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methylene glycol
methanediol; formaldehyde hydrate

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CAS Number: 463-57-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:207-339-5
FDA UNII: 6Z20YM9257
Nikkaji Web:J196.183G
Beilstein Number:1730798
XlogP3-AA:-1.00 (est)
Molecular Weight:48.04128000
Formula:C H4 O2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 193.70 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.100000 mmHg @ 25.00 °C. (est)
Flash Point: 212.00 °F. TCC ( 99.80 °C. ) (est)
logP (o/w): -1.920 (est)
Soluble in:
 water, 6.355e+005 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antimicrobial agents
nail conditioning
BOC Sciences
For experimental / research use only.
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic agents
Recommendation for methylene glycol usage levels up to:
 not for fragrance use.
Recommendation for methylene glycol flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :79015
National Institute of Allergy and Infectious Diseases:Data
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):79015
Pubchem (sid):135035895
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
 methanediol; formaldehyde hydrate


PubMed:NMR Studies of the Equilibria and Reaction Rates in Aqueous Solutions of Formaldehyde.
PubMed:Formaldehyde and methylene glycol equivalence: critical assessment of chemical and toxicological aspects.
PubMed:NMR studies of proton exchange kinetics in aqueous formaldehyde solutions.
PubMed:Amended safety assessment of formaldehyde and methylene glycol as used in cosmetics.
PubMed:Product study of the OH radical and Cl atom initiated oxidation of 1,3-dioxane.
PubMed:pH oscillations and bistability in the methylene glycol-sulfite-gluconolactone reaction.
PubMed:An organic-based pH oscillator.
PubMed:Redox chemistry of tungsten and iron-sulfur prosthetic groups in Pyrococcus furiosus formaldehyde ferredoxin oxidoreductase.
PubMed:Quantitative NMR spectroscopy of complex technical mixtures using a virtual reference: chemical equilibria and reaction kinetics of formaldehyde-water-1,3,5-trioxane.
PubMed:In vitro degradation of polyurethane orthodontic elastomeric modules.
PubMed:A distributed-parameter model for formaldehyde uptake and disposition in the rat nasal lining.
PubMed:Studies on the effect of virtual crosslinking on the hydrolytic stability of novel aliphatic polyurethane ureas for blood contact applications.
PubMed:Urea-formaldehyde resins and free formaldehyde content.
PubMed:Immunocytochemistry of formalin-fixed human brain tissues: microwave irradiation of free-floating sections.
PubMed:Reactions of hydrated formaldehyde in nasal mucus.
PubMed:Studies of the thiadiazine, taurolidine-I. Identification of the molecular species present in aqueous solutions by (1)H- and (13)C-NMR spectroscopy.
PubMed:Heparinizable segmented polyurethanes containing poly-amidoamine blocks.
PubMed:Formaldehyde fixation and microwave irradiation.
PubMed:Inhibition of electron and energy transfer in mitochondria. I. Effects of Amytal, thiopental, rotenone, progesterone, and methylene glycol.
PubMed:[Formation of trimethyleneglycol by fermentation of glycerin].
None found
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