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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 579.70 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 580.00 °F. TCC ( 304.40 °C. ) (est)
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| logP (o/w): | 4.770 (est) |
| Soluble in: |
| | water, 0.05795 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 390 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: SLEEP
Yakugaku Zasshi. Journal of Pharmacy. Vol. 101, Pg. 1030, 1981.
oral-mouse LD50 777 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: SLEEP
Yakugaku Zasshi. Journal of Pharmacy. Vol. 101, Pg. 1030, 1981.
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| Dermal Toxicity: |
subcutaneous-mouse LD50 500 mg/kg
BEHAVIORAL: SLEEP
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakugaku Zasshi. Journal of Pharmacy. Vol. 101, Pg. 1030, 1981.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for gomisin A usage levels up to: | | | not for fragrance use.
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| Recommendation for gomisin A flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxol-6-ol, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, (6R,7R)- | | | besigomsin | | | schisandrol B | | | schizandrol B | | (+)-(6S,7S, biar-R)-5,6,7,8- | tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethylbenzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-6-ol | | (6R,7R)-1,2,3,13- | tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxol-6-ol | | | wuweizi alcohol B | | | wuweizichun B |
Articles:
| PubMed:Gomisin A decreases the LPS-induced expression of iNOS and COX-2 and activation of RIP2/NF-κB in mouse peritoneal macrophages. |
| PubMed:Gomisin A inhibits lipopolysaccharide-induced inflammatory responses in N9 microglia via blocking the NF-κB/MAPKs pathway. |
| PubMed:An efficient strategy for the extraction and purification of lignans from Schisandra chinensis by a combination of supercritical fluid extraction and high-speed counter-current chromatography. |
| PubMed:Micelle-Mediated Extraction of Dibenzocyclooctadiene Lignans from Schisandra chinensis with Analysis by High-Performance Liquid Chromatography. |
| PubMed:Protective effects of gomisin A isolated from Schisandra chinensis against CCl(4)-induced hepatic and renal injury. |
| PubMed:Gomisin A enhances tumor necrosis factor-α-induced G1 cell cycle arrest via signal transducer and activator of transcription 1-mediated phosphorylation of retinoblastoma protein. |
| PubMed:Therapeutic potential of Schisandra chinensis extracts for treatment of hypertension. Introduction to: 'antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability' by Park et al. |
| PubMed:Antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability. |
| PubMed:The molecular mechanisms of the hepatoprotective effect of gomisin A against oxidative stress and inflammatory response in rats with carbon tetrachloride-induced acute liver injury. |
| PubMed:Production of lignans in calluses of Schisandra chinensis. |
| PubMed:A compound isolated from Schisandra chinensis induces apoptosis. |
| PubMed:Transcriptome analysis of the effects of gomisin a on the recovery of carbon tetrachloride-induced damage in rat liver. |
| PubMed:The immuno-regulatory effects of Schisandra chinensis and its constituents on human monocytic leukemia cells. |
| PubMed:The lignan-rich fractions of Fructus Schisandrae improve insulin sensitivity via the PPAR-γ pathways in in vitro and in vivo studies. |
| PubMed:Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways. |
| PubMed:Effects of gomisin A on vascular contraction in rat aortic rings. |
| PubMed:Quantitative analysis of major dibenzocyclooctane lignans in Schisandrae fructus by online TLC-DART-MS. |
| PubMed:Identification of marker compounds in herbal drugs on TLC with DART-MS. |
| PubMed:Evaluation of cytotoxic activity of Schisandra chinensis lignans. |
| PubMed:Dibenzocyclooctadiene lignans from Fructus Schisandrae Chinensis improve glucose uptake in vitro. |
| PubMed:Inhibition of cytochrome P450 3A4 activity by schisandrol A and gomisin A isolated from Fructus Schisandrae chinensis. |
| PubMed:Validated method for bioactive lignans in Schisandra chinensis in vitro cultures using a solid phase extraction and a monolithic column application. |
| PubMed:Apoptosis induction of human leukemia U937 cells by gomisin N, a dibenzocyclooctadiene lignan, isolated from Schizandra chinensis Baill. |
| PubMed:[Study on the chemical constituents of the fruit handles from Schizandra chinensis]. |
| PubMed:Non-thermal extraction of effective ingredients from Schisandra chinensis Baill and the antioxidant activity of its extract. |
| PubMed:Gomisin A induces Ca2+-dependent activation of eNOS in human coronary artery endothelial cells. |
| PubMed:Dibenzocyclooctadiene lignans overcome drug resistance in lung cancer cells--study of structure-activity relationship. |
| PubMed:Wuweizisu C from Schisandra chinensis decreases membrane potential in C6 glioma cells. |
| PubMed:Transport of Schisandra chinensis extract and its biologically-active constituents across Caco-2 cell monolayers - an in-vitro model of intestinal transport. |
| PubMed:Anti-apoptotic and hepatoprotective effects of gomisin A on fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice. |
| PubMed:Gomisin A from Schisandra chinensis induces endothelium-dependent and direct relaxation in rat thoracic aorta. |
| PubMed:High-performance liquid chromatography-electrospray mass spectrometry for the simultaneous determination of multiple active components in Sheng-Mai San, a prescription of traditional Chinese medicine. |
| PubMed:Acetylcholinesterase inhibitory effect of lignans isolated from Schizandra chinensis. |
| PubMed:Composition and biological activity of different extracts from Schisandra sphenanthera and Schisandra chinensis. |
| PubMed:Development of a quality evaluation method for Fructus schisandrae by pressurized capillary electrochromatography. |
| PubMed:Natural products and chronic hepatitis C virus. |
| PubMed:Gomisin A alters substrate interaction and reverses P-glycoprotein-mediated multidrug resistance in HepG2-DR cells. |
| PubMed:Gomisin A improves scopolamine-induced memory impairment in mice. |
| PubMed:Application of preparative high-speed counter-current chromatography for isolation and separation of schizandrin and gomisin A from Schisandra chinensis. |
| PubMed:[Determination of lignans of Schisandra medicinal plants by HPLC]. |
| PubMed:Dibenzo[a,c]cyclooctadiene lignans of the genus Schisandra: importance, isolation and determination. |
| PubMed:Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity. |
| PubMed:Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation. |
| PubMed:Liquid chromatographic analysis of supercritical carbon dioxide extracts of Schizandra chinensis. |
| PubMed:[Phytotherapeutic aspects of diseases of the circulatory system. 7. Schisandra chinensis (Turcz.) Baill.): its composition and biological activity]. |
| PubMed:Application of capillary electrochromatography using macroporous polyacrylamide columns for the analysis of lignans from seeds of Schisandra chinensis. |
| PubMed:Clinical and pharmacological studies on liver diseases treated with Kampo herbal medicine. |
| PubMed:Lignans in the seeds and fruits of Schisandra chinensis cultured in Europe. |
| PubMed:Rapid induction of hepatocyte growth factor mRNA after administration of gomisin A, a lignan component of shizandra fruits. |
| PubMed:Deoxycholic acid as an endogenous risk factor for hepatocarcinogenesis and effects of gomisin A, a lignan component of Schizandra fruits. |
| PubMed:Effects of gomisin A on the promotor action and serum bile acid concentration in hepatocarcinogenesis induced by 3'-methyl-4-dimethylamino-azobenzene. |
| PubMed:Inhibition of early 3-methyl-4-dimethylaminoazobenzene-induced hepatocarcinogenesis by gomisin A in rats. |
| PubMed:Inhibition by gomisin A, a lignan compound, of hepatocarcinogenesis by 3'-methyl-4-dimethylaminoazobenzene in rats. |
| PubMed:Gomisin A, a lignan component of Schizandora fruits, inhibits development of preneoplastic lesions in rat liver by 3'-methyl-4-dimethylamino-azobenzene. |
| PubMed:Preventive effect of gomisin A, a lignan component of shizandra fruits, on acetaminophen-induced hepatotoxicity in rats. |
| PubMed:Effect of Gomisin A (TJN-101) on liver regeneration. |
| PubMed:Gomisin A inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. |
| PubMed:[Determination of gomisin A (TJN-101) and its metabolite in rat serum by gas chromatography-mass spectrometry]. |
| PubMed:Effects of gomisin A on hepatocarcinogenesis by 3'-methyl-4-dimethylaminoazobenzene in rats. |
| PubMed:[Studies on the metabolic fate of gomisin A (TJN-101). II. Absorption and excretion in CCl4 treated rats]. |
| PubMed:[Studies on the metabolic fate of gomisin A (TJN-101). I. Absorption in rats]. |
| PubMed:Effect of gomisin A in the prevention of acute hepatic failure induction. |
| PubMed:Effect of gomisin A in an immunologically-induced acute hepatic failure model. |
| PubMed:Effect of gomisin A (TJN-101) on the arachidonic acid cascade in macrophages. |
| PubMed:Studies on the metabolism of gomisin A (TJN-101). II. Structure determination of biliary and urinary metabolites in rat. |
| PubMed:The effect of gomisin A on immunologic liver injury in mice. |
| PubMed:Studies on the metabolism of gomisin A (TJN-101). I. Oxidative products of gomisin A formed by rat liver S9 mix. |
| PubMed:[Effect of gomisin A (TJN-101), a lignan compound isolated from Schisandra fruits, on liver function in rats]. |
| PubMed:[The protective effect of gomisin A on experimentally induced acute hepatic injury]. |
| PubMed:[Effects of gomisin A, a lignan component of Schizandra fruits, on experimental liver injuries and liver microsomal drug-metabolizing enzymes]. |
| PubMed:Mechanism of antihepatotoxic activity of wuweizisu C and gomisin A1. |
| PubMed:Mechanism of antihepatotoxic activity of wuweizisu C and gomisin A. |
| PubMed:Effects of gomisin A on liver functions in hepatotoxic chemicals-treated rats. |
| PubMed:[Pharmacological studies on Schizandra fruit. I. General pharmacological effects of gomisin A and schizandrin (author's transl)]. |
| PubMed:The constituents of Schizandra chinensis Baill. I. Isolation and structure determination of five new lignans, gomisin A, B, C, F and G, and the absolute structure of schizandrin. |
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3D/inchi