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nivalenol
trichothec-9-en-8-one, 12,13-epoxy-3a,4β,7a,15-tetrahydroxy- (8CI)

Supplier Sponsors

CAS Number: 23282-20-4Picture of molecule3D/inchi
FDA UNII: 5WOP02RM1U
Beilstein Number:3625724
MDL:MFCD10567355
XlogP3-AA:-1.70 (est)
Molecular Weight:312.31880000
Formula:C15 H20 O7
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:toxic natural substances
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 222.00 °C. @ 760.00 mm Hg
Boiling Point: 585.09 °C. @ 760.00 mm Hg (est)
Flash Point: 432.00 °F. TCC ( 221.90 °C. ) (est)
logP (o/w): -1.558 (est)
Soluble in:
 water, 8.589e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Standard Solution Nivalenol
Odor: characteristic
Use: The 100 ppm acetonitrile solution of Nivalenol, a kind of type-B trichothecene mycotoxin, could be used as standard solution.
Santa Cruz Biotechnology
For experimental / research use only.
Nivalenol hydrate
Santa Cruz Biotechnology
For experimental / research use only.
Nivalenol in acetonitrile
Sigma-Aldrich
For experimental / research use only.
Nivalenol hydrate
analytical standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 4 mg/kg
GASTROINTESTINAL: OTHER CHANGES BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE ENDOCRINE: OTHER CHANGES
Cancer Research. Vol. 28, Pg. 2393, 1968.

intravenous-mouse LD50 6300 ug/kg
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Fundamental and Applied Toxicology. Vol. 4, Pg. S124, 1984.

oral-mouse LD50 5 mg/kg
Eisei Kagaku. Hygienic Chemistry. Vol. 30, Pg. 251, 1984.

intraperitoneal-rat LD50 4100 ug/kg
Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. Vol. 31, Pg. 144, 1990.

oral-rat LD50 19500 ug/kg
Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. Vol. 31, Pg. 144, 1990.

Dermal Toxicity:
subcutaneous-mouse LD50 5200 ug/kg
Japanese Journal of Experimental Medicine. Vol. 42, Pg. 91, 1972.

subcutaneous-rat LD50 900 ug/kg
Developments in Food Science. Vol. 4, Pg. 135, 1983.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
toxic natural substances
Recommendation for nivalenol usage levels up to:
 not for fragrance use.
 
Recommendation for nivalenol flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on risks for animal and public health related to the presence of nivalenol in food and feed
View page or View pdf

The in vivo genotoxicity studies on nivalenol and deoxynivalenol
View page or View pdf

Appropriateness to set a group health based guidance value for nivalenol and its modified forms
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :31829
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0023282204
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):31829
Pubchem (sid):134994769
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):C06080
HMDB (The Human Metabolome Database):HMDB04304
FooDB:FDB023361
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 fusarium nivale
Search PMC Picture
 
Synonyms:
12,13-epoxy-3,4,7,15-tetrahydroxytrichothec-9-en-8-one
(3alpha,4beta,7alpha)-3,4,7,15-tetrahydroxy-12,13-epoxytrichothec-9-en-8-one
3-alpha,4-beta,7-alpha,15-tetrahydroxy-12,13-epoxytrichothec-9-en-8-one
3-alpha,4-beta,7-alpha,15-tetrahydroxyscirp-9-en-8-one
 trichothec-9-en-8-one, 12,13-epoxy-3,4,7,15-tetrahydroxy-, (3-alpha,4-beta,7-alpha)-
 trichothec-9-en-8-one, 12,13-epoxy-3,4,7,15-tetrahydroxy-, (3alpha,4beta,7alpha)-
 trichothec-9-en-8-one, 12,13-epoxy-3a,4β,7a,15-tetrahydroxy- (8CI)
 

Articles:

PubMed:Utilising an LC-MS/MS-based multi-biomarker approach to assess mycotoxin exposure in the Bangkok metropolitan area and surrounding provinces.
PubMed:Natural occurrence of mycotoxins in forage maize during crop growth in Japan: case study.
PubMed:Genetic approaches to chemotype determination in type B-trichothecene producing Fusaria.
PubMed:Development, optimization and validation of a multimethod for the determination of 36 mycotoxins in wines by liquid chromatography-tandem mass spectrometry.
PubMed:Genetic relationships, carbendazim sensitivity and mycotoxin production of the Fusarium graminearum populations from maize, wheat and rice in eastern China.
PubMed:Occurrence of pre- and post-harvest mycotoxins and other secondary metabolites in Danish maize silage.
PubMed:Exposure assessment approach through mycotoxin/creatinine ratio evaluation in urine by GC-MS/MS.
PubMed:Toxicological interactions between the mycotoxins deoxynivalenol, nivalenol and their acetylated derivatives in intestinal epithelial cells.
PubMed:Improved method for the simultaneous determination of aflatoxins, ochratoxin A and Fusarium toxins in cereals and derived products by liquid chromatography-tandem mass spectrometry after multi-toxin immunoaffinity clean up.
PubMed:Simultaneous determination of major type B trichothecenes and deoxynivalenol-3-glucoside in animal feed and raw materials using improved DSPE combined with LC-MS/MS.
PubMed:Fusarium species, chemotype characterisation and trichothecene contamination of durum and soft wheat in an area of central Italy.
PubMed:Evidence for a reversible drought induced shift in the species composition of mycotoxin producing Fusarium head blight pathogens isolated from symptomatic wheat heads.
PubMed:Quantitative determination of trichothecenes in breadsticks by gas chromatography-triple quadrupole tandem mass spectrometry.
PubMed:Effects of oral exposure to naturally-occurring and synthetic deoxynivalenol congeners on proinflammatory cytokine and chemokine mRNA expression in the mouse.
PubMed:The Kidneys of Infant Mice are not Sensitive to the Food Mycotoxin Contaminant Nivalenol.
PubMed:Multiclass analysis of mycotoxins in biscuits by high performance liquid chromatography-tandem mass spectrometry. Comparison of different extraction procedures.
PubMed:Trichothecene genotypes and production profiles of Fusarium graminearum isolates obtained from barley cultivated in Argentina.
PubMed:The prevalence and impact of Fusarium head blight pathogens and mycotoxins on malting barley quality in UK.
PubMed:Combining the quick, easy, cheap, effective, rugged and safe approach and clean-up by immunoaffinity column for the analysis of 15 mycotoxins by isotope dilution liquid chromatography tandem mass spectrometry.
PubMed:Real-time loop-mediated isothermal amplification (LAMP) assay for group specific detection of important trichothecene producing Fusarium species in wheat.
PubMed:[Simultaneous trichothecenes analysis by LC-MS/MS with a pentafluorophenyl column].
PubMed:Toxicokinetics and tissue depletion of Fusarenon-X and its metabolite nivalenol in piglets.
PubMed:Modulation of mucin mRNA (MUC5AC and MUC5B) expression and protein production and secretion in Caco-2/HT29-MTX co-cultures following exposure to individual and combined Fusarium mycotoxins.
PubMed:Phytotoxicity evaluation of type B trichothecenes using a Chlamydomonas reinhardtii model system.
PubMed:Structural determination of a nivalenol glucoside and development of an analytical method for the simultaneous determination of nivalenol and deoxynivalenol, and their glucosides, in wheat.
PubMed:Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol.
PubMed:Cooccurrence of mycotoxins in maize and poultry feeds from Brazil by liquid chromatography/tandem mass spectrometry.
PubMed:Surface binding of toxins and heavy metals by probiotics.
PubMed:Incidence and multiplex PCR based detection of trichothecene chemotypes of Fusarium culmorum isolates collected from freshly harvested Maize kernels in Southern India.
PubMed:QuickTox Kit for QuickScan DON (Vomitoxin).
PubMed:Mycotoxins: diffuse and point source contributions of natural contaminants of emerging concern to streams.
PubMed:A survey of trichothecenes, zearalenone and patulin in milled grain-based products using GC-MS/MS.
PubMed:Fusarial toxins: secondary metabolites of Fusarium fungi.
PubMed:Bio-monitoring of mycotoxin exposure in Cameroon using a urinary multi-biomarker approach.
PubMed:Exposure estimates to Fusarium mycotoxins through cereals intake.
PubMed:Development of a liquid chromatography-tandem mass spectrometry with ultrasound-assisted extraction and auto solid-phase clean-up method for the determination of Fusarium toxins in animal derived foods.
PubMed:Multiple mycotoxin exposure determined by urinary biomarkers in rural subsistence farmers in the former Transkei, South Africa.
PubMed:Deoxynivalenol and other selected Fusarium toxins in Swedish wheat--occurrence and correlation to specific Fusarium species.
PubMed:Deoxynivalenol and other selected Fusarium toxins in Swedish oats--occurrence and correlation to specific Fusarium species.
PubMed:Occurrence of Fusarium mycotoxins in Italian cereal and cereal products from organic farming.
PubMed:Survey of 7 trichothecenes in corn-derived feed and feed ingredients.
PubMed:Regional differences in species composition and toxigenic potential among Fusarium head blight isolates from Uruguay indicate a risk of nivalenol contamination in new wheat production areas.
PubMed:Monitoring of Fusarium trichothecenes in Canadian cereal grain shipments from 2010 to 2012.
PubMed:Comparative hematoxicity of fusirium mycotoxin in experimental sprague-dawley rats.
PubMed:Mycoflora and mycotoxin contamination of Roundup Ready soybean harvested in the Pampean Region, Argentina.
PubMed:New insights into mycotoxin mixtures: the toxicity of low doses of Type B trichothecenes on intestinal epithelial cells is synergistic.
PubMed:Occurrence of different trichothecenes and deoxynivalenol-3-β-D-glucoside in naturally and artificially contaminated Danish cereal grains and whole maize plants.
PubMed:Development, validation and application of a multi-mycotoxin method for the analysis of whole wheat plants.
PubMed:Individual and combined cytotoxic effects of Fusarium toxins (deoxynivalenol, nivalenol, zearalenone and fumonisins B1) on swine jejunal epithelial cells.
PubMed:Development and certification of a reference material for Fusarium mycotoxins in wheat flour.
PubMed:Multiclass mycotoxin analysis in Silybum marianum by ultra high performance liquid chromatography-tandem mass spectrometry using a procedure based on QuEChERS and dispersive liquid-liquid microextraction.
PubMed:Trichothecene genotypes of Fusarium graminearum from wheat in Uruguay.
PubMed:Development of a monoclonal antibody against deoxynivalenol for magnetic nanoparticle-based extraction and an enzyme-linked immunosorbent assay.
PubMed:Determination of mycotoxins in bee pollen by gas chromatography-tandem mass spectrometry.
PubMed:Modulation of porcine β-defensins 1 and 2 upon individual and combined Fusarium toxin exposure in a swine jejunal epithelial cell line.
PubMed:Nivalenol and deoxynivalenol affect rat intestinal epithelial cells: a concentration related study.
PubMed:Factors influencing deoxynivalenol accumulation in small grain cereals.
PubMed:Multi-mycotoxin analysis in wheat semolina using an acetonitrile-based extraction procedure and gas chromatography-tandem mass spectrometry.
PubMed:Occurrence and distribution of 13 trichothecene toxins in naturally contaminated maize plants in Germany.
PubMed:Contamination of barley seeds with Fusarium species and their toxins in Spain: an integrated approach.
PubMed:Mycotoxins in the environment: I. Production and emission from an agricultural test field.
PubMed:Masked mycotoxins: a review.
PubMed:Comparison of emetic potencies of the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol.
PubMed:Analysis of mycotoxins in barley using ultra high liquid chromatography high resolution mass spectrometry: comparison of efficiency and efficacy of different extraction procedures.
PubMed:Opposite effects of two trichothecene mycotoxins, deoxynivalenol and nivalenol, on the levels of macrophage inflammatory protein (MIP)-1α and MIP-1β in HL60 cells.
PubMed:Comprehensive gene expression analysis of type B trichothecenes.
PubMed:Co-occurrence and risk assessment of mycotoxins in food and diet from Mediterranean area.
PubMed:Determination of deoxynivalenol and nivalenol by liquid chromatography and fluorimetric detection with on-line chemical post-column derivatization.
PubMed:Quantitation of mycotoxins in food and feed from Burkina Faso and Mozambique using a modern LC-MS/MS multitoxin method.
PubMed:Trichothecenes and zearalenone production by Fusarium equiseti and Fusarium semitectum species isolated from Argentinean soybean.
PubMed:Interlaboratory study of LC-UV and LC-MS methods for the simultaneous determination of deoxynivalenol and nivalenol in wheat.
PubMed:TRI12 based quantitative real-time PCR assays reveal the distribution of trichothecene genotypes of F. graminearum and F. culmorum isolates in Danish small grain cereals.
PubMed:A Dutch field survey on fungal infection and mycotoxin concentrations in maize.
PubMed:Mycotoxin contamination of cereal grain commodities in relation to climate in North West Europe.
PubMed:Durum wheat in conventional and organic farming: yield amount and pasta quality in Southern Italy.
PubMed:Development and validation of a rapid multi-biomarker liquid chromatography/tandem mass spectrometry method to assess human exposure to mycotoxins.
PubMed:Phylogenetic analyses and toxigenic profiles of Fusarium equiseti and Fusarium acuminatum isolated from cereals from Southern Europe.
PubMed:Development of a PCR assay to detect the potential production of nivalenol in Fusarium poae.
PubMed:Molecular studies to identify the Fusarium species responsible for HT-2 and T-2 mycotoxins in UK oats.
PubMed:Comparison of murine anorectic responses to the 8-ketotrichothecenes 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, fusarenon X and nivalenol.
PubMed:Analytical method for the accurate determination of tricothecenes in grains using LC-MS/MS: a comparison between MRM transition and MS3 quantitation.
PubMed:Chemical and physical characteristics of the principal mycotoxins.
PubMed:Development of a simultaneous liquid chromatography/tandem mass spectrometric method for the determination of type B trichothecenes, their derivatives, and precursors in wheat.
PubMed:Deoxynivalenol, deoxynivalenol-3-glucoside, and enniatins: the major mycotoxins found in cereal-based products on the Czech market.
PubMed:Incidence of Fusarium species and mycotoxins in silage maize.
PubMed:Distribution of Fusarium mycotoxins in UK wheat mill fractions.
PubMed:Genotyping and phenotyping of Fusarium graminearum isolates from Germany related to their mycotoxin biosynthesis.
PubMed:Detection of a new Fusarium masked mycotoxin in wheat grain by high-resolution LC-Orbitrap™ MS.
PubMed:Cross-reactivity of some commercially available deoxynivalenol (DON) and zearalenone (ZEN) immunoaffinity columns to DON- and ZEN-conjugated forms and metabolites.
PubMed:Nuclear factor-κB inhibitors alleviate nivalenol-induced cytotoxicity in HL60 cells.
PubMed:Occurrence of Fusarium mycotoxins in rice and its milling by-products in Korea.
PubMed:Development of a multi-mycotoxin analysis in beer-based drinks by a modified QuEChERS method and ultra-high-performance liquid chromatography coupled with tandem mass spectrometry.
PubMed:Molecular survey of trichothecene genotypes of Fusarium graminearum species complex from barley in southern Brazil.
PubMed:Verification of the effectiveness of SCAR (sequence characterized amplified region) primers for the identification of Polish strains of Fusarium culmorum and their potential ability to produce B-trichothecenes and zearalenone.
PubMed:Evaluation of matrix solid-phase dispersion (MSPD) extraction for multi-mycotoxin determination in different flours using LC-MS/MS.
PubMed:Natural occurrence of type-B trichothecene mycotoxins in Korean cereal-based products.
PubMed:Natural deoxynivalenol occurrence and genotype and chemotype determination of a field population of the Fusarium graminearum complex associated with soybean in Argentina.
PubMed:Fusarium sibiricum sp. nov, a novel type A trichothecene-producing Fusarium from northern Asia closely related to F. sporotrichioides and F. langsethiae.
PubMed:Distinct distribution of deoxynivalenol, nivalenol, and ergosterol in Fusarium-infected Japanese soft red winter wheat milling fractions.
PubMed:[Natural occurrence of masked deoxynivalenol and multi-mycotoxins in cereals from China harvested in 2007 and 2008].
PubMed:[Dietary exposure assessment of some important Fusarium toxins in cereal-based products in China].
PubMed:Biomonitoring of Fusarium spp. mycotoxins: perspectives for an individual exposure assessment tool.
PubMed:Trichothecene genotypes and chemotypes in Fusarium graminearum strains isolated from wheat in Argentina.
PubMed:Species diversity and toxigenic potential of Fusarium graminearum complex isolates from maize fields in northwest Argentina.
PubMed:Cross-reactivity of antibodies in some commercial deoxynivalenol test kits against some fusariotoxins.
PubMed:Distribution of deoxynivalenol and nivalenol in milling fractions from fusarium-infected Japanese wheat cultivars.
PubMed:Simultaneous determination of 10 mycotoxins in grain by ultra-high-performance liquid chromatography-tandem mass spectrometry using ¹³C₁₅-deoxynivalenol as internal standard.
PubMed:Multi-residue screening method to quantify mycotoxins in aqueous environmental samples.
PubMed:Analysis of multiple mycotoxins in cereals under ambient conditions using direct analysis in real time (DART) ionization coupled to high resolution mass spectrometry.
PubMed:Fusarium mycotoxins in various barley cultivars and their transfer into malt.
PubMed:Effects of microbial inoculants on corn silage fermentation, microbial contents, aerobic stability, and milk production under field conditions.
PubMed:Rapid detection of nivalenol and deoxynivalenol in wheat using surface plasmon resonance immunoassay.
PubMed:Development and comparison of two multiresidue methods for the analysis of 17 mycotoxins in cereals by liquid chromatography electrospray ionization tandem mass spectrometry.
PubMed:Detection of Fusarium graminearum DNA using a loop-mediated isothermal amplification (LAMP) assay.
PubMed:Reaction of winter wheat (Triticum aestivum L.) cultivars to infection with Fusarium spp.: mycotoxin contamination in grain and chaff.
PubMed:Less Fusarium infestation and mycotoxin contamination in organic than in conventional cereals.
PubMed:Multi-mycotoxin analysis of maize silage by LC-MS/MS.
PubMed:Trichothecene and beauvericin mycotoxin production and genetic variability in Fusarium poae isolated from wheat kernels from northern Italy.
PubMed:Trichothecene chemotypes of Fusarium culmorum infecting wheat in Tunisia.
PubMed:Acidic pH as a determinant of TRI gene expression and trichothecene B biosynthesis in Fusarium graminearum.
PubMed:Use of the modified quick easy cheap effective rugged and safe sample preparation approach for the simultaneous analysis of type A- and B-trichothecenes in wheat flour.
PubMed:Genetic Fusarium chemotyping as a useful tool for predicting nivalenol contamination in winter wheat.
PubMed:Occurrence of mycotoxins in feed as analyzed by a multi-mycotoxin LC-MS/MS method.
PubMed:A novel and sensitive method for the detection of deoxynivalenol in food by time-resolved fluoroimmunoassay.
PubMed:Fusarium mycotoxin content of UK organic and conventional oats.
PubMed:Changes in ochratoxin A and type B trichothecenes contained in wheat flour during dough fermentation and bread-baking.
PubMed:LC-MS/MS multi-analyte method for mycotoxin determination in food supplements.
PubMed:Fusarium mycotoxin content of UK organic and conventional wheat.
PubMed:Occurrence of Fusarium mycotoxins in maize imported into the UK, 2004-2007.
PubMed:Metabolic pathways of trichothecenes.
PubMed:Trichothecenes NIV and DON modulate the maturation of murine dendritic cells.
PubMed:Development of a generic PCR detection of 3-acetyldeoxy-nivalenol-, 15-acetyldeoxynivalenol- and nivalenol-chemotypes of Fusarium graminearum Clade.
PubMed:Quantification of Fusarium poae DNA and associated mycotoxins in asymptomatically contaminated wheat.
PubMed:Development of a multi-mycotoxin liquid chromatography/tandem mass spectrometry method for sweet pepper analysis.
PubMed:Determination of trichothecenes in wheat grain without sample cleanup using comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry.
PubMed:Nivalenol and the targeting of the female reproductive system as well as haematopoietic and immune systems in rats after 90-day exposure through the diet.
PubMed:Distribution of trichothecenes, zearalenone, and ergosterol in a fractionated wheat harvest lot.
PubMed:Gibberella ear rot of maize (Zea mays) in Nepal: distribution of the mycotoxins nivalenol and deoxynivalenol in naturally and experimentally infected maize.
PubMed:Transfer of Fusarium mycotoxins and 'masked' deoxynivalenol (deoxynivalenol-3-glucoside) from field barley through malt to beer.
PubMed:Effects of B-trichothecenes on luminal glucose transport across the isolated jejunal epithelium of broiler chickens.
PubMed:Fate of trichothecene mycotoxins during the processing: milling and baking.
PubMed:Immunochemical methods in health risk assessment: cross reactivity of antibodies against mycotoxin deoxynivalenol with deoxynivalenol-3-glucoside.
PubMed:LC-MS/MS multi-method for mycotoxins after single extraction, with validation data for peanut, pistachio, wheat, maize, cornflakes, raisins and figs.
PubMed:Mycotoxins in breakfast cereals from the Canadian retail market: a 3-year survey.
PubMed:Fate of the fusarium mycotoxins, deoxynivalenol, nivalenol and zearalenone, during extrusion of wholemeal wheat grain.
PubMed:Mycotoxins in rice.
PubMed:Determination of trichothecenes in cereals and cereal-based products by liquid chromatography-tandem mass spectrometry.
PubMed:Immunotoxicity of nivalenol after subchronic dietary exposure to rats.
PubMed:A 90-day subchronic toxicity study of nivalenol, a trichothecene mycotoxin, in F344 rats.
PubMed:Comparison of four C18 columns for the liquid chromatographic determination of deoxynivalenol in naturally contaminated wheat.
PubMed:Estimating mycotoxin contents of Fusarium-damaged winter wheat kernels.
PubMed:Changes in fungi and mycotoxins in pearl millet under controlled storage conditions.
PubMed:Levels of fungi and mycotoxins in the samples of grain and grain dust collected from five various cereal crops in eastern Poland.
PubMed:Effect of subacute oral doses of nivalenol on immune and metabolic defence systems in mice.
PubMed:Occurrence of Fusarium species and trichothecenes in Nigerian maize.
PubMed:Development and application of analytical methods for the determination of mycotoxins in organic and conventional wheat.
PubMed:Degradation of trichothecene mycotoxins by chicken intestinal microbes.
PubMed:Production and characterization of a monoclonal antibody that cross-reacts with the mycotoxins nivalenol and 4-deoxynivalenol.
PubMed:Mycotoxins in developing countries: A case study of maize in Nepal.
PubMed:Multiplex PCR assay for the identification of nivalenol, 3- and 15-acetyl-deoxynivalenol chemotypes in Fusarium.
PubMed:Development of a liquid chromatography/time-of-flight mass spectrometric method for the simultaneous determination of trichothecenes, zearalenone and aflatoxins in foodstuffs.
PubMed:A new solid phase extraction clean-up method for the determination of 12 type A and B trichothecenes in cereals and cereal-based food by LC-MS/MS.
PubMed:Development of a liquid chromatography/tandem mass spectrometry method for the simultaneous determination of 16 mycotoxins on cellulose filters and in fungal cultures.
PubMed:Survey of the mycobiota of Spanish malting barley and evaluation of the mycotoxin producing potential of species of Alternaria, Aspergillus and Fusarium.
PubMed:Individual and combined effects of low oral doses of deoxynivalenol and nivalenol in mice.
PubMed:Determination of 12 type A and B trichothecenes in cereals by liquid chromatography-electrospray ionization tandem mass spectrometry.
PubMed:Characterization of Fusarium spp. isolates by PCR-RFLP analysis of the intergenic spacer region of the rRNA gene (rDNA).
PubMed:Development of a multicomponent method for Fusarium toxins using LC-MS/MS and its application during a survey for the content of T-2 toxin and deoxynivalenol in various feed and food samples.
PubMed:Intake estimates for trichothecene toxins of the population in Southwest Germany in 1998 and in 1999.
PubMed:Incidence of trichothecenes and zearalenone in poultry feed mixtures from Slovakia.
PubMed:Estimated dietary exposure to principal food mycotoxins from the first French Total Diet Study.
PubMed:Recent advances on the use of adsorbent materials for detoxification of Fusarium mycotoxins.
PubMed:Effects of trichothecene mycotoxins on eukaryotic cells: a review.
PubMed:Assessment of trichothecene chemotypes of Fusarium culmorum occurring in Europe.
PubMed:A rapid multiresidual determination of type A and type B trichothecenes in wheat flour by HPLC-ESI-MS.
PubMed:Development of a multiresidue method for analysis of major Fusarium mycotoxins in corn meal using liquid chromatography/tandem mass spectrometry.
PubMed:Fusarium graminearum, F. cortaderiae and F. pseudograminearum in New Zealand: molecular phylogenetic analysis, mycotoxin chemotypes and co-existence of species.
PubMed:Mycotoxins in laboratory rodent feed.
PubMed:Determination of trichothecenes in duplicate diets of young children by capillary gas chromatography with mass spectrometric detection.
PubMed:[Analysis of trichothecenes in barley tea and beer by liquid chromatography/tandem mass spectrometry].
PubMed:Structural elucidation and analysis of thermal degradation products of the Fusarium mycotoxin nivalenol.
PubMed:Morphological, chemical and molecular differentiation of Fusarium equiseti isolated from Norwegian cereals.
PubMed:A multicomponent method for Fusarium toxins in cereal based food and feed samples using HPLC-MS/MS.
PubMed:[Isolation and structural elucidation of thermal degradation products of theFusarium mycotoxin nivalenol].
PubMed:Dietary origin of mycotoxins with estrogenic potential and possible health implications to female dogs.
PubMed:Induction of apoptosis and cytokine production in the Jurkat human T cells by deoxynivalenol: role of mitogen-activated protein kinases and comparison to other 8-ketotrichothecenes.
PubMed:Survey of Fusarium toxins in foodstuffs of plant origin marketed in Germany.
PubMed:A practical method for measuring deoxynivalenol, nivalenol, and T-2 + HT-2 toxin in foods by an enzyme-linked immunosorbent assay using monoclonal antibodies.
PubMed:Cytotoxicity induced by nivalenol, deoxynivalenol, and fumonisin B1 in the SF-9 insect cell line.
PubMed:Simultaneous liquid chromatography-fluorescence analysis of type A and type B trichothecenes as fluorescent derivatives via reaction with coumarin-3-carbonyl chloride.
PubMed:Patterns of trichothecene production, genetic variability, and virulence to wheat of Fusarium graminearum from smallholder farms in Nepal.
PubMed:Effects of grain sampling procedures on fusarium mycotoxin assays in wheat grains.
PubMed:The risk assessment paradigm and its application for trichothecenes.
PubMed:Report from SCOOP task 3.2.10 "collection of occurrence data of Fusarium toxins in food and assessment of dietary intake by the population of EU member states". Subtask: trichothecenes.
PubMed:Toxicity data relevant for hazard characterization.
PubMed:Diversity in metabolite production by Fusarium langsethiae, Fusarium poae, and Fusarium sporotrichioides.
PubMed:Natural occurrence of trichothecenes on lodged and water-damaged domestic rice in Japan.
PubMed:Nivalenol, a main Fusarium toxin in dietary foods from high-risk areas of cancer of esophagus and gastric cardia in China, induced benign and malignant tumors in mice.
PubMed:Influence of environmental factors on the biosynthesis of type B trichothecenes by isolates of Fusarium spp. from Spanish crops.
PubMed:Microbial loads, mycotoxins, and quality of durum wheat from the 2001 harvest of the northern plains region of the United States.
PubMed:Evaluation of the intestinal absorption of deoxynivalenol and nivalenol by an in vitro gastrointestinal model, and the binding efficacy of activated carbon and other adsorbent materials.
PubMed:Analysis of the Fusarium mycotoxins fusaproliferin and trichothecenes in grains using gas chromatography-mass spectrometry.
PubMed:Comparative cytotoxicity of deoxynivalenol, nivalenol, their acetylated derivatives and de-epoxy metabolites.
PubMed:Survey of ochratoxin A and deoxynivalenol in stored grains from the 1999 harvest in the UK.
PubMed:Zearalenone in maize: stability testing and matrix characterisation of a certified reference material.
PubMed:Effects of heating procedures on deoxynivalenol, nivalenol and zearalenone levels in naturally contaminated barley and wheat.
PubMed:Rapid surface plasmon resonance-based inhibition assay of deoxynivalenol.
PubMed:A rapid and sensitive cytotoxicity screening assay for trichothecenes in cereal samples.
PubMed:Lack of de-epoxidation of type B trichothecenes in incubates with human faeces.
PubMed:Two-dimensional environmental profiles of growth, deoxynivalenol and nivalenol production by Fusarium culmorum on a wheat-based substrate.
PubMed:Deoxynivalenol and other Fusarium toxins in wheat and rye flours on the Danish market.
PubMed:Mycotoxins in infant cereal foods from the Canadian retail market.
PubMed:Transformation of trichothecenes in ileal digesta and faeces from pigs.
PubMed:Removal of common Fusarium toxins in vitro by strains of Lactobacillus and Propionibacterium.
PubMed:Statistically designed experiments in a tiered approach to screen mixtures of Fusarium mycotoxins for possible interactions.
PubMed:Cytotoxicity of trichothecenes and fusarochromanone produced by Fusarium equiseti strains isolated from Norwegian cereals.
PubMed:Effects of mould and toxin contaminated barley on laying hens performance and health.
PubMed:Further survey of the occurrence of Fusarium toxins in wheat grown in southwest Germany.
PubMed:Fusarium toxins in wheat flour collected in an area in southwest Germany.
PubMed:Fusarium toxins in wheat from an area in Henan Province, PR China, with a previous human red mould intoxication episode.
PubMed:Differential upregulation of TNF-alpha, IL-6, and IL-8 production by deoxynivalenol (vomitoxin) and other 8-ketotrichothecenes in a human macrophage model.
PubMed:Levels of fungi and mycotoxins in samples of grain and grain dust collected on farms in Eastern Poland.
PubMed:Production of culmorin compounds and other secondary metabolites by Fusarium culmorum and F. graminearum strains isolated from Norwegian cereals.
PubMed:Toxigenic potential of Fusarium culmorum strains isolated from French wheat.
PubMed:Effect of time, temperature and solvent on the stability of T-2 toxin, HT-2 toxin, deoxynivalenol and nivalenol calibrants.
PubMed:Stability of the fusarium mycotoxins nivalenol, deoxynivalenol and zearalenone in ground maize under typical cooking environments.
PubMed:Detection of trichothecenes in animal feeds and foodstuffs during the years 1997 to 2000 in Saudi Arabia.
PubMed:Trichothecenes, ochratoxin A and zearalenone contamination and fusarium infection in Finnish cereal samples in 1998.
PubMed:Sources of variation in the analysis of trichothecenes in cereals by gas chromatography-mass spectrometry.
PubMed:Effects of mycotoxins on human immune functions in vitro.
PubMed:Fusariotoxins in kernels of winter wheat cultivars field samples collected during 1993 in Poland.
PubMed:Impact of competitive fungi on Trichothecene production by Fusarium graminearum.
PubMed:Occurrence of trichothecenes in Argentinean beer: a preliminary exposure assessment.
PubMed:Evaluation of mycotoxin-contaminated cereals for their use in animal feeds in Hungary.
PubMed:Chromatographic methods for trichothecenes.
PubMed:The occurrence of HT-2 toxin and other trichothecenes in Norwegian cereals.
PubMed:Production of T-2 toxin by a Fusarium resembling Fusarium poae.
PubMed:A survey of Fusarium toxins in cereal-based foods marketed in an area of southwest Germany.
PubMed:Nivalenol inhibits total and antigen-specific IgE production in mice.
PubMed:Occurrence of Fusarium species and mycotoxins in nepalese maize and wheat and the effect of traditional processing methods on mycotoxin levels.
PubMed:Apoptosis induction by the satratoxins and other trichothecene mycotoxins: relationship to ERK, p38 MAPK, and SAPK/JNK activation.
PubMed:Fusarium species from nepalese rice and production of mycotoxins and gibberellic acid by selected species.
PubMed:Mycotoxins (trichothecenes, zearalenone and fumonisins) in cereals associated with human red-mold intoxications stored since 1989 and 1991 in China.
PubMed:Quantitative determination and structure elucidation of type A- and B-trichothecenes by HPLC/ion trap multiple mass spectrometry.
PubMed:Co-occurrence of Fusarium mycotoxins in mouldy and healthy corn from Korea.
PubMed:Mycotoxin production and cytotoxicity of Fusarium strains isolated from Norwegian cereals.
PubMed:In vitro exposure of human lymphocytes to trichothecenes: individual variation in sensitivity and effects of combined exposure on lymphocyte function.
PubMed:A colorimetric technique for detecting trichothecenes and assessing relative potencies.
PubMed:Natural occurrence of Fusarium toxins in oats harvested during five years in an area of southwest Germany.
PubMed:Determination of trichothecenes in cereals.
PubMed:Natural co-occurrence of aflatoxins and Fusarium mycotoxins (fumonisins, deoxynivalenol, nivalenol and zearalenone) in corn from Indonesia.
PubMed:Mycotoxins in ingredients of animal feeding stuffs: II. Determination of mycotoxins in maize and maize products.
PubMed:Novel detoxification of the trichothecene mycotoxin deoxynivalenol by a soil bacterium isolated by enrichment culture.
PubMed:Determination of the fate of three Fusarium mycotoxins through wet-milling of maize using an improved HPLC analytical technique.
PubMed:Multi-year monitoring of Canadian grains and grain-based foods for trichothecenes and zearalenone.
PubMed:Production of trichothecenes and zearalenone by isolates of Fusarium spp. from Argentinian maize.
PubMed:Natural occurrence of trichothecenes and zearalenone in Korean and imported beers.
PubMed:Mycotoxins in fungal contaminated samples of animal feed from western Canada, 1982-1994.
PubMed:Physicochemical data for some selected Fusarium toxins.
PubMed:Analysis of trichothecene mycotoxins in contaminated grains by gas chromatography/matrix isolation/Fourier transform infrared spectroscopy and gas chromatography/mass spectrometry.
PubMed:Survey of natural occurrence of trichothecene mycotoxins and zearalenone in Korean cereals harvested in 1992 using gas chromatography/mass spectrometry.
PubMed:Effects of trichothecene structure on cytokine secretion and gene expression in murine CD4+ T-cells.
PubMed:Mycotoxins and fungi in wheat harvested during 1990 in test plots in the state of São Paulo, Brazil.
PubMed:Natural occurrence of acetylated derivatives of deoxynivalenol and nivalenol in wheat and barley in Japan.
PubMed:Mycotoxins and fungi in wheat stored in elevators in the state of Rio Grande do Sul, Brazil.
PubMed:[Comparative investigations of mycotoxological status of alternatively and conventionally grown crops].
PubMed:Nivalenol in Swedish cereals--occurrence, production and toxicity towards chickens.
PubMed:Effects of feeding nivalenol-contaminated diets to male broiler chickens.
PubMed:Production of trichothecene mycotoxins by Fusarium graminearum and Fusarium culmorum on barley and wheat.
PubMed:Ear-rot fungi and mycotoxins in South African corn of the 1989 crop exported to Taiwan.
PubMed:Occurrence of nivalenol, deoxynivalenol, and zearalenone in imported cereals in Papua, New Guinea.
PubMed:Natural occurrence of Fusarium mycotoxins (trichothecenes and zearalenone) in barley and corn in Korea.
PubMed:Effects of nivalenol on hepatic drug-metabolizing activity in rats.
PubMed:Analysis of Canadian and imported beers for Fusarium mycotoxins by gas chromatography-mass spectrometry.
PubMed:Fusarium mycotoxins nivalenol and 4-acetyl-nivalenol (fusarenon-X) in mouldy maize harvested from farms in Jos district, Nigeria.
PubMed:Production of polyclonal antibodies to the trichothecene mycotoxin 4,15-diacetylnivalenol with the carrier-adjuvant cholera toxin.
PubMed:Toxins derived from Fusarium graminearum, F. culmorum and F. crookwellense: zearalenone, deoxynivalenol, nivalenol and fusarenone X.
PubMed:Natural occurrence of Fusarium mycotoxins of the 1990 barley crop in Korea.
PubMed:Enhancement of GST-P-positive liver cell foci development by nivalenol, a trichothecene mycotoxin.
PubMed:Decontamination ofFusarium mycotoxins, nivalenol, deoxynivalenol, and zearalenone, in barley by the polishing process.
PubMed:A survey of the natural occurrence of Fusarium mycotoxins in cereals grown in New Zealand in 1986-1989.
PubMed:Survey of the presence of the Fusarium mycotoxins nivalenol, deoxynivalenol and T-2 toxin in Korean cereals of the 1989 harvest.
PubMed:Production and characterization of antibodies against nivalenol tetraacetate.
PubMed:Contents of Fusarium toxins in Finnish and imported grains and feeds.
PubMed:Production of mycotoxins by selected Fusarium graminearum and F. crookwellense isolates.
PubMed:Comparative study on the natural occurrence of Fusarium mycotoxins (trichothecenes and zearalenone) in corn and wheat from high- and low-risk areas for human esophageal cancer in China.
PubMed:A survey of the natural occurrence of Fusarium mycotoxins, deoxynivalenol, nivalenol and zearalenone, in cereals harvested in the Netherlands.
PubMed:Radioimmunoassay of nivalenol in barley.
PubMed:Absence of trichothecenes in toxigenic isolates of Fusarium moniliforme.
PubMed:Determination of deoxynivalenol (DON, vomitoxin) in wheat by high-performance liquid chromatography with photolysis and electrochemical detection (HPLC-hv-EC).
PubMed:Production and characterization of monoclonal antibodies to nivalenol tetraacetate and their application to enzyme-linked immunoassay of nivalenol.
PubMed:Application of capillary gas chromatography to a survey of wheat for five trichothecenes.
PubMed:Subchronic feeding studies with nivalenol in C57BL/6 mice.
PubMed:[Gas chromatography with electron capture detector for determining DON and NIV in scabby wheat].
PubMed:Chronic toxicity of nivalenol in female mice: a 2-year feeding study with Fusarium nivale Fn 2B-moulded rice.
PubMed:A survey on the occurrence of Fusarium mycotoxins in Bavarian cereals from the 1987 harvest.
PubMed:Worldwide occurrence of mycotoxins in foods and feeds--an update.
PubMed:Outbreak of trichothecene mycotoxicosis associated with consumption of mould-damaged wheat production in Kashmir Valley, India.
PubMed:[Determination of trichothecenes in cereals].
PubMed:A sensitive enzyme-linked immunosorbent assay for detection of T-2 toxin with monoclonal antibodies.
PubMed:Gas chromatographic screening method for T-2 toxin, diacetoxyscirpenol, deoxynivalenol, and related trichothecenes in feeds.
PubMed:[Advances in research on the trichothecenes T-2, DON and NIV].
PubMed:A case report on a minor contamination of nivalenol in cereals harvested in Canada.
PubMed:Natural occurrence and clastogenic effects of nivalenol, deoxynivalenol, 3-acetyl-deoxynivalenol, 15-acetyl-deoxynivalenol, and zearalenone in corn from a high-risk area of esophageal cancer.
PubMed:Simultaneous analysis of nivalenol and deoxynivalenol in cereals by liquid chromatography.
PubMed:Fusarium species as pathogens of potato tubers during storage and their ability to produce mycotoxins.
PubMed:Occurrence of Trichothecenes in feed and cereals in Finland.
PubMed:Detection of trace levels of trichothecene mycotoxins in environmental residues and foodstuffs using gas chromatography with mass spectrometric or electron-capture detection.
PubMed:Production and characterization of a generic antibody against group A trichothecenes.
PubMed:Mycological survey of Korean cereals and production of mycotoxins by Fusarium isolates.
PubMed:Determination of nivalenol and deoxynivalenol in cereals by electron-capture gas chromatography.
PubMed:Use of small charcoal/alumina cleanup columns in determination of trichothecene mycotoxins in foods and feeds.
PubMed:Further survey on the Fusarium mycotoxins in Korean cereals.
PubMed:A limited survey of Fusarium mycotoxins nivalenol, deoxynivalenol and zearalenone in 1984 UK harvested wheat and barley.
PubMed:[Studies on the chemical analysis of mycotoxin (XVI). Fate of nivalenol and deoxynivalenol in foods and contaminated wheat during cooking, cleaning and milling processes].
PubMed:[Studies on the chemical analysis of mycotoxin (XV). Analysis of nivalenol and deoxynivalenol in imported cereals, baby foods and processed foods (confectioneries)].
PubMed:Examination of Chinese and U.S.S.R. cereals for the Fusarium mycotoxins, nivalenol, deoxynivalenol and zearalenone.
PubMed:A survey of the occurrence of nivalenol, deoxynivalenol and zearalenone in food stuffs and health foods in Japan.
PubMed:[Gas chromatographic study of deoxynivalenol and nivalenol in cereals following derivatization with heptafluorobutyrates].
PubMed:The coexistence of the Fusarium mycotoxins nivalenol, deoxynivalenol and zearalenone in Korean cereals harvested in 1983.
PubMed:Rapid and sensitive determination of zearalenone in cereals by high-performance liquid chromatography with fluorescence detection.
PubMed:Improved methodology for the simultaneous detection of the trichothecene mycotoxins deoxynivalenol and nivalenol in cereals.
PubMed:[Determination of deoxynivalenol and nivalenol in cereals at the microgram/kilogram range].
PubMed:Chemotaxonomy of Gibberella zeae with special reference to production of trichothecenes and zearalenone.
PubMed:Simultaneous detection of several Fusarium mycotoxins in cereals, grains, and foodstuffs.
 
Notes:
Nivalenol is a trichothecene produced by Fusaria, Stachybotrys, Trichoderma and other fungi, and some higher plants. They may contaminate food or feed grains, induce emesis and hemorrhage in lungs and brain, and damage bone marrow due to protein and DNA synthesis inhibition.(PubChem) It has been reported in the urine of patients suffering chronic idiopathic spastic paraparesis. These patients are usually found in hot and humid regions, most of which have heavy rains, and these conditions allow foods to be polluted by fungi some of which become toxigenic (PubMed ID 8855894 ) [HMDB]
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