EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

glycitin
3-(4-hydroxyphenyl)-6-methoxy-4-oxo-4H-chromen-7-yl b-D-glucopyranoside

Supplier Sponsors

CAS Number: 40246-10-4Picture of molecule3D/inchi
FDA UNII: G2S44P62XC
Nikkaji Web:J396.591K
MDL:MFCD00800711
XlogP3-AA:0.60 (est)
Molecular Weight:446.40934000
Formula:C22 H22 O10
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 751.06 °C. @ 760.00 mm Hg (est)
Flash Point: 507.00 °F. TCC ( 264.10 °C. ) (est)
logP (o/w): 0.156 (est)
Soluble in:
 water, 4884 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Glycitin 98%
BOC Sciences
For experimental / research use only.
Glycitin
Carbosynth
For experimental / research use only.
Glycitin
Coompo
For experimental / research use only.
Glycitin from Plants ≥98%
Odor: characteristic
Use: Glycitin may modulate differentiation of MSC to cause a lineage shift toward the osteoblast and away from the adipocytes, and could inhibit adipocytic transdifferen-tiation of osteoblasts. It could also be helpful in preventing the development of osteonecrosis. A rat model study demonstrated glycitin to be effective in preventing bone loss and reversing the unfavorable changes of lipid metabolism in this model.
ExtraSynthese
For experimental / research use only.
Glycitin (HPLC) ≥95%
Nacalai USA
For experimental / research use only.
Glycitin
Santa Cruz Biotechnology
For experimental / research use only.
Glycitin >99%
Sigma-Aldrich: Sigma
For experimental / research use only.
Glycitin
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for glycitin usage levels up to:
 not for fragrance use.
 
Recommendation for glycitin flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Risk assessment for peri- and post-menopausal women taking food supplements containing isolated isoflavones
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :187808
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
3-(4-hydroxyphenyl)-6-methoxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
Chemidplus:0040246104
 
References:
 3-(4-hydroxyphenyl)-6-methoxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):187808
Pubchem (sid):135166110
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
KEGG (GenomeNet):C16195
HMDB (The Human Metabolome Database):HMDB02219
FooDB:FDB017323
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 soybean
Search Trop Picture
 soybean cotyledon
Search Trop Picture
 soybean hypocotyl
Search Trop Picture
 soybean seed
Search Trop Picture
 
Synonyms:
4',7-dihydroxy-6-methoxyisoflavone-7-D-glucoside
3-(4-hydroxyphenyl)-6-methoxy-4-oxo-4H-chromen-7-yl b-D-glucopyranoside
3-(4-hydroxyphenyl)-6-methoxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
 

Articles:

PubMed:Isoflavones of the Soybean Components and the Effect of Germination Time in the Cotyledons and Embryonic Axis.
PubMed:Profile of the contents of different forms of soybean isoflavones and the effect of germination time on these compounds and the physical parameters in soybean sprouts.
PubMed:Simultaneous Estimation of Glycosidic Isoflavones in Fermented and Unfermented Soybeans by TLC-Densitometric Method.
PubMed:Identification and quantification of the main isoflavones and other phytochemicals in soy based nutraceutical products by liquid chromatography-orbitrap high resolution mass spectrometry.
PubMed:Isoflavones profiling of soybean [Glycine max (L.) Merrill] germplasms and their correlations with metabolic pathways.
PubMed:Isoflavone intake inhibits the development of 7,12-dimethylbenz(a)anthracene(DMBA)-induced mammary tumors in normal and ovariectomized rats.
PubMed:Chemical compounds related to nutraceutical and industrial qualities of non-transgenic soybean genotypes.
PubMed:Inhibitory effects of a major soy isoflavone, genistein, on human DNA topoisomerase II activity and cancer cell proliferation.
PubMed:Rapid magnetic solid-phase extraction for the selective determination of isoflavones in soymilk using baicalin-functionalized magnetic nanoparticles.
PubMed:Multiple phytoestrogens inhibit cell growth and confer cytoprotection by inducing manganese superoxide dismutase expression.
PubMed:A modified QuEChERS method as sample treatment before the determination of isoflavones in foods by ultra-performance liquid chromatography-triple quadrupole mass spectrometry.
PubMed:Fast simultaneous determination of free and conjugated isoflavones in soy milk by UHPLC-UV.
PubMed:Screening and identification of BSA bound ligands from Puerariae lobata flower by BSA functionalized Fe₃O₄ magnetic nanoparticles coupled with HPLC-MS/MS.
PubMed:Hydrolysis of isoflavone glycosides by a thermostable β-glucosidase from Pyrococcus furiosus.
PubMed:Pharmacological screening of Coriandrum sativum Linn. for hepatoprotective activity.
PubMed:NTP-CERHR expert panel report on the developmental toxicity of soy infant formula.
PubMed:Soy isoflavones and other isoflavonoids activate the human bitter taste receptors hTAS2R14 and hTAS2R39.
PubMed:Characterization of a GH3 family β-glucosidase from Dictyoglomus turgidum and its application to the hydrolysis of isoflavone glycosides in spent coffee grounds.
PubMed:Characterization of a β-glucosidase from Sulfolobus solfataricus for isoflavone glycosides.
PubMed:UHPLC method for the simultaneous determination of β-blockers, isoflavones and their metabolites in human urine.
PubMed:Metabolism of Isoflavones Found in the Pueraria thomsonii Flower by Human Intestinal Microbiota.
PubMed:A study of characteristic fragmentation of isoflavonoids by using negative ion ESI-MSn.
PubMed:Optimizing time and temperature of enzymatic conversion of isoflavone glucosides to aglycones in soy germ flour.
PubMed:Analysis of isoflavones and flavonoids in human urine by UHPLC.
PubMed:Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cells.
PubMed:Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression.
PubMed:Hypolipidemic effects of Monascus-fermented soybean extracts in rats fed a high-fat and -cholesterol diet.
PubMed:Soya isoflavone supplementation enhances spatial working memory in men.
PubMed:Effects of a methanolic fraction of soybean seeds on the transcriptional activity of peroxisome proliferator-activated receptors (PPAR).
PubMed:Effect of glycosidation of isoflavones on their bioavailability and pharmacokinetics in aged male rats.
PubMed:[Isoflavone glycosides from the bark of Maackia amurensis].
PubMed:Stability of isoflavone isomers in steamed black soybeans and black soybean koji stored under different conditions.
PubMed:Equol is more active than soy isoflavone itself to compete for binding to thromboxane A(2) receptor in human platelets.
PubMed:Skim milk powder supplementation affects lactose utilization, microbial survival and biotransformation of isoflavone glycosides to isoflavone aglycones in soymilk by Lactobacillus.
PubMed:Ultrahigh-pressure liquid chromatography of isoflavones and phenolic acids on different stationary phases.
PubMed:Hydrolysis of isoflavone glucosides in soymilk fermented with single or mixed cultures of Lactobacillus paraplantarum KM, Weissella sp. 33, and Enterococcus faecium 35 isolated from humans.
PubMed:Enhanced bioavailability of soy isoflavones by complexation with beta-cyclodextrin in rats.
PubMed:Conversion of isoflavone glucosides to aglycones in soymilk by fermentation with lactic acid bacteria.
PubMed:Comparison of isoflavone concentrations in soybean (Glycine max (L.) Merrill) sprouts grown under two different light conditions.
PubMed:Rapid-resolution HPLC with spectrometric detection for the determination and identification of isoflavones in soy preparations and plant extracts.
PubMed:Solvent effects on extraction and HPLC analysis of soybean isoflavones and variations of isoflavone compositions as affected by crop season.
PubMed:Anti-obesity activities of fermented soygerm isoflavones by Bifidobacterium breve.
PubMed:Bioavailability of soy isoflavones in rats Part I: application of accurate methodology for studying the effects of gender and source of isoflavones.
PubMed:Inhibitory effects of glycitein on hydrogen peroxide induced cell damage by scavenging reactive oxygen species and inhibiting c-Jun N-terminal kinase.
PubMed:Biotransformation of common bean (Phaseolus vulgaris L.) flavonoid glycosides by bifidobacterium species from human intestinal origin.
PubMed:Isolation of six isoflavones from Semen sojae praeparatum by preparative HPLC.
PubMed:Isoflavone phytoestrogen degradation in fermented soymilk with selected beta-glucosidase producing L. acidophilus strains during storage at different temperatures.
PubMed:Enhanced estrogenic responses and sensitivity to azoxymethane following dietary soy isoflavone supplementation in older female rats.
PubMed:[Preparation of soybean isoflavone glucosides by reversed-phase high performance liquid chromatography].
PubMed:An accurate and reproducible method for the quantitative analysis of isoflavones and their metabolites in rat plasma using liquid chromatography/mass spectrometry combined with photodiode array detection.
PubMed:Influence of the application of three different elicitors on soybean plants on the concentrations of several isoflavones in soybean seeds.
PubMed:Method development and validation for isoflavones in soy germ pharmaceutical capsules using micellar electrokinetic chromatography.
PubMed:Distribution profiles of isoflavone isomers in black bean kojis prepared with various filamentous fungi.
PubMed:Supercritical fluid extraction of isoflavones from biological samples with ultra-fast high-performance liquid chromatography/mass spectrometry.
PubMed:Effect of daidzin, genistin, and glycitin on osteogenic and adipogenic differentiation of bone marrow stromal cells and adipocytic transdifferentiation of osteoblasts.
PubMed:Determination of isoflavones in soy bits by fast column high-performance liquid chromatography coupled with UV-visible diode-array detection.
PubMed:Quantitative determination and structural characterization of isoflavones in nutrition supplements by liquid chromatography-mass spectrometry.
PubMed:Evaluation of isoflavone aglycon and glycoside distribution in soy plants and soybeans by fast column high-performance liquid chromatography coupled with a diode-array detector.
PubMed:Isoflavonoids in the Rutaceae family: 1. Fortunella obovata, Murraya paniculata and four Citrus species.
PubMed:Soy isoflavones suppress invasiveness of breast cancer cells by the inhibition of NF-kappaB/AP-1-dependent and -independent pathways.
PubMed:Isoflavonoid accumulation in soybean hairy roots upon treatment with Fusarium solani.
PubMed:Cytotoxic effects of some animal and vegetable extracts and some chemicals on liver and colon carcinoma and myosarcoma.
PubMed:Simultaneous determination of isoflavones and bisphenol A in rat serum by high-performance liquid chromatography coupled with coulometric array detection.
PubMed:Ultrasound-assisted extraction of soy isoflavones.
PubMed:Determination of isoflavones in ready-to-feed soy-based infant formula.
PubMed:Evaluation of a soybean product fujiflavone P40 as an antiosteoporotic agent in rats.
PubMed:Isoflavone, glyphosate, and aminomethylphosphonic acid levels in seeds of glyphosate-treated, glyphosate-resistant soybean.
PubMed:Stabilities of daidzin, glycitin, genistin, and generation of derivatives during heating.
PubMed:Potent antimutagenic and their anti-lipid peroxidative effect of kaikasaponin III and tectorigenin from the flower of Pueraria thunbergiana.
PubMed:Efficacy and safety of a phytoestrogen preparation derived from Glycine max (L.) Merr in climacteric symptomatology: a multicentric, open, prospective and non-randomized trial.
PubMed:Isoflavone aglycon and glucoconjugate content of high- and low-soy U.K. foods used in nutritional studies.
PubMed:Effects of naturally occurring isoflavones on prostaglandin E2 production.
PubMed:Determination of isoflavones in soy and selected foods containing soy by extraction, saponification, and liquid chromatography: collaborative study.
PubMed:Tectorigenin, an isoflavone of Pueraria thunbergiana Benth., induces differentiation and apoptosis in human promyelocytic leukemia HL-60 cells.
PubMed:Separation and purification of isoflavones from a crude soybean extract by high-speed counter-current chromatography.
PubMed:[Daily intake of isoflavones based on the market basket method].
PubMed:Comparative study on reduction of bone loss and lipid metabolism abnormality in ovariectomized rats by soy isoflavones, daidzin, genistin, and glycitin.
PubMed:Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements.
PubMed:Determination of the levels of isoflavonoids in soybeans and soy-derived foods and estimation of isoflavonoids in the Japanese daily intake.
PubMed:Quantification of isoflavones by capillary zone electrophoresis in soybean seeds: effects of variety and environment.
PubMed:Soy isoflavone analysis: quality control and a new internal standard.
 
Notes:
Present in soya foods; potential nutriceutical
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