EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

monensin sodium
monensin, monosodium salt

Supplier Sponsors

CAS Number: 22373-78-0Picture of molecule3D/inchi
Other(deleted CASRN):22136-43-2
ECHA EINECS - REACH Pre-Reg:244-941-7
FDA UNII: 1GS872GAFV
Beilstein Number:4122200
MDL:MFCD00077826
Molecular Weight:692.86313928
Formula:C36 H61 Na O11
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white to pale yellow powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 766.30 °C. @ 760.00 mm Hg (est)
Flash Point: 445.00 °F. TCC ( 229.20 °C. ) (est)
logP (o/w): 3.716 (est)
Soluble in:
 water, 1.614 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Monensin sodium salt >98%
Odor: characteristic
Use: Sodium Monensin, isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics.It is widely used in ruminant animal feeds.
Carbosynth
For experimental / research use only.
Monensin sodium salt
EMD Millipore
For experimental / research use only.
Monensin, Sodium Salt, High Purity
sds
Glentham Life Sciences
Monensin sodium salt
Santa Cruz Biotechnology
For experimental / research use only.
Monensin Na
Sigma-Aldrich: Sigma
For experimental / research use only.
Monensin sodium salt 90-95% (TLC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-cattle LD50 26 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: ATAXIA
Journal of Animal Science. Vol. 58, Pg. 1512, 1984.

oral-chicken LD50 145 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: MUSCLE WEAKNESS PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
MBI, Mediko Biologicheskaya Informatsiya. Medical-Biological Information. Vol. (3), Pg. 3, 1984.

oral-dog LD50 > 10 mg/kg
BEHAVIORAL: ATAXIA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Journal of Animal Science. Vol. 58, Pg. 1512, 1984.

oral-mouse LD50 44 mg/kg
Journal of Antibiotics. Vol. 36, Pg. 1195, 1983.

oral-rabbit LD50 42 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: ATAXIA
Journal of Animal Science. Vol. 58, Pg. 1512, 1984.

oral-rat LD50 29 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: ATAXIA
Journal of Animal Science. Vol. 58, Pg. 1512, 1984.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for monensin sodium usage levels up to:
 not for fragrance use.
 
Recommendation for monensin sodium flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Review of substances/agents that have direct beneficial effect on the environment: mode of action and assessment of efficacy
View page or View pdf

Safety and efficacy of Monimax® (monensin sodium and nicarbazin) for turkeys for fattening
View page or View pdf

EPI System: View
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :23690927
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0022373780
RTECS:JH2830000 for cas# 22373-78-0
 
References:
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:22373-78-0
Pubchem (cid):23690927
Pubchem (sid):135046468
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 monensin sodium salt
 monensin, monosodium salt
 monensin, sodium salt
 rumensin
 sodium monensin
 

Articles:

PubMed:Analysis of veterinary drug and pesticide residues in animal feed by high-resolution mass spectrometry: comparison between time-of-flight and Orbitrap.
PubMed:Influence of Ionophore Supplementation on Growth Performance, Dietary Energetics and Carcass Characteristics in Finishing Cattle during Period of Heat Stress.
PubMed:Trace level determination of polyether ionophores in feed.
PubMed:Effects of monensin on metabolism and production in dairy saanen goats in periparturient period.
PubMed:Effect of the granulometric characteristics of monensin sodium on controlling experimental coccidiosis in broiler chickens.
PubMed:Determination of ionophore coccidiostats in feeding stuffs by liquid chromatography-tandem mass spectrometry. Part II. Application to cross-contamination levels and non-targeted feed.
PubMed:Multi-residue method for detecting coccidiostats at carry-over level in feed by HPLC-MS/MS.
PubMed:Greenhouse gas, animal performance, and bacterial population structure responses to dietary monensin fed to dairy cows.
PubMed:[The use of monensin premix in dairy cows: simple and essential steps for ensuring its proper use].
PubMed:Long-term assessment of horses and ponies post exposure to monensin sodium in commercial feed.
PubMed:Effects of ionophores and antibiotics on in vitro hydrogen sulfide production, dry matter disappearance, and total gas production in cultures with a steam-flaked corn-based substrate with or without added sulfur.
PubMed:A randomized herd-level field study of dietary interactions with monensin on milk fat percentage in dairy cows.
PubMed:Interaction of molasses and monensin in alfalfa hay- or corn silage-based diets on rumen fermentation, total tract digestibility, and milk production by Holstein cows.
PubMed:Chromatographic analysis of banned antibacterial growth promoters in animal feed.
PubMed:Effect of monensin delivery method on dry matter intake, body condition score, and metabolic parameters in transition dairy cows.
PubMed:Monensin might protect Ontario, Canada dairy cows from paratuberculosis milk-ELISA positivity.
PubMed:Efficacy of monensin sodium for the reduction of fecal shedding of Mycobacterium avium subsp. paratuberculosis in infected dairy cattle.
PubMed:Susceptibility of Mycobacterium avium sbsp paratuberculosis to monensin sodium or tilmicosin phosphate in vitro and resulting infectivity in a murine model.
PubMed:Effect of monensin sodium on lactational performance of autumn- and spring-calving cows.
PubMed:The effect of season and monensin sodium on the digestive characteristics of autumn and spring pasture fed to sheep.
PubMed:Effect of monensin sodium on histological lesions of naturally occurring bovine paratuberculosis.
PubMed:Effect of monensin on milk production and efficiency of dairy cows fed two diets differing in forage to concentrate ratios.
PubMed:Effects of ionophore feeding and anthelmintic administration on age and weight at puberty in spring-born beef heifers.
PubMed:Outbreaks of proliferative haemorrhagic enteropathy on two pig farms.
PubMed:Use of monensin sodium in sheep feeds.
PubMed:Prophylactic effect of monensin sodium against experimentally induced paratuberculosis in mice.
PubMed:Polyether ionophores--effect on rumen function in feedlot cattle.
PubMed:Potential of chemical regulation of food intake and body weight of broiler breeder chicks.
PubMed:Virginiamycin and monensin, alone or in combination, in turkey broiler diets.
PubMed:Effects of concurrent oral administration of monensin on the toxicity of increasing doses of selenium in lambs.
PubMed:Occupational dermatitis in animal feed mill workers.
PubMed:Evaluation of anti-coccidial drugs' inhibition of Neospora caninum development in cell cultures.
PubMed:Concurrent use of the oxfendazole pulse release bolus and the monensin rumen delivery device in young grazing cattle.
PubMed:The effect of monensin against swine dysentery.
PubMed:A myopathy of sheep associated with sarcocystis infection and monensin administration.
PubMed:Use of monensin sodium against Toxoplasma.
PubMed:Influence of lasalocid and monensin plus tylosin on comparative feeding value of steam-flaked versus dry-rolled corn in diets for feedlot cattle.
PubMed:Effects of feeding monensin to lactating goats: acetyl coenzyme A carboxylase, hormone-sensitive lipase, plasma glucose, and circulating hormones.
PubMed:[Toxicity and nutritive action of Pharmakhim's sodium monensin in weaned lambs].
PubMed:[14C]monensin balance in bile-fistulated ponies.
PubMed:Determination of monensin sodium residues in beef liver tissue by liquid chromatography of a fluorescent derivative.
PubMed:The effects of dietary monensin sodium upon superovulation and embryo viability from mature cows.
PubMed:Effects of feeding monensin sodium to lactating goats: milk composition and ruminal volatile fatty acids.
PubMed:[Tolerance, toxicity and residues of Pharmachim's sodium monensin in pigs].
PubMed:Identification and semiquantitation of monensin sodium in liver tissue.
PubMed:Comparative toxicology of monensin sodium in laboratory animals.
PubMed:Accidental monensin sodium intoxication of feedlot cattle.
PubMed:Identification and semiquantitation of monensin sodium in animal feeds by thin layer bioautography.
PubMed:Comparison of two forms and two levels of lasalocid with monensin on feedlot cattle performance.
PubMed:Effect of monensin sodium on the performance and proportions of rumen volatile fatty acids of Friesian bulls.
PubMed:Monensin toxicosis in broiler chickens.
PubMed:Delayed monensin sodium toxicity in horses.
PubMed:The effect of dietary monensin on th luteinizing hormone response of prepuberal heifers given a multiple gonadotropin-releasing hormone challenge.
PubMed:Effect of dietary monensin on ovarian response following gonadotropin treatment in prepuberal heifers.
PubMed:Effect of dietary ingredients on monensin toxicity in chicks.
PubMed:Toxic myopathy in a dog associated with the presence of monensin in dry food.
PubMed:Monensin sodium toxicity in cattle.
PubMed:Monensin sodium toxicity in cattle.
PubMed:Effect of high dietary copper on the ceca of chicks.
PubMed:[Effects of monensin sodium on various hematologic parameters in growing calves].
PubMed:[Effects of monensin sodium on the pH and on the concentration of volatile fatty acids of the ruminal fluid].
PubMed:The influence of monensin sodium upon feather development of male chickens.
PubMed:Kinetics of monensin complexation with sodium ions by 23NaNMR spectroscopy.
PubMed:Anticoccidial activity of eight compounds in domestic mink.
PubMed:Effect of dietary methionine status on response of chicks to coccidial infection.
PubMed:Interaction of aflatoxin with Eimeria tenella infection and monensin in young broiler chickens.
PubMed:Letter: Monensin sodium in horses.
 
Notes:
an antiprotozoal agent produced by streptomyces cinnamonensis. it exerts its effect during the development of first-generation trophozoites into first-generation schizonts within the intestinal epithelial cells. it does not interfere with hosts' development of acquired immunity to the majority of coccidial species. monensin is a sodium and proton selective ionophore and is widely used as such in biochemical studies.
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