EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

chelerythrine hydrochloride
1,2-dimethoxy-N-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride

Supplier Sponsors

CAS Number: 3895-92-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:223-444-9
FDA UNII: 7IC98TZ0PZ
MDL:MFCD00060717
Molecular Weight:383.83026000
Formula:C21 H18 Cl N O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Chelerythrine chloride 98%
BOC Sciences
For experimental / research use only.
Chelerythrine ≥98%
Odor: characteristic
Use: Chelerythrine Chloride, a sort of benzophenanthridine alkaloid, could be obtained from plant Greater celandine and has been found to be a PKC inhibitor that probably be effective in anti-inflammatory and anti-tumor studies. IC50: 660 nM.
Changsha Organic Herb
Celandine (Greater) Extract
EMD Millipore
For experimental / research use only.
Chelerythrine Chloride
sds
ExtraSynthese
For experimental / research use only.
Chelerythrine chloride (HPLC) ≥90%
Glentham Life Sciences
Chelerythrine chloride
Santa Cruz Biotechnology
For experimental / research use only.
Chelerythrine Chloride
Sigma-Aldrich: Sigma
For experimental / research use only.
Chelerythrine chloride ≥95% (TLC), powder
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 18500 ug/kg
Planta Medica. Vol. 43, Pg. 161, 1981.

Dermal Toxicity:
subcutaneous-mouse LD50 95 mg/kg
Planta Medica. Vol. 43, Pg. 161, 1981.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for chelerythrine hydrochloride usage levels up to:
 not for fragrance use.
 
Recommendation for chelerythrine hydrochloride flavor usage levels up to:
 not for flavor use.
 
Safety References:
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :72311
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride
Chemidplus:0003895929
RTECS:FL9200000 for cas# 3895-92-9
 
References:
 1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):72311
Pubchem (sid):135102464
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 celandine greater celandine
Search Trop Picture
 
Synonyms:
 chelerythrine chloride
 chelerythrine HCl
 chelerythrine, chloride
1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride
1,2-dimethoxy-12-methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-ium chloride
1,2-dimethoxy-12-methyl-9H-phenanthridino[4',3'-5,4]benzo[d]1,3-dioxolane, chloride
1,2-dimethoxy-12-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride
1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium chloride
1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride
1,2-dimethoxy-N-methyl(1,3)benzodioxolo(5,6-c) phenanthridinium chloride
1,2-dimethoxy-N-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride
 

Articles:

PubMed:Dexmedetomidine-Induced Contraction in the Isolated Endothelium-Denuded Rat Aorta Involves PKC-δ-mediated JNK Phosphorylation.
PubMed:Muscarinic receptor control of pyramidal neuron membrane potential in the medial prefrontal cortex (mPFC) in rats.
PubMed:Functional effects of β3-adrenoceptor on pacemaker activity in interstitial cells of Cajal from the mouse colon.
PubMed:Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A-receptor knockout mice.
PubMed:Delta-opioid receptor activation promotes mesenchymal stem cell survival via PKC/STAT3 signaling pathway.
PubMed:Role of mitochondrial ATP-sensitive potassium channels on fatigue in mouse muscle fibers.
PubMed:Calcium sensitization in human esophageal muscle: role for RhoA kinase in maintenance of lower esophageal sphincter tone.
PubMed:Effect of purines on calcium-independent acetylcholine release at the mouse neuromuscular junction.
PubMed:l-Stepholidine increases the frequency of sEPSC via the activation of D1 dopamine signaling pathway in rat prelimbic cortical neurons.
PubMed:Presynaptic inhibition of spontaneous acetylcholine release mediated by P2Y receptors at the mouse neuromuscular junction.
PubMed:Calcium channel and glutamate receptor activities regulate actin organization in salamander retinal neurons.
PubMed:Purine release from spinal cord microglia after elevation of calcium by glutamate.
PubMed:The beneficial in vitro effects of lovastatin and chelerythrine on relaxatory response to acetylcholine in the perfused mesentric bed isolated from diabetic rats.
PubMed:Dopamine acutely decreases type 3 Na(+)/H(+) exchanger activity in renal OK cells through the activation of protein kinases A and C signalling cascades.
PubMed:Differential roles of spinal protein kinases C and a in development of primary heat and mechanical hypersensitivity induced by subcutaneous bee venom chemical injury in the rat.
PubMed:Pharmacological characterisation of neuropeptide F (NPF)-induced effects on the motility of Mesocestoides corti (syn. Mesocestoides vogae) larvae.
PubMed:Diverse regulation of atrial natriuretic peptide secretion by serotonin receptor subtypes.
PubMed:Effect of protein kinase C activation and inhibition on rat hepatic stellate cell activation.
PubMed:Lipoxin A4 stimulates a cytosolic Ca2+ increase in human bronchial epithelium.
PubMed:Rapid non-genomic inhibition of ATP-induced Cl- secretion by dexamethasone in human bronchial epithelium.
PubMed:Interactions between ionotropic and metabotropic glutamate receptors regulate cAMP response element-binding protein phosphorylation in cultured striatal neurons.
PubMed:Bradykinin-evoked Ca2+ mobilization in Madin Darby canine kidney cells.
PubMed:Ca2+-independent protein kinase C isoforms may modulate parietal cell HCl secretion.
 
Notes:
None found
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