EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

(3S,3'S,5R,5'R,6S)-3,5'-dihydroxy-8-oxo-6',7'-didehydro-5,5',6,6',7,8-hexahydro-5,6-epoxy-beta,beta-caroten-3'-yl acetate

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CAS Number: 3351-86-8Picture of molecule3D/inchi
Nikkaji Web:J221.693K
Beilstein Number:0073179
XlogP3-AA:8.10 (est)
Molecular Weight:658.91946000
Formula:C42 H58 O6
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Pubchem Patents:Search
Physical Properties:
Appearance:brown-Yellow powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 168.00 °C. @ 760.00 mm Hg
Boiling Point: 764.10 °C. @ 760.00 mm Hg (est)
Flash Point: 433.00 °F. TCC ( 223.00 °C. ) (est)
logP (o/w): 7.830 (est)
Soluble in:
 water, 1.211e-008 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
Alfa Biotechnology
For experimental / research use only.
Fucoxanthin 98%
BOC Sciences
For experimental / research use only.
Jiangyin Healthway
New functional food ingredients
Jiangyin Healthway
Sigma-Aldrich: Sigma
For experimental / research use only.
carotenoid antioxidant
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic agents
Recommendation for fucoxanthin usage levels up to:
 not for fragrance use.
Recommendation for fucoxanthin flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5281239
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5281239
Pubchem (sid):135047615
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):C08596
HMDB (The Human Metabolome Database):HMDB02741
VCF-Online:VCF Volatile Compounds in Food
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 found in nature
(3S,3'S,5R,5'R,6S)-3,5'-dihydroxy-8-oxo-6',7'-didehydro-5,5',6,6',7,8-hexahydro-5,6-epoxy-beta,beta-caroten-3'-yl acetate


PubMed:Fucoxanthin induces apoptosis in human cervical cancer cell line HeLa via PI3K/Akt pathway.
PubMed:The cytotoxicity and cellular stress by temperature fabricated polyshaped gold nanoparticles, using marine macroalgae, Padina gymnospora.
PubMed:Fucoxanthin enhances the level of reduced glutathione via the Nrf2-mediated pathway in human keratinocytes.
PubMed:Comparative effect of fucoxanthin and vitamin C on oxidative and functional parameters of human lymphocytes.
PubMed:Extracts from New Zealand Undaria pinnatifida Containing Fucoxanthin as Potential Functional Biomaterials against Cancer in Vitro.
PubMed:Siphonaxanthin, a green algal carotenoid, as a novel functional compound.
PubMed:Genome-Wide Transcript Profiling Reveals the Coevolution of Plastid Gene Sequences and Transcript Processing Pathways in the Fucoxanthin Dinoflagellate Karlodinium veneficum.
PubMed:Tackling the challenge of selective analytical clean-up of complex natural extracts: the curious case of chlorophyll removal.
PubMed:Marennine, promising blue pigments from a widespread Haslea diatom species complex.
PubMed:Photosynthetic and molecular responses of the marine diatom Thalassiosira pseudonana to triphenyltin exposure.
PubMed:TLC densitometric method for the preliminary evaluation of fucoxanthin-based products.
PubMed:Extraction of fucoxanthin from raw macroalgae excluding drying and cell wall disruption by liquefied dimethyl ether.
PubMed:Light-harvesting ability of the fucoxanthin chlorophyll a/c-binding protein associated with photosystem II from the Diatom Chaetoceros gracilis as revealed by picosecond time-resolved fluorescence spectroscopy.
PubMed:Inhibitory effects of fucoxanthinol on the viability of human breast cancer cell lines MCF-7 and MDA-MB-231 are correlated with modulation of the NF-kappaB pathway.
PubMed:Supramolecular organization of fucoxanthin-chlorophyll proteins in centric and pennate diatoms.
PubMed:Comparative environmental assessment of valorization strategies of the invasive macroalgae Sargassum muticum.
PubMed:Induction of ROS-dependent mitochondria-mediated intrinsic apoptosis in MDA-MB-231 cells by glycoprotein from Codium decorticatum.
PubMed:Peridinin from the marine symbiotic dinoflagellate, Symbiodinium sp., regulates eosinophilia in mice.
PubMed:Characterization of the intramolecular transfer state of marine carotenoid fucoxanthin by femtosecond pump-probe spectroscopy.
PubMed:Disentangling two non-photochemical quenching processes in Cyclotella meneghiniana by spectrally-resolved picosecond fluorescence at 77K.
PubMed:Comparative evaluation of the radical-scavenging activities of fucoxanthin and its stereoisomers.
PubMed:Dietary fucoxanthin increases metabolic rate and upregulated mRNA expressions of the PGC-1alpha network, mitochondrial biogenesis and fusion genes in white adipose tissues of mice.
PubMed:Excitation relaxation dynamics and energy transfer in fucoxanthin-chlorophyll a/c-protein complexes, probed by time-resolved fluorescence.
PubMed:Anticancer and antitumor potential of fucoidan and fucoxanthin, two main metabolites isolated from brown algae.
PubMed:Suppressive effects of carotenoids on the antigen-induced degranulation in RBL-2H3 rat basophilic leukemia cells.
PubMed:Antioxidative activities of algal keto carotenoids acting as antioxidative protectants in the chloroplast.
PubMed:Anticholinesterase and antioxidant activities of fucoxanthin purified from the microalga Phaeodactylum tricornutum.
PubMed:Antioxidant effects of fucoxanthin rich powder in rats fed with high fat diet.
PubMed:Fucoxanthin: a marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms.
PubMed:Effect of Fucoxanthin Alone and in Combination with D-glucosamine Hydrochloride on Carrageenan/kaolin-induced Experimental Arthritis in Rats.
PubMed:Cancer preventive efficacy of marine carotenoid fucoxanthin: cell cycle arrest and apoptosis.
PubMed:[Phytoplankton pigment patterns and community structure in the Yangtze Estuary and its adjacent areas].
PubMed:Fucoxanthin Protects Cultured Human Keratinocytes against Oxidative Stress by Blocking Free Radicals and Inhibiting Apoptosis.
PubMed:Gene expression studies for the analysis of domoic acid production in the marine diatom Pseudo-nitzschia multiseries.
PubMed:Regulation of polyunsaturated fatty acid biosynthesis by seaweed fucoxanthin and its metabolite in cultured hepatocytes.
PubMed:First evidence for the anti-inflammatory activity of fucoxanthin in high-fat-diet-induced obesity in mice and the antioxidant functions in PC12 cells.
PubMed:Inhibition of the enzyme activity of cytochrome P450 1A1, 1A2 and 3A4 by fucoxanthin, a marine carotenoid.
PubMed:Effects of heating, aerial exposure and illumination on stability of fucoxanthin in canola oil.
PubMed:Selective feeding of bdelloid rotifers in river biofilms.
PubMed:Fucoxanthin in association with vitamin C acts as modulators of human neutrophil function.
PubMed:Stark fluorescence spectroscopy reveals two emitting sites in the dissipative state of FCP antennas.
PubMed:Marine algal fucoxanthin inhibits the metastatic potential of cancer cells.
PubMed:Role of diatoms in the spatial-temporal distribution of intracellular nitrate in intertidal sediment.
PubMed:Essential role of autophagy in fucoxanthin-induced cytotoxicity to human epithelial cervical cancer HeLa cells.
PubMed:The effect of fucoxanthin rich power on the lipid metabolism in rats with a high fat diet.
PubMed:Comparison of oligomeric states and polypeptide compositions of fucoxanthin chlorophyll a/c-binding protein complexes among various diatom species.
PubMed:A novel type of light-harvesting antenna protein of red algal origin in algae with secondary plastids.
PubMed:Production, characterization, and antioxidant activity of fucoxanthin from the marine diatom Odontella aurita.
PubMed:Anticancer effects of marine carotenoids, fucoxanthin and its deacetylated product, fucoxanthinol, on osteosarcoma.
PubMed:Triplet-triplet energy transfer in fucoxanthin-chlorophyll protein from diatom Cyclotella meneghiniana: insights into the structure of the complex.
PubMed:Pigment organization effects on energy transfer and Chl a emission imaged in the diatoms C. meneghiniana and P. tricornutum in vivo: a confocal laser scanning fluorescence (CLSF) microscopy and spectroscopy study.
PubMed:Biosynthetic pathway and health benefits of fucoxanthin, an algae-specific xanthophyll in brown seaweeds.
PubMed:The trade-off between the light-harvesting and photoprotective functions of fucoxanthin-chlorophyll proteins dominates light acclimation in Emiliania huxleyi (clone CCMP 1516).
PubMed:Isolation and Partial Characterization of Bioactive Fucoxanthin from Himanthalia elongata Brown Seaweed: A TLC-Based Approach.
PubMed:Fucoxanthin from Undaria pinnatifida: photostability and coextractive effects.
PubMed:Seasonal variation in the antifouling defence of the temperate brown alga Fucus vesiculosus.
PubMed:Plasticity in the proteome of Emiliania huxleyi CCMP 1516 to extremes of light is highly targeted.
PubMed:Isolation of fucoxanthin and highly unsaturated monogalactosyldiacylglycerol from brown alga Fucus evanescens C Agardh and in vitro investigation of their antitumor activity.
PubMed:Supercritical carbon dioxide extraction of fucoxanthin from Undaria pinnatifida.
PubMed:Anti-cancer mechanism and possibility of nano-suspension formulations for a marine algae product fucoxanthin.
PubMed:High excitation energy quenching in fucoxanthin chlorophyll a/c-binding protein complexes from the diatom Chaetoceros gracilis.
PubMed:Assessment of potential anti-cancer stem cell activity of marine algal compounds using an in vitro mammosphere assay.
PubMed:Marine algal carotenoids inhibit angiogenesis by down-regulating FGF-2-mediated intracellular signals in vascular endothelial cells.
PubMed:Determination of fucoxanthin isomers in microalgae (Isochrysis sp.) by high-performance liquid chromatography coupled with diode-array detector multistage mass spectrometry coupled with positive electrospray ionization.
PubMed:Fucoxanthin ameliorates inflammation and oxidative reponses in microglia.
PubMed:Molecular and photosynthetic responses to prolonged darkness and subsequent acclimation to re-illumination in the diatom Phaeodactylum tricornutum.
PubMed:Down-regulation of hepatic stearoyl-CoA desaturase-1 expression by fucoxanthin via leptin signaling in diabetic/obese KK-A(y) mice.
PubMed:Light harvesting complexes of Chromera velia, photosynthetic relative of apicomplexan parasites.
PubMed:Two types of fucoxanthin-chlorophyll-binding proteins I tightly bound to the photosystem I core complex in marine centric diatoms.
PubMed:Anti-inflammatory activity of edible brown alga Saccharina japonica and its constituents pheophorbide a and pheophytin a in LPS-stimulated RAW 264.7 macrophage cells.
PubMed:Modulation of platelet aggregation-related eicosanoid production by dietary F-fucoidan from brown alga Laminaria japonica in human subjects.
PubMed:The anti-apoptotic effect of fucoxanthin on carbon tetrachloride-induced hepatotoxicity.
PubMed:Compounds associated with algal surfaces mediate epiphytic colonization of the marine macroalga Fucus vesiculosus.
PubMed:Fucoxanthin enhances cisplatin-induced cytotoxicity via NFκB-mediated pathway and downregulates DNA repair gene expression in human hepatoma HepG2 cells.
PubMed:Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells.
PubMed:Identification of several sub-populations in the pool of light harvesting proteins in the pennate diatom Phaeodactylum tricornutum.
PubMed:Fucoxanthin content and antioxidant properties of Undaria pinnatifida.
PubMed:In vivo induction of apoptosis by fucoxanthin, a marine carotenoid, associated with down-regulating STAT3/EGFR signaling in sarcoma 180 (S180) xenografts-bearing mice.
PubMed:Hyperdiversity of genes encoding integral light-harvesting proteins in the dinoflagellate Symbiodinium sp.
PubMed:Effect of nutrient enrichment on seagrass associated meiofauna in Tanzania.
PubMed:Variations in the first steps of photosynthesis for the diatom Cyclotella meneghiniana grown under different light conditions.
PubMed:Chlorophyll triplet quenching by fucoxanthin in the fucoxanthin-chlorophyll protein from the diatom Cyclotella meneghiniana.
PubMed:Proteases are associated with a minor fucoxanthin chlorophyll a/c-binding protein from the diatom, Chaetoceros gracilis.
PubMed:Effects of dietary fucoxanthin on cholesterol metabolism in diabetic/obese KK-A(y) mice.
PubMed:Capacity of fucoxanthin for scavenging peroxyl radicals and inhibition of lipid peroxidation in model systems.
PubMed:Biosynthesis of fucoxanthin and diadinoxanthin and function of initial pathway genes in Phaeodactylum tricornutum.
PubMed:Anti-neoplastic effects of fucoxanthin and its deacetylated product, fucoxanthinol, on Burkitt's and Hodgkin's lymphoma cells.
PubMed:Isolation of fucoxanthin from edible brown algae by microwave-assisted extraction coupled with high-speed countercurrent chromatography.
PubMed:Disruption-free imaging by Raman spectroscopy reveals a chemical sphere with antifouling metabolites around macroalgae.
PubMed:Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters.
PubMed:Anti-inflammatory effect of fucoxanthin derivatives isolated from Sargassum siliquastrum in lipopolysaccharide-stimulated RAW 264.7 macrophage.
PubMed:Quantification of diatom gene expression in the sea by selecting uniformly transcribed mRNA as the basis for normalization.
PubMed:The harmful alga Aureococcus anophagefferens utilizes 19'-butanoyloxyfucoxanthin as well as xanthophyll cycle carotenoids in acclimating to higher light intensities.
PubMed:Fucoxantin: a treasure from the sea.
PubMed:Hexane fraction from Laminaria japonica exerts anti-inflammatory effects on lipopolysaccharide-stimulated RAW 264.7 macrophages via inhibiting NF-kappaB pathway.
PubMed:Properties of photosystem I antenna protein complexes of the diatom Cyclotella meneghiniana.
PubMed:Factors determining the fluorescence yield of fucoxanthin-chlorophyll complexes (FCP) involved in non-photochemical quenching in diatoms.
PubMed:Extraction and analysis of carotenoids from the New Zealand sea urchin Evechinus chloroticus gonads.
PubMed:Cancer chemoprevention by carotenoids.
PubMed:Antioxidant activity of Hawaiian marine algae.
PubMed:Petalonia binghamiae extract and its constituent fucoxanthin ameliorate high-fat diet-induced obesity by activating AMP-activated protein kinase.
PubMed:Fucoxanthin induces GADD45A expression and G1 arrest with SAPK/JNK activation in LNCap human prostate cancer cells.
PubMed:A potential commercial source of fucoxanthin extracted from the microalga Phaeodactylum tricornutum.
PubMed:In silico study of fucoxanthin as a tumor cytotoxic agent.
PubMed:Fucoxanthin attenuates rifampin-induced cytochrome P450 3A4 (CYP3A4) and multiple drug resistance 1 (MDR1) gene expression through pregnane X receptor (PXR)-mediated pathways in human hepatoma HepG2 and colon adenocarcinoma LS174T cells.
PubMed:Marine carotenoids and oxidative stress.
PubMed:Fucoxanthin promotes translocation and induction of glucose transporter 4 in skeletal muscles of diabetic/obese KK-A(y) mice.
PubMed:Combination of fucoxanthin and conjugated linoleic acid attenuates body weight gain and improves lipid metabolism in high-fat diet-induced obese rats.
PubMed:Identification of carotenoids in the freshwater shellfish Unio douglasiae nipponensis, Anodonta lauta, Cipangopaludina chinensis laeta, and Semisulcospira libertina.
PubMed:Stereocontrolled total synthesis of fucoxanthin and its polyene chain-modified derivative.
PubMed:Xanthigen suppresses preadipocyte differentiation and adipogenesis through down-regulation of PPARγ and C/EBPs and modulation of SIRT-1, AMPK, and FoxO pathways.
PubMed:Photo-excitation of carotenoids causes cytotoxicity via singlet oxygen production.
PubMed:Phylogenetic analysis of the light-harvesting system in Chromera velia.
PubMed:Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: metabolism and bioactivities relevant to human health.
PubMed:Extracts of marine algae show inhibitory activity against osteoclast differentiation.
PubMed:Biological activities and potential health benefits of fucoxanthin derived from marine brown algae.
PubMed:Antioxidant, cytotoxic, antitumor, and protective DNA damage metabolites from the red sea brown alga Sargassum sp.
PubMed:The thylakoid membrane proteome of two marine diatoms outlines both diatom-specific and species-specific features of the photosynthetic machinery.
PubMed:The pigment stoichiometry in a chlorophyll a/c type photosynthetic antenna.
PubMed:A marine carotenoid, fucoxanthin, induces regulatory T cells and inhibits Th17 cell differentiation in vitro.
PubMed:Fat burners: nutrition supplements that increase fat metabolism.
PubMed:Isolation and purification of the major photosynthetic antenna, fucoxanthin-Chl a/c protein, from cultured discoid germilings of the brown Alga, Cladosiphon okamuranus TOKIDA (Okinawa Mozuku).
PubMed:Pharmacokinetics of fucoxanthinol in human plasma after the oral administration of kombu extract.
PubMed:Fucoxanthin enhances HO-1 and NQO1 expression in murine hepatic BNL CL.2 cells through activation of the Nrf2/ARE system partially by its pro-oxidant activity.
PubMed:Nitrocapsanthin and nitrofucoxanthin, respective products of capsanthin and fucoxanthin reaction with peroxynitrite.
PubMed:Marine carotenoids and cardiovascular risk markers.
PubMed:Metabolomic assessment with CE-MS of the nutraceutical effect of Cystoseira spp extracts in an animal model.
PubMed:Carotenoids in algae: distributions, biosyntheses and functions.
PubMed:[Bacterial reverse mutation test and micronucleus test of fucoxanthin oil from microalgae].
PubMed:[Single and 13-week oral toxicity study of fucoxanthin oil from microalgae in rats].
PubMed:Fucoxanthin exerts differing effects on 3T3-L1 cells according to differentiation stage and inhibits glucose uptake in mature adipocytes.
PubMed:In vitro cytotoxic effect of ethanol extract prepared from sporophyll of Undaria pinnatifida on human colorectal cancer cells.
PubMed:Protective effects of fucoxanthin against ferric nitrilotriacetate-induced oxidative stress in murine hepatic BNL CL.2 cells.
PubMed:Carotenoids in marine animals.
PubMed:Ultrafast excited state dynamics of fucoxanthin: excitation energy dependent intramolecular charge transfer dynamics.
PubMed:Surface-associated fucoxanthin mediates settlement of bacterial epiphytes on the rockweed Fucus vesiculosus.
PubMed:Antiobesity effects of Undaria lipid capsules prepared with scallop phospholipids.
PubMed:Comparative antioxidant activity of edible Japanese brown seaweeds.
PubMed:Protective effect of Fucoxanthin against UVB-induced skin photoaging in hairless mice.
PubMed:Structure of PSI, PSII and antennae complexes from yellow-green alga Xanthonema debile.
PubMed:The allenic carotenoid fucoxanthin, a novel marine nutraceutical from brown seaweeds.
PubMed:Effect of brown seaweed lipids on fatty acid composition and lipid hydroperoxide levels of mouse liver.
PubMed:Siphonaxanthin, a marine carotenoid from green algae, effectively induces apoptosis in human leukemia (HL-60) cells.
PubMed:Femtosecond transient absorption spectroscopic study of a carbonyl-containing carotenoid analogue, 2-(all-trans-retinylidene)-indan-1,3-dione.
PubMed:A preparative method for isolation of fucoxanthin from Eisenia bicyclis by centrifugal partition chromatography.
PubMed:Suppressive effects of Amarouciaxanthin A on 3T3-L1 adipocyte differentiation through down-regulation of PPARγ and C/EBPα mRNA expression.
PubMed:Microarray estimation of genomic inter-strain variability in the genus Ectocarpus (Phaeophyceae).
PubMed:Natural products and body weight control.
PubMed:Effects of fucoxanthin on proliferation and apoptosis in human gastric adenocarcinoma MGC-803 cells via JAK/STAT signal pathway.
PubMed:Beneficial effects of Undaria pinnatifida ethanol extract on diet-induced-insulin resistance in C57BL/6J mice.
PubMed:Chlorophyll-binding proteins revisited--a multigenic family of light-harvesting and stress proteins from a brown algal perspective.
PubMed:Pressurized liquid method for fucoxanthin extraction from Eisenia bicyclis (Kjellman) Setchell.
PubMed:Fucoxanthin and its deacetylated product, fucoxanthinol, induce apoptosis of primary effusion lymphomas.
PubMed:The physical and functional borders of transit peptide-like sequences in secondary endosymbionts.
PubMed:Evidence for the existence of one antenna-associated, lipid-dissolved and two protein-bound pools of diadinoxanthin cycle pigments in diatoms.
PubMed:[Antimicrobic and hemolytic activity of low-molecular metabolits of brown seaweed Laminaria cichorioides Miyabe].
PubMed:Fucoxanthin inhibits the inflammatory response by suppressing the activation of NF-κB and MAPKs in lipopolysaccharide-induced RAW 264.7 macrophages.
PubMed:Fucoxanthin-rich seaweed extract suppresses body weight gain and improves lipid metabolism in high-fat-fed C57BL/6J mice.
PubMed:Anti-pigmentary activity of fucoxanthin and its influence on skin mRNA expression of melanogenic molecules.
PubMed:Keto-carotenoids are the major metabolites of dietary lutein and fucoxanthin in mouse tissues.
PubMed:Carotenoid biosynthesis in diatoms.
PubMed:Purified canola lutein selectively inhibits specific isoforms of mammalian DNA polymerases and reduces inflammatory response.
PubMed:Fucoxanthin induces apoptosis in human leukemia HL-60 cells through a ROS-mediated Bcl-xL pathway.
PubMed:Shallow sink in an antenna pigment system of photosystem I of a marine centric diatom, Chaetoceros gracilis, revealed by ultrafast fluorescence spectroscopy at 17 K.
PubMed:Did trypanosomatid parasites contain a eukaryotic alga-derived plastid in their evolutionary past?
PubMed:Fucoxanthin supplementation improves plasma and hepatic lipid metabolism and blood glucose concentration in high-fat fed C57BL/6N mice.
PubMed:Fucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of diabetic/obese KK-Ay mice.
PubMed:Characterization of a trimeric light-harvesting complex in the diatom Phaeodactylum tricornutum built of FcpA and FcpE proteins.
PubMed:Pigment organization in fucoxanthin chlorophyll a/c(2) proteins (FCP) based on resonance Raman spectroscopy and sequence analysis.
PubMed:Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages.
PubMed:Fucoxanthin induces apoptosis in osteoclast-like cells differentiated from RAW264.7 cells.
PubMed:Carotenoids in clams, Ruditapes philippinarum and Meretrix petechialis.
PubMed:Oligomerization and pigmentation dependent excitation energy transfer in fucoxanthin-chlorophyll proteins.
PubMed:In vitro and in vivo evaluation of mutagenicity of fucoxanthin (FX) and its metabolite fucoxanthinol (FXOH).
PubMed:Phylogenetically-based variation in the regulation of the Calvin cycle enzymes, phosphoribulokinase and glyceraldehyde-3-phosphate dehydrogenase, in algae.
PubMed:Dynamic response of the transcriptome of a psychrophilic diatom, Chaetoceros neogracile, to high irradiance.
PubMed:Comparative ecophysiology and genomics of the toxic unicellular alga Fibrocapsa japonica.
PubMed:Suppressive effects of the marine carotenoids, fucoxanthin and fucoxanthinol on triglyceride absorption in lymph duct-cannulated rats.
PubMed:Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine model.
PubMed:Anti-obese property of fucoxanthin is partly mediated by altering lipid-regulating enzymes and uncoupling proteins of visceral adipose tissue in mice.
PubMed:The effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat.
PubMed:Single and repeated oral dose toxicity study of fucoxanthin (FX), a marine carotenoid, in mice.
PubMed:Purification and characterization of a stable oxygen-evolving Photosystem II complex from a marine centric diatom, Chaetoceros gracilis.
PubMed:Inhibition of proliferation of a hepatoma cell line by fucoxanthin in relation to cell cycle arrest and enhanced gap junctional intercellular communication.
PubMed:Antifouling activity of macroalgal extracts on Fragilaria pinnata (Bacillariophyceae): a comparison with Diuron.
PubMed:Implication of mitogen-activated protein kinase in the induction of G1 cell cycle arrest and gadd45 expression by the carotenoid fucoxanthin in human cancer cells.
PubMed:Bioavailability and metabolism of fucoxanthin in rats: structural characterization of metabolites by LC-MS (APCI).
PubMed:Inhibitory effect of carotenoids on the degranulation of mast cells via suppression of antigen-induced aggregation of high affinity IgE receptors.
PubMed:Carotenoid structures and environments in trimeric and oligomeric fucoxanthin chlorophyll a/c2 proteins from resonance Raman spectroscopy.
PubMed:Diterpenoids from the Mediterranean brown alga Dictyota sp. evaluated as antifouling substances against a marine bacterial biofilm.
PubMed:Ultrafast fluorescence study on the location and mechanism of non-photochemical quenching in diatoms.
PubMed:[Effects of temperature and light intensity on the growth and biochemical composition of Sargassum thunbergii].
PubMed:Comparative effects of beta-carotene and fucoxanthin on retinol deficiency induced oxidative stress in rats.
PubMed:Identification of a specific fucoxanthin-chlorophyll protein in the light harvesting complex of photosystem I in the diatom Cyclotella meneghiniana.
PubMed:Function of marine carotenoids.
PubMed:Protective effect of fucoxanthin isolated from Sargassum siliquastrum on UV-B induced cell damage.
PubMed:Fucoxanthin, tetraprenylated toluquinone and toluhydroquinone metabolites from Sargassum heterophyllum inhibit the in vitro growth of the malaria parasite Plasmodium falciparum.
PubMed:The distribution and accumulation of fucoxanthin and its metabolites after oral administration in mice.
PubMed:Carotenoid synthesis: retrospect and recent progress.
PubMed:Esterification of xanthophylls by human intestinal Caco-2 cells.
PubMed:Potential chemoprevention effect of dietary fucoxanthin on urinary bladder cancer EJ-1 cell line.
PubMed:Fucoxanthin restrains oxidative stress induced by retinol deficiency through modulation of Na(+)K(+)-ATPase [corrected] and antioxidant enzyme activities in rats.
PubMed:Physiological and transcriptomic evidence for a close coupling between chloroplast ontogeny and cell cycle progression in the pennate diatom Seminavis robusta.
PubMed:Anti-adult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol.
PubMed:The charge-transfer properties of the S2 state of fucoxanthin in solution and in fucoxanthin chlorophyll-a/c2 protein (FCP) based on stark spectroscopy and molecular-orbital theory.
PubMed:Toxicity and antioxidant activity in vitro and in vivo of two Fucus vesiculosus extracts.
PubMed:A new multicomponent NPQ mechanism in the diatom Cyclotella meneghiniana.
PubMed:Pigment alterations in the brown mussel Perna perna.
PubMed:Seaweed carotenoid, fucoxanthin, as a multi-functional nutrient.
PubMed:Microalgal mediation of ripple mobility.
PubMed:Photosystem I complexes associated with fucoxanthin-chlorophyll-binding proteins from a marine centric diatom, Chaetoceros gracilis.
PubMed:Growth inhibition of human hepatic carcinoma HepG2 cells by fucoxanthin is associated with down-regulation of cyclin D.
PubMed:Transcriptome analysis of acclimatory responses to thermal stress in Antarctic algae.
PubMed:Low bioavailability of dietary epoxyxanthophylls in humans.
PubMed:Annotation and expression profile analysis of cDNas from the Antarctic diatom Chaetoceros neogracile.
PubMed:The monomeric photosystem I-complex of the diatom Phaeodactylum tricornutum binds specific fucoxanthin chlorophyll proteins (FCPs) as light-harvesting complexes.
PubMed:Isolation and characterization of oxygen-evolving thylakoid membranes and photosystem II particles from a marine diatom Chaetoceros gracilis.
PubMed:Novel diterpenes with cytotoxic, anti-malarial and anti-tuberculosis activities from a brown alga Dictyota sp.
PubMed:Effect of medium-chain triacylglycerols on anti-obesity effect of fucoxanthin.
PubMed:Morphology and cultural behavior of Botryococcus protuberans with notes on the genus.
PubMed:The fluorescence yield of the trimeric fucoxanthin-chlorophyll-protein FCPa in the diatom Cyclotella meneghiniana is dependent on the amount of bound diatoxanthin.
PubMed:Radical scavenging and singlet oxygen quenching activity of marine carotenoid fucoxanthin and its metabolites.
PubMed:Structurally flexible macro-organization of the pigment-protein complexes of the diatom Phaeodactylum tricornutum.
PubMed:Phytoplankton abundance and pigment biomarkers in the oligotrophic, eastern Adriatic estuary.
PubMed:Fast, sensitive, and inexpensive alternative to analytical pigment HPLC: quantification of chlorophylls and carotenoids in crude extracts by fitting with Gauss peak spectra.
PubMed:Carotenoids in the sea urchin Paracentrotus lividus: occurrence of 9'-cis-echinenone as the dominant carotenoid in gonad colour determination.
PubMed:Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay mice.
PubMed:Spectroscopic and molecular characterization of the oligomeric antenna of the diatom Phaeodactylum tricornutum.
PubMed:Computational study on spectral properties of the selected pigments from various photosystems: structure-transition energy relationship.
PubMed:Fucoxanthin and fucoxanthinol enhance the amount of docosahexaenoic acid in the liver of KKAy obese/diabetic mice.
PubMed:The use of pigment "fingerprints" in the study of harmful algal blooms.
PubMed:Fucoxanthin, a natural carotenoid, induces G1 arrest and GADD45 gene expression in human cancer cells.
PubMed:Characterization of fucoxanthin and fucoxanthinol esters in the Chinese surf clam, Mactra chinensis.
PubMed:Effects of enhanced UV-B on pigment-based phytoplankton biomass and composition of mesocosm-enclosed natural marine communities from three latitudes.
PubMed:A highly polar xanthophyll of 9'-cis-neoxanthin induces apoptosis in HCT116 human colon cancer cells through mitochondrial dysfunction.
PubMed:Antiangiogenic activity of brown algae fucoxanthin and its deacetylated product, fucoxanthinol.
PubMed:Community structure and physiological characterization of microbial mats in Byers Peninsula, Livingston Island (South Shetland Islands, Antarctica).
PubMed:Statistical analysis of a database of absorption spectra of phytoplankton and pigment concentrations using self-organizing maps.
PubMed:Subunit composition and pigmentation of fucoxanthin-chlorophyll proteins in diatoms: evidence for a subunit involved in diadinoxanthin and diatoxanthin binding.
PubMed:Century-long synchrony of fossil algae in a chain of Canadian prairie lakes.
PubMed:Association of fucoxanthin chlorophyll a/c-binding polypeptides with photosystems and phosphorylation in the centric diatom Cyclotella cryptica.
PubMed:[The current concepts of functional role of carotenoids in the eukaryotic chloroplasts].
PubMed:Cultivated microalgae and the carotenoid fucoxanthin from Odontella aurita as potent anti-proliferative agents in bronchopulmonary and epithelial cell lines.
PubMed:Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells.
PubMed:Immuno-electron microscopic quantification of the fucoxanthin chlorophyll a/c binding polypeptides Fcp2, Fcp4, and Fcp6 of Cyclotella cryptica grown under low- and high-light intensities.
PubMed:Solvent polarity effect on excited-state lifetime of carotenoids and some dyes.
PubMed:Halocynthiaxanthin and fucoxanthinol isolated from Halocynthia roretzi induce apoptosis in human leukemia, breast and colon cancer cells.
PubMed:Fucoxanthin induces cell cycle arrest at G0/G1 phase in human colon carcinoma cells through up-regulation of p21WAF1/Cip1.
PubMed:A fluorometric method for the differentiation of algal populations in vivo and in situ.
PubMed:Assembly of the photosynthetic apparatus in embryos from Fucus serratus L.
PubMed:Spectroscopic characterization of the excitation energy transfer in the fucoxanthin-chlorophyll protein of diatoms.
PubMed:Long-term temperature acclimation of photosynthesis in steady-state cultures of the polar diatom Fragilariopsis cylindrus.
PubMed:The light-harvesting antenna of the diatom Phaeodactylum tricornutum. Evidence for a diadinoxanthin-binding subcomplex.
PubMed:Localisation of fucoxanthin chlorophyll a/c-binding polypeptides of the centric diatom Cyclotella cryptica by immuno-electron microscopy.
PubMed:Effects of fucoxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo.
PubMed:Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues.
PubMed:Tertiary endosymbiosis driven genome evolution in dinoflagellate algae.
PubMed:Neoxanthin and fucoxanthin induce apoptosis in PC-3 human prostate cancer cells.
PubMed:HSP90, tubulin and actin are retained in the tertiary endosymbiont genome of Kryptoperidinium foliaceum.
PubMed:Characterization of apoptosis induced by fucoxanthin in human promyelocytic leukemia cells.
PubMed:Phylogeny of nuclear-encoded plastid-targeted GAPDH gene supports separate origins for the peridinin- and the fucoxanthin derivative-containing plastids of dinoflagellates.
PubMed:Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARgamma ligand, troglitazone, on colon cancer cells.
PubMed:Ecosystem history of Mississippi River-influenced continental shelf revealed through preserved phytoplankton pigments.
PubMed:Differential circadian expression of genes fcp2 and fcp6 in Cyclotella cryptica.
PubMed:Acclimation of Haslea ostrearia to light of different spectral qualities - confirmation of 'chromatic adaptation' in diatoms.
PubMed:On the 710 nm fluorescence emitted by the diatom Phaeodactylum tricornutum at room temperature.
PubMed:Qualitative and quantitative composition of pigments in Phaeodactylum tricornutum (Bacillariophyceae) stressed by iron.
PubMed:Biotransformation of fucoxanthinol into amarouciaxanthin A in mice and HepG2 cells: formation and cytotoxicity of fucoxanthin metabolites.
PubMed:Fucoxanthin-chlorophyll proteins in diatoms: 18 and 19 kDa subunits assemble into different oligomeric states.
PubMed:Schizocladia ischiensis: a new filamentous marine chromophyte belonging to a new class, Schizocladiophyceae.
PubMed:HPLC pigment analysis of marine phytoplankton during a red tide occurrence in Tolo Harbour, Hong Kong.
PubMed:Horizontal transfer of functional nuclear genes between multicellular organisms.
PubMed:Enrichment of the light-harvesting complex in diadinoxanthin and implications for the nonphotochemical fluorescence quenching in diatoms.
PubMed:A methodological approach to investigate steady state fucoxanthin chlorophyll a/c binding protein mRNA levels in Wadden Sea sediments.
PubMed:Density-dependent patterns of thiamine and pigment production in the diatom Nitzschia microcephala.
PubMed:A novel PCR method for identifying plankton in cases of death by drowning.
PubMed:Genomic reduction and evolution of novel genetic membranes and protein-targeting machinery in eukaryote-eukaryote chimaeras (meta-algae).
PubMed:Carotenoids in cancer chemoprevention.
PubMed:Effect of Undaria pinnatifida (Wakame) on the development of cerebrovascular diseases in stroke-prone spontaneously hypertensive rats.
PubMed:Derivative analysis of absorption features in hyperspectral remote sensing data of carbonate sediments.
PubMed:A single origin of the peridinin- and fucoxanthin-containing plastids in dinoflagellates through tertiary endosymbiosis.
PubMed:Second- and third-hand chloroplasts in dinoflagellates: phylogeny of oxygen-evolving enhancer 1 (PsbO) protein reveals replacement of a nuclear-encoded plastid gene by that of a haptophyte tertiary endosymbiont.
PubMed:Brown algae fucoxanthin is hydrolyzed to fucoxanthinol during absorption by Caco-2 human intestinal cells and mice.
PubMed:Vitamin A-related compounds, all-trans retinal and retinoic acids, selectively inhibit activities of mammalian replicative DNA polymerases.
PubMed:Plastid state- and light-dependent regulation of the expression of nucleus-encoded genes for chloroplast proteins in the flagellate Euglena gracilis.
PubMed:Exploring bioinorganic pattern formation in diatoms. A story of polarized trafficking.
PubMed:Carotenoids affect proliferation of human prostate cancer cells.
PubMed:Lysophosphatidylcholine enhances carotenoid uptake from mixed micelles by Caco-2 human intestinal cells.
PubMed:Photoprotection and long-term acclimation to UV radiation in the marine diatom Thalassiosira weissflogii.
PubMed:Light regulation of circadian clock-controlled gene expression in rice.
PubMed:Xanthophyll synthesis in diatoms: quantification of putative intermediates and comparison of pigment conversion kinetics with rate constants derived from a model.
PubMed:[The role of labile complexes with oxygen in antioxidant activity of carotenoids].
PubMed:Chlorophyll and carotenoid binding in a simple red algal light-harvesting complex crosses phylogenetic lines.
PubMed:Diatom fucoxanthin chlorophyll a/c-binding protein (FCP) and land plant light-harvesting proteins use a similar pathway for thylakoid membrane Insertion.
PubMed:Breakdown of phytoplankton pigments in Baltic sediments: effects of anoxia and loss of deposit-feeding macrofauna.
PubMed:Investigations on gene copy number, introns and chromosomal arrangement of genes encoding the fucoxanthin chlorophyll a/c-binding proteins of the centric diatom Cyclotella cryptica.
PubMed:Pigment signatures associated with an anoxic coastal zone: Bahia Concepcion, Gulf of California.
PubMed:Phylogenetic analyses indicate that the 19'Hexanoyloxy-fucoxanthin-containing dinoflagellates have tertiary plastids of haptophyte origin.
PubMed:Semi-quantitative RT-PCR analysis of photoregulated gene expression in marine diatoms.
PubMed:Diversity and abundance of Bolidophyceae (Heterokonta) in two oceanic regions.
PubMed:Algae displaying the diadinoxanthin cycle also possess the violaxanthin cycle.
PubMed:Transformation of Nonselectable Reporter Genes in Marine Diatoms.
PubMed:Fucoxanthin as the major antioxidant in Hijikia fusiformis, a common edible seaweed.
PubMed:A phylogenetic assessment of the eukaryotic light-harvesting antenna proteins, with implications for plastid evolution.
PubMed:Fucoxanthin metabolites in egg yolks of laying hens.
PubMed:Phaeothamniophyceae Classis Nova: A New Lineage of Chromophytes Based upon Photosynthetic Pigments, rbcL Sequence Analysis and Ultrastructure.
PubMed:Cancer prevention by carotenoids.
PubMed:Resonance Raman spectroscopy of a light-harvesting protein from the brown alga Laminaria saccharina.
PubMed:Chemopreventive effects of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation.
PubMed:Proton-donative antioxidant activity of fucoxanthin with 1,1-diphenyl-2-picrylhydrazyl (DPPH).
PubMed:The fucoxanthin-chlorophyll proteins from a chromophyte alga are part of a large multigene family: structural and evolutionary relationships to other light harvesting antennae.
PubMed:Stable nuclear transformation of the diatom Phaeodactylum tricornutum.
PubMed:Gene structure of a chlorophyll a/c-binding protein from a brown alga: presence of an intron and phylogenetic implications.
PubMed:Molecular study of a light-harvesting apoprotein of Giraudyopsis stellifer (Chrysophyceae).
PubMed:Sequence conservation of light-harvesting and stress-response proteins in relation to the three-dimensional molecular structure of LHCII.
PubMed:The light-harvesting chlorophyll a-c-binding protein of dinoflagellates: a putative polyprotein.
PubMed:The gene family encoding the fucoxanthin chlorophyll proteins from the brown alga Macrocystis pyrifera.
PubMed:Nucleotide sequence of two cDNAs encoding fucoxanthin chlorophyll a/c proteins in the diatom Odontella sinensis.
PubMed:Ecophysiology of stromatolitic microbial mats, Stocking Island, exuma cays, Bahamas.
PubMed:Cancer chemoprevention by natural carotenoids and their related compounds.
PubMed:Cloning and nucleotide sequence of a cDNA encoding a major fucoxanthin-, chlorophyll a/c-containing protein from the chrysophyte Isochrysis galbana: implications for evolution of the cab gene family.
PubMed:Fucoxanthin-chlorophyll a/c light-harvesting complexes of Laminaria saccharina: partial amino acid sequences and arrangement in thylakoid membranes.
PubMed:Characterization of gene clusters encoding the fucoxanthin chlorophyll proteins of the diatom Phaeodactylum tricornutum.
PubMed:Isolation and characterization of PSII core complexes from a brown alga, Laminaria saccharina.
PubMed:Inhibitory effects of fucoxanthin, a natural carotenoid, on N-ethyl-N'-nitro-N-nitrosoguanidine-induced mouse duodenal carcinogenesis.
PubMed:Anti-neoplastic effect of halocynthiaxanthin, a metabolite of fucoxanthin.
PubMed:Targeting proteins to diatom plastids involves transport through an endoplasmic reticulum.
PubMed:In Vivo and In Vitro Protein Phosphorylation Studies on Ochromonas danica, an Alga with a Chlorophyll a/c/Fucoxanthin Binding Protein.
PubMed:Light-harvesting complexes of brown algae. Biochemical characterization and immunological relationships.
PubMed:Fluorescence properties of the allenic carotenoid fucoxanthin: Implication for energy transfer in photosynthetic pigment systems.
PubMed:Inhibitory effects of fucoxanthin, a natural carotenoid, on N-myc expression and cell cycle progression in human malignant tumor cells.
PubMed:Light-harvesting proteins of diatoms: their relationship to the chlorophyll a/b binding proteins of higher plants and their mode of transport into plastids.
PubMed:Regulation of the distribution of excitation energy in Ochromonas danica, an organism containing a chlorophyll-A/C/carotenoid light harvesting antenna.
PubMed:Lipophilic pigments from cyanobacterial (blue-green algal) and diatom mats in Hamelin Pool, Shark Bay, Western Australia.
PubMed:Lipophilic pigments from the benthos of a perennially ice-covered Antarctic lake.
PubMed:Animal carotenoids. 32. Carotenoids of Mytilus edulis (edible mussel).
PubMed:High-performance liquid chromatography of carotenoids from some marine shellfish.
PubMed:Analysis of lipophilic pigments from a phototrophic microbial mat community by high performance liquid chromatography.
PubMed:Photosystem Stoichiometry and Excitation Distribution in Chloroplasts from Surface and Minus 20 Meter Blades of Macrocystis pyrifera, the Giant Kelp.
PubMed:Polypeptides of a Light-Harvesting Complex of the Diatom Phaeodactylum tricornutum Are Synthesized in the Cytoplasm of the Cell as Precursors.
PubMed:Light-Harvesting Function in the Diatom Phaeodactylum tricornutum: I. Isolation and Characterization of Pigment-Protein Complexes.
PubMed:Antheraxanthin, a light harvesting carotenoid found in a chromophyte alga.
PubMed:Photosynthetic and respiratory rates of two psychrophilic diatoms.
PubMed:Carotenoids of tunicates. III. The structural elucidation of two new marine carotenoids, amarouciaxanthin A and B.
PubMed:A diatom light-harvesting pigment-protein complex : purification and characterization.
PubMed:Antibacterial constituents of the diatom Navicula delognei.
PubMed:Isolation of chlorophyll-protein complexes and quantification of electron transport components in Synura petersenii and Tribonema aequale.
PubMed:Isolation of chlorophyll-protein complexes and quantification of electron transport components in Synura petersenil and Tribonema aequale.
PubMed:[Quenching of chlorophyll and pheophytin fluorescence with fucoxanthin].
PubMed:Light-harvesting systems of brown algae and diatoms. Isolation and characterization of chlorophyll a/c and chlorophyll a/fucoxanthin pigment-protein complexes.
PubMed:The P-700-chlorophyl alpha-protein complex and two major light-harvesting complexes of Acrocarpia paniculata and other brown seaweeds.
PubMed:Chlorophyll-protein complexes of brown algae: P700 reaction centre and light-harvesting complexes.
PubMed:[The photoelectrochemical effect in solid films of flucoxanthine].
PubMed:["Synthetical" aiptasia mutabilis RAPP (coelenterata) (author's transl)].
PubMed:Dinoflagellate evolution: speculation and evidence.
PubMed:Purification and characterization of peridinin-chlorophyll a-proteins from the marine dinoflagellates Glenodinium sp. and Gonyaulax polyedra.
PubMed:Photosynthetic Enhancement in the Diatom Phaeodactylum tricornutum.
PubMed:Photosynthetic action spectra of marine algae.
Fucoxanthin is a carotenoid, with formula C40H60O6. It is found as an accessory pigment in the chloroplasts of brown algae and most other heterokonts, giving them a brown or olive-green color. Fucoxanthin absorbs light primarily in the blue-green to yellow-green part of the visible spectrum, peaking at around 510-525 nm by various estimates and absorbing significantly in the range of 450 to 540 nm. -- Wikipedia [HMDB]
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