gastrodin
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        Carbosynth
        Gastrodin
        For experimental / research use only.
        Changsha Organic Herb
        Gastrodin Gastrodia Tuber Extract
        Coompo
        Gastrodin from Plants ≥98%
        Odor: characteristic
        Use: Phenolic glucoside gastrodin (Gas), which is a main component extracted from the Chinese herbs Gastrodia elata Bl, is a well-known natural calcium antagonist with antioxidant and anti-inflammatory functions. It has long been used clinically for treatment of cardiovascular and cerebrovascular diseases. Previous studies have shown that gastrodin possesses comprehensive pharmacological functions. However, very little is known about whether gastrodin has protective role on cardiac hypertrophy. The aim of this study was to determine whether gastrodin attenuates pressure overload-induced cardiac hypertrophy in mice and to clarify the underlying molecular mechanisms. Our data demonstrated that gastrodin prevented cardiac hypertrophy induced by aortic banding (AB), as assessed by heart weight/body weight and lung weight/body weight ratios, echocardiographic parameters, and gene expression of hypertrophic markers. The inhibitory effect of gastrodin on cardiac hypertrophy is mediated by ERK1/2 signaling and GATA-4 activation. Further studies showed that gastrodin attenuated fibrosis and collagen synthesis through abrogating ERK1/2 signaling pathway. Therefore, these findings indicated that gastrodin, which is a potentially safe and inexpensive therapy for clinical use, has protective potential in targeting cardiac hypertrophy and fibrosis through suppression of ERK1/2 signaling. Gastrodin significantly attenuate levels of neurotoxic proinflammatory mediators and proinflammatory cytokines by inhibition of the NF-?B signaling pathway and phosphorylation of MAPKs in LPS-stimulated microglial cells. Arising from the above, we suggest that gastrodin has a potential as an anti-inflammatory drug candidate in neurodegenerative diseases. Gastrodin is an effective and a safe drug for the prevention of neurocognitive decline in patients undergoing mitral valve replacement surgery with CPB.
        For experimental / research use only.
  • Organoleptics
      • Organoleptic Properties
  • Properties
      • Physical Properties
        Assay : 95.00 to 100.00 % 
        Food Chemicals Codex Listed :No
        Boiling Point : 563.20 °C. @ 760.00 mm Hg (est)
        Flash Point : 562.00 °F. TCC ( 294.40 °C. ) (est)
        logP (o/w) : -1.939 (est)
  • Safety
      • Safety Information
        Oral/Parenteral Toxicity : 
          Not determined
        Dermal Toxicity : 
          Not determined
        Inhalation Toxicity : 
          Not determined
  • Safety in Use
      • Safety in Use Information
        Category :cosmetic agents
        Recommendation for gastrodin fragrance usage levels up to :
         not for fragrance use.
        Recommendation for gastrodin flavor usage levels up to :
         not for flavor use.
  • Safety References
  • Articles
(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[4-(hydroxymethyl)phenoxy]oxane-3,4,5-triol (Click)
CAS Number : 62499-27-8
XlogP3 :-0.80 (est)
Molecular Weight :286.28086000
Formula :C13 H18 O7
BioActivity Summary :listing
NMR Predictor :Predict
Category :cosmetic agents
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(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[4-(hydroxymethyl)phenoxy]oxane-3,4,5-triol
Synonyms :
 gastrodine
beta-D-glucopyranoside, 4-(hydroxymethyl)phenyl
4-(beta-D-glucopyranosyloxy) benzyl alcohol
(2R,3S,4S,5R,6S)-2-hydroxymethyl-6-(4-hydroxymethyl-phenoxy)-tetrahydro-pyran-3,4,5-triol
(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-(hydroxymethyl)phenoxy)-tetrahydro-2H-pyran-3,4,5-triol
(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-(hydroxymethyl)phenoxy)tetrahydro-2H-pyran-3,4,5-triol
(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[4-(hydroxymethyl)phenoxy]oxane-3,4,5-triol
4-(hydroxymethyl)phenyl b-D-glucopyranoside
4-(hydroxymethyl)phenyl-beta-D-glucopyranoside
Soluble in :
 water, 2.38e+005 mg/L @ 25 °C (est)
Stability :
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