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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 1003.90 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 638.00 °F. TCC ( 336.50 °C. ) (est)
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| logP (o/w): | 1.165 (est) |
| Soluble in: |
| | water, 44.99 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Theaflavin 98%
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| BOC Sciences |
| For experimental / research use only. |
| Theaflavin >98%
Odor: characteristic Use: Theaflavin is antioxidant polyphenols which is formed from the condensation of flavan-3-ols in tea leaves during the enzymatic oxidation (fermentation) of black?tea. It can inhibit HIV-1 replication with multiple mechanisms of action. |
| Changsha Organic Herb |
| Black Tea Extract Teaflavin Theaflavin
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| Coompo |
| For experimental / research use only. |
| Theaflavine from Plants ≥98%
Odor: characteristic Use: Theaflavins have recognized medicinal benefits, and scientists have studied their positive effects on cardiovascular health, cancer, the immune system, metabolism, diabetes, and other areas.
Theaflavin are antioxidant polyphenols that are formed from flavan-3-ols such as in tea leaves.
Theaflavin can inhibit HIV-1 replication with multiple mechanisms of action.
Theaflavins and Thearubigins compounds found in black teas penetrate the blood brain barrier, and have been shown to be effective against dementia in aging as well as AIDS related dementia plaques in vitro.
Theaflavins have also been found to reduce blood cholesterol levels in human trials, both total and LDL.theaflavins are found to reduce angiogenesis, which is implicated in non-liquid cancers, an area of intense current research, by decreasing vascular endothelial growth factor production and receptor phosphorylation.
Theaflavin as mimics the effects of insulin/IGF-1 action on mammalian FOXO1a, which is involved in longevity and aging.
Theaflavin inhibited tumor necrosis factor-alpha mediated Interleukin-8 gene expression, as measured by luciferase assay and Northern blot analysis, at concentrations of 10 and 30 microg/mL.
Theaflavins have differential inhibitory activity in cancer cell lines and has the potential to be used individually for functional food applications and for therapy targeting specific cancer treatments. The most active theaflavin (TF2A) is a promising compound that can be used as a drug or a template for drug synthesis for anticancer research. |
| Matrix Scientific |
| For experimental / research use only. |
| Theaflavine, 95+%
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| Nacalai USA |
| For experimental / research use only. |
| Theaflavine
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| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Theaflavine
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| Sigma-Aldrich |
| For experimental / research use only. |
| Theaflavine
analytical standard |
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 562 mg/kg
Planta Medica. Vol. 42, Pg. 75, 1981.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for theaflavine usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for theaflavine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 3,4,5-trihydroxy-1,8-bis[(2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]benzo[7]annulen-6-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 114777 |
| Pubchem (sid): | 135071214 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 5H- | benzocyclohepten-5-one, 1,8-bis[(2R,3R)-3,4-dihydro-3,5,7-trihydroxy-2H-1-benzopyran-2-yl]-3,4,6-trihydroxy- | | | theaflavin derivative | | 3,4,6- | trihydroxy-1,8-bis-((2R,3R)-3,5,7-trihydroxy-chroman-2-yl)-benzocyclohepten-5-one | | 3,4,6- | trihydroxy-1,8-bis[(2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]-5H-benzo[7]annulen-5-one | | 3,4,5- | trihydroxy-1,8-bis[(2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]benzo[7]annulen-6-one | | 1,8-bis(3-a,5,7- | trihydroxy-2-a-chromanyl)-5H-benzocyclohepten-5-one |
Articles:
| PubMed:Theaflavins enhance intestinal barrier of Caco-2 Cell monolayers through the expression of AMP-activated protein kinase-mediated Occludin, Claudin-1, and ZO-1. |
| PubMed:The microbiota is essential for the generation of black tea theaflavins-derived metabolites. |
| PubMed:Black tea polyphenols inhibit tumor proteasome activity. |
| PubMed:Oxidative cascade reactions yielding polyhydroxy-theaflavins and theacitrins in the formation of black tea thearubigins: evidence by tandem LC-MS. |
| PubMed:Theaflavins extracted from black tea inhibit airway mucous hypersecretion induced by cigarette smoke in rats. |
| PubMed:Increase of theaflavin gallates and thearubigins by acceleration of catechin oxidation in a new fermented tea product obtained by the tea-rolling processing of loquat ( Eriobotrya japonica ) and green tea leaves. |
| PubMed:Theaflavins from black tea, especially theaflavin-3-gallate, reduce the incorporation of cholesterol into mixed micelles. |
| PubMed:PCR differential display-based identification of regulator of G protein signaling 10 as the target gene in human colon cancer cells induced by black tea polyphenol theaflavin monogallate. |
| PubMed:Radical-scavenging abilities and antioxidant properties of theaflavins and their gallate esters in H2O2-mediated oxidative damage system in the HPF-1 cells. |
| PubMed:Characteristics of catechin- and theaflavin-mediated cardioprotection. |
| PubMed:Theaflavin-3-gallate and theaflavin-3'-gallate, polyphenols in black tea with prooxidant properties. |
| PubMed:Combination of HSCCC and Sephadex LH-20 methods An approach to isolation and purification of the main individual theaflavins from black tea. |
| PubMed:Modulation of the oxidative stress and nuclear factor kappaB activation by theaflavin 3,3'-gallate in the rats exposed to cerebral ischemia-reperfusion. |
| PubMed:alpha-Glucosidase inhibitory profile of catechins and theaflavins. |
| PubMed:Inhibitory effects of black tea theaflavin derivatives on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and arachidonic acid metabolism in mouse ears. |
| PubMed:[Studies on antioxidant constituents from black tea]. |
| PubMed:Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins. |
| PubMed:Differential effects of theaflavin monogallates on cell growth, apoptosis, and Cox-2 gene expression in cancerous versus normal cells. |
| PubMed:Effect of black and green tea polyphenols on c-jun phosphorylation and H(2)O(2) production in transformed and non-transformed human bronchial cell lines: possible mechanisms of cell growth inhibition and apoptosis induction. |
| PubMed:Suppression of extracellular signals and cell proliferation by the black tea polyphenol, theaflavin-3,3'-digallate. |
| PubMed:An in vitro study of theaflavins extracted from black tea to neutralize bovine rotavirus and bovine coronavirus infections. |
| PubMed:Inhibition of phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate-caused inflammatory responses in SENCAR mouse skin by black tea polyphenols. |
| PubMed:The antioxidant properties of theaflavins and their gallate esters--radical scavengers or metal chelators? |
| PubMed:Prevention of heterocyclic amine formation by tea and tea polyphenols. |
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3D/inchi