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guazatine
2-[8-[8-(diaminomethylideneamino)octylamino]octyl]guanidine

Supplier Sponsors

CAS Number:	13516-27-3	3D/inchi
ECHA EINECS - REACH Pre-Reg:	236-855-3
FDA UNII:	C376JTX506
Nikkaji Web:	J1.861I
XlogP3-AA:	1.70 (est)
Molecular Weight:	355.57377000
Formula:	C18 H41 N7
BioActivity Summary:	listing
NMR Predictor:	Predict (works with chrome, Edge or firefox)
CAS Number:	108173-90-6	3D/inchi
Other(deleted CASRN):	79956-56-2
FDA UNII:	C376JTX506
Nikkaji Web:	J1.861I
Molecular Weight:	355.57377000
Formula:	C18 H41 N7
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:herbicides / pesticides

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
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Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Boiling Point:	558.38 °C. @ 760.00 mm Hg (est)
Flash Point:	557.00 °F. TCC ( 291.50 °C. ) (est)
logP (o/w):	3.048 (est)
Soluble in:
	water, 7.64E+05 mg/L @ 25 °C (exp)
	water, 27.74 mg/L @ 25 °C (est)

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

None found

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-duck LD50 985 mg/kg Pesticide Manual. Vol. 9, Pg. 492, 1991. oral-mouse LD50 300 mg/kg "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A223, Pg. 1984 oral-rat LD50 300 mg/kg Pesticide Manual. Vol. 9, Pg. 492, 1991.
Dermal Toxicity:
skin-rat LD50 1500 mg/kg Pesticide Manual. Vol. 9, Pg. 492, 1991.
Inhalation Toxicity:
inhalation-rat LC50 73 mg/m3/4H Pesticide Manual. Vol. 9, Pg. 492, 1991.

Safety in Use Information:

Category:
herbicides / pesticides
Recommendation for guazatine usage levels up to:
	not for fragrance use.

Recommendation for guazatine flavor usage levels up to:
	not for flavor use.

Safety References:

European Food Safety Authority (EFSA) reference(s):

Reasoned opinion on the review of the existing maximum residue levels (MRLs) for guazatine according to Article 12 of Regulation (EC) No 396/2005
View page or View pdf

Reasoned opinion on the modification of the existing MRL for guazatine in citrus fruits
View page or View pdf

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :3526

National Institute of Allergy and Infectious Diseases:Data

2-[8-[8-(diaminomethylideneamino)octylamino]octyl]guanidine

Chemidplus:0013516273

2-[8-[8-(diaminomethylideneamino)octylamino]octyl]guanidine

Chemidplus:0108173906

References:

	2-[8-[8-(diaminomethylideneamino)octylamino]octyl]guanidine
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	3526
Pubchem (sid):	134988958
	2-[8-[8-(diaminomethylideneamino)octylamino]octyl]guanidine
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	3526
Pubchem (sid):	135235770

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEBI:	View
CHEMBL:	View
KEGG (GenomeNet):	C10997
HMDB (The Human Metabolome Database):	Search
ChemSpider:	View
Wikipedia:	View

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

not found in nature

Synonyms:

2-[8-[8-(

diaminomethylideneamino)octylamino]octyl]guanidine

Articles:

PubMed:Perturbation of polyamine catabolism affects grape ripening of Vitis vinifera cv. Trincadeira.

PubMed:Evaluating eco-friendly botanicals (natural plant extracts) as alternatives to synthetic fungicides.

PubMed:Guanylated diamines, triamines, and polyamines: chemistry and biological properties.

PubMed:Ectopic expression of MdSPDS1 in sweet orange (Citrus sinensis Osbeck) reduces canker susceptibility: involvement of H₂O₂ production and transcriptional alteration.

PubMed:Inhibition of citrus fungal pathogens by using lactic acid bacteria.

PubMed:Synthesis and biological evaluation of guanidino compounds endowed with subnanomolar affinity as competitive inhibitors of maize polyamine oxidase.

PubMed:Involvement of polyamine oxidase in abscisic acid-induced cytosolic antioxidant defense in leaves of maize.

PubMed:In vitro and in vivo inhibition of plant polyamine oxidase activity by polyamine analogues.

PubMed:Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis.

PubMed:LC/ESI/MS method for the quantitative detection of guazatine residues in cereals.

PubMed:Analysis of guazatine mixture by LC and LC-MS and antimycotic activity determination of principal components.

PubMed:[The mechanism of ABA-induced apoplastic H2O2 accumulation in maize leaves].

PubMed:Heterologous expression and biochemical characterization of a polyamine oxidase from Arabidopsis involved in polyamine back conversion.

PubMed:Analytical method for determining iminoctadine triacetate by LC/ESI/MS using hydrophilic interaction chromatography.

PubMed:Inhibition of polyamine and spermine oxidases by polyamine analogues.

PubMed:Isolation, identification and antifungal susceptibility of lemon pathogenic and non pathogenic fungi.

PubMed:Molecular basis for the binding of competitive inhibitors of maize polyamine oxidase.

PubMed:Induction of hypersensitive cell death by hydrogen peroxide produced through polyamine degradation in tobacco plants.

PubMed:Inhibition of pig liver and Zea mays L. polyamine oxidase: a comparative study.

PubMed:Structural bases for inhibitor binding and catalysis in polyamine oxidase.

PubMed:Action against Vibrio cholerae O1 Tox+ of chemical products used in the lemon production.

PubMed:Bactericidal activity against Vibrio cholerae of chemical products used in lemon production in Tucumán, Argentina.

PubMed:Circulatory failure caused by a fungicide containing iminoctadine and a surfactant: a pharmacological analysis in rats.

PubMed:Mechanisms of hypotension in iminoctadine poisoning: pharmacological analysis in rats.

PubMed:A fungicide containing iminoctadine causes circulatory failure in acute oral poisoning.

PubMed:Postharvest-applied agrochemicals and their residues in fresh fruits and vegetables.

PubMed:Hypusine formation in protein by a two-step process in cell lysates.

PubMed:A method for the determination of guazatine residues in crops and soil.

Notes:

None found

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