EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

flavomycin

Supplier Sponsors

CAS Number: 11015-37-5Picture of molecule3D/inchi
Other(deleted CASRN):11103-61-0
ECHA EINECS - REACH Pre-Reg:234-246-7
FDA UNII: PP922A42V2
MDL:MFCD01742468
XlogP3-AA:-0.50 (est)
Molecular Weight:1597.61249200
Formula:C70 H109 N4 O35 P
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Appearance:white amorphous solid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): 1.983 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Moenomycin complex >95% by HPLC
Odor: characteristic
Use: A mixture of five major components, A, A12, C1, C3 and C4; isolated from several strains of streptomyces; has potent antibiotic activity used in animal health
Santa Cruz Biotechnology
For experimental / research use only.
Moenomycin complex
Sigma-Aldrich
For experimental / research use only.
Flavomycin VETRANAL™, analytical standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-dog LDLo 600 mg/kg
AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" BEHAVIORAL: WAKEFULNESS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Antimicrobial Agents and Chemotherapy Vol. -, Pg. 743, 1965.

intravenous-mouse LD50 200 mg/kg
"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 740, 1978.

Dermal Toxicity:
subcutaneous-mouse LD50 500 mg/kg
"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 740, 1978.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for flavomycin usage levels up to:
 not for fragrance use.
 
Recommendation for flavomycin flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Review of substances/agents that have direct beneficial effect on the environment: mode of action and assessment of efficacy
View page or View pdf

EPI System: View
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6433554
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
Chemidplus:0011015375
RTECS:QA3020000 for cas# 11015-37-5
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):6433554
Pubchem (sid):134989085
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 streptomyces bambergiensis
Search PMC Picture
 
Synonyms:
 bambermycine
 flavofosfolipol
 menomycin
 

Articles:

PubMed:Antimicrobial resistance status of Enterococcus from Australian cattle populations at slaughter.
PubMed:Deciphering the mode of action of cell wall-inhibiting antibiotics using metabolic labeling of growing peptidoglycan in Streptococcus pyogenes.
PubMed:Monensin, virginiamycin, and flavomycin in a no-roughage finishing diet fed to zebu cattle.
PubMed:A gene cluster for the biosynthesis of moenomycin family antibiotics in the genome of teicoplanin producer Actinoplanes teichomyceticus.
PubMed:Effects of dietary fermentation concentrate of Hericium caput-medusae (Bull.:Fr.) Pers. on growth performance, digestibility, and intestinal microbiology and morphology in broiler chickens.
PubMed:Effects of Lactobacillus acidophilus dietary supplementation on the performance, intestinal barrier function, rectal microflora and serum immune function in weaned piglets challenged with Escherichia coli lipopolysaccharide.
PubMed:Positive cooperativity between acceptor and donor sites of the peptidoglycan glycosyltransferase.
PubMed:Structure-based design, synthesis, and biological evaluation of isatin derivatives as potential glycosyltransferase inhibitors.
PubMed:Development of bacterial transglycosylase inhibitors as new antibiotics: moenomycin A treatment for drug-resistant Helicobacter pylori.
PubMed:Regulation of expression of abcA and its response to environmental conditions.
PubMed:MoeH5: a natural glycorandomizer from the moenomycin biosynthetic pathway.
PubMed:Can probiotics improve the environmental microbiome and resistome of commercial poultry production?
PubMed:Tuning the moenomycin pharmacophore to enable discovery of bacterial cell wall synthesis inhibitors.
PubMed:Discovery of nosokophic acid, a predicted intermediate of moenomycins, from nosokomycin-producing Streptomyces sp. K04-0144.
PubMed:Evaluation of the effect of low dietary fermentable carbohydrate content on growth performance, nutrient digestibility, blood characteristics, and meat quality in finishing pigs.
PubMed:Effects of flavomycin and probiotic supplementation to diets containing different sources of fat on growth performance, intestinal morphology, apparent metabolizable energy, and fat digestibility in broiler chickens.
PubMed:Development of a modified selective medium to enhance the recovery rate of Brachyspira hyodysenteriae and other porcine intestinal spirochaetes from faeces.
PubMed:Multiple-antibiotic resistance of Enterococcus faecalis and Enterococcus faecium from cecal contents in broiler chicken and turkey flocks slaughtered in Canada and plasmid colocalization of tetO and ermB genes.
PubMed:Influence of antimicrobial feed additives on broiler commensal posthatch gut microbiota development and performance.
PubMed:Induction kinetics of the Staphylococcus aureus cell wall stress stimulon in response to different cell wall active antibiotics.
PubMed:Prevalence, species distribution and antimicrobial resistance of enterococci isolated from US dairy cattle.
PubMed:Susceptibility of Clostridium difficile toward antimicrobial agents used as feed additives for food animals.
PubMed:Effects of the antibiotic growth promoters flavomycin and florfenicol on the autochthonous intestinal microbiota of hybrid tilapia (Oreochromis niloticus ♀ × O. aureus ♂).
PubMed:Contamination rates and antimicrobial resistance in bacteria isolated from "grass-fed" labeled beef products.
PubMed:Functional and structural analysis of a key region of the cell wall inhibitor moenomycin.
PubMed:The molecular biology of moenomycins: towards novel antibiotics based on inhibition of bacterial peptidoglycan glycosyltransferases.
PubMed:Determination of the banned growth promoter moenomycin A in feed stuffs by liquid chromatography coupled to electrospray ion trap mass spectrometry.
PubMed:Genetic factors that influence moenomycin production in streptomycetes.
PubMed:Synthesis and evaluation of a new fluorescent transglycosylase substrate: lipid II-based molecule possessing a dansyl-C20 polyprenyl moiety.
PubMed:Species distribution and resistance patterns to growth-promoting antimicrobials of enterococci isolated from pigs and chickens in Korea.
PubMed:Complete characterization of the seventeen step moenomycin biosynthetic pathway.
PubMed:Effect of inulin on growth performance, intestinal tract sizes, mineral retention and tibial bone mineralisation in broiler chickens.
PubMed:Effect of dietary antibiotic, probiotic and prebiotic as growth promoters, on growth performance, carcass characteristics and hematological indices of broiler chickens.
PubMed:Risk assessment of ciprofloxacin, flavomycin, olaquindox and colistin sulfate based on microbiological impact on human gut biota.
PubMed:Diversity and susceptibility of Enterococcus isolated from cattle before and after harvest.
PubMed:Fluorescence correlation spectroscopy (FCS)-based characterisation of aptamer ligand interaction.
PubMed:Sodium-butyrate as a growth promoter in milk replacer formula for young calves.
PubMed:Identification and characterization of Streptomyces ghanaensis ATCC14672 integration sites for three actinophage-based plasmids.
PubMed:Effect of a dried Bacillus subtilis culture on gosling growth performance.
PubMed:Effect of the anticoccidial agents halofuginone and monensin when given with growth promoting antibiotics upon the control of coccidiosis in the turkey.
PubMed:Antimicrobial resistance and virulence of Enterococcus faecalis isolated from retail food.
PubMed:Adaptation to flavomycin in the ruminal bacterium, Prevotella bryantii.
PubMed:Determination of the antimicrobial growth promoter moenomycin-A in chicken litter.
PubMed:A long research story culminates in the first total synthesis of moenomycin A.
PubMed:Effect of dietary lactoferrin on the immune functions and serum iron level of weanling piglets.
PubMed:A streamlined metabolic pathway for the biosynthesis of moenomycin A.
PubMed:The total synthesis of moenomycin A.
PubMed:Degradation and reconstruction of moenomycin A and derivatives: dissecting the function of the isoprenoid chain.
PubMed:Effect of lactoferrin on the growth performance, intestinal morphology, and expression of PR-39 and protegrin-1 genes in weaned piglets.
PubMed:Effect of flavophospholipol on conjugation frequency between Escherichia coli donor and recipient pairs in vitro and in the chicken gastrointestinal tract.
PubMed:Screening of Bacillus strains as potential probiotics and subsequent confirmation of the in vivo effectiveness of Bacillus subtilis MA139 in pigs.
PubMed:Characterization of moenomycin antibiotic complex by multistage MALDI-IT/RTOF-MS and ESI-IT-MS.
PubMed:Flavophospholipol use in animals: positive implications for antimicrobial resistance based on its microbiologic properties.
PubMed:Effect of subtherapeutic antimicrobials on genetic diversity of Enterococcus faecium from chickens.
PubMed:Effect of growth promotant usage on enterococci species on a poultry farm.
PubMed:Effect of dietary oligochitosan supplementation on ileal digestibility of nutrients and performance in broilers.
PubMed:Influence of flavomycin on microbial numbers, microbial metabolism and gut tissue protein turnover in the digestive tract of sheep.
PubMed:Efficiency of Echinacea purpurea on performance and immune status in pigs.
PubMed:Purification and structure elucidation of antifungal and antibacterial activities of newly isolated Streptomyces sp. strain US80.
PubMed:Influence of flavomycin on ruminal fermentation and microbial populations in sheep.
PubMed:Performance and caecal adaptation of turkeys to diets without or with antibiotic and with different levels of mannan-oligosaccharide.
PubMed:Synthesis of mono- and disaccharide analogs of moenomycin and lipid II for inhibition of transglycosylase activity of penicillin-binding protein 1b.
PubMed:Susceptibility of Clostridium perfringens strains from broiler chickens to antibiotics and anticoccidials.
PubMed:Aptamers that recognize the lipid moiety of the antibiotic moenomycin A.
PubMed:Species distribution and antibiotic resistance patterns of enterococci isolated from food of animal origin in Germany.
PubMed:Acceptor specificity and inhibition of the bacterial cell-wall glycosyltransferase MurG.
PubMed:Studies on the interaction of the antibiotic moenomycin A with the enzyme penicillin-binding protein 1b.
PubMed:Antimicrobial susceptibilities of Staphylococcus aureus isolated from commercial broilers in northeastern Georgia.
PubMed:Effect of feeding the ionophores monensin and laidlomycin propionate and the antimicrobial bambermycin to sheep experimentally infected with E. coli O157:H7 and Salmonella typhimurium.
PubMed:Effects of the antibiotic ionophores monensin, lasalocid, laidlomycin propionate and bambermycin on Salmonella and E. coli O157:H7 in vitro.
PubMed:A surface plasmon resonance analysis of the interaction between the antibiotic moenomycin A and penicillin-binding protein 1b.
PubMed:A multitarget assay for inhibitors of membrane-associated steps of peptidoglycan biosynthesis.
PubMed:Moenomycin-mediated affinity purification of penicillin-binding protein 1b.
PubMed:Development of a whole-cell assay for peptidoglycan biosynthesis inhibitors.
PubMed:Comparative investigation of salinomycin and flavophospholipol in sheep fed different composed diets.
PubMed:Effects of flavophospholipol on resistance in fecal Escherichia coli and enterococci of fattening pigs.
PubMed:Aptamers that bind to the antibiotic moenomycin A.
PubMed:The effect of mannanoligosaccharides, bambermycins, and virginiamycin on performance of large white male market turkeys.
PubMed:Effects of hen age, Bio-Mos, and Flavomycin on poult susceptibility to oral Escherichia coli challenge.
PubMed:Differences in antibiotic resistance patterns of Enterococcus faecalis and Enterococcus faecium strains isolated from farm and pet animals.
PubMed:Occurrence, selection and spread of resistance to antimicrobial agents used for growth promotion for food animals in Denmark.
PubMed:Antibacterial activity of synthetic analogues based on the disaccharide structure of moenomycin, an inhibitor of bacterial transglycosylase.
PubMed:Influence of different medium components on the in vitro activity of the growth-promoting antibiotic flavomycin against enterococci.
PubMed:Impact of flavophospholipol and vancomycin on conjugational transfer of vancomycin resistance plasmids.
PubMed:In situ assay for identifying inhibitors of bacterial transglycosylase.
PubMed:Some selective reactions of moenomycin A.
PubMed:Associations between the use of antimicrobial agents for growth promotion and the occurrence of resistance among Enterococcus faecium from broilers and pigs in Denmark, Finland, and Norway.
PubMed:Antibiotic-resistant gram-negative bacteria in a virtually closed water reticulation system.
PubMed:Inhibition of transglycosylation involved in bacterial peptidoglycan synthesis.
PubMed:Isolation and structural elucidation of AC326-alpha, a new member of the moenomycin group.
PubMed:A simple screen for murein transglycosylase inhibitors.
PubMed:Assessment of various treatments to reduce carriage of Salmonella in swine.
PubMed:The effect of flavophospholipol (Flavomycin) and salinomycin sodium (Sacox) on the excretion of Clostridium perfringens, Salmonella enteritidis, and Campylobacter jejuni in broilers after experimental infection.
PubMed:Gene disruption studies of penicillin-binding proteins 1a, 1b, and 2a in Streptococcus pneumoniae.
PubMed:Interactions of soluble penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus with moenomycin.
PubMed:Single-cell analysis of glycopeptide resistance gene expression in teicoplanin-resistant mutants of a VanB-type Enterococcus faecalis.
PubMed:Identification and semiquantitative estimation of antibiotics added to complete feeds, premixes, and concentrates.
PubMed:Surveillance of antimicrobial resistance in bacteria isolated from food animals to antimicrobial growth promoters and related therapeutic agents in Denmark.
PubMed:Effects of different test conditions on MICs of food animal growth-promoting antibacterial agents for enterococci.
PubMed:Three-dimensional structure of moenomycin A--a potent inhibitor of penicillin-binding protein 1b.
PubMed:Bioefficacy of enzyme preparations containing beta-glucanase and xylanase activities in broiler diets based on barley or wheat, in combination with flavomycin.
PubMed:Isolation and analysis of moenomycin and its biosynthetic intermediates from Streptomyces ghanaensis (ATCC 14672) wildtype and selected mutants.
PubMed:Characterisation of antibiotic moenomycin A interaction with phospholipid model membranes.
PubMed:Impact of antibiotic use in animal feeding on resistance of bacterial pathogens in humans.
PubMed:Inhibition of the trehalose-P synthase of mycobacteria by various antibiotics.
PubMed:The monofunctional glycosyltransferase of Escherichia coli is a member of a new class of peptidoglycan-synthesising enzymes.
PubMed:Effect of probiotic supplementation on growth, nitrogen utilisation and serum cholesterol in broilers.
PubMed:Influence of Trichoderma viride enzyme complex on nutrient utilization and performance of laying hens in diets with and without antibiotic supplementation.
PubMed:Effect of combination of oxacillin and non-beta-lactam antibiotics on methicillin-resistant Staphylococcus aureus.
PubMed:[Functioning of integrative vectors, based on phage phi C 31, in the strain Streptomyces bambergiensis 712].
PubMed:[The effect of different flavophospholipol levels in rabbit feed on the fattening rate of hybrid rabbits].
PubMed:In vitro susceptibility of Clostridium perfringens isolated from farm animals to growth-enhancing antibiotics.
PubMed:[The effect of flavomycin on the fattening performance of bulls].
PubMed:[The effect of flavomycin on digestion in fattening bulls].
PubMed:Effect of four antibiotic additives on the Salmonella contamination of chicks protected by an adult caecal flora.
PubMed:Analysis of murein and murein precursors during antibiotic-induced lysis of Escherichia coli.
PubMed:[Effect of flavomycin on the apparent digestibility of crude nutrients in wethers, parameters of rumen fermentation in cattle and feed intake and weight gain of heifers].
PubMed:Flavomycin effects on performance of beef bulls and nutrient digestibility in wethers.
PubMed:Influence of a dried Bacillus subtilis culture and antibiotics on performance and intestinal microflora in turkeys.
PubMed:Effects of different antibiotics on performance, processing characteristics, and parts yield of broiler chickens.
PubMed:Effect of bambermycins (Flavomycin) in diets for growing turkeys.
PubMed:Discrepancy between in vitro and in vivo assays for the susceptibility of Bacillus C.I.P. 5832 to antimicrobial agents.
PubMed:[The discovery of giant linear plasmids in strains of Streptomyces bambergiensis].
PubMed:Effects of monensin and bambermycins on the performance of market turkeys.
PubMed:[Effect of plasmid pIJ350 on genetic stability of antibiotic production by Streptomyces bambergiensis].
PubMed:Influence of peas (Pisum sativum) as a dietary ingredient and flavomycin supplementation on the performance and intestinal microflora of broiler chicks.
PubMed:Effect of some antibiotics as growth promoters on performance of broiler chicks fed different protein levels.
PubMed:In vitro analytical system for determining the ability of antibiotics at residue levels to select for resistance in bacteria.
PubMed:Effect of salinomycin, flavomycin and avoparcin on some physiological traits of growing lambs, with particular respect to rumen fermentation.
PubMed:[Phenotypic and genotypic properties of 4 virulence plasmids of Salmonella typhimurium].
PubMed:Effect of antibiotics on tissue trace mineral concentration and intestinal tract weight of broiler chicks.
PubMed:Effects of moenomycin on Escherichia coli.
PubMed:[Morphological changes in broilers produced by feeding antibiotics].
PubMed:A differential response in turkey poults to various antibiotics in diets designed to be deficient or adequate in certain essential nutrients.
PubMed:The use of bambermycins (Flavomycin) and halofuginone (Stenorol) in diets for growing turkeys.
PubMed:[Electrophoretic method of demonstrating antibiotic residues in meat and eggs].
PubMed:[Ergotrophic action of flavophospholipol during the fattening of geese].
PubMed:Murein hydrolases of Caulobacter crescentus.
PubMed:Effect of bambermycins, in vitro, on plasmid-mediated antimicrobial resistance.
PubMed:Properties of cell wall peptidoglycan synthesized by amino acid deprived re1A mutants of Escherichia coli.
PubMed:Effects of diet and antimicrobials on growth, feed efficiency, intestinal Clostridium perfringens, and ileal weight of broiler chicks.
PubMed:Broiler chick growth response to antibiotics, 1981-1982.
PubMed:The effect of bambermycin, carbadox, chlortetracycline and olaquindox on antibiotic resistance in intestinal coliforms: a new animal model.
PubMed:[Detection of flavomycin in eggs].
PubMed:Inhibitors of the biosynthesis and processing of N-linked oligosaccharides.
PubMed:Susceptibility of clostridia from farm animals to 21 antimicrobial agents including some used for growth promotion.
PubMed:Long-term broiler performance with bambermycins and bambermycins plus roxarsone.
PubMed:[Antibiotics and chemotherapeutic agents--from research to practice. VII. Some remarks to practitioners on the properties of polymyxins, lincosanides, spectinomycin, synergistines, bacitracin, novobiocin and flavomycin].
PubMed:Susceptibility of fecal streptococci of poultry origin to nine growth-promoting agents.
PubMed:The effect of flavomycin on the synthesis and transfer of lipid-linked saccharides in pig brain.
PubMed:Effect of bambermycins on quantity, prevalence, duration, and antimicrobial resistance of Salmonella typhimurium in experimentally infected broiler chickens.
PubMed:[Determination of flavomycin in poultry meat].
PubMed:[Tolerance and acute and subchronic toxicity of flavophospholipol from the Pharmaceutical Chemical Research Institute].
PubMed:[Current animal feeds with antimicrobial activity].
PubMed:[Effect of salinomycin (K-364) on calves for fattening].
PubMed:[Transfer of vitamin A to the egg influenced by bacitracin or flavomycin (author's transl)].
PubMed:[Ureolytic activity in the intestinal tract of layers, effects of bacitracin and flavomycin (author's transl)].
PubMed:[Broad beans (Vicia fava, L.) as an alternative source of protein in chick diets].
PubMed:Effect of bambermycins and tylosin on performance of growing-finishing swine.
PubMed:Compatibility and anticoccidial activity of lasalocid in combination with roxarsone and antibiotics against Eimeria mixed infection in chicks.
PubMed:Sensitivity of staphylococci from farm animals to antibacterial agents used for growth promotion and therapy. A ten year study.
PubMed:[Staphylococcus aureus in poultry--biochemical characteristics, antibiotic resistance and phage pattern (author's transl)].
PubMed:Factors affecting the incidence and anti-salmonella activity of the anaerobic caecal flora of the young chick.
PubMed:Effect of bambermycins on Escherichia coli and antibiotic resistance in calves.
PubMed:Experimental results of the use of flavofosfolipol in dairy cattle.
PubMed:Influence of bambermycins on Salmonella infection and antibiotic resistance in calves.
PubMed:[Antibiotic residues in organs and muscle tissues of broilers. I. Bacitracin, flavomycin, spiramycin and viriniamycin residues following administration of diets containing low levels of these antibiotics (author's transl)].
PubMed:Influence of bambermycins on Salmonella infection and antibiotic resistance in swine.
PubMed:[Nutritive action of flavophospholipol and virginiamycin on broiler pullets].
PubMed:The effect of feeding diets containing permitted antibiotics on the faecal excretion of Salmonella typhimurium by experimentally infected chickens.
PubMed:[New heptaene antibiotic, flavomycin, formed by Act. flavus var. geptinicus var. nov].
PubMed:[Influence of a colicinogenic strain, given perorally, on the occurence of various plasmids of E. coli in piglets fed by flavomycin (author's transl)].
PubMed:[Use of payzone-nitrovin and flavomycin in the fattening of poultry].
PubMed:[Studies on the antigenicity of Flavomycin].
PubMed:The effect of actinomycin D and flavomycin on Escherichia coli R+ strains.
PubMed:[Effect of flavomycin on episomal resistant bacteria].
PubMed:[Effect of 2 differently pretreated Flavomycin mycelia on the growth of calves].
 
Notes:
antibiotic complex obtained from streptomyces bambergiensis containing mainly moenomycins a and c. they are used as feed additives and growth promoters for poultry, swine, and cattle.
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