aminosuberic acid
L-a-aminosuberic acid
 
Notes:
None found
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(2S)-2-aminooctanedioic acid (Click)
CAS Number: 4254-88-0Picture of molecule
ECHA EINECS - REACH Pre-Reg: 224-231-3
FDA UNII: B347Q73CGH
Nikkaji Web: J205.668B
XlogP3: -2.20 (est)
Molecular Weight: 189.21135000
Formula: C8 H15 N O4
NMR Predictor: Predict (works with chrome or firefox)
Category: emollients
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 385.52 °C. @ 760.00 mm Hg (est)
Flash Point: 369.00 °F. TCC ( 187.00 °C. ) (est)
logP (o/w): -0.075 (est)
Soluble in:
 water, 4.359e+004mg/L @ 25 °C (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses:
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Suppliers:
Santa Cruz Biotechnology
For experimental / research use only.
L-alpha-Aminosuberic Acid
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: emollients
Recommendation for aminosuberic acid usage levels up to:
 not for fragrance use.
 
Recommendation for aminosuberic acid flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 7009575
National Institute of Allergy and Infectious Diseases: Data
 (2S)-2-aminooctanedioic acid
Chemidplus: 0004254880
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References:
 (2S)-2-aminooctanedioic acid
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 7009575
Pubchem (sid): 135034733
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): Search
ChemSpider: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
(2S)-2-aminooctanedioic acid
(S)-2-aminooctanedioic acid
L-a-aminosuberic acid
 octanedioic acid, 2-amino-, (2S)-
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Articles:
PubMed: A simple route to [11C]N-Me labeling of aminosuberic acid for proof of feasibility imaging of the x(C)⁻ transporter.
PubMed: Functional imaging of oxidative stress with a novel PET imaging agent, 18F-5-fluoro-L-aminosuberic acid.
PubMed: Design, synthesis, potency, and cytoselectivity of anticancer agents derived by parallel synthesis from alpha-aminosuberic acid.
PubMed: The peptides of alpha-aminosuberic acid I. New intermediates for synthetic studies.
PubMed: Resolution of DL-2-aminosuberic acid via protease-catalyzed ester hydrolysis.
PubMed: The peptides of alpha-aminosuberic acid II. Synthesis of deamino-dicarba-eel-calcitonin sequence 1-9.
PubMed: 1,6-Aminosuberic acid analogs of lysine- and arginine-vasopressin and -vasotocin. Synthesis and biological properties.
PubMed: [Tritium-labeled reactive analogs of [1,6-alpha-aminosuberic acid, 8-arginine] vasopressin (deamino-dicarba-[8-arginine] vasopressin. synthesis and properties].
PubMed: [1,6-alpha-aminosuberic acid,3-(p-azidophenylalanine), 8-arginine] vasopressin as a photoaffinity label for renal vasopressin receptors: an evaluation.
PubMed: [1,6-alpha-aminosuberic acid, 3-(p-azidophenylalanine), 8-arginine] vasopressin: a new photoaffinity label for hydroosmotic hormone receptors. Characterization of the ligand and irreversible stimulation of hydroosmotic water flow in toad bladder by photoaffinity labeling.
PubMed: Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors.
PubMed: Ex vivo activity of histone deacetylase inhibitors against multidrug-resistant clinical isolates of Plasmodium falciparum and P. vivax.
PubMed: Amino acids with aryl-keto function in their side chains.
PubMed: Tandem enzymatic resolution yielding L-alpha-aminoalkanedioic acid omega-esters.
PubMed: Selective antagonism of amino acid-induced and synaptic excitation in the cat spinal cord.
PubMed: A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid.
PubMed: Cyclic hydroxamic-acid-containing peptide 31, a potent synthetic histone deacetylase inhibitor with antitumor activity.
PubMed: Potent antimalarial activity of histone deacetylase inhibitor analogues.
PubMed: Methotrexate analogues. 20. Replacement of glutamate by longer-chain amino diacids: effects on dihydrofolate reductase inhibition, cytotoxicity, and in vivo antitumor activity.
PubMed: Conformational studies of oxytocin analogues with different ring sizes. I. Circular dichroism.
PubMed: Enzymatic semisynthesis of dicarba analogs of calcitonin.
PubMed: Neurohypophyseal hormones, analogs, and fragments: their effect on puromycin-induced amnesia.
PubMed: Aliphatic amino diacid Asu functions as an effective mimic of Tyr(SO3H) in sulfakinins for myotropic and food intake-inhibition activity in insects.
PubMed: [Asu(1,7)E-CT, an analog of eel calcitonin. A comparative study in man with reference to other synthetic calcitonins].
PubMed: Non-cancer uses of histone deacetylase inhibitors: effects on infectious diseases and beta-hemoglobinopathies.
PubMed: Investigation of cyclic depsipeptides by fast atom bombardment-mass spectrometry.
PubMed: Analogues of the cytostatic and antimitogenic agents chlamydocin and HC-toxin: synthesis and biological activity of chloromethyl ketone and diazomethyl ketone functionalized cyclic tetrapeptides.
PubMed: [Effect of Asu-AVT on electroacupuncture (EA) analgesia].
PubMed: A dicarba analog of beta-atrial natriuretic peptide (beta-ANP) inhibits guanosine 3',5'-cyclic monophosphate production induced by alpha-ANP in cultured rat vascular smooth muscle cells.
PubMed: Calcitonin binding and degradation by two cultured human breast cancer cell lines (MCF 7 and T 47D).
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