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Category:pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 430.68 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 305.00 °F. TCC ( 151.90 °C. ) (est)
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| logP (o/w): | 2.357 (est) |
| Soluble in: |
| | water, 13.23 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 83 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmaceutical Sciences. Vol. 61, Pg. 813, 1972.
oral-mouse LD50 240 mg/kg
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 197, Pg. 261, 1972.
oral-rat LD50 280 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 197, Pg. 261, 1972.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | pharmaceuticals / chemical synthisis |
| Recommendation for nuciferine usage levels up to: | | | not for fragrance use.
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| Recommendation for nuciferine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | (6aR)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 10146 |
| Pubchem (sid): | 134973322 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H- | dibenzo(de,g)quinoline, 5,6,6a,7-tetrahydro-1,2-dimethoxy-6-methyl-, (R)- (9CI) | | (6aR)-1,2- | dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline | | (R)-1,2- | dimethoxyaporphine | | (R)- | nuciferine | | (-)- | nucipherine | | | sanjoinine E |
Articles:
| PubMed:Bioactive constituents from Michelia champaca. |
| PubMed:Application of ionic liquids based microwave-assisted extraction of three alkaloids N-nornuciferine, O-nornuciferine, and nuciferine from lotus leaf. |
| PubMed:[Alkaloids of plumula Nelumbinis]. |
| PubMed:Alkaloids from Papaver armeniacum, P. fugax and P. tauricola. |
| PubMed:Alkaloids of Nelumbo lutea (Wild.) pers. (Nymphaeaceae) |
| PubMed:Nuciferine, extracted from Nelumbo nucifera Gaertn, inhibits tumor-promoting effect of nicotine involving Wnt/β-catenin signaling in non-small cell lung cancer. |
| PubMed:Nuciferine restores potassium oxonate-induced hyperuricemia and kidney inflammation in mice. |
| PubMed:Nuciferine relaxes rat mesenteric arteries through endothelium-dependent and -independent mechanisms. |
| PubMed:Antioxidant and anticancer aporphine alkaloids from the leaves of Nelumbo nucifera Gaertn. cv. Rosa-plena. |
| PubMed:Comparative analysis of antioxidant activity and functional components of the ethanol extract of lotus (Nelumbo nucifera) from various growing regions. |
| PubMed:A sensitive liquid chromatography-tandem mass spectrometry method for pharmacokinetics and tissue distribution of nuciferine in rats. |
| PubMed:[Cytotoxic alkaloids from stems of Nelumbo nucifera]. |
| PubMed:Hugan Qingzhi medication ameliorates hepatic steatosis by activating AMPK and PPARα pathways in L02 cells and HepG2 cells. |
| PubMed:Anthelmintic activities of aporphine from Nelumbo nucifera Gaertn. cv. Rosa-plena against Hymenolepis nana. |
| PubMed:Purification and characterization of aporphine alkaloids from leaves of Nelumbo nucifera Gaertn and their effects on glucose consumption in 3T3-L1 adipocytes. |
| PubMed:Identification and characterization of potent CYP2D6 inhibitors in lotus leaves. |
| PubMed:Bioactivity of five components of Chinese herbal formula Jiangzhi granules against hepatocellular steatosis. |
| PubMed:Analysis of alkaloids in Lotus (Nelumbo nucifera Gaertn.) leaves by non-aqueous capillary electrophoresis using ultraviolet and mass spectrometric detection. |
| PubMed:Nuciferine prevents hepatic steatosis and injury induced by a high-fat diet in hamsters. |
| PubMed:Alkaloid constituents from flower buds and leaves of sacred lotus (Nelumbo nucifera, Nymphaeaceae) with melanogenesis inhibitory activity in B16 melanoma cells. |
| PubMed:Structure-based identification of aporphines with selective 5-HT(2A) receptor-binding activity. |
| PubMed:Nuciferine stimulates insulin secretion from beta cells-an in vitro comparison with glibenclamide. |
| PubMed:Bioactive constituents from Michelia champaca. |
| PubMed:An aporphine alkaloid from Nelumbo nucifera as an acetylcholinesterase inhibitor and the primary investigation for structure-activity correlations. |
| PubMed:LC/MS guided isolation of alkaloids from lotus leaves by pH-zone-refining counter-current chromatography. |
| PubMed:Characterization of nuciferine metabolism by P450 enzymes and uridine diphosphate glucuronosyltransferases in liver microsomes from humans and animals. |
| PubMed:In-vitro and in-vivo evaluations of cytochrome P450 1A2 interactions with nuciferine. |
| PubMed:Application of ionic liquids based microwave-assisted extraction of three alkaloids N-nornuciferine, O-nornuciferine, and nuciferine from lotus leaf. |
| PubMed:[Optimal extraction of nuciferine and flavone from lotus leaf based on central composite design and response surface methodology]. |
| PubMed:[HPLC determination of 2-hydroxy-1-methoxyaporphine, pronuciferine, nuciferine and roemerine in Nelumbo nucifera and its alkaloid fraction]. |
| PubMed:Application of activated glassy carbon electrode for the detection of nuciferine in lotus leaves. |
| PubMed:Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids. |
| PubMed:[Alkaloids of plumula Nelumbinis]. |
| PubMed:Effects of anticonvulsants and other agents on seizures induced by intracerebral L-glutamate. |
| PubMed:Alkaloids from Papaver armeniacum, P. fugax and P. tauricola. |
| PubMed:Antagonism of intrastriatal and intravenous kainic acid by 1-nuciferine: comparison with various anticonvulsants and GABAmimetics. |
| PubMed:Effects of anticonvulsants and glutamate antagonists on the convulsive action of kainic acid. |
| PubMed:Nuciferine and central glutamate receptors. |
| PubMed:Effects of L-nuciferine on kainate, N-methyl-D-aspartate and acetylcholine excitation of cat spinal neurons. |
| PubMed:Alkaloids of Nelumbo lutea (Wild.) pers. (Nymphaeaceae) |
| PubMed:Effects of intravenous kainic acid, N-methyl-D-aspartate, and (--)-nuciferine on the cat spinal cord. |
| PubMed:Dimethoxyaporphine as an antagonist of chemical excitation in the pigeon optic tectum. |
| PubMed:Aporphines. 16. Action of aporphine alkaloids on locomotor activity in rats with 6-hydroxydopamine lesions of the nucleus accumbens. |
| PubMed:Proceedings: Specificity of nuciferine as an antagonist of amino acid and synaptically evoked activity in cells of the feline thalamus. |
| PubMed:The blockade of synaptic and amino acid evoked firing in the cuneate nucleus by the "glutamic acid antagonist' nuciferine (1-5,6-dimethoxyaporphine). |
| PubMed:Centrally acting emetics. 9. Hofmann and Emde degradation products of nuciferine. |
| PubMed:Effect of nuciferine on the chemical excitation of Renshaw cells in the rat. |
| PubMed:Studies on the pharmacology of nuciferine and related aporphines. |
| PubMed:Phtochemical routes to aporphines. New synthesis of nuciferine and glaucine. |
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3D/inchi