EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

2H-1-benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, (2R)-

Supplier Sponsors

CAS Number: 54-28-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-201-5
Nikkaji Web:J213.540J
Beilstein Number:93072
XlogP3-AA:10.30 (est)
Molecular Weight:416.68896000
Formula:C28 H48 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 518.10 °C. @ 760.00 mm Hg (est)
Flash Point: 403.00 °F. TCC ( 206.00 °C. ) (est)
logP (o/w): 11.440 (est)
Soluble in:
 water, 1.069e-006 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antioxidants
skin conditioning
BOC Sciences
For experimental / research use only.
D-gamma-ToCopherol 95%
Odor: characteristic
Use: One of the naturally occurring forms of Vitamin E. Most abundant Tocopherol in soybean and corn oils.
Santa Cruz Biotechnology
For experimental / research use only.
(+)-gamma-Tocopherol ≥96%
Sigma-Aldrich: Sigma
For experimental / research use only.
TRI-K Industries
D-Gamma Tocopherol
Odor: characteristic
Use: Vitamin E exists in 8 different forms, each of which has its own biological activity. D-?-tocopherol has been found to effectively lighten and brighten the skin while simultaneously providing both anti-inflammatory and anti-oxidant protection as well.
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic agents
Recommendation for dextro-gamma-tocopherol usage levels up to:
 not for fragrance use.
Recommendation for dextro-gamma-tocopherol flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the re-evaluation of tocopherol-rich extract (E 306), a-tocopherol (E 307), ?-tocopherol (E 308) and d-tocopherol (E 309) as food additives
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):54-28-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :92729
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:54-28-4
Pubchem (cid):92729
Pubchem (sid):135051177
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):C02483
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 found in nature
2H-1-benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-, (2R)-
2H-1-benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, (2R)-


PubMed:Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophersolan.
PubMed:Vitamin E isoforms differentially regulate intercellular adhesion molecule-1 activation of PKCĪ± in human microvascular endothelial cells.
PubMed:Comparison of the inhibitory effects of vitamin E analogues on melanogenesis in mouse B16 melanoma cells.
PubMed:Isoforms of vitamin E have opposing immunoregulatory functions during inflammation by regulating leukocyte recruitment.
PubMed:A pharmacological action of vitamin E unrelated to its antioxidant capacity.
PubMed:Chemopreventive effect of dietary d-alpha-tocopheryl succinate supplementation on precancer colon aberrant crypt formation and vitamin E analogue levels in young and old rats.
PubMed:Dose-dependent effects of dietary alpha- and gamma-tocopherols on genetic instability in mouse Mutatect tumors.
PubMed:Novel d-gamma-tocopherol derivative as a prodrug for d-gamma-tocopherol and a two-step prodrug for S-gamma-CEHC.
PubMed:Antioxidant and cytotoxic tocopheryl quinones in normal and cancer cells.
PubMed:The vitamin E nutritional status of rats fed on diets high in fish oil, linseed oil or sunflower seed oil.
PubMed:NO2-induced DNA single strand breaks are inhibited by antioxidative vitamins in V79 cells.
PubMed:Mammary transfer of vitamin E in dairy cows.
PubMed:Mechanisms of absorption, transport and tissue uptake of RRR-alpha-tocopherol and d-gamma-tocopherol in the white rat.
PubMed:Biopotency of vitamin E in barley.
PubMed:Relative antioxidant effectiveness of alpha-tocopherol and gamma-tocopherol in iron-loaded rats.
PubMed:Biological activity of vitamin E compounds and natural materials by the resorption-gestation test, and chemical determination of the vitamin E activity in foods and feeds.
None found
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2021 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy