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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 549.15 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 440.00 °F. TCC ( 226.70 °C. ) (est)
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| logP (o/w): | 5.623 (est) |
| Soluble in: |
| | water, 0.0004255 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LDLo 2000 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Chinese Medical Journal Vol. 93, Pg. 41, 1980.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for schizandrin C usage levels up to: | | | not for fragrance use.
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| Recommendation for schizandrin C flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 1,3- | benzodioxolo[5',6':3,4]cycloocta[1,2-f][1,3]benzodioxole, 5,6,7,8-tetrahydro-13,14-dimethoxy-6,7-dimethyl- | | 13,14- | dimethoxy-6,7-dimethyl-5,6,7,8-tetrahydro[1,3]benzodioxolo[5',6':3,4]cycloocta[1,2-f][1,3]benzodioxole | | | schisandrin C | | | wuweizisu C |
Articles:
| PubMed:[Correlation study on lignin contents of Schisandra chinensis and ecological factors]. |
| PubMed:Comprehensive chemical analysis of Schisandra chinensis by HPLC-DAD-MS combined with chemometrics. |
| PubMed:Schizandrin C exerts anti-neuroinflammatory effects by upregulating phase II detoxifying/antioxidant enzymes in microglia. |
| PubMed:Schisandrin B enhances the glutathione redox cycling and protects against oxidant injury in different types of cultured cells. |
| PubMed:Simultaneous and rapid determination of main lignans in different parts of Schisandra sphenanthera by micellar electrokinetic capillary chromatography. |
| PubMed:Protective effects of dibenzocyclooctadiene lignans from Schisandra chinensis against beta-amyloid and homocysteine neurotoxicity in PC12 cells. |
| PubMed:Schisandrin B-induced glutathione antioxidant response and cardioprotection are mediated by reactive oxidant species production in rat hearts. |
| PubMed:A simple and sensitive HPLC method for the simultaneous determination of eight bioactive components and fingerprint analysis of Schisandra sphenanthera. |
| PubMed:Anti-inflammatory effects of gomisin N, gomisin J, and schisandrin C isolated from the fruit of Schisandra chinensis. |
| PubMed:Synthesis and biological activity of Wuweizisu C and analogs. |
| PubMed:[Study on the chemical constituents of the fruit handles from Schizandra chinensis]. |
| PubMed:Induction of G1 arrest and apoptosis by schisandrin C isolated from Schizandra chinensis Baill in human leukemia U937 cells. |
| PubMed:Bicyclol: a novel drug for treating chronic viral hepatitis B and C. |
| PubMed:Wuweizisu C from Schisandra chinensis decreases membrane potential in C6 glioma cells. |
| PubMed:Transport of Schisandra chinensis extract and its biologically-active constituents across Caco-2 cell monolayers - an in-vitro model of intestinal transport. |
| PubMed:Reversal of P-glycoprotein-mediated multidrug resistance of cancer cells by five schizandrins isolated from the Chinese herb Fructus Schizandrae. |
| PubMed:Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity. |
| PubMed:New synthesis of (S)-dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethenedioxy-biphenyl-2,2'-dicarboxylate by configuration transform. |
| PubMed:[Studies on chemical constituents of Schisandra propinqua (Wall.) Hook. f. et Thoms]. |
| PubMed:New drugs derived from medicinal plants. |
| PubMed:Solubilization of biphenyl dimethyl dicarboxylate by cosolvency. |
| PubMed:Structure-activity relationship of schisandrins in enhancing liver mitochondrial glutathione status in CCl4-poisoned mice. |
| PubMed:Methylenedioxy group and cyclooctadiene ring as structural determinants of schisandrin in protecting against myocardial ischemia-reperfusion injury in rats. |
| PubMed:Adaptogenic screening in rats. |
| PubMed:Induction of liver microsomal cytochrome P-450 2B1 by dimethyl diphenyl bicarboxylate in rats. |
| PubMed:Gomisin A inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. |
| PubMed:Effect of dibenzo[a,c]cyclooctene lignans isolated from Fructus schizandrae on lipid peroxidation and anti-oxidative enzyme activity. |
| PubMed:[Determination of the active ingredients in Chinese drug wuweizi (Schisandra chinensis) by TLC-densitometry]. |
| PubMed:Scavenging effects on active oxygen radicals by schizandrins with different structures and configurations. |
| PubMed:Pharmacological actions and clinical use of fructus schizandrae. |
| PubMed:[Biochemical and pharmacologic effects of wuweizi (Schizandra chinensis (Turcz.) Baill.) and its chemical contents on animal livers]. |
| PubMed:The effect of DDB on dystrophic hamsters: an in vivo and in vitro study. |
| PubMed:Mechanism of antihepatotoxic activity of wuweizisu C and gomisin A. |
| PubMed:[Pharmacological studies on schizandra fruits. III. Effects of wuweizisu C, a lignan component of schizandra fruits, on experimental liver injuries in rats]. |
| PubMed:Studies on antihepatitic drugs. Total synthesis of (+/-)schizandrin C and its analogs. |
| PubMed:Pharmacological properties of Dibenzo[a,c]cyclooctene derivatives isolated from Fructus Schizandrae Chinensis III. Inhibitory effects on carbon tetrachloride-induced lipid peroxidation, metabolism and covalent binding of carbon tetrachloride to lipids. |
| PubMed:Pharmacological properties of dibenzo[a,c]cyclooctene derivatives isolated from Fructus Schizandrae chinensis. I. Interaction with rat liver cytochrome P-450 and inhibition of xenobiotic metabolism and mutagenicity. |
| PubMed:[Synthesis of schizandrin C analogs. II. Synthesis of dimethyl-4, 4'-dimethoxy-5, 6, 5', 6'- dimethylenedioxybiphenyl-2, 2'-dicarboxylate and its isomers (author's transl)]. |
| PubMed:[Synthesis of Schizandrin C analogs (author's transl)]. |
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3D/inchi