EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

deoxyschizandrin
schisandrin A

Supplier Sponsors

CAS Number: 61281-38-7Picture of molecule3D/inchi
FDA UNII: 74XQL5DO3S
Nikkaji Web:J527.345E
MDL:MFCD09026934
XlogP3-AA:5.30 (est)
Molecular Weight:416.51424000
Formula:C24 H32 O6
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 544.20 °C. @ 760.00 mm Hg (est)
Flash Point: 420.00 °F. TCC ( 215.60 °C. ) (est)
logP (o/w): 5.870 (est)
Soluble in:
 water, 0.00323 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Doxyschizandrin 98%
BOC Sciences
For experimental / research use only.
Schisandrin A >98%
Odor: characteristic
Use: Schizandrin A is extracted from the seeds of Schisandra chinensis (Turcz.) Baill.
Carbosynth
For experimental / research use only.
Deoxyschizandrin
Nacalai USA
For experimental / research use only.
Deoxyschizandrin
Santa Cruz Biotechnology
For experimental / research use only.
Deoxyschizandrin
Sigma-Aldrich
For experimental / research use only.
Schisandrin A analytical standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LDLo 1000 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Chinese Medical Journal Vol. 93, Pg. 41, 1980.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for deoxyschizandrin usage levels up to:
 not for fragrance use.
 
Recommendation for deoxyschizandrin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :43595
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0061281387
RTECS:HP1595000 for cas# 61281-38-7
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):43595
Pubchem (sid):135004854
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C16951
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 schisandra incarnata
Search Trop Picture
 
Synonyms:
 dibenzo(a,c)cyclooctene, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, stereoisomer
 dibenzo(a,c)cyclooctene, 5,6,7,8-tetrahydro-6,7-dimethyl-1,2,3,10,11,12-hexamethoxy-
 dibenzo[a,c]cyclooctene, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-
1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c][8]annulene
 schisandrin A
 schizandrin A
 

Articles:

PubMed:[Correlation study on lignin contents of Schisandra chinensis and ecological factors].
PubMed:Inhibitory effects of phytochemicals on metabolic capabilities of CYP2D6(*)1 and CYP2D6(*)10 using cell-based models in vitro.
PubMed:[High performance preparation and structural confirmation of lignans from Schisandrae chinensis fructus by using HSCCC combined with ESI-MSn method].
PubMed:Optimization of vinegar-steaming process for Wuweizi (Fructus Schisandrae Chinensis) with response surface method.
PubMed:Identification of metabolites of deoxyschizandrin in rats by UPLC-Q-TOF-MS/MS based on multiple mass defect filter data acquisition and multiple data processing techniques.
PubMed:[Determination of lignans in four fruits of Schisandra genus in Qinling mountains].
PubMed:Deoxyschizandrin, a naturally occurring lignan, is a specific probe substrate of human cytochrome P450 3A.
PubMed:Determination of lignans in Wuweizi by using magnetic bar microextraction and HPLC.
PubMed:Chemical-pharmacokinetic-pharmacodynamic fingerprints of Schisandra chinensis alcoholic extract.
PubMed:Effects of piperine and deoxyschizandrin on synchronized Ca²⁺ oscillations in cultured hippocampal neuronal cells.
PubMed:[Quality evaluation and antioxidant activity research of Schisandra chinensis from various habitats].
PubMed:Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay.
PubMed:Effects of traditional chinese medicine Wuzhi capsule on pharmacokinetics of tacrolimus in rats.
PubMed:Protective role of deoxyschizandrin and schisantherin A against myocardial ischemia-reperfusion injury in rats.
PubMed:Production of deoxyschizandrin and γ-schizandrin in shoot-differentiating and undifferentiating callus cultures of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine).
PubMed:Effect of acupuncture on target tissue distribution of Schisandra lignans.
PubMed:Schisandra lignans-loaded enteric nanoparticles: preparation, characterization, and in vitro-in vivo evaluation.
PubMed:Strong inhibition of deoxyschizandrin and schisantherin A toward UDP-glucuronosyltransferase (UGT) 1A3 indicating UGT inhibition-based herb–drug interaction.
PubMed:Pharmacokinetic study of schisandrin, schisandrol B, schisantherin A, deoxyschisandrin, and schisandrin B in rat plasma after oral administration of Shengmaisan formula by UPLC-MS.
PubMed:[Chemical constituents of petroleum ether extract of fruits of Schisandra sphenanthera].
PubMed:[Simultaneous quantitative analysis of four lignanoids in Schisandra chinensis by quantitative analysis of multi-components by single marker].
PubMed:Schisandrin B attenuates cancer invasion and metastasis via inhibiting epithelial-mesenchymal transition.
PubMed:Application of ultrahigh-performance liquid chromatography coupled with mass spectrometry for analysis of lignans and quality control of Fructus Schisandrae chinensis.
PubMed:[Correlation of lignans content and antioxidant activities of Schisandra chinensis fruits by using stoichiometry method].
PubMed:Deoxyschizandrin isolated from the fruits of Schisandra chinensis ameliorates Aβ₁₋₄₂-induced memory impairment in mice.
PubMed:Aqueous two-phase system coupled with ultrasound for the extraction of lignans from seeds of Schisandra chinensis (turcz.) Baill.
PubMed:Response surface modeling and optimization of accelerated solvent extraction of four lignans from fructus schisandrae.
PubMed:Effects of H(2)O(2), paraquat, and ethephon on herbal drug quality of Schiandra chinensis based on reactive oxygen species system.
PubMed:Enrichment and purification of deoxyschizandrin and γ-schizandrin from the extract of Schisandra chinensis fruit by macroporous resins.
PubMed:On-line continuous sampling dynamic microwave-assisted extraction coupled with high performance liquid chromatographic separation for the determination of lignans in Wuweizi and naphthoquinones in Zicao.
PubMed:A concise total synthesis of deoxyschizandrin and exploration of its antiproliferative effects and those of structurally related derivatives.
PubMed:Homogeneous ionic liquid microextraction of the active constituents from fruits of Schisandra chinensis and Schisandra sphenanthera.
PubMed:Schisandrin B enhances the glutathione redox cycling and protects against oxidant injury in different types of cultured cells.
PubMed:[Study on the clinical application of wuzhi capsule after renal transplantation].
PubMed:Preparation of high purity biphenyl cyclooctene lignans from Schisandra extract by ion exchange resin catalytic transformation combined with macroporous resin separation.
PubMed:Screening vasoconstriction inhibitors from traditional Chinese medicines using a vascular smooth muscle/cell membrane chromatography-offline-liquid chromatography-mass spectrometry.
PubMed:[Identification of the lignans components after oral administration of fuzheng huayu decoction in rat serum by HPLC-MSn].
PubMed:Simultaneous and rapid determination of main lignans in different parts of Schisandra sphenanthera by micellar electrokinetic capillary chromatography.
PubMed:The lignan-rich fractions of Fructus Schisandrae improve insulin sensitivity via the PPAR-γ pathways in in vitro and in vivo studies.
PubMed:[Dual effects of extract of Schisandra chinensis Baill on rat hepatic CYP3A].
PubMed:Study on ionic liquid-based ultrasonic-assisted extraction of biphenyl cyclooctene lignans from the fruit of Schisandra chinensis Baill.
PubMed:[Intestinal absorption of the effective components of Schisandra chinensis Baill by rats single-pass perfusion in situ].
PubMed:Rapid determination and pharmacokinetics study of lignans in rat plasma after oral administration of Schisandra chinensis extract and pure deoxyschisandrin.
PubMed:Deoxyschisandrin inhibits H2O2-induced apoptotic cell death in intestinal epithelial cells through nuclear factor-kappaB.
PubMed:Synthesis and MDR inhibitory activity evaluation of derivatives of schizandrin A.
PubMed:Inhibitory effects of schisandrin A and schisandrin B on CYP3A activity.
PubMed:[Changes of lignans' content in stems of Schisandra chinensis].
PubMed:[Research on liposoluble ingredients of Quchiling].
PubMed:Validated method for bioactive lignans in Schisandra chinensis in vitro cultures using a solid phase extraction and a monolithic column application.
PubMed:Non-thermal extraction of effective ingredients from Schisandra chinensis Baill and the antioxidant activity of its extract.
PubMed:[Selection of mobile phases for the determination of gamma-schisandrin and multi-active constituents in Schisandra chinensis and its preparations by high performance liquid chromatography].
PubMed:The effect of deoxyschisandrin on blood tacrolimus levels: a case report.
PubMed:Schisanwilsonins A-G and related anti-HBV lignans from the fruits of Schisandra wilsoniana.
PubMed:Growth inhibition and cell cycle arrest in the G0/G1 by schizandrin, a dibenzocyclooctadiene lignan isolated from Schisandra chinensis, on T47D human breast cancer cells.
PubMed:Dibenzocyclooctadiene lignans overcome drug resistance in lung cancer cells--study of structure-activity relationship.
PubMed:Resolution of two-way chromatographic data of Schisandra chinensis Baill. using a modified slice-scan method for direct determination of the components in overlapping peaks.
PubMed:[Lignans from different processed products of Schisandra chinensis fruits].
PubMed:Optimization of extraction and purification of active fractions from Schisandra chinensis (Turcz.) and its osteoblastic proliferation stimulating activity.
PubMed:Deoxyschisandrin modulates synchronized Ca2+ oscillations and spontaneous synaptic transmission of cultured hippocampal neurons.
PubMed:Reversal of P-glycoprotein-mediated multidrug resistance of cancer cells by five schizandrins isolated from the Chinese herb Fructus Schizandrae.
PubMed:Determination of deoxyschizandrin in rat plasma by LC-MS.
PubMed:Molecular mechanism of apoptosis induced by schizandrae-derived lignans in human leukemia HL-60 cells.
PubMed:[Determination of tanshinone II A and deoxyschizandrin in danshenwuweizi tablet by RP-HPLC].
PubMed:Composition and biological activity of different extracts from Schisandra sphenanthera and Schisandra chinensis.
PubMed:Effects of Schisandra lignans on P-glycoprotein-mediated drug efflux in human intestinal Caco-2.
PubMed:Development of a quality evaluation method for Fructus schisandrae by pressurized capillary electrochromatography.
PubMed:Microwave-assisted extraction and fingerprint studies of Schisandra chinensis (Turcz.) by high performance liquid chromatography and gas chromatography.
PubMed:Dibenzocyclooctadiene lingnans: a class of novel inhibitors of P-glycoprotein.
PubMed:Separation and determination of active components in Schisandra chinensis Baill. and its medicinal preparations by non-aqueous capillary electrophoresis.
PubMed:Preparative separation and purification of deoxyschisandrin and gamma-schisandrin from Schisandra chinensis (Turcz.) Baill by high-speed counter-current chromatography.
PubMed:[Study on the simultaneous spectrophotometric determination of three components including deoxyschizandrin by ridge regression method].
PubMed:[Determination of lignans of Schisandra medicinal plants by HPLC].
PubMed:Dibenzo[a,c]cyclooctadiene lignans of the genus Schisandra: importance, isolation and determination.
PubMed:[Studies on extraction process of Fructus Schisandrae chinensis and Fructus Ligustri lucidi in gandening tablet].
PubMed:Determination of specific receptor sites for platelet activating factor in bovine neutrophils.
PubMed:Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity.
PubMed:[Determination of schisandrin in shengmaiyin by HPLC].
PubMed:[Study on supercritical CO2 fluid extraction and separation of components from fruits of Schisandra sphenanthera].
PubMed:Liquid chromatographic analysis of supercritical carbon dioxide extracts of Schizandra chinensis.
PubMed:Release of intermediate reactive hydrogen peroxide by macrophage cells activated by natural products.
PubMed:Methylenedioxy group and cyclooctadiene ring as structural determinants of schisandrin in protecting against myocardial ischemia-reperfusion injury in rats.
PubMed:Methylenedioxy group as determinant of schisandrin in enhancing hepatic mitochondrial glutathione in carbon tetrachloride-intoxicated mice.
PubMed:Detection of free radical scavenging activity of schisanhenol by electron spin resonance.
PubMed:[Mass spectrometric studies on dibenzocyclooctadiene lignan compounds from Schisandraceae plants].
PubMed:Pharmacological actions and clinical use of fructus schizandrae.
PubMed:Pharmacological properties of dibenzo[a,c]cyclooctene derivatives isolated from Fructus Schizandrae chinensis. I. Interaction with rat liver cytochrome P-450 and inhibition of xenobiotic metabolism and mutagenicity.
 
Notes:
None found
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