ciclopirox olamine
6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone - 2-aminoethanol (1:1)
 
Notes:
synthetic antifungal agent.
  • Jiangyin Healthway
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      Product(s):
      HLC-1101 Ciclopirox Olamine
       
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2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one (Click)
CAS Number: 41621-49-2Picture of molecule
ECHA EINECS - REACH Pre-Reg: 255-464-9
FDA UNII: 50MD4SB4AP
MDL: MFCD00078997
Molecular Weight: 268.35688000
Formula: C14 H24 N2 O3
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: antidandruff, antimicrobial agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antidandruff agents
antimicrobial agents
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Suppliers:
Jiangyin Healthway
Ciclopirox Olamine
New functional food ingredients
M.C.Biotec
Ciclopirox Olamine
Odor: characteristic
Use: Ciclopirox has broad-spectrum action against dermatophytes, yeast, and fungi. Its anti-inflammatory activity has been demonstrated in human polymorphonuclear cells. This agent also inhibits prostaglandin and leukotriene synthesis. Ciclopirox olamine was effective and safe for mild-to-moderate dandruff.
Santa Cruz Biotechnology
For experimental / research use only.
Ciclopirox Olamine ≥98%
Sigma-Aldrich
For experimental / research use only.
Ciclopirox Olamine
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50  83 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 57, 1975.

intravenous-mouse LD50  71 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 57, 1975.

oral-mouse LD50  1740 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 107, 1977.

oral-rabbit LD50  > 3065 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1328, 1981.

intraperitoneal-rat LD50  146 mg/kg
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 57, 1975.

intravenous-rat LD50  72 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 107, 1977.

oral-rat LD50  2350 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 107, 1977.

Dermal Toxicity:
subcutaneous-mouse LD50 1730 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 107, 1977.

subcutaneous-rat LD50 > 2500 mg/kg
Drugs in Japan Vol. -, Pg. 510, 1995.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antidandruff, antimicrobial agents
Recommendation for ciclopirox olamine usage levels up to:
 not for fragrance use.
 
Recommendation for ciclopirox olamine flavor usage levels up to:
 not for flavor use.
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Safety References:
ClinicalTrials.gov: search
Daily Med: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 38911
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one
Chemidplus: 0041621492
RTECS: UU7785500 for cas# 41621-49-2
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References:
 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 38911
Pubchem (sid): 135001742
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEMBL: View
KEGG (GenomeNet): D01364
HMDB (The Human Metabolome Database): Search
MedlinePlusSupp: View
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
2-aminoethanol compd. with 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone (1:1)
2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one
 batrafen
 ciclobirox olamine
 ciclopirox
 ciclopirox ethanolamine
 ciclopirox ethanolamine salt (1:1)
 ciclopiroxethanolamine salt
 ciclopiroxolamin
 ciclopiroxolamine
6-cyclohexyl-1-hydroxy-4-methyl-1H-pyridin-2-one, 2-amino-ethanol
6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone - 2-aminoethanol (1:1)
6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone compd. with 2-aminoethanol (1:1)
6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone compound with 2-aminoethanol (1:1)
6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone ethanolamine salt
6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone, 2-aminoethanol salt
6-cyclohexyl-1-hydroxy-4-methylhydropyridin-2-one, 2-aminoethan-1-ol
6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-on--2-aminoethanol(1:1)
6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
 mycoster
2(1H)-pyridinone, 6-cyclohexyl-1-hydroxy-4-methyl-, compd. with 2-aminoethanol (1:1)
 terit
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Articles:
PubMed: Seborrhoeic dermatitis of the scalp.
PubMed: Fungal toenail infections.
PubMed: FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity.
PubMed: Fungal toenail infections.
PubMed: Athlete's foot.
PubMed: Determination of the efficacy of terbinafine hydrochloride nail solution in the topical treatment of dermatophytosis in a guinea pig model.
PubMed: Fungal toenail infections.
PubMed: Athlete's foot.
PubMed: Fusarium infections of the skin.
PubMed: Successful treatment of onychomycosis with ciclopirox nail lacquer: a case report.
PubMed: Use of caryophyllene oxide as an antifungal agent in an in vitro experimental model of onychomycosis.
PubMed: Ciclopirox nail lacquer and podiatric practice.
PubMed: Ciclopirox 8% nail lacquer in the treatment of onychomycosis of the toenails in the United States.
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