EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

15-acetyl deoxynivalenol

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CAS Number: 88337-96-6Picture of molecule3D/inchi
FDA UNII: 0430X4R3Z1
Nikkaji Web:J275.533E
MDL:MFCD00083218
XlogP3-AA:-0.70 (est)
Molecular Weight:338.35674000
Formula:C17 H22 O7
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:toxic natural substances
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 538.59 °C. @ 760.00 mm Hg (est)
Flash Point: 387.00 °F. TCC ( 197.40 °C. ) (est)
logP (o/w): -0.400 (est)
Soluble in:
 water, 4044 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Standard Solution 15-Acetyl-DON
Odor: characteristic
Use: The 100 ppm acetonitrile solution of 15-Acetyl-DON, a kind of type B trichothecene mycotoxin, could be commonly used as standard solution.
Santa Cruz Biotechnology
For experimental / research use only.
15-Acetyl-deoxynivalenol
Sigma-Aldrich: Sigma
For experimental / research use only.
15-O-Acetyl-4-deoxynivalenol from Fusarium graminearum
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 113 mg/kg
Applied and Environmental Microbiology. Vol. 50, Pg. 1304, 1985.

oral-mouse LD50 34 mg/kg
BLOOD: CHANGES IN SPLEEN GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE KIDNEY, URETER, AND BLADDER: "INFLAMMATION, NECROSIS, OR SCARRING OF BLADDER"
Food and Chemical Toxicology. Vol. 25, Pg. 155, 1987.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
toxic natural substances
Recommendation for 15-acetyl deoxynivalenol usage levels up to:
 not for fragrance use.
 
Recommendation for 15-acetyl deoxynivalenol flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Deoxynivalenol in food and feed: occurrence and exposure
View page or View pdf

Risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :3034750
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0088337966
RTECS:YD0155000 for cas# 88337-96-6
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):3034750
Pubchem (sid):135062059
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):HMDB33444
FooDB:FDB011482
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
15-acetyldeoxynivalenol
 trichothec-9-en-8-one, 15-(acetyloxy)-12,13-epoxy-3,7-dihydroxy-, (3-a,7-a)-
 

Articles:

PubMed:Biodegradation and biodetoxification of Fusarium mycotoxins by Sphaerodes mycoparasitica.
PubMed:Identification and trichothecene genotypes of Fusarium graminearum species complex from wheat in Taiwan.
PubMed:Multi-Mycotoxin Analysis in Durum Wheat Pasta by  Liquid Chromatography Coupled to Quadrupole  Orbitrap Mass Spectrometry.
PubMed:Deoxynivalenol and Its Modified Forms: Are There Major Differences?
PubMed:Multi-mycotoxin stable isotope dilution LC-MS/MS method for Fusarium toxins in beer.
PubMed:Multi-mycotoxin contamination of couscous semolina commercialized in Morocco.
PubMed:Endocrine activity of mycotoxins and mycotoxin mixtures.
PubMed:Comparative in vitro cytotoxicity of modified deoxynivalenol on porcine intestinal epithelial cells.
PubMed:Protein engineering of Saccharomyces cerevisiae transporter Pdr5p identifies key residues that impact Fusarium mycotoxin export and resistance to inhibition.
PubMed:Binary and tertiary combination of alternariol, 3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol on HepG2 cells: Toxic effects and evaluation of degradation products.
PubMed:Effect of 4-week feeding of deoxynivalenol- or T-2-toxin-contaminated diet on lipid peroxidation and glutathione redox system in the hepatopancreas of common carp (Cyprinus carpio L.).
PubMed:Transformation of deoxynivalenol and its acetylated derivatives in Chinese steamed bread making, as affected by pH, yeast, and steaming time.
PubMed:Identification and Characterization of Carboxylesterases from Brachypodium distachyon Deacetylating Trichothecene Mycotoxins.
PubMed:[Dietary exposure assessment of deoxynivalenol and its acetylate & derivatives in wheat flour in Shanghai].
PubMed:The Metabolic Fate of Deoxynivalenol and Its Acetylated Derivatives in a Wheat Suspension Culture: Identification and Detection of DON-15-O-Glucoside, 15-Acetyl-DON-3-O-Glucoside and 15-Acetyl-DON-3-Sulfate.
PubMed:A method for simultaneous determination of 20 Fusarium toxins in cereals by high-resolution liquid chromatography-Orbitrap mass spectrometry with a pentafluorophenyl column.
PubMed:Evaluation on levels and conversion profiles of DON, 3-ADON, and 15-ADON during bread making process.
PubMed:Comparative assessment of three cleanup procedures after QuEChERS extraction for determination of trichothecenes (type A and type B) in processed cereal-based baby foods by GC-MS.
PubMed:Cytotoxic effects and degradation products of three mycotoxins: alternariol, 3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol in liver hepatocellular carcinoma cells.
PubMed:Development and validation of an LC-MS/MS method for the toxicokinetic study of deoxynivalenol and its acetylated derivatives in chicken and pig plasma.
PubMed:Mycotoxigenic potential of fungi isolated from freshly harvested Argentinean blueberries.
PubMed:Fusarium species, chemotype characterisation and trichothecene contamination of durum and soft wheat in an area of central Italy.
PubMed:Transcriptome profiling of wheat differentially expressed genes exposed to different chemotypes of Fusarium graminearum.
PubMed:Evidence for a reversible drought induced shift in the species composition of mycotoxin producing Fusarium head blight pathogens isolated from symptomatic wheat heads.
PubMed:Fitness attributes of Fusarium graminearum isolates from wheat in New York possessing a 3-ADON or 15-ADON trichothecene genotype.
PubMed:Occurrence of Fusarium mycotoxins in Italian cereal and cereal products from organic farming.
PubMed:Survey of 7 trichothecenes in corn-derived feed and feed ingredients.
PubMed:Inter-laboratory study of an LC-MS/MS method for simultaneous determination of deoxynivalenol and its acetylated derivatives, 3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol in wheat.
PubMed:Simultaneous determination of masked deoxynivalenol and some important type B trichothecenes in Chinese corn kernels and corn-based products by ultra-performance liquid chromatography-tandem mass spectrometry.
PubMed:Development of a purification method for simultaneous determination of deoxynivalenol and its acetylated and glycosylated derivatives in corn grits and corn flour by liquid chromatography-tandem mass spectrometry.
PubMed:TRI12 based quantitative real-time PCR assays reveal the distribution of trichothecene genotypes of F. graminearum and F. culmorum isolates in Danish small grain cereals.
PubMed:Heat- and cold-shock responses in Fusarium graminearum 3 acetyl- and 15 acetyl-deoxynivalenol chemotypes.
PubMed:Population analysis of the Fusarium graminearum species complex from wheat in China show a shift to more aggressive isolates.
PubMed:Chemotaxonomic diagnostics: combining sucrose-water agar with TLC to discriminate Fusarium graminearum 3-acetyl-DON and 15-acetyl-DON chemotypes.
PubMed:Cross-reactivity of some commercially available deoxynivalenol (DON) and zearalenone (ZEN) immunoaffinity columns to DON- and ZEN-conjugated forms and metabolites.
PubMed:Construction and characterization of a cDNA library from wheat infected with Fusarium graminearum Fg 2.
PubMed:The 3ADON population of Fusarium graminearum found in North Dakota is more aggressive and produces a higher level of DON than the prevalent 15ADON population in spring wheat.
PubMed:Effects of dietary Fusarium mycotoxins on intestinal lymphocyte subset populations, cell proliferation and histological changes in avian lymphoid organs.
PubMed:Trichothecene chemotypes of Fusarium culmorum infecting wheat in Tunisia.
PubMed:Quantification of Fusarium graminearum in harvested grain by real-time polymerase chain reaction to assess efficacies of fungicides on fusarium head blight, deoxynivalenol contamination, and yield of winter wheat.
PubMed:Comparative mycotoxin profiles of Gibberella zeae populations from barley, wheat, potatoes, and sugar beets.
PubMed:Cloning, expression, and characterization of a single-domain antibody fragment with affinity for 15-acetyl-deoxynivalenol.
PubMed:LC-MS/MS multi-method for mycotoxins after single extraction, with validation data for peanut, pistachio, wheat, maize, cornflakes, raisins and figs.
PubMed:Effects of foodborne Fusarium mycotoxins with and without a polymeric glucomannan mycotoxin adsorbent on food intake and nutrient digestibility, body weight, and physical and clinicopathologic variables of mature dogs.
PubMed:Estimating mycotoxin contents of Fusarium-damaged winter wheat kernels.
PubMed:Effects of feeding grains naturally contaminated with Fusarium mycotoxins on performance and metabolism of broiler breeders.
PubMed:Multiplex PCR assay for the identification of nivalenol, 3- and 15-acetyl-deoxynivalenol chemotypes in Fusarium.
PubMed:Simultaneous determination of type A-& B-trichothecenes and zearalenone in cereals by High Performance Liquid Chromatography - Tandem Mass Spectrometry.
PubMed:[Determination of DON-3-Glucoside in artificially and naturally contaminated wheat with LC-MS/MS].
PubMed:Solvolysis procedures for the determination of bound residues of the mycotoxin deoxynivalenol in fusarium species infected grain of two winter wheat cultivars preinfected with barley yellow dwarf virus.
PubMed:Incidence of trichothecenes and zearalenone in poultry feed mixtures from Slovakia.
PubMed:Assessment of trichothecene chemotypes of Fusarium culmorum occurring in Europe.
PubMed:DON calibrant: Towards the production of certified B-trichothecene calibrants.
PubMed:Rapid simultaneous determination of major type A- and B-trichothecenes as well as zearalenone in maize by high performance liquid chromatography-tandem mass spectrometry.
PubMed:Induction of apoptosis and cytokine production in the Jurkat human T cells by deoxynivalenol: role of mitogen-activated protein kinases and comparison to other 8-ketotrichothecenes.
PubMed:Report from SCOOP task 3.2.10 "collection of occurrence data of Fusarium toxins in food and assessment of dietary intake by the population of EU member states". Subtask: trichothecenes.
PubMed:Zearalenone in maize: stability testing and matrix characterisation of a certified reference material.
PubMed:Rapid surface plasmon resonance-based inhibition assay of deoxynivalenol.
PubMed:Detoxification of the Fusarium mycotoxin deoxynivalenol by a UDP-glucosyltransferase from Arabidopsis thaliana.
PubMed:Fast methods for screening of trichothecenes in fungal cultures using gas chromatography-tandem mass spectrometry.
PubMed:Occurrence of trichothecenes in Argentinean beer: a preliminary exposure assessment.
PubMed:A survey of Fusarium toxins in cereal-based foods marketed in an area of southwest Germany.
PubMed:Natural occurrence of Fusarium toxins in oats harvested during five years in an area of southwest Germany.
PubMed:Production of trichothecenes and zearalenone by isolates of Fusarium spp. from Argentinian maize.
PubMed:Mycotoxins in fungal contaminated samples of animal feed from western Canada, 1982-1994.
PubMed:Effects of trichothecene structure on cytokine secretion and gene expression in murine CD4+ T-cells.
PubMed:Cumulation of mycotoxins in maize cobs infected withFusarium gramihearum.
PubMed:Natural occurrence of deoxynivalenol, 3-acetyl-deoxynivalenol, 15-acetyl-deoxynivalenol, nivalenol, 4,7-dideoxynivalenol, and zearalenone in polish wheat.
PubMed:Mycotoxins and Fusarium spp. associated with infected ears of corn in Minnesota.
PubMed:Natural occurrence and clastogenic effects of nivalenol, deoxynivalenol, 3-acetyl-deoxynivalenol, 15-acetyl-deoxynivalenol, and zearalenone in corn from a high-risk area of esophageal cancer.
PubMed:[Trichothecenes in staple food from a high-incidence area of carcinoma of the esophagus and gastric cardia and their carcinogenic potential].
PubMed:Natural occurrence of deoxynivalenol, 15-acetyl-deoxynivalenol, and zearalenone in refusal factor corn stored since 1972.
PubMed:Deoxynivalenol and 15-monoacetyl deoxynivalenol production by Fusarium graminearum R6576 in liquid media.
 
Notes:
Mycotoxin prod. by Fusarium graminearum and Gibberella zeae
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