effects of methoxyfenozide and spinosad on Spodoptera littoralis (Lepidoptera: Noctuidae). |
| PubMed:Identification and expression profile of a putative basement membrane protein gene in the midgut of Helicoverpa armigera. |
| PubMed:Novel life stage targets against plum curculio, Conotrachelus nenuphar (Herbst), in apple integrated pest management. |
| PubMed:Applications of EcR gene switch technology in functional genomics. |
| PubMed:Molecular cloning and characterization of a C-type lectin from the cotton bollworm, Helicoverpa armigera. |
| PubMed:Effects of ecdysteroid agonist RH-2485 reveal interactions between ecdysteroids and juvenile hormones in the development of Sesamia nonagrioides. |
| PubMed:Ovicidal and larvicidal effectiveness of insecticides applied by dipping apples on the small fruit tortrix Grapholita lobarzewskii. |
| PubMed:Side effects of conventional and non-conventional insecticides on eggs and larvae of Chrysoperla externa (Hagen) (Neuroptera: Chrysopidae) in Argentine. |
| PubMed:Efficacy of some plant oils alone and/or combined with different insecticides on the cotton leaf-worm Spodoptera littoralis (Boisd.) (Lepidoptera: Noctuidae) in Egypt. |
| PubMed:Sublethal exposure to methoxyfenozide-treated surfaces reduces the attractiveness and responsiveness in adult oriental fruit moth (Lepidoptera: Tortricidae). |
| PubMed:QSAR and mode of action studies of insecticidal ecdysone agonists. |
| PubMed:Development of a tightly regulated and highly inducible ecdysone receptor gene switch for plants through the use of retinoid X receptor chimeras. |
| PubMed:Bumblebees can be used in combination with juvenile hormone analogues and ecdysone agonists. |
| PubMed:Tebufenozide resistance selected in Plutella xylostella and its cross-resistance and fitness cost. |
| PubMed:Cathepsin B-like proteinase is involved in the decomposition of the adult fat body of Helicoverpa armigera. |
| PubMed:Development, oviposition, and mortality of Neoseiulus fallacis (Acari: Phytoseiidae) in response to reduced-risk insecticides. |
| PubMed:Development of a methoxyfenozide-responsive gene switch for applications in plants. |
| PubMed:Nonsteroidal ecdysone agonists. |
| PubMed:Resistance and cross-resistance in populations of the leafrollers, Choristoneura rosaceana and Pandemis pyrusana , in Washington apples. |
| PubMed:Assessment of sublethal effects of methoxyfenozide on oriental fruit Moth (Lepidoptera: Tortricidae). |
| PubMed:Effects of methoxyfenozide on Lobesia botrana Den & Schiff (Lepidoptera: Tortricidae) egg, larval and adult stages. |
| PubMed:Stage-specific control of grape berry moth, Endopiza viteana (Clemens) (Lepidoptera: Tortricidae), by selective and broad-spectrum insecticides. |
| PubMed:Classical and three-dimensional QSAR for the inhibition of [3H]ponasterone A binding by diacylhydrazine-type ecdysone agonists to insect Sf-9 cells. |
| PubMed:Effects of two biorational insecticides, spinosad and methoxyfenozide, on Spodoptera littoralis (Lepidoptera: Noctuidae) under laboratory conditions. |
| PubMed:Comparative larvicidal toxicities of three ecdysone agonists on the mosquitoes Aedes aegypti, Culex quinquefasciatus, and Anopheles gambiae. |
| PubMed:Integrated pest management approach for a new pest, Lacanobia subjuncta (Lepidoptera: Noctuidae), in Washington apple orchards. |
| PubMed:Oriental fruit moth (Lepidoptera: Tortricidae) phenology and management with methoxyfenozide in North Carolina apples. |
| PubMed:Toxicity and residual activity of methoxyfenozide and tebufenozide to codling moth (Lepidoptera: Tortricidae) and oriental fruit moth (Lepidoptera: Tortricidae). |
| PubMed:Incidence and control of dogwood borer (Lepidoptera: Sesiidae) and American plum borer (Lepidoptera: Pyralidae) infesting burrknots on clonal apple rootstocks in New York. |
| PubMed:Methoxyfenozide, a reliable IPM compatible compound against Lepidoptera in pome fruit and vegetables with sterilising, ovicidal and larvicidal efficacy on codling moth. |
| PubMed:Analysis of methoxyfenozide residues in fruits, vegetables, and mint by liquid chromatography-tandem mass spectrometry (LC-MS/MS). |
| PubMed:Ecdysone agonist-inducible expression of a coat protein gene from tobacco mosaic virus confers viral resistance in transgenic Arabidopsis. |
| PubMed:Ecdysone agonists: mechanism and importance in controlling insect pests of agriculture and forestry. |
| PubMed:Toxicity and kinetics of methoxyfenozide in greenhouse-selected Spodoptera exigua (Lepidoptera: Noctuidae). |
| PubMed:Effects of methoxyfenozide, indoxacarb, and other insecticides on the beneficial egg parasitoid Trichogramma nr. brassicae (Hymenoptera: Trichogrammatidae) under laboratory and field conditions. |
| PubMed:Toxicity and pharmacokinetics of insect growth regulators and other novel insecticides on pupae of Hyposoter didmator (Hymenoptera: Ichneumonidae), a parasitoid of early larval instars of lepidopteran pests. |
| PubMed:Effects of ecdysone agonists on the expression of EcR, USP and other specific proteins in the ovaries of the codling moth (Cydia pomonella L.). |
| PubMed:Effects of methoxyfenozide-treated surfaces on the attractiveness and responsiveness of adult codling moth (Lepidoptera: Tortricidae). |
| PubMed:Chemically regulated gene expression in plants. |
| PubMed:Chemical-inducible, ecdysone receptor-based gene expression system for plants. |
| PubMed:Effect of ecdysone agonists on vitellogenesis and the expression of EcR and USP in codling moth (Cydia pomonella). |
| PubMed:A chimeric ecdysone receptor facilitates methoxyfenozide-dependent restoration of male fertility in ms45 maize. |
| PubMed:Resistance and cross-resistance to four insecticides in populations of obliquebanded leafroller (Lepidoptera: Tortricidae). |
| PubMed:Broad-spectrum insecticide resistance in obliquebanded leafroller Choristoneura rosaceana (Lepidoptera: Tortricidae) from Michigan. |
| PubMed:Pro-active management of beet armyworm (Lepidoptera: Noctuidae) resistance to tebufenozide and methoxyfenozide: baseline monitoring, risk assessment, and isolation of resistance. |
| PubMed:Comparative toxicity and ecdysone receptor affinity of non-steroidal ecdysone agonists and 20-hydroxyecdysone in Chironomus tentans. |
| PubMed:Inhibition of [3H]ponasterone A binding by ecdysone agonists in the intact Kc cell line. |
| PubMed:The chemical and biological properties of methoxyfenozide, a new insecticidal ecdysteroid agonist. |
| PubMed:Significance of absorption, oxidation, and binding to toxicity of four ecdysone agonists in multi-resistant cotton leafworm. |
| PubMed:Baseline monitoring of codling moth (Lepidoptera: Tortricidae) larval response to benzoylhydrazine insecticides. |
| PubMed:Inhibition of [(3)H]ponasterone a binding by ecdysone agonists in the intact Sf-9 cell line. |
| PubMed:Establishment and characterization of an Ostrinia nubilalis cell line, and its response to ecdysone agonists. |
| PubMed:Effect of insecticides on Trichogramma exiguum (Trichogrammatidae: Hymenoptera) preimaginal development and adult survival. |
| PubMed:Relationships between structure and molting hormonal activity of tebufenozide, methoxyfenozide, and their analogs in cultured integument system of Chilo suppressalis Walker. |
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