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gymnemic acid

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CAS Number: 1399-64-0
ECHA EC Number:215-746-4
FDA UNII: 327O38FRK1
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
gymnemic acid 95%
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for gymnemic acid usage levels up to:
 not for fragrance use.
 
Recommendation for gymnemic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
Chemidplus:0001399640
 
References:
Pubchem (sid):135320931
 
Other Information:
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 gymnema sylvestre
Search Trop Picture
 
Synonyms:
 gymnemic acid
 

Articles:

PubMed:Abiotic elicitation of gymnemic acid in the suspension cultures of Gymnema sylvestre.
PubMed:Variation in gymnemic acid content and non-destructive harvesting of Gymnema sylvestre (Gudmar).
PubMed:[Advances in the study on hypoglycemic constituents of Gymnema sylvestre (Retz.) Schult].
PubMed:In vivo anti-ulcer, anti-stress, anti-allergic, and functional properties of gymnemic acid isolated from Gymnema sylvestre R Br.
PubMed:A systematic review of Gymnema sylvestre in obesity and diabetes management.
PubMed:Gymnemic acids inhibit hyphal growth and virulence in Candida albicans.
PubMed:Effect of a deacyl gymnemic acid on glucose homeostasis & metabolic parameters in a rat model of metabolic syndrome.
PubMed:Abiotic elicitation of gymnemic acid in the suspension cultures of Gymnema sylvestre.
PubMed:Anti-apoptotic potential of gymnemic acid phospholipid complex pretreatment in Wistar rats with experimental cardiomyopathy.
PubMed:Production of gymnemic acid depends on medium, explants, PGRs, color lights, temperature, photoperiod, and sucrose sources in batch culture of Gymnema sylvestre.
PubMed:Protective effect of herbomineral formulation (Dolabi) on early diabetic nephropathy in streptozotocin-induced diabetic rats.
PubMed:Variation in gymnemic acid content and non-destructive harvesting of Gymnema sylvestre (Gudmar).
PubMed:In vitro callus and in vivo leaf extract of Gymnema sylvestre stimulate β-cells regeneration and anti-diabetic activity in Wistar rats.
PubMed:A novel dihydroxy gymnemic triacetate isolated from Gymnema sylvestre possessing normoglycemic and hypolipidemic activity on STZ-induced diabetic rats.
PubMed:In vitro production of gymnemic acid from Gymnema sylvestre (Retz) R. Br. ex roemer and schultes through callus culture under abiotic stress conditions.
PubMed:Gymnemic acid interacts with mammalian glycerol-3-phosphate dehydrogenase.
PubMed:Extraction and quantification of gymnemic acids through gymnemagenin from callus cultures of Gymnema sylvestre.
PubMed:Standardisation of Gymnema sylvestre R.Br. by high-performance thin-layer chromatography: an improved method.
PubMed:Decreased bodyweight without rebound and regulated lipoprotein metabolism by gymnemate in genetic multifactor syndrome animal.
PubMed:Medical benefits of using natural compounds and their derivatives having multiple pharmacological actions.
PubMed:Efficacy of a novel calcium/potassium salt of (-)-hydroxycitric acid in weight control.
PubMed:Interaction of gymnemic acid with cyclodextrins analyzed by isothermal titration calorimetry, NMR and dynamic light scattering.
PubMed:[Advances in the study on hypoglycemic constituents of Gymnema sylvestre (Retz.) Schult].
PubMed:An overview on the advances of Gymnema sylvestre: chemistry, pharmacology and patents.
PubMed:Inhibitory effect of voglibose and gymnemic acid on maltose absorption in vivo.
PubMed:Inhibitory effect and mechanism of acarbose combined with gymnemic acid on maltose absorption in rat intestine.
PubMed:Caloric restriction in primates and relevance to humans.
PubMed:Structure-activity relationships of triterpenoid derivatives extracted from Gymnema inodorum leaves on glucose absorption.
PubMed:Antihyperglycemic effects of gymnemic acid IV, a compound derived from Gymnema sylvestre leaves in streptozotocin-diabetic mice.
PubMed:Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability.
PubMed:Taste confusions following gymnemic acid rinse.
PubMed:Fecal steroid excretion is increased in rats by oral administration of gymnemic acids contained in Gymnema sylvestre leaves.
PubMed:Inhibitory effect of gymnemic acid on intestinal absorption of oleic acid in rats.
PubMed:Taste in chimpanzees. III: Labeled-line coding in sweet taste.
PubMed:Influence of sweet suppressing agent on gustatory brain evoked potentials generated by taste stimuli.
PubMed:Sweet and sweetness-inducing activities of new triterpene glycosides, strogins.
PubMed:Medicinal foodstuffs. X. Structures of new triterpene glycosides, gymnemosides-c, -d, -e, and -f, from the leaves of Gymnema sylvestre R. Br.: influence of gymnema glycosides on glucose uptake in rat small intestinal fragments.
PubMed:Medicinal foodstuffs. IX. The inhibitors of glucose absorption from the leaves of Gymnema sylvestre R. BR. (Asclepiadaceae): structures of gymnemosides a and b.
PubMed:Suppression of glucose absorption by some fractions extracted from Gymnema sylvestre leaves.
PubMed:Taste in chimpanzee: I. The summated response to sweeteners and the effect of gymnemic acid.
PubMed:New hypoglycemic constituents in "gymnemic acid" from Gymnema sylvestre.
PubMed:An extract of Gymnema sylvestre leaves and purified gymnemic acid inhibits glucose-stimulated gastric inhibitory peptide secretion in rats.
PubMed:Isolation and structure elucidation of gymnemic acids, antisweet principles of Gymnema sylvestre.
PubMed:Characteristics of antisweet substances, sweet proteins, and sweetness-inducing proteins.
PubMed:On the taste of umami in chimpanzee.
PubMed:Binding proteins for sweet compounds from gustatory papillae of the cow, pig and rat.
PubMed:Effects of gymnemic acid on the chorda tympani proper nerve responses to sweet, sour, salty and bitter taste stimuli in the chimpanzee.
PubMed:Sweet taste receptor mechanisms.
PubMed:Studies on snake venom enzymes: Part II--Partial characterization of ATPases from Russell's viper (Vipera russelli) venom & their interaction with potassium gymnemate.
PubMed:Studies on snake venom enzymes: Part I. Purification of ATPase, a toxic component of Naja naja venom & its inhibition by potassium gymnemate.
PubMed:Time-dependent inhibition of sucrose sweetness with gymnemic acid: mode of action.
PubMed:On the effects of gymnemic acid in the hamster and rat.
PubMed:Sweetening agents from natural sources.
PubMed:Effect of gymnemic acid on single taste hairs of the housefly, Musca domestica.
PubMed:[Physiology of smell and taste].
PubMed:Gymnemic acid, the antisaccharine principle of Gymnema sylvestre. Studies on the isolation and heterogeneity of gymnemic acid A1.
PubMed:Inhibition of ATPases by gymnemic acid.
PubMed:Reduction of sucrose preference in the hamster by gymnemic acid.
PubMed:Biological effects of Gymnema sylvestre fractions. II. Electrophysiology--effect of gymnemic acid on taste receptor response.
 
Notes:
triterpene antisweetening agent from gymnema (asclepiadaceae).
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