EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

piperazine citrate
piperazine 2-hydroxypropane-1,2,3-tricarboxylate (1:1)

Supplier Sponsors

CAS Number: 144-29-6Picture of molecule3D/inchi
Other(deleted CASRN):113484-97-2
ECHA EINECS - REACH Pre-Reg:205-622-8
FDA UNII: RI85381D5G
Beilstein Number:3777748
MDL:MFCD00038961
Molecular Weight:278.26186000
Formula:C10 H18 N2 O7
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 309.60 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000057 mmHg @ 25.00 °C. (est)
Flash Point: 311.00 °F. TCC ( 155.20 °C. ) (est)
logP (o/w): -1.721 (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Piperazine citrate >98%
Odor: characteristic
Use: Piperazine Citrate is an organic compound that consists of a six-membered ring, containting two nitrogen atoms at opposite positions in the ring; first introduced in 1953 as an Anthelmintic.
Maypro Industries
Piperazine Citrate
TCI AMERICA
For experimental / research use only.
Piperazine Citrate Hydrate >98.0%(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-child LDLo 260 mg/kg/3D-I
BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: COMA BEHAVIORAL: HEADACHE
Lancet. Vol. 1, Pg. 895, 1967.

oral-man TDLo 150 mg/kg/5D
GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: TREMOR SENSE ORGANS AND SPECIAL SENSES: DIPLOPIA: EYE
JAMA, Journal of the American Medical Association. Vol. 161, Pg. 515, 1956.

intraperitoneal-mouse LD50 3548 mg/kg
SKIN AND APPENDAGES (SKIN): SWEATING: OTHER BEHAVIORAL: EXCITEMENT
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 274, Pg. 253, 1985.

oral-mouse LD50 8500 mg/kg
BEHAVIORAL: ATAXIA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Medicinal Chemistry. Vol. 6, Pg. 336, 1963.

intravenous-mouse LDLo 100 mg/kg
Compilation of LD50 Values of New Drugs.

intravenous-rabbit LDLo 175 mg/kg
Compilation of LD50 Values of New Drugs.

oral-rat LD50 11200 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Journal of Medicinal Chemistry. Vol. 6, Pg. 336, 1963.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for piperazine citrate usage levels up to:
 not for fragrance use.
 
Recommendation for piperazine citrate flavor usage levels up to:
 not for flavor use.
 
Safety References:
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):144-29-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :114763
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
2-hydroxypropane-1,2,3-tricarboxylic acid;piperazine
Chemidplus:0000144296
RTECS:TL3485000 for cas# 144-29-6
 
References:
 2-hydroxypropane-1,2,3-tricarboxylic acid;piperazine
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):114763
Pubchem (sid):135071059
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.59.9500
MedlinePlusSupp:View
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 helmizin
2-hydroxy-1,2,3-propanetricarboxylate piperazine
2-hydroxypropane-1,2,3-tricarboxylic acid;piperazine
 multifuge citrate
 piperazine 2-hydroxypropane-1,2,3-tricarboxylate (1:1)
 piperazine citrate anhydrous
 piperazine compound with citric acid
 piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt)
 piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (3:2)
 piperazine, citrate (3:2)
 

Articles:

PubMed:Piperazine citrate induced myoclonus in a child.
PubMed:Phytochemical, anti-oxidant and Anthelmintic activities of various leaf extracts of Flacourtia sepiaria Roxb.
PubMed:Anthelmintic and in vitro antioxidant evaluation of fractions of methanol extract of Leea asiatica leaves.
PubMed:Determination of anthelmintic activity of the leaf and bark extract of tamarindus indica linn.
PubMed:A comparative study of the anthelmintic potential of cleome viscosa L. And cleome burmanni w. And a.
PubMed:Cytotoxic and anthelmintic potential of crude saponins isolated from Achillea Wilhelmsii C. Koch and Teucrium Stocksianum boiss.
PubMed:Synthesis and biological evaluation of novel benzothiazole clubbed fluoroquinolone derivatives.
PubMed:Studies on the anthelmintic property of aminobenzylated mannich bases.
PubMed:Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles.
PubMed:Evaluation of Anthelmintic Activities of Aerial Parts of Cynodon dactylon Pers.
PubMed:Impact of subchronic administration of piperazine citrate on the electrocardiogram of the rat.
PubMed:Evaluation of Anthelmintic Activity of Pistia stratiotes Linn.
PubMed:Hypokalemic paralysis following severe vomiting in a child with intestinal obstruction due to round worms.
PubMed:Piperazine protects the rat heart against sudden cardiac death from barium chloride-induced ventricular fibrillation.
PubMed:Anti-inflammatory and anthelmintic activities of Solanum khasianum Clarke.
PubMed:Human infection with Moniliformis moniliformis (Bremser 1811) (Travassos 1915) in Iran: another case report after three decades.
PubMed:Patent Toxocara canis infections in previously exposed and in helminth-free dogs after infection with low numbers of embryonated eggs.
PubMed:Evaluation of anthelmintic activity of nuts of Semecarpus anacardium.
PubMed:In Vitro Anthelmintic Activity of Baliospermum montanum Muell. Arg roots.
PubMed:Time course of effect of piperazine citrate on the electrocardiogram of the rat.
PubMed:Anthelmintic activity of leaves of justicia beddomei.
PubMed:First total synthesis and biological screening of hymenamide E.
PubMed:Anthelmintic activity of aerial parts of melothria heterophylla lour.
PubMed:Occupational asthma due to piperazine citrate.
PubMed:Electrocardiographic profile of oral piperazine citrate in healthy volunteers.
PubMed:EVALUATION OF ANTHELMINTIC ACTIVITIES OF AERIAL PARTS of Celsia coromandeliane Vahl AND Mollugo pentaphylla Linn.
PubMed:Unusual cerebellar ataxia: "worm wobble" revisited.
PubMed:Comparison of practical treatment methods to eradicate pinworm (Dentostomella translucida) infections from Mongolian gerbils (Meroines unguiculatus).
PubMed:Anthelmintic activity of the stem bark extracts of Berlina grandiflora and one of its active principles, Betulinic acid.
PubMed:Management of intestinal obstruction caused by ascariasis.
PubMed:Piperazine neurotoxicity: worm wobble revisited.
PubMed:Ultrasound in the diagnosis of roundworms in gallbladder and common bile duct. Report of four cases.
PubMed:Significant changes in gastrointestinal tract parasitic infections in children of St. Kitts over the 9-year period 1982-1991.
PubMed:Surgical manifestations of ascariasis in childhood.
PubMed:[Ascariasis of the gallbladder. Report of 2 cases and review of the literature].
PubMed:Endogenous formation of N-nitrosamines from piperazine and their urinary excretion following antihelmintic treatment with piperazine citrate.
PubMed:A field evaluation of anthelmintics for control of cyathostomes of horses in Brazil.
PubMed:Mebendazole poisoning in infancy.
PubMed:Prevalence, incidence, intensity and associated morbidity of intestinal helminths in south Thailand.
PubMed:Experimental chemotherapy in horses infected with benzimidazole-resistant small strongyles.
PubMed:Antibodies to diethylcarbamazine cross-react with microfilariae of Wuchereria bancrofti.
PubMed:Some effects of piperazine citrate on skeletal muscle and central nervous system.
PubMed:Piperazine toxicity in Afghan puppies.
PubMed:A comparison of the genetic activity of pyrvinium pamoate with that of several other anthelmintic drugs in Saccharomyces cerevisiae.
PubMed:Mortality of captive tortoises due to viviparous nematodes of the genus Proatractis (Family Atractidae).
PubMed:Piperazine toxicity in a kitten.
PubMed:Biliary ascariasis: ultrasonography, endoscopic retrograde cholangiopancreatography, and biliary drainage.
PubMed:[Determination of piperazine in hen eggs with HPLC following oral administration].
PubMed:Effect of Ascaris lumbricoides on zinc level in blood and urine.
PubMed:Treatment of helminthic diseases.
PubMed:Intestinal nematode infections.
PubMed:Comparative antiarrhythmic and local anaesthetic effects of piperazine citrate and lignocaine hydrochloride.
PubMed:Evaluation of febantel used concurrently with piperazine citrate in horses.
PubMed:A comparative evaluation of mebendazole, piperazine and pyrantel in threadworm infection. Anthelmintic Study Group on Enterobiasis.
PubMed:Effects of piperazine citrate and of the anti-Ascaris fraction of the ethanolic extract of the bark of Polyadoa umbellata (erin) on mammalian non-vascular smooth muscle.
PubMed:Electrophysiological effects of piperazine and diethylcarbamazine on Ascaris suum somatic muscle.
PubMed:Prevention of the platelet alpha-granule release reaction by membrane-active drugs.
PubMed:Single dose piperazine therapy for Ascaris lumbricoides: an unsuccessful method of promoting growth.
PubMed:Hypocalcemic tetany induced by piperazine citrate in a mountain lion.
PubMed:Erythema annulare centrifugum associated with ascariasis.
PubMed:Controlled comparative study of the efficacy of pyrantel pamoate and a combined regimen of piperazine citrate and bephenium hydroxynaphthoate in the treatment of intestinal nemathelminthiases.
PubMed:Piperazine toxicity in a new born.
PubMed:Treatment of Syphacia obvelata in the Syrian hamster (Mesocricetus auratus) with piperazine citrate.
PubMed:Absorption of macronutrients from a rice-vegetable diet before and after treatment of ascariasis in children.
PubMed:Ascariasis and malnutrition. A study in urban Ethiopian children.
PubMed:Eradication of the pinworm Syphacia obvelata from an animal unit by anthelmintic therapy.
PubMed:Ethylenediamine sensitivity with a systemic reaction to piperazine citrate.
PubMed:[Frequency of vulvovaginitis in girls with intestinal enterobiasis].
PubMed:An evaluation of levamisole for treatment of ascariasis.
PubMed:Control of ascariasis by mass treatment with piperazine citrate.
PubMed:Ascaris lumbricoides--a reminder.
PubMed:Treatment of intestinal parasitic disease.
PubMed:Quantitative determination of piperazine citrate in piperazine citrate syrup USP.
PubMed:Human urinary excretion of piperazine citrate from syrup formulations.
PubMed:Pyrantel pamoate in roundworm infestations: a comparative trial with piperazine citrate given in a single dose.
PubMed:Levamisole in the treatment of ascariasis in children.
PubMed:[The result of a single treatment with piperazine citrate in endemic infestation of Ascaris lumbricoides in Usambara, Tanzania].
PubMed:Comparative efficacy of levo-tetramisole, parbendazole, and piperazine citrate against some common helminths of turkeys.
PubMed:Evaluation of the efficacy of methyridine, piperazine citrate and a worm pill for the elimination of Ascaridia galli infection in fowls in intensive confined system.
PubMed:Obliquely striated muscle. 3. Contraction mechanism of Ascaris body muscle.
PubMed:Single-dose treatment for Ascaris infection with piperazine citrate; with a study of the egg-parasite ratio.
PubMed:Possible precipitation of petit mal seizures with piperazine citrate.
PubMed:Some aspects of the pharmacology of piperazine citrate (Antepar) and of the anti-ascaris fraction of the ethanolic extract of the bark of the erin tree (Polyadoa umbellata-Dalziel).
PubMed:A study of the efficacy of thiabendazole and dithiazanine iodide-piperazine citrate suspension against intestinal parasites in the Macaca mulatta.
PubMed:[COLORIMETRIC DETERMINATION OF HETRAZAN, PIPERAZINE CITRATE, AND THEIR PREPARATIONS].
PubMed:[Results of the treatment of oxyuriasis with Adipinian and piperazine citrate in children's homes in Gdansk and Sopot].
PubMed:Effect of diethylcarbamazine, oxophenarsine hydrochloride and piperazine citrate on toxocara canis larvae in mice.
PubMed:An evaluation of piperazine citrate for preventing prenatal infections with the common dog ascarid (Toxocara canis).
PubMed:Two case histories of serum sickness-like reaction following piperazine citrate (antepar).
PubMed:An acute urticarial reaction to piperazine citrate.
PubMed:Efficacy of piperazine citrate in removing worms from the alimentary canal of cattle.
PubMed:[Piperazine citrate in ascariasis associated with typhoid fever].
PubMed:On the single-dose treatment of ascariasis with piperazine citrate.
PubMed:[Piperazine citrate in the management of ascariasis].
PubMed:Mass treatment of ascariasis with a single dose of piperazine citrate.
PubMed:Preliminary studies on the anthelmintic properties of piperazine citrate in dogs.
PubMed:The effectiveness of piperazine citrate against intestinal helminths of the cat and dog.
PubMed:Treatment of multiple intestinal worm infections with piperazine citrate.
PubMed:[Piperazine citrate for treatment of oxyuriasis].
PubMed:[Piperazine citrate and hexylresorcinol therapy of ascariasis; study of 157 cases].
PubMed:Treatment of ascariasis in children with a single dose of piperazine citrate.
PubMed:Comparison of two regimes for the treatment of enterobiasis with piperazine citrate.
PubMed:[Infections by Ascaris lumbricoides in children treated with piperazine citrate].
PubMed:Oxyuriasis: incidence in two socioeconomic groups of negro children; use of piperazine citrate in therapy.
PubMed:[Anthelmintic effect of piperazine citrate on oxyria and ascarides].
PubMed:Anaphylactogenic properties of piperazine citrate.
PubMed:The treatment of cases of ascariasis with piperazine citrate with observations of the effect of the drug on other helminthiases.
PubMed:Treatment of roundworm with piperazine citrate: antepar.
PubMed:Treatment of Ascaris lumbricoides infections with piperazine citrate.
 
Notes:
None found
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