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Category:antioxidants
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 570.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 595.00 °F. TCC ( 312.60 °C. ) (est)
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| logP (o/w): | 7.870 (est) |
| Soluble in: |
| | water, 0.00396 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | antioxidants |
| Recommendation for maslinic acid usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for maslinic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :73659 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| (4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid |
| Chemidplus:0004373415 |
References:
| | (4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 73659 |
| Pubchem (sid): | 135033519 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | crategolic acid | | (4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11- | dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid | | | maslic acid | | | maslinicacid | | | olean-12-en-28-oic acid, 2,3-dihydroxy-, | | | olean-12-en-28-oic acid, 2,3-dihydroxy-, (2alpha,3beta)-
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Articles:
| PubMed:Maslinic Acid Induces Mitochondrial Apoptosis and Suppresses HIF-1α Expression in A549 Lung Cancer Cells under Normoxic and Hypoxic Conditions. |
| PubMed:In vitro effects of triterpenic acids from olive leaf extracts on the mitochondrial membrane potential of promastigote stage of Leishmania spp. |
| PubMed:Protective effects of maslinic acid against alcohol-induced acute liver injury in mice. |
| PubMed:Antibacterial oleanane-type triterpenoids from pericarps of Akebia trifoliata. |
| PubMed:Maslinic acid, a natural phytoalexin-type triterpene from olives--a promising nutraceutical? |
| PubMed:Maslinic acid activates mitochondria-dependent apoptotic pathway in cardiac carcinoma. |
| PubMed:Population pharmacokinetics of maslinic acid, a triterpene from olives, after intravenous and oral administration in rats. |
| PubMed:Solid-phase library synthesis of bi-functional derivatives of oleanolic and maslinic acids and their cytotoxicity on three cancer cell lines. |
| PubMed:Phytochemistry and bioactivity of aromatic and medicinal plants from the genus Agastache (Lamiaceae). |
| PubMed:Maslinic acid modulates glycogen metabolism by enhancing the insulin signaling pathway and inhibiting glycogen phosphorylase. |
| PubMed:Maslinic acid induced apoptosis in bladder cancer cells through activating p38 MAPK signaling pathway. |
| PubMed:Maslinic acid protects vascular smooth muscle cells from oxidative stress through Akt/Nrf2/HO-1 pathway. |
| PubMed:Oleanolic and maslinic acid sensitize soft tissue sarcoma cells to doxorubicin by inhibiting the multidrug resistance protein MRP-1, but not P-glycoprotein. |
| PubMed:Semi-synthesis of acylated triterpenes from olive-oil industry wastes for the development of anticancer and anti-HIV agents. |
| PubMed:Membrane damaging activity of a maslinic acid analog. |
| PubMed:Four new triterpenoids isolated from the resin of Garcinia hanburyi. |
| PubMed:Antioxidant effects of maslinic acid in livers, hearts and kidneys of streptozotocin-induced diabetic rats: effects on kidney function. |
| PubMed:Bioactive properties of the main triterpenes found in olives, virgin olive oil, and leaves of Olea europaea. |
| PubMed:Effects of Syzygium aromaticum-derived triterpenes on postprandial blood glucose in streptozotocin-induced diabetic rats following carbohydrate challenge. |
| PubMed:Towards cytotoxic and selective derivatives of maslinic acid. |
| PubMed:Esters and amides of maslinic acid trigger apoptosis in human tumor cells and alter their mode of action with respect to the substitution pattern at C-28. |
| PubMed:Maslinic acid and its in vitro anti-neoplastic effects. |
| PubMed:Liquid chromatography-mass spectrometry determination in plasma of maslinic acid, a bioactive compound from Olea europaea L. |
| PubMed:Antitumour activity on extrinsic apoptotic targets of the triterpenoid maslinic acid in p53-deficient Caco-2 adenocarcinoma cells. |
| PubMed:Biotransformation of oleanolic and maslinic acids by Rhizomucor miehei. |
| PubMed:Time course of pentacyclic triterpenoids from fruits and leaves of olive tree (Olea europaea L.) cv. Picual and cv. Cornezuelo during ripening. |
| PubMed:[Chemical constituents of Rabdosia japonica var. glaucocalyx and their anti-complementary activity]. |
| PubMed:Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea. |
| PubMed:[Protective effect of maslinic acid preconditioning against oxygen-glucose deprivation- induced injuries in embryonic rat cortical neurons]. |
| PubMed:Maslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+) mice through transcriptomic and metabolomic reprogramming. |
| PubMed:Maslinic acid, a triterpenic anti-tumoural agent, interferes with cytoskeleton protein expression in HT29 human colon-cancer cells. |
| PubMed:Anti-Proliferative Activities and Apoptosis Induction by Triterpenes Derived from Eriobotrya japonica in Human Leukemia Cell Lines. |
| PubMed:Chemical constituents of flowers and fruits of Rabdosia excisa. |
| PubMed:Assessment of the safety of maslinic acid, a bioactive compound from Olea europaea L. |
| PubMed:Simultaneous determination of seven major triterpenoids in Pyrola decorata H. Andres by LC-MS method. |
| PubMed:[Non-anthraquinones constituents from the roots of Knoxia valerianoides]. |
| PubMed:A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients. |
| PubMed:Determination of maslinic acid, a pentacyclic triterpene from olives, in rat plasma by high-performance liquid chromatography. |
| PubMed:[Chemical constituents from Sambucus chinensis]. |
| PubMed:Maslinic acid protects against isoproterenol-induced cardiotoxicity in albino Wistar rats. |
| PubMed:Bioavailability, distribution, and antioxidative effects of selected triterpenes in mice. |
| PubMed:Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells. |
| PubMed:Efficacy of bioactive compounds from extra virgin olive oil to modulate atherosclerosis development. |
| PubMed:Maslinic acid inhibits the metastatic capacity of DU145 human prostate cancer cells: possible mediation via hypoxia-inducible factor-1α signalling. |
| PubMed:New terpenes from Salvia palaestina Benth. and Salvia syriaca L. growing wild in Jordan. |
| PubMed:Nonsterol Triterpenoids as Major Constituents of Olea europaea. |
| PubMed:A new triterpenoid from the rhizomes of Nelumbo nucifera. |
| PubMed:[Study on the triterpenoids from the fruits of Ligustrum lucidum]. |
| PubMed:Unusual isomeric corniculatolides from mangrove, Aegiceras corniculatum. |
| PubMed:Towards an efficient protocol for the determination of triterpenic acids in olive fruit: a comparative study of drying and extraction methods. |
| PubMed:[Chemical constituents of Swertia hispidicalyx]. |
| PubMed:Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer. |
| PubMed:[Chemical constituents about the stem of Rabdosia excisa]. |
| PubMed:Maslinic acid derivatives induce significant apoptosis in b16f10 murine melanoma cells. |
| PubMed:Anti-inflammatory effects of maslinic acid, a natural triterpene, in cultured cortical astrocytes via suppression of nuclear factor-kappa B. |
| PubMed:Proteomic analysis of the molecular response of Raji cells to maslinic acid treatment. |
| PubMed:Maslinic acid, a natural triterpenoid compound from Olea europaea, protects cortical neurons against oxygen-glucose deprivation-induced injury. |
| PubMed:[Studies on the chemical constituents from the leave of Paulownia tomentosa]. |
| PubMed:Maslinic acid, a natural inhibitor of glycogen phosphorylase, reduces cerebral ischemic injury in hyperglycemic rats by GLT-1 up-regulation. |
| PubMed:Proteomics in the liver of gilthead sea bream (Sparus aurata) to elucidate the cellular response induced by the intake of maslinic acid. |
| PubMed:Effect of olive pomace extracts on hyperlipidaemia. |
| PubMed:Identification and determination of carboxylic acids in food samples using 2-(2-(anthracen-10-yl)-1H-phenanthro[9,10-d]imidazol-1-yl)ethyl 4-methylbenzenesulfonate (APIETS) as labeling reagent by HPLC with FLD and APCI/MS. |
| PubMed:Multi-targeted activity of maslinic acid as an antimalarial natural compound. |
| PubMed:Simultaneous qualitative and quantitative analysis of triterpenic acids, saponins and flavonoids in the leaves of two Ziziphus species by HPLC-PDA-MS/ELSD. |
| PubMed:The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism. |
| PubMed:Parasitostatic effect of maslinic acid. II. Survival increase and immune protection in lethal Plasmodium yoelii-infected mice. |
| PubMed:[Triterpenoids and triterpenoid saponins of Viscum liquidambaricolum]. |
| PubMed:Parasitostatic effect of maslinic acid. I. Growth arrest of Plasmodium falciparum intraerythrocytic stages. |
| PubMed:Development of a new HPLC method with precolumn fluorescent derivatization for rapid, selective and sensitive detection of triterpenic acids in fruits. |
| PubMed:Triterpenoid saponins from Symplocos lancifolia. |
| PubMed:Maslinic acid induces apoptosis in salivary gland adenoid cystic carcinoma cells by Ca2+-evoked p38 signaling pathway. |
| PubMed:Phenylpropanoids from the stem bark of Jacaranda mimosaefolia. |
| PubMed:Antiangiogenic potential of three triterpenic acids in human liver cancer cells. |
| PubMed:Antioxidant, antiproliferative, and pro-apoptotic capacities of pentacyclic triterpenes found in the skin of olives on MCF-7 human breast cancer cells and their effects on DNA damage. |
| PubMed:Astrocytic glutamate transporter-dependent neuroprotection against glutamate toxicity: an in vitro study of maslinic acid. |
| PubMed:[Studies on the chemical constituents of Ficus microcarpa]. |
| PubMed:Pentacyclic triterpenoids and ceramide mediate the vasorelaxant activity of Vitex cienkowskii via involvement of NO/cGMP pathway in isolated rat aortic rings. |
| PubMed:Maslinic acid suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating RANKL-mediated NF-κB and MAPK signaling pathways. |
| PubMed:Isolation and identification of intestinal CYP3A inhibitors from cranberry (Vaccinium macrocarpon) using human intestinal microsomes. |
| PubMed:Pharmacological manipulation of brain glycogenolysis as a therapeutic approach to cerebral ischemia. |
| PubMed:Chemical constituents with free-radical-scavenging activities from the stem of Microcos paniculata. |
| PubMed:Pentacyclic triterpenoids from olive fruit and leaf. |
| PubMed:Cancer chemopreventive activity of maslinic acid: suppression of COX-2 expression and inhibition of NF-κB and AP-1 activation in Raji cells. |
| PubMed:Antioxidant and antiatherogenic activities of pentacyclic triterpenic diols and acids. |
| PubMed:Anticoccidial activity of maslinic acid against infection with Eimeria tenella in chickens. |
| PubMed:Chemopreventive properties of phytosterols and maslinic acid extracted from Coleus tuberosus in inhibiting the expression of EBV early-antigen in Raji cells. |
| PubMed:Action of a pentacyclic triterpenoid, maslinic acid, against Toxoplasma gondii. |
| PubMed:Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor alpha by inhibiting NF-kappaB signaling pathway. |
| PubMed:Two new secoiridoid glycosides from the leaves of Olea europaea L. |
| PubMed:Bioactive compounds with added value prepared from terpenes contained in solid wastes from the olive oil industry. |
| PubMed:Different pathways for the deoxygenation of the A-ring of natural triterpene compounds. |
| PubMed:[Chemical constituents of roots of Boehmeria nivea]. |
| PubMed:[Determination of triterpenoid acids in leaves of Eriobotrya japonica collected at in different seasons]. |
| PubMed:Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B. |
| PubMed:Transformed cell suspension culture of Galphimia glauca producing sedative nor-friedelanes. |
| PubMed:Fruit quality and olive leaf and stone addition affect Picual virgin olive oil triterpenic content. |
| PubMed:Triterpenic content and chemometric analysis of virgin olive oils from forty olive cultivars. |
| PubMed:Effects of maslinic acid, a natural triterpene, on glycogen metabolism in cultured cortical astrocytes. |
| PubMed:[Chemical constituents from herbs of Swertia mileensis]. |
| PubMed:Novel binding studies of human serum albumin with trans-feruloyl maslinic acid. |
| PubMed:[Studies on the triterpenes from loquat leaf (Eriobotrya japonica)]. |
| PubMed:Solution- and solid-phase synthesis and anti-HIV activity of maslinic acid derivatives containing amino acids and peptides. |
| PubMed:Triterpene acids isolated from Lagerstroemia speciosa leaves as alpha-glucosidase inhibitors. |
| PubMed:Triterpenoic acids of Prunella vulgaris var. lilacina and their cytotoxic activities in vitro. |
| PubMed:Apolipoprotein E determines the hepatic transcriptional profile of dietary maslinic acid in mice. |
| PubMed:Medicinal flowers. XXIII. New taraxastane-type triterpene, punicanolic acid, with tumor necrosis factor-alpha inhibitory activity from the flowers of Punica granatum. |
| PubMed:Practical synthesis of bredemolic acid, a natural inhibitor of glycogen phosphorylase. |
| PubMed:Maslinic acid, a natural triterpene from Olea europaea L., induces apoptosis in HT29 human colon-cancer cells via the mitochondrial apoptotic pathway. |
| PubMed:Anti-inflammatory and antioxidant activities and constituents of Platostoma africanum P. Beauv. |
| PubMed:Evaluation of gastroprotective activity of Plinia edulis (Vell.) Sobral (Myrtaceae) leaves in rats. |
| PubMed:Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies. |
| PubMed:Antiproliferative and apoptosis-inducing effects of maslinic and oleanolic acids, two pentacyclic triterpenes from olives, on HT-29 colon cancer cells. |
| PubMed:Aldose-reductase- and protein-glycation-inhibitory principles from the whole plant of Duchesnea chrysantha. |
| PubMed:Bioactivity-guided isolation of the active compounds from Rosa nutkana and quantitative analysis of ascorbic acid by HPLC. |
| PubMed:Maslinic acid reduces blood glucose in KK-Ay mice. |
| PubMed:Maslinic acid added to the diet increases growth and protein-turnover rates in the white muscle of rainbow trout (Oncorhynchus mykiss). |
| PubMed:Antielastase and free radical scavenging activities of compounds from the stems of Cornus kousa. |
| PubMed:Tyrosinase inhibitory pentacyclic triterpenes and analgesic and spasmolytic activities of methanol extracts of Rhododendron collettianum. |
| PubMed:Inhibition of DNA topoisomerase I and growth inhibition of human cancer cell lines by an oleanane from Junellia aspera (Verbenaceae). |
| PubMed:Triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for apple's anticancer activity. |
| PubMed:Production of triterpene acids by cell suspension cultures of Olea europaea. |
| PubMed:Acidic triterpenes compromise growth and survival of astrocytoma cell lines by regulating reactive oxygen species accumulation. |
| PubMed:Remote hydroxylation of methyl groups by regioselective cyclopalladation. Partial synthesis of hyptatic acid-A. |
| PubMed:Formation of triterpenoids throughout Olea europaea fruit ontogeny. |
| PubMed:Modulation of cytokine secretion by pentacyclic triterpenes from olive pomace oil in human mononuclear cells. |
| PubMed:[Triterpenes from herb of Potentilla chinesis]. |
| PubMed:Triterpenoids from Hippophae rhamnoides L. and their nitric oxide production-inhibitory and DPPH radical-scavenging activities. |
| PubMed:New glycosides from Tetracentron sinense and their cytotoxic activity. |
| PubMed:(2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid, a new natural triterpene from Olea europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells. |
| PubMed:Olive fruit extracts inhibit proliferation and induce apoptosis in HT-29 human colon cancer cells. |
| PubMed:Maslinic acid as a feed additive to stimulate growth and hepatic protein-turnover rates in rainbow trout (Onchorhynchus mykiss). |
| PubMed:Secondary metabolites from the wood bark of Durio zibethinus and Durio kutejensis. |
| PubMed:Constituents of the flowers of Punica granatum. |
| PubMed:Diterpenes from Leucas aspera inhibiting prostaglandin-induced contractions. |
| PubMed:An efficient chemical method for separation of corsolic acid from its isomeric maslinic acid. |
| PubMed:New triterpenoids isolated from the root bark of Ulmus pumila L. |
| PubMed:Production of triterpenoids in liquid-cultivated hairy roots of Galphimia glauca. |
| PubMed:Triterpenic compounds from "orujo" olive oil elicit vasorelaxation in aorta from spontaneously hypertensive rats. |
| PubMed:Supressive effect of maslinic acid from pomace olive oil on oxidative stress and cytokine production in stimulated murine macrophages. |
| PubMed:Pentacyclic triterpenes. Part 2: Synthesis and biological evaluation of maslinic acid derivatives as glycogen phosphorylase inhibitors. |
| PubMed:Pentacyclic triterpenes. Part 1: the first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases. |
| PubMed:Triterpenoids from the flower of Campsis grandiflora K. Schum. as human acyl-CoA: cholesterol acyltransferase inhibitors. |
| PubMed:[Studies on chemical constituents in fruit of Rubus chingii]. |
| PubMed:Novel ceramides and a new glucoceramide from the roots of Incarvillea arguta. |
| PubMed:Anti-complementary activity of triterpenoides from fruits of Zizyphus jujuba. |
| PubMed:Antitumor-promoting constituents from Chaenomeles sinensis KOEHNE and their activities in JB6 mouse epidermal cells. |
| PubMed:Antioxidant activity of maslinic acid, a triterpene derivative obtained from Olea europaea. |
| PubMed:Epoxides, cyclic sulfites, and sulfate from natural pentacyclic triterpenoids: theoretical calculations and chemical transformations. |
| PubMed:Production of bioactive triterpenes by Eriobotrya japonica calli. |
| PubMed:Phytochemical study and anti-inflammatory properties of Lampaya hieronymi Schum. ex Moldenke. |
| PubMed:Antimicrobial triterpenoids from Licania heteromorpha. |
| PubMed:Cytotoxic triterpenes from stem bark of Physocarpus intermedius. |
| PubMed:Two glycosides from the stem bark of Tetracentron sinense. |
| PubMed:Flavonoids and terpenoids from Luma gayana (Barn.) Burret. |
| PubMed:DNA polymerase beta inhibitors from Tetracera boiviniana. |
| PubMed:Anti-HIV triterpene acids from Geum japonicum. |
| PubMed:Antiviral activity of new triterpenic derivatives. |
| PubMed:Screening of plant constituents for effect on glucose transport activity in Ehrlich ascites tumour cells. |
| PubMed:[Studies on the chemical constituents from roots of Agastache rugosa]. |
| PubMed:Triterpene saponins from Cylicodiscus gabunensis. |
| PubMed:Cytotoxic triterpenes from a Chinese medicine, Goreishi. |
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isolated from the stem bark of physocarpus intermedius. Maslinic acid is a compound derived from dry olive-pomace oil (an olive skin wax) which is a byproduct of olive oil extraction. It is a member of the group of triterpenes known as oleananes.; Maslinic acid is a pentacyclic triterpene, found in the non-glyceride fraction of olive pomace oil (Olive pomace oil, also known as "orujo" olive oil, is a blend of refined-pomace oil and virgin olive oil, fit for human consumption). Pentacyclic triterpenes are natural compounds which are widely distributed in plants. These natural products have been demonstrated to possess anti-inflammatory properties. Triterpenoids have been reported to possess antioxidant properties, since they prevent lipid peroxidation and suppress superoxide anion generation. The triterpenes have a history of medicinal use in many Asian countries. Maslinic acid exhibits both pro- and anti-inflammatory properties depending on chemical structure and dose and may be useful in modulating the immune response; further studies are required to confirm the immunomodulatory behaviour of this triterpenoid, and characterise the mechanisms underlying the biphasic nature of some aspects of the inflammatory response. (PMID: 17292619)
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