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tanshinone II
phenanthro[1,2-b]furan-10,11-dione, 6,7,8,9-tetrahydro-1,6,6-trimethyl-

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CAS Number: 568-72-9Picture of molecule3D/inchi
FDA UNII: 4GPC9FQG6L
Nikkaji Web:J12.293I
MDL:MFCD00238692
XlogP3-AA:4.30 (est)
Molecular Weight:294.35006000
Formula:C19 H18 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 480.71 °C. @ 760.00 mm Hg (est)
Flash Point: 457.00 °F. TCC ( 236.40 °C. ) (est)
logP (o/w): 4.925 (est)
Soluble in:
 water, 0.004204 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Tanshinone IIA 98%
BOC Sciences
For experimental / research use only.
Tanshinone II
Changsha Organic Herb
Dan-shen Extract
Coompo
For experimental / research use only.
Tanshinone IIA from Plants ≥96%
Odor: characteristic
Use: Tanshinone IIA is one of the most abundant constituents of the root of Salvia miltiorrhiza which exerts antioxidant and anti-inflammatory actions in many experimental disease models, Tanshinone IIA has been widely used for various cardiovascular and cerebrovascular disorders in Asian countries. Tanshinone IIA pretreatment reduces infarct size and improves cardiac dysfunction after I/R injury in diabetic rats. This was accompanied with decreased cardiac apoptosis and inflammation. The possible mechanism responsible for the effects of TSN is associated with the PI3K/Akt-dependent pathway. Tanshinone IIA might be a novel promising therapeutic agent for oxidative stress injury in neurodegenerative diseases. Tanshinone IIA may improve renal dysfunction associated with chronic kidney disease. Tanshinone IIA was effective for attenuating the extent of brain edema formation in response to ischemia injury in rats. TIIA has a prominent protective effect against Spinal cord injury (SCI) through inhibiting the inflammatory response and apoptosis in the spinal cord tissue after SCI. tanshinone IIA prevents cardiac fibroblast proliferation by interfering with the generation of ROS and involves the activation of the eNOS-NO pathway. Tanshinone IIA pretreatment attenuated the enlargement of cell surface area induced by ISO in cultured cardiomyocytes. The mRNA level of ANP, BNP and β-MHC was obviously elevated in ISO-treated cardiac cells, which was effectively inhibited by Tanshinone IIA. Moreover, we found that Tanshinone IIA pretreatment could prevent the augment of intracellular calcium transient in ISO-treated cardiomyocytes. The further study revealed that Calcineurin, NFATc3, ANP, BNP and β-MHC proteins were upregulated by ISO in ventricular myocytes, and Tanshinone IIA pretreatment significantly attenuate the increased expression of Calcineurin, NFATc3, ANP, BNP and β-MHC proteins. In summary, Tanshinone IIA attenuated cardiomyocyte hypertrophy induced by ISO through inhibiting Calcineurin/NFATc3 pathway, which provides new insights into the pharmacological role and therapeutic mechanism of Tanshinone IIA in heart diseases.
ExtraSynthese
For experimental / research use only.
Tanshinone II A (HPLC) ≥98%
Glentham Life Sciences
Tanshinone IIA
Santa Cruz Biotechnology
For experimental / research use only.
Tanshinone IIA
Sigma-Aldrich
For experimental / research use only.
Tanshinone IIA
analytical standard
TCI AMERICA
For experimental / research use only.
Tanshinone IIA >97.0%(HPLC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for tanshinone II usage levels up to:
 not for fragrance use.
 
Recommendation for tanshinone II flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :164676
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione
Chemidplus:0000568729
RTECS:SF8282695 for cas# 568-72-9
 
References:
 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):164676
Pubchem (sid):135142942
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2932.99.7000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 sage red sage root
Search Trop Picture
 
Synonyms:
 dan shen ketone
 phenanthro(1,2-b)furan-10,11-dione, 6,7,8,9-tetrahydro-1,6,6-trimethyl-
 phenanthro[1,2-b]furan-10,11-dione, 6,7,8,9-tetrahydro-1,6,6-trimethyl-
 tanshinone A
 tanshinone B
 tanshinone IIA
 tanshinonebIIA
6,7,8,9-tetrahydro-1,6,6-trimethylphenanthro[1,2-b]furan-10,11-dione
1,6,6-trimethyl-6,7,8,9-tetrahydro-phenanthro[1,2-b]furan-10,11-dione
1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione
1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione
 

Articles:

PubMed:[Study on solid dispersion of copovidone-based tanshinone II(A)].
PubMed:Tanshinone II-A: new perspectives for old remedies.
PubMed:[Chemical constituents contained in Salvia castanea].
PubMed:Tanshinone II A, a multiple target neuroprotectant, promotes caveolae-dependent neuronal differentiation.
PubMed:[Advances in cardiovascular effects of tanshinone II(A)].
PubMed:Sodium tanshinone II a sulfonate ameliorates microcirculatory disturbance of small intestine by attenuating the production of reactie oxygen species in rats with sepsis.
PubMed:[Correlation analysis between meteorological factors, biomass, and active components of Salvia miltiorrhiza in different climatic zones].
PubMed:Pharmacokinetic investigation on interaction between hydrophilic lithospermic acid B and lipophilic tanshinone IIA in rats: an experi- mental study.
PubMed:[Extraction technology optimization of huoxuehuayu granules].
PubMed:[Development of biphasic drug-loading lipid emulsion of Salvia miltiorrhiza and its quality evaluation].
PubMed:Effects of tanshinone IIA on the transforming growth factor β1/Smad signaling pathway in rat cardiac fibroblasts.
PubMed:Effect of sodium tanshinone IIA sulfonate treatment in a rat model of preeclampsia.
PubMed:Tanshinone II-A sodium sulfonate (DS-201) enhances human BKCa channel activity by selectively targeting the pore-forming α subunit.
PubMed:Effect of tanshinone II on cell growth of breast cancer cell line type MCF-7 and MD-MB-231.
PubMed:[Effects of plant-derived smoke water on accumulation of biomass and active substance of Salvia miltiorrhiza f. alba].
PubMed:Anti-inflammatory mechanism research of tanshinone II A by module-based network analysis.
PubMed:[Effect of spray drying process on physical properties and dissolution of tanshinone].
PubMed:[Study on pharmacokinetics-pharmacodynamics correlation of yin teng gu bi kang prescription].
PubMed:Sodium tanshinone IIA sulfonate attenuates radiation-induced fibrosis damage in cardiac fibroblasts.
PubMed:Sodium tanshinone IIA sulfonate and sodium danshensu open the placental barrier through down-regulation of placental P-glycoprotein in mice: implications in the transplacental digoxin treatment for fetal heart failure.
PubMed:[Simultaneous determination of six Salvia miltiorrhiza gradients in rat plasma and brain by LC-MS/MS].
PubMed:[Effect of Glomus versiforme and Trichoderma harzianum on growth and quality of Salvia miltiorrhiza].
PubMed:[Clinical efficacy of sodium tanshinone IIA sulfonate in treatment of advanced schistosomiasis].
PubMed:[Effect of tanshinone II(A) on expression of different components in renin-angiotensin system of left ventricles of hypertensive rats].
PubMed:[Influence of different original processing methods on quality of Salvia Miltiorrhizae Radix et Rhizoma from Shandong].
PubMed:Sodium tanshinone IIA sulfonate prolongs the survival of skin allografts by inhibiting inflammatory cell infiltration and T cell proliferation.
PubMed:Salvia miltiorrhiza compounds protect the liver from acute injury by regulation of p38 and NFκB signaling in Kupffer cells.
PubMed:[Tanshinone IIA sulfonate upregulated pulmonary artery smooth muscle peroxisome proliferator-activated receptor γ expression in monocrotaline induced pulmonary hypertension rat].
PubMed:Tanshinone II-A is protective against human umbilical vein endothelial cell injury after exposure to serum from preeclampsia patients.
PubMed:Tanshinone II A sulfonate, but not tanshinone II A, acts as potent negative allosteric modulator of the human purinergic receptor P2X7.
PubMed:[Effect of sodium tanshinone II (A) sulfonate on Ang II -induced atrial fibroblast collagen synthesis and TGF-beta1 activation].
PubMed:[Determination of five components in rongxin pills by HPLC].
PubMed:[Effect of tanshinone II A on leukemia cell line K562].
PubMed:Screening compounds of Chinese medicinal herbs anti-Marek's disease virus.
PubMed:The cardioprotective effect of sodium tanshinone IIA sulfonate and the optimizing of therapeutic time window in myocardial ischemia/reperfusion injury in rats.
PubMed:[Effects on Salvia miltiorrhiza hairy roots of tanshinones content accumulation after treated with fosmidomycin].
PubMed:[Influence of continuous cropping years on yield and active compounds in Salvia miltiorrhiza f. alba].
PubMed:Sodium tanshinone IIA sulfonate inhibits the meq, ul49 and VP22 expression of Marek's disease virus.
PubMed:Tanshinone II a protects against lipopolysaccharides-induced endothelial cell injury via Rho/Rho kinase pathway.
PubMed:[Comparison of different preparation methods of tanshinoneporous silica solid dispersion].
PubMed:Tanshinone II A inhibits tat-induced HIV-1 transactivation through redox-regulated AMPK/Nampt pathway.
PubMed:Development of Salvianolic acid B-Tanshinone II A-Glycyrrhetinic acid compound liposomes: formulation optimization and its effects on proliferation of hepatic stellate cells.
PubMed:[The effect of tanshinone II A on the transmembrance action potential of myocardial cells in LQT2 rabbit models].
PubMed:[Adverse reactions of tanshinone II(A) sodium sulfonate injection in treating 18 cases: an analysis of clinical features].
PubMed:[Effect of tanshinone II A on the expressions of NeuN, GFAP and CD11b in Aβ1-42; induced newborn rat hippocampal slices in vitro].
PubMed:Sodium tanshinone IIA sulfonate inhibits porcine reproductive and respiratory syndrome virus via suppressing N gene expression and blocking virus-induced apoptosis.
PubMed:Sodium tanshinone IIA sulfonate protects rat myocardium against ischemia-reperfusion injury via activation of PI3K/Akt/FOXO3A/Bim pathway.
PubMed:[Investigation on equilibrium solubility and apparent oil/water partition coefficient of diterpenoid tanshinone component by similarity analysis methods].
PubMed:[Effects of sodium tanshinone II A sulfonate on proliferation of fibroblasts in scar and the mRNA and protein expressions of transforming growth factor beta 1 and alpha smooth muscle actin].
PubMed:[Effects of ABA on tanshinones accumulation of Salvia miltiorrhiza hairy root].
PubMed:[The influence of spray drying process conditions on physical, chemical properties and lung inhaling performance of Panax notoginseng saponins - tanshinone II A composite particles].
PubMed:Regulation of antioxidant system, lipids and fatty acid β-oxidation contributes to the cardioprotective effect of sodium tanshinone IIA sulphonate in isoproterenol-induced myocardial infarction in rats.
PubMed:Chinese herbal medicine-derived compounds for cancer therapy: a focus on hepatocellular carcinoma.
PubMed:[Clinical efficiency of tanshinone IIA-sulfonate in treatment of liver fibrosis of advanced schistosomiasis].
PubMed:[Synergistic antitumor effects of tanshinone II A in combination with cisplatin via apoptosis in the prostate cancer cells].
PubMed:[Preparation of panax notoginseng saponins-tanshinone H(A) composite method for pulmonary delivery with spray-drying method and its characterization].
PubMed:[Study on solid dispersion of copovidone-based tanshinone II(A)].
PubMed:Active Component of Danshen (Salvia miltiorrhiza Bunge), Tanshinone I, Attenuates Lung Tumorigenesis via Inhibitions of VEGF, Cyclin A, and Cyclin B Expressions.
PubMed:[Effect of tanshinone II A to B7H3 expression in human nasopharyngeal carcinoma CNE1 cell lines].
PubMed:[Effects of tanshinone- II A sulfonate on expression of nuclear factor-kappaB, vascular cell adhesion molecule-1 and hemorrheology during spinal cord ischemia reperfusion injury].
PubMed:[Study on regulation of tanshinone II(A) on GFAP and ATPase and PDI of cerebral ischemia reperfusion injury in rats].
PubMed:Nanovesicles system for rapid-onset sublingual delivery containing sodium tanshinone IIA sulfonate: in vitro and in vivo evaluation.
PubMed:Effects of sodium tanshinone IIA sulfonate against Marek's disease virus in experimentally infected chickens.
PubMed:Impurities preparation of sodium tanshinone IIA sulfonate by high-speed counter-current chromatography and identification by liquid chromatography/multistage tandem mass spectrometry.
PubMed:Tanshinone II-A: new perspectives for old remedies.
PubMed:Tanshinone II--a inhibits angiogenesis through down regulation of COX-2 in human colorectal cancer.
PubMed:Sodium tanshinone IIA sulfonate inhibits canonical transient receptor potential expression in pulmonary arterial smooth muscle from pulmonary hypertensive rats.
PubMed:[Chemical constituents contained in Salvia castanea].
PubMed:Tanshinone II A inhibits dendritic cell-mediated adaptive immunity: potential role in anti-atherosclerotic activity.
PubMed:[Pharmacokinetics of Danshen multi-component osmotic pump tablets in Beagle dogs].
PubMed:Tanshinone IIA protects rabbits against LPS-induced disseminated intravascular coagulation (DIC).
PubMed:On-line ionic liquid-based dynamic microwave-assisted extraction-high performance liquid chromatography for the determination of lipophilic constituents in root of Salvia miltiorrhiza Bunge.
PubMed:[Study on solid dispersion of binary vector of tanshinone II A].
PubMed:[Anti-tumor effect of tanshinone II A, tetrandrine, honokiol, curcumin, oridonin and paeonol on leukemia cell lines].
PubMed:[Simultaneous determination of four tanshinones in Salvia miltiorrhiza by QAMS].
PubMed:Tanshinone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-κB activation.
PubMed:Isolation and structure characterization of related impurities in Sodium Tanshinone IIA Sulfonate by LC/ESI-MS(n) and NMR.
PubMed:Anti-PRRSV effect and mechanism of sodium tanshinone IIA sulfonate in vitro.
PubMed:[Correlation between expression level of functional genes and tanshinones' accumulation in Salvia miltiorrhiza from different areas].
PubMed:Protective effect of sodium tanshinone IIA sulfonate on injury of small intestine in rats with sepsis and its mechanism.
PubMed:[Network pharmacology study on major active compounds of Fufang Danshen formula].
PubMed:Determination of 20(S)-protopanaxadiol ocotillol type epimers in rat plasma by liquid chromatography tandem mass spectrometry.
PubMed:[Investigation on the molecular structures and electronic absorption spectra of Tanshinone II A and Tanshinone II A -Cu(II) complex].
PubMed:Evaluation of the antioxidant potential of Salvia miltiorrhiza ethanol extract in a rat model of ischemia-reperfusion injury.
PubMed:Novel Tanshinone II A ternary solid dispersion pellets prepared by a single-step technique: in vitro and in vivo evaluation.
PubMed:[Flavonoids of puerarin versus tanshinone II A for ischemic stroke: a randomized controlled trial].
PubMed:[Apoptosis inducing effect of tanshinone II(A) on human nasopharyngeal carcinoma CNE cells].
PubMed:[Liposolubility constituents from leaves of Aquilaria sinensis].
PubMed:ortho-Quinone tanshinones directly inhibit telomerase through an oxidative mechanism mediated by hydrogen peroxide.
PubMed:[Chemical constituents from Salvia przewalskii Maxim].
PubMed:[Effects of phytohormones on hairy root growth and tanshinone biosynthesis of Salvia miltiorrhiza].
PubMed:Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in apolipoprotein-E knockout mice fed a high cholesterol diet.
PubMed:Protective effect and mechanism of sodium tanshinone II A sulfonate on microcirculatory disturbance of small intestine in rats with sepsis.
PubMed:Development of fluorescence imaging-based assay for screening cardioprotective compounds from medicinal plants.
PubMed:[The quality of Salvia miltforthiza from Beijing suburbs with different growing modes].
PubMed:Sodium tanshinone iia sulfonate attenuates seawater aspiration-induced acute pulmonary edema by up-regulating Na(+),K(+)-ATPase activity.
PubMed:[Effect of tanshinone II A on TLR4 and TNF-α of endothelial cells induced by LPS].
PubMed:Ultrasonication-assisted extraction and preconcentration of medicinal products from herb by ionic liquids.
PubMed:Proteomic assessment of tanshinone IIA sodium sulfonate on doxorubicin induced nephropathy.
PubMed:A novel protocol for the preparation of sodium tanshinone sulphonates by direct ultrasound-assisted sulphonation of the crude extract of the roots of Salvia miltiorrhiza Bunge and following counter-current chromatography purification.
PubMed:Antiplasmodial and antitrypanosomal activity of tanshinone-type diterpenoids from Salvia miltiorrhiza.
PubMed:[Effects of combination of Salvia miltiorrhiza and Panax notoginseng on the pharmacokinetics of their major bioactive components in Beagle dog].
PubMed:[Absorption mechanism of tanshinone II A, cryptotanshinone, tanshinone I and tanshinones extract in rat small intestine in vivo].
PubMed:Unique action of sodium tanshinone II-A sulfonate (DS-201) on the Ca(2+) dependent BK(Ca) activation in mouse cerebral arterial smooth muscle cells.
PubMed:[A successful case of tanshinone II A treatment for relapsed acute promyelocytic leukemia after maintainance therapy of all-trans retinoic acid and arsenic trioxide].
PubMed:Study of sodium tanshinone II A sulfonate tissue distribution in rat by liquid chromatography/tandem mass spectrometry.
PubMed:[Preparation and in vitro evaluation of tanshinone IIA pulsatile release pellets].
PubMed:[Neuroprotective effects of tanshinone II A on vascular dementia in rats].
PubMed:[A diterpenoid quinone from Periploca forrestii].
PubMed:[Effect of tanshinone II A on the transforming growth factor beta1/Smads signal pathway in rats with hypertensive myocardial hypertrophy].
PubMed:Tanshinone II-A attenuates cardiac fibrosis and modulates collagen metabolism in rats with renovascular hypertension.
PubMed:Tanshinone IIA improves impaired nerve functions in experimental diabetic rats.
PubMed:[Effects of E-selectin and their ligands on the adhesive metastasis of hepatocellular carcinoma].
PubMed:[A study on the effect of Tanshinone II A against human breast cancer in vivo].
PubMed:[Apoptosis of NB4 cells induced by Tanshinone II A combined with arsenic trioxide].
PubMed:[Effect of tanshinone II on hepatic fibrosis in mice].
PubMed:Tanshinone II-A inhibits invasion and metastasis of human hepatocellular carcinoma cells in vitro and in vivo.
PubMed:Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia.
PubMed:Anti-inflammatory effects of tanshinone IIA on radiation-induced microglia BV-2 cells inflammatory response.
PubMed:[Apoptosis of MR2 cells induced by Tanshinone II A combined with arsenic trioxide].
PubMed:Tanshinone II A induces apoptosis and S phase cell cycle arrest in activated rat hepatic stellate cells.
PubMed:[A new identification and quautitation method for radix Salviae miltiorrhizae].
PubMed:Inhibitory effects of tanshinone II-A on invasion and metastasis of human colon carcinoma cells.
PubMed:Effects of tanshinone II A on the myocardial hypertrophy signal transduction system protein kinase B in rats.
PubMed:Tanshinone II A attenuates inflammatory responses of rats with myocardial infarction by reducing MCP-1 expression.
PubMed:Effects of sodium tanshinone II A sulphonate on hypoxic pulmonary hypertension in rats in vivo and on Kv2.1 expression in pulmonary artery smooth muscle cells in vitro.
PubMed:Sodium tanshinone IIA sulfonate increased intestinal hemodynamics without systemic circulatory changes in healthy newborn piglets.
PubMed:Tanshinone II(A) elicited vasodilation in rat coronary arteriole: roles of nitric oxide and potassium channels.
PubMed:Effect of sodium tanshinone II A sulfonate on the activity of CYP1A2 in healthy volunteers.
PubMed:[A study on anticancer activity of tanshinone II A against human breast cancer].
PubMed:[AOTF-near infrared spectroscopy for determining tanshinone II A in returning extraction process of Salvia miltiorrhiza].
PubMed:[Effect of tanshinone II A on the calcineurin activity in proliferating vascular smooth muscle cells of rats].
PubMed:[Effect of Tanshinone II A on expression of EGF and EGFR in hepatocellular carcinoma cell line SMMC-7721].
PubMed:Sodium tanshinone IIA sulfonate attenuates angiotensin II-induced collagen type I expression in cardiac fibroblasts in vitro.
PubMed:[Study of molecular mechanism of tanshinone II A inducing differentiation in acute promyelocytic leukemia NB4 cells].
PubMed:[Effect of tanshinone II A on NB4 cell induced procoagulant activity in human umbilical vein endothelial cells].
PubMed:Effect of sodium tanshinone II A sulfonate on cardiac myocyte hypertrophy and its underlying mechanism.
PubMed:Changes of c-fos and c-jun mRNA expression in angiotensin II-induced cardiomyocyte hypertrophy and effects of sodium tanshinone IIA sulfonate.
PubMed:[Effect of tashinone on nitric oxide synthase in hypertrophic cardiomyocyte of rats suffered abdominal aorta constriction].
PubMed:Activation of high conductance Ca(2+)-activated K(+) channels by sodium tanshinoneII-A sulfonate (DS-201) in porcine coronary artery smooth muscle cells.
PubMed:[Preparation and quality evaluation of intravenous tanshinone II (A) emulsion].
PubMed:[Effect of tanshinone II A on angiotensin receptor in hypertrophic myocardium of rats with pressure over-loading].
PubMed:Effect of sodium tanshinone II A sulfonate on phosphorylation of extracellular signal-regulated kinase 1/2 in angiotensin II-induced hypertrophy of myocardial cells.
PubMed:[Tanshinone II A inhibits in vitro cellular proliferation and migration of vascular smooth muscle cell of rabbit].
PubMed:[Changes of c-fos, c-jun mRNA expressions in cardiomyocyte hypertrophy induced by angiotensin II and effects of tanshinone II A].
PubMed:[Studies on the chemical constituents of Salvia miltiorrhiz of Lijiang].
PubMed:[A new method for quick analysis of tanshinone II(A) and salvianolic acid in Fufang Danshen tablets by AOTF-near infrared spectroscopy].
PubMed:Sodium tanshinone IIA sulfonate protects mice from ConA-induced hepatitis via inhibiting NF-kappaB and IFN-gamma/STAT1 pathways.
PubMed:Sodium tanshinone IIA sulfonate protects cardiomyocytes against oxidative stress-mediated apoptosis through inhibiting JNK activation.
PubMed:[Inhibitive effect of local perfusion of tanshinone II A nanoparticles on MMP-2 secretion].
PubMed:[Analysis on biomasses and contents of active components in roots of Salvia miltiorrhiza from different populations].
PubMed:[Contrast studies on content of hydrophobic components between Salvia yunnanensis roots and Salvia miltiorrhiza roots].
PubMed:Growth-inhibiting and apoptosis-inducing effects of Tanshinone II A on human gastric carcinoma cells.
PubMed:Orthogonal array design for the optimization of supercritical fluid extraction of tanshinones from Danshen.
PubMed:[Inhibition effects of constituents of Radix Salviae Miltiorrhizae on proliferation and procollagen transcription of dermal fibroblasts in systemic sclerosis].
PubMed:[In situ extraction effect of macroporous resins on tanshinones in Salvia miltiorrhiza hairy root culture].
PubMed:Pharmacological activity of cardiovascular agents from herbal medicine.
PubMed:[The inhibitive effect of sodium tanshinone II A sulfonic acid on intimal hyperplasia in rabbit iliac artery ballon injury model].
PubMed:Effects of the coexisting diterpenoid tanshinones on the pharmacokinetics of cryptotanshinone and tanshinone IIA in rat.
PubMed:[Determination of tanshinone II A and deoxyschizandrin in danshenwuweizi tablet by RP-HPLC].
PubMed:[Quality analysis of Radix Salviae Miltiorrhizae from different habitats by HPLC and TLC].
PubMed:[Effect of tanshinone II A on angiotensin II induced nitric oxide production and endothelial nitric oxide synthase gene expression in cultured porcine aortic endothelial cells].
PubMed:Determination of sodium tanshinone IIA sulfonate in plasma by liquid chromatography-electrospray ionisation-tandem mass spectrometry.
PubMed:Protective effect of tanshinone II A on lipopolysaccharide-induced lung injury in rats.
PubMed:[Comparison of two preparation methods applied in tanshinone II(A)-loaded PLGA nanoparticles].
PubMed:[Effects of 2-n-nonyl-1,3-dioxolane as an enhanceron transdermal absorption of Salvia miltiorrhiza gel].
PubMed:[Pharmacokinetic interactions between the main components in the extracts of Salvia miltiorrhiza Bge. in rat].
PubMed:Ion-pair reversed-phase HPLC method for determination of sodium tanshinone IIA sulfonate in biological samples and its pharmacokinetics and biodistribution in mice.
PubMed:[Effects of methyl jasmonat on accumulation and release of tanshinones in suspension cultures of Salvia miltiorrhiza hairy root].
PubMed:A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1.
PubMed:Tanshinone II A attenuates atherosclerotic calcification in rat model by inhibition of oxidative stress.
PubMed:Sodium tanshinone IIA sulfonate depresses angiotensin II-induced cardiomyocyte hypertrophy through MEK/ERK pathway.
PubMed:[Complete remission of acute promyelocytic leukemia resisting all-trans retinoic acid of one case treated by tanshinone II A].
PubMed:Endothelial nitric oxide synthase is a molecular vascular target for the Chinese herb Danshen in hypertension.
PubMed:[Studies on in vitro culture of adventitious root in Salvia miltiorrhiza].
PubMed:[Effect of micronization on the quality of Salvia miltiorrhiza Bge].
PubMed:Activation of the iberiotoxin-sensitive BKCa channels by salvianolic acid B of the porcine coronary artery smooth muscle cells.
PubMed:Sodium tanshinone IIA sulfonate derived from Slavia miltiorrhiza Bunge up-regulate the expression of prolactin releasing peptide (PrRP) in the medulla oblongata in ovariectomized rats.
PubMed:[Synergistic effects of biotic and abiotic elicitors on the production of tanshinones in Salvia miltiorrhiza hairy root culture].
PubMed:[Analysis of four components in Fufang Danshen Tablets by high performance liquid chromatography with electrochemical and ultraviolet detections].
PubMed:[Inhibitive effect to collagen fiber of tanshinone II A in iliac artery following balloon injury in rabbit].
PubMed:Ion-pair reversed-phase HPLC: assay validation of sodium tanshinone IIA sulfonate in mouse plasma.
PubMed:Determination of cryptotanshinone and its metabolite in rat plasma by liquid chromatography-tandem mass spectrometry.
PubMed:[Effects of mineral cations on the accumulation of tanshinone II A and protocatechuic aldehyde in the adventitious root culture of Salvia niltiorrhiza].
PubMed:[Inhibition of proliferation and induction of apoptosis by tanshinone II A in NCI-H460 cell].
PubMed:[Studies on chemical constituents in roots of Peucedanum praeruptorum].
PubMed:[Purification and fingerprinting development of Salvia miltiorrhiza Bunge by high-speed counter-current chromatography].
PubMed:Quantitative analysis of the marker compounds in Salvia miltiorrihiza root and its phytomedicinal preparations.
PubMed:[The growth of Salvia miltiorrhiza seedling and root system following transplantation].
PubMed:[Differentiation and apoptosis of NB4 cells synergistically induced by Tanshinone II A and all-trans retinoic acid].
PubMed:Growth inhibition and apoptosis induction of tanshinone II-A on human hepatocellular carcinoma cells.
PubMed:Tanshinone prevents cancellous bone loss induced by ovariectomy in rats.
PubMed:Growth inhibition and apoptosis induction in human hepatoma cells by tanshinone II A.
PubMed:[Chemical constituents in the roots of Salvia przewalskii Maxim].
PubMed:[A study on apoptosis of nasopharyngeal carcinoma cell line induced by Tanshinone II A and its molecular mechanism].
PubMed:[Study on the differentiation of K562 cell-line induced by Tanshinone II A].
PubMed:[Extraction of three tanshinones from the root of Salvia miltiorrhiza Bunge by supercritical carbon dioxide fluid and their analysis with high performance liquid chromatography].
PubMed:[Terminal differentiation of human acute promyelocytic leukemia (APL) cells induced by Tanshinone II A in primary culture].
PubMed:Sodium tanshinone IIA sulfonate mediates electron transfer reaction in rat heart mitochondria.
PubMed:[Medicinal resources of Salvia yunnanensis].
PubMed:Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells.
PubMed:[Acute promyelocytic leukemia cell differentiation induced by tanshinone II A and its molecular mechanism].
PubMed:[Influence of blood-activating drugs on adhesion and invasion of cells in lung cancer patients].
PubMed:Inhibition of serum deprivation-induced PC12 cell apoptosis by tanshinone II A.
PubMed:Effects of ligustrazine, tanshinone II A, ubiquinone, and idebenone on mouse water maze performance.
PubMed:Tanshinone II-A inhibits low density lipoprotein oxidation in vitro.
PubMed:Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3.
PubMed:Effects of tanshinone II-A sulfonate on adhesion molecule expression of endothelial cells and platelets in vitro.
PubMed:[Study on the effect of ofloxacin and tanshinone II A on human leukocyte chemotactic migration in vitro].
PubMed:Effect of natural antioxidant tanshinone II-A on DNA damage by lipid peroxidation in liver cells.
PubMed:[Effects of tanshionone to bleomycin induced pulmonary fibrosis of rats on histological changes and production of lipid peroxides and hydroxyproline].
PubMed:Effect of sodium tanshinone IIA sulfonate in the rabbit myocardium and on human cardiomyocytes and vascular endothelial cells.
PubMed:[Studies and preparations of fufang danshen granules].
PubMed:[No promoting effects of sodium tanshinone II-A sulfonate on growth and metastasis of Lewis carcinoma].
PubMed:[Antioxidation mechanism of schizandrin and tanshinonatic acid A and their effects on the protection of cardiotoxic action of adriamycin].
PubMed:[Chemical studies of Salvia miltiorrhiza f. alba].
PubMed:[Effects of sodium tanshinone II-A sulfonate on slow action potentials of dissociated single ventricular cells of adult guinea pig heart].
PubMed:[Effects of sodium tanshinone II-A sulfonate on the electrical and mechanical properties of the myocardium].
PubMed:Therapeutic effect of sodium tanshinone IIA sulfonate in patients with coronary heart disease. A double blind study. Shanghai Cooperative Group for the Study of Tanshinone IIA.
PubMed:[Effects of tanshinone II-A sulfonate on thrombus formation, platelet and blood coagulation in rats and mice].
PubMed:[Comparison of antihemolytic effects of sodium tanshinone II-A sulfonate and propranolol in vitro (author's transl)].
PubMed:[Effects of intracoronary injections of sodium tanshinone II-A sulfonate and dipyridamole on myocardial infarct size in acute ischemic dogs (author's transl)].
PubMed:[Effects of sodium tanshinone II-A sulfonate and propranolol on coronary collaterals in acutely infarcted dogs (author's transl)].
 
Notes:
from root of salvia miltiorrhiza bunge; cardioprotective agent and neuroprotective agent.
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