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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 891.58 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 599.00 °F. TCC ( 314.90 °C. ) (est)
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| logP (o/w): | 0.426 (est) |
| Soluble in: |
| | water, 7023 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-mouse LD50 1314 mg/kg
Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 14, Pg. 33, 1983.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for breviscapine usage levels up to: | | | not for fragrance use.
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| Recommendation for breviscapine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :185617 |
| National Institute of Allergy and Infectious Diseases:Data |
| (2S,3S,4S,5R,6S)-6-[5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid |
| Chemidplus:0116122362 |
References:
| | (2S,3S,4S,5R,6S)-6-[5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 185617 |
| Pubchem (sid): | 135164598 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | breviscapin | | (2S,3S,4S,5R,6S)-6-[5,6- | dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid | | | scutellarein 7-b-D-glucuronide | | | scutellarin | | | viminol R2 |
Articles:
| PubMed:[Evaluation of transdermal property in vitro of different breviscapine lipid carrier gels]. |
| PubMed:[Study on the extraction of breviscapine from Erigeron breviscapus with ultrasonic wave technology optimized by central composite design-response surface method]. |
| PubMed:Improved oral bioavailability of breviscapine via a Pluronic P85-modified liposomal delivery system. |
| PubMed:Mixed polyethylene glycol-modified breviscapine-loaded solid lipid nanoparticles for improved brain bioavailability: preparation, characterization, and in vivo cerebral microdialysis evaluation in adult Sprague Dawley rats. |
| PubMed:Progress on the protective effect of compounds from natural medicines on cerebral ischemia. |
| PubMed:Therapeutic time window and underlying therapeutic mechanism of breviscapine injection against cerebral ischemia/reperfusion injury in rats. |
| PubMed:Breviscapine reduces acute lung injury induced by left heart ischemic reperfusion in rats by inhibiting the expression of ICAM-1 and IL-18. |
| PubMed:Solid dispersion tablets of breviscapine with polyvinylpyrrolidone K30 for improved dissolution and bioavailability to commercial breviscapine tablets in beagle dogs. |
| PubMed:Pharmacokinetic interaction between scutellarin and valsartan in rats. |
| PubMed:Development of ionic-complex-based nanostructured lipid carriers to improve the pharmacokinetic profiles of breviscapine. |
| PubMed:Superior renoprotective effects of the combination of breviscapine with enalapril and its mechanism in diabetic rats. |
| PubMed:[Evaluation of transdermal property in vitro of different breviscapine lipid carrier gels]. |
| PubMed:[Protective effect of breviscapine on human hepatocytes under hypoxia/re-oxygenation and its possible mechanism]. |
| PubMed:Lipid emulsion as a drug delivery system for breviscapine: formulation development and optimization. |
| PubMed:UPLC-MS-MS method for simultaneous determination of caffeine, tolbutamide, metoprolol, and dapsone in rat plasma and its application to cytochrome P450 activity study in rats. |
| PubMed:Breviscapine inhibits high glucose-induced proliferation and migration of cultured vascular smooth muscle cells of rats via suppressing the ERK1/2 MAPK signaling pathway. |
| PubMed:Effects of breviscapine on pulmonary inflammatory response and lung injury in children undergoing open heart surgery. |
| PubMed:[Intestinal lymphatic transport of breviscapine orally administered in rat]. |
| PubMed:Metabolic transformation of DMBA-induced carcinogenesis and inhibitory effect of salvianolic acid b and breviscapine treatment. |
| PubMed:Preparation, characterization and evaluation of breviscapine lipid emulsions coated with monooleate-PEG-COOH. |
| PubMed:[The anti-injury effect of breviscapine injection on the hypoxic ischemic brain damage of neonatal rats and the expression of Bcl-2 and Bax]. |
| PubMed:[Study on the extraction of breviscapine from Erigeron breviscapus with ultrasonic wave technology optimized by central composite design-response surface method]. |
| PubMed:Optimized preparation, characterization and biodistribution in heart of breviscapine lipid emulsion. |
| PubMed:Characterization, biodistribution and targeting evaluation of breviscapine lipid emulsions following intravenous injection in mice. |
| PubMed:[Formula screening and optimizing for the dispersible tablets of breviscapine by orthogonal experiment]. |
| PubMed:[Protective effect of breviscapine on cardiac function in children after cardiopulmonary bypass undergoing open heart surgery]. |
| PubMed:[Protective effects of Fufangdengzhanhua dripping pill on apoptosis induced by glutamate in cultured primary hippocampal neurons of rats]. |
| PubMed:[Advances in studies on pharmacokinetics of scutellarin and scutellarein]. |
| PubMed:Breviscapine protects against cardiac hypertrophy through blocking PKC-alpha-dependent signaling. |
| PubMed:Breviscapine-induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity. |
| PubMed:Breviscapine ameliorates cardiac dysfunction and regulates the myocardial Ca(2+)-cycling proteins in streptozotocin-induced diabetic rats. |
| PubMed:Breviscapine improves functions of spatial learning and memory of focal cerebral ischemia rats. |
| PubMed:[Study on physicochemical properties and influence factors on stability of breviscapine]. |
| PubMed:[Comparison of the distribution of breviscapine in the brain by different administration routes]. |
| PubMed:Breviscapine ameliorates hypertrophy of cardiomyocytes induced by high glucose in diabetic rats via the PKC signaling pathway. |
| PubMed:Preparation, characterization, and biodistribution of breviscapine proliposomes in heart. |
| PubMed:[The effect of polyamidoamine (PAMAM) dendrimers on the solubility and pharmacokinetics of breviscapine]. |
| PubMed:[Effects of Dengzhan Xixin on blood-brain barrier permeability and metabolites after cerebral ischemia-reperfusion injuries]. |
| PubMed:[Effects of in vitro conditions on release behavior of different types of sustained and controlled release formulations of breviscapin]. |
| PubMed:Breviscapine, a traditional Chinese medicine, alleviates myocardial ischaemia reperfusion injury in diabetic rats. |
| PubMed:[The effect of breviscapine on the pulmonary arterial pressure and the expression of Rho-kinase in pulmonary arterioles of hypoxic rats]. |
| PubMed:Studies on antioxidant activities of breviscapine in the cell-free system. |
| PubMed:Dengzhanhua preparations for acute cerebral infarction. |
| PubMed:Comparative pharmacokinetics of breviscapine liposomes in dogs, rabbits and rats. |
| PubMed:Pharmacokinetics and biodistribution of surface modification polymeric nanoparticles. |
| PubMed:Effect of ion-pairing and enhancers on scutellarin skin permeability. |
| PubMed:Neuroprotective effects of breviscapine against apoptosis induced by transient focal cerebral ischaemia in rats. |
| PubMed:Breviscapine alleviates hepatic injury and inhibits PKC-mRNA and its protein expression in brain-dead BA-Ma mini pigs. |
| PubMed:[Effect of Erigeron Breviscapine on premaxillary suture distraction osteogenesis in rabbit]. |
| PubMed:Protective effects of scutellarin and breviscapine on brain and heart ischemia in rats. |
| PubMed:[Protective effects of breviscapine against cultured rat hippocampal neuronal toxicity induced by glutamate]. |
| PubMed:Isolation and identification of ten metabolites of breviscapine in rat urine. |
| PubMed:Prevention of early liver injury by breviscapine in streptozotocin-induced diabetic rats. |
| PubMed:Two major urinary metabolites of scutellarin in rats. |
| PubMed:Amelioration of graft ischemia-reperfusion injury by breviscapine in rat small bowel transplantation. |
| PubMed:[Protective effects of Denghuang injection on cerebral infarction in animal]. |
| PubMed:Effect of breviscapine on fractalkine expression in chronic hypoxic rats. |
| PubMed:Protective effects of breviscapine on ischemic vascular dementia in rats. |
| PubMed:Renoprotective effect of breviscapine through suppression of renal macrophage recruitment in streptozotocin-induced diabetic rats. |
| PubMed:[How brain-dead state affects the hepatic morphology and function of Ba-Ma mini pigs and its mechanism]. |
| PubMed:[Pharmacokinetics of breviscapine liposomes following intravenous injection in Beagle dogs]. |
| PubMed:Preparation and pharmacokinetics in rabbits of breviscapine unilamellar vesicles. |
| PubMed:[Pharmacokinetics of breviscapine in dogs and rabbits following single intravenous administration]. |
| PubMed:Distribution of liposomal breviscapine in brain following intravenous injection in rats. |
| PubMed:Pharmacokinetics of scutellarin and its aglycone conjugated metabolites in rats. |
| PubMed:Determination of aglycone conjugated metabolites of scutellarin in rat plasma by HPLC. |
| PubMed:[Pharmacokinetics of breviscapine and its beta-cyclodextrin complex in rats]. |
| PubMed:Multivesicular liposome formulation for the sustained delivery of breviscapine. |
| PubMed:Enhanced oral bioavailability of breviscapine after encapsulation in a liposomal formulation. |
| PubMed:Clinical observation on Breviscapine in treating hypertension patients complicated with micro-albuminuria of renal impairment. |
| PubMed:[Enhanced absorption of breviscapine photosomes in small intestine of rats]. |
| PubMed:[Determination of entrapment efficiency of breviscapine nanoliposomes]. |
| PubMed:[Regulation of pre-mRNA alternative spicing in U251 cells by TPA]. |
| PubMed:A study of the cardioprotective effect of breviscapine during hypoxia of cardiomyocytes. |
| PubMed:Study on pharmacokinetics of scutellarin in rabbits. |
| PubMed:[Pharmacokinetics of scutellarin in rabbits]. |
| PubMed:[Effect of breviscapine on urinary micro-albumine in patients with diabetes mellitus type 2]. |
| PubMed:[Regulation of the expression of pulmonary arterial collagen by protein kinase C and breviscapine in chronic hypoxic rats]. |
| PubMed:Differential effects of new breviscapine on arachidonic acid metabolisms in blood cells and endothelial cells. |
| PubMed:Effect of new-breviscapine on fibrinolysis and anticoagulation of human vascular endothelial cells. |
| PubMed:[An experimental study on the anti-reoxidation injury on myocardium of Erigeron breviscapus]. |
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3D/inchi