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notoginsenoside R1
O-acetylseudolaric acid C

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CAS Number: 80418-24-2Picture of molecule3D/inchi
FDA UNII: Z62692362Z
Nikkaji Web:J850.095I
MDL:MFCD00210535
XlogP3-AA:1.10 (est)
Molecular Weight:933.14020000
Formula:C47 H80 O18
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point:1010.53 °C. @ 760.00 mm Hg (est)
Flash Point:1049.00 °F. TCC ( 564.90 °C. ) (est)
logP (o/w): 1.354 (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Notoginsenoside R1 98%
BOC Sciences
For experimental / research use only.
Notoginsenoside R1
Carbosynth
For experimental / research use only.
Notoginsenoside R1
Changsha Organic Herb
Notoginseng Extract
Santa Cruz Biotechnology
For experimental / research use only.
Notoginsenoside R1
Sigma-Aldrich
For experimental / research use only.
Notoginsenoside R1
analytical standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for notoginsenoside R1 usage levels up to:
 not for fragrance use.
 
Recommendation for notoginsenoside R1 flavor usage levels up to:
 not for flavor use.
 
Safety References:
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :441934
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0080418242
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):441934
Pubchem (sid):135088779
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C08961
HMDB (The Human Metabolome Database):HMDB35363
FooDB:FDB014036
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 panax notoginseng root
Search Trop Picture
 
Synonyms:
O-acetylseudolaric acid C
beta-d-glucopyranoside, (3beta,6alpha,12beta)-20-(beta-d-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-beta-D-xylopyranosyl-
(-)-pseudolaric acid B
pseudolaric acid B
 

Articles:

PubMed:Saponins composition of rhizomes, taproots, and lateral roots of Satsuma-ninjin (Panax japonicus).
PubMed:New triterpenoid saponins from fruits specimens of Panax japonicus collected in Kumamoto and Miyazaki prefectures (1).
PubMed:[Influence of particle sizes and content of effective compositions of Panax notoginseng powders crashing by superfine somminution technique].
PubMed:Notoginsenoside R1 attenuates hypoxia and hypercapnia-induced vasoconstriction in isolated rat pulmonary arterial rings by reducing the expression of ERK.
PubMed:Notoginsenoside R1 attenuates amyloid-β-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation.
PubMed:Notoginsenoside R1 attenuates atherosclerotic lesions in ApoE deficient mouse model.
PubMed:Dissecting active ingredients of Chinese medicine by content-weighted ingredient-target network.
PubMed:[Major hypoglycemic ingredients of panax notoginseng saponins for treating diabetes].
PubMed:Suppression of NADPH oxidase- and mitochondrion-derived superoxide by Notoginsenoside R1 protects against cerebral ischemia-reperfusion injury through estrogen receptor-dependent activation of Akt/Nrf2 pathways.
PubMed:Preparation of a monoclonal antibody against notoginsenoside R1, a distinctive saponin from Panax notoginseng, and its application to indirect competitive ELISA.
PubMed:[Chemical constituents from processed rhizomes of Panax notoginseng].
PubMed:On-line coupling of macroporous resin column chromatography with direct analysis in real time mass spectrometry utilizing a surface flowing mode sample holder.
PubMed:Notoginsenoside R1-mediated neuroprotection involves estrogen receptor-dependent crosstalk between Akt and ERK1/2 pathways: a novel mechanism of Nrf2/ARE signaling activation.
PubMed:[Chemical constituents from roots and rhizomes of Panax ginseng cultivated in Jilin province].
PubMed:[Simultaneous content determination of notoginsenoside R1, ginsenoside Rg1, Re, Rb1 and dracorhodin in ZJHX rubber paste by double wavelength HPLC].
PubMed:Simultaneous determination of 30 ginsenosides in Panax ginseng preparations using ultra performance liquid chromatography.
PubMed:Protective effects of Notoginsenoside R1 on intestinal ischemia-reperfusion injury in rats.
PubMed:Influence of gastrointestinal digestion and edible plant combination on oral bioavailability of triterpene saponins, using a biomimetic digestion and absorption system and determination by HPLC.
PubMed:A novel strategy with standardized reference extract qualification and single compound quantitative evaluation for quality control of Panax notoginseng used as a functional food.
PubMed:Components of Panax notoginseng saponins enhance the cytotoxicity of cisplatin via their effects on gap junctions.
PubMed:Effects of Borneol on Pharmacokinetics and Tissue Distribution of Notoginsenoside R1 and Ginsenosides Rg1 and Re in Panax notoginseng in Rabbits.
PubMed:Combinatorial metabolism notably affects human systemic exposure to ginsenosides from orally administered extract of Panax notoginseng roots (Sanqi).
PubMed:[Systematic study on QAMS method for quality control of Panax notoginseng].
PubMed:Saponins composition of rhizomes, taproots, and lateral roots of Satsuma-ninjin (Panax japonicus).
PubMed:Notoginsenoside R1 attenuates cardiac dysfunction in endotoxemic mice: an insight into oestrogen receptor activation and PI3K/Akt signalling.
PubMed:[Effects of the combination of active component extracts from Astragalus membranaceus and Panax notoginseng on apoptosis, reactive oxygen species and mitochondrial membrane potential of PC12 cells with oxidative injury].
PubMed:[Analysis of saponins in Panax notoginseng by UPLC-LTQ-Orbitrap MS/MS].
PubMed:Core-shell hybrid liposomal vesicles loaded with panax notoginsenoside: preparation, characterization and protective effects on global cerebral ischemia/reperfusion injury and acute myocardial ischemia in rats.
PubMed:The effects of notoginsenoside R₁ on the intestinal absorption of geniposide by the everted rat gut sac model.
PubMed:Analysis of Panax notoginseng metabolites in rat bile by liquid chromatography-quadrupole time-of-flight mass spectrometry with microdialysis sampling.
PubMed:New triterpenoid saponins from fruits specimens of Panax japonicus collected in Kumamoto and Miyazaki prefectures (1).
PubMed:Antioxidant, antiproliferative, and pro-apoptotic activities of a saponin extract derived from the roots of Panax notoginseng (Burk.) F.H. Chen.
PubMed:[Network pharmacology study on major active compounds of Fufang Danshen formula].
PubMed:Metabolite profiling and pharmacokinetics of herbal compounds following oral administration of a cardiovascular multi-herb medicine (Qishen yiqi pills) in rats.
PubMed:[Study on methodology of determination of Yizhi osmotic pump tablets active ingredient in Beagle dog plasma by LC-MS/MS].
PubMed:Pharmacokinetics study of bio-adhesive tablet of Panax notoginseng saponins.
PubMed:[Effects of combination of Salvia miltiorrhiza and Panax notoginseng on the pharmacokinetics of their major bioactive components in Beagle dog].
PubMed:[In vitro balanced sustained-release of Panax notoginseng saponins controlled with various matrix materials].
PubMed:Displacement of bilirubin from albumin in plasma from jaundiced newborns. An in vitro study of purified Chinese herbal constituents and sulfisoxazole.
PubMed:[Study on preparation and quality standard of Xueshuantong Drop Pills].
PubMed:Metabolism study of notoginsenoside r1, ginsenoside rg1 and ginsenoside rb1 of radix panax notoginseng in zebrafish.
PubMed:Simultaneous determination of three Panax notoginseng saponins at sub-nanograms by LC-MS/MS in dog plasma for pharmacokinetics of compound Danshen tablets.
PubMed:Anti-diabetic effects of Panax notoginseng saponins and its major anti-hyperglycemic components.
PubMed:[Determination of effective components in different positions of Panax notoginseng by HPLC].
PubMed:Characterization of metabolism and in vitro permeability study of notoginsenoside R1 from Radix notoginseng.
PubMed:Simultaneous determination of three major bioactive saponins of Panax notoginseng using liquid chromatography-tandem mass spectrometry and a pharmacokinetic study.
PubMed:Notoginsenoside R1 attenuates renal ischemia-reperfusion injury in rats.
PubMed:[HPLC-CAD in optimizating of saponins extraction from Radix et Rhizoma Notoginseng].
PubMed:[Study on preparation and release mechanism of effervescent osmotic pump tablet of compound Danshen].
PubMed:Simultaneous determination of notoginsenoside R1, ginsenoside Rg1, Re, Rb1 and icariin in rat plasma by ultra-performance liquid chromatography-tandem mass spectrometry.
PubMed:[Preparation and release characterization in vitro of pulsed-release tablets of compound Danshen].
PubMed:Possible protection by notoginsenoside R1 against glutamate neurotoxicity mediated by N-methyl-D-aspartate receptors composed of an NR1/NR2B subunit assembly.
PubMed:Antiproliferative effects of different plant parts of Panax notoginseng on SW480 human colorectal cancer cells.
PubMed:Simultaneous determination of nucleobases, nucleosides and saponins in Panax notoginseng using multiple columns high performance liquid chromatography.
PubMed:[Studies on chemical constituents from rhizomes of Panax notoginseng].
PubMed:Effect of notoginsenoside R1 on hepatic microcirculation disturbance induced by gut ischemia and reperfusion.
PubMed:Chemopreventive effects of Panax notoginseng and its major constituents on SW480 human colorectal cancer cells.
PubMed:Protective effects of ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1 on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery.
PubMed:[Effect compound decoction on notoginsenosides in Panax notoginseng].
PubMed:Microbial transformation of 20(S)-protopanaxatriol-type saponins by Absidia coerulea.
PubMed:Chemical characteristics of three medicinal plants of the Panax genus determined by HPLC-ELSD.
PubMed:A rapid method for the simultaneous determination of 11 saponins in Panax notoginseng using ultra performance liquid chromatography.
PubMed:Pharmacokinetic and absolute bioavailability study of total panax notoginsenoside, a typical multiple constituent traditional chinese medicine (TCM) in rats.
PubMed:Application of atmospheric pressure chemical ionisation mass spectrometry in the identification and differentiation of Panax species.
PubMed:Simultaneous determination of panax notoginsenoside R1, ginsenoside Rg1, Rd, Re and Rb1 in rat plasma by HPLC/ESI/MS: platform for the pharmacokinetic evaluation of total panax notoginsenoside, a typical kind of multiple constituent traditional Chinese medicine.
PubMed:[RP-HPLC characteristics of Panax notoginseng].
PubMed:Ginsenoside Re and notoginsenoside R1: Immunologic adjuvants with low haemolytic effect.
PubMed:Simultaneous determination of 11 saponins in Panax notoginseng using HPLC-ELSD and pressurized liquid extraction.
PubMed:[Determination of notoginsenoside R1 and ginsenoside Rg1 in Rupixiao tablets by HPLC].
PubMed:Notoginsenoside R1 inhibits TNF-alpha-induced fibronectin production in smooth muscle cells via the ROS/ERK pathway.
PubMed:Simultaneous determination of components in preparation Naodesheng injection by high performance liquid chromatograph-atmospheric pressure chemical ionization mass spectrometry (HPLC-MS/APCI).
PubMed:Chemical characteristics for different parts of Panax notoginseng using pressurized liquid extraction and HPLC-ELSD.
PubMed:Notoginsenoside R1 from Panax notoginseng inhibits TNF-alpha-induced PAI-1 production in human aortic smooth muscle cells.
PubMed:A rapid HPLC-ESI-MS/MS for qualitative and quantitative analysis of saponins in "XUESETONG" injection.
PubMed:Simultaneous determination of nine saponins from Panax notoginseng using HPLC and pressurized liquid extraction.
PubMed:Determination of four active saponins of Panax notoginseng in rat feces by high-performance liquid chromatography.
PubMed:Orthogonal array design in optimizing the extraction efficiency of active constituents from roots of Panax notoginseng.
PubMed:[Cell proliferation inhibitive and apoptosis promoting effects of sanchi extract on GES-1 cell after being transformed by MNNG].
PubMed:[Effects of panax notoginseng saponins on the process of renal interstitial fibrosis after unilateral ureteral obstruction in rats].
PubMed:Simultaneous quantification of six major active saponins of Panax notoginseng by high-performance liquid chromatography-UV method.
PubMed:[Determination of notoginsenoside R1, ginsenoside Rg1 and Rb1 in Radix Notoginseng and its preparation by HPLC-ELSD].
PubMed:HPLC determination of four active saponins from Panax notoginseng in rat serum and its application to pharmacokinetic studies.
PubMed:Liquid chromatographic method for determination of four active saponins from Panax notoginseng in rat urine using solid-phase extraction.
PubMed:[Identification of Panax notoginseng and its preparations by LC/MS].
PubMed:[Up-regulation of transcription factors NF-E2, c-jun and c-fos of AP-1 family induced by Panax Notoginosides in hematopoietic cells].
PubMed:[Effects of root rot on saponin content in Panax notoginseng].
PubMed:Chemical assessment of roots of Panax notoginseng in China: regional and seasonal variations in its active constituents.
PubMed:[Effect of Panax notoginsenosides on the proliferation of hematopoietic progenitor cells in mice with immune-mediated aplastic anemia].
PubMed:Analysis of saponins in raw and steamed Panax notoginseng using high-performance liquid chromatography with diode array detection.
PubMed:Isolation of dammarane saponins from Panax notoginseng by high-speed counter-current chromatography.
PubMed:[Proliferation and differentiation of human CD34+ hematopoietic stem/progenitor cells induced by Panax notoginosides].
PubMed:Notoginseny cream in the treatment of phlebitis.
PubMed:[Determination of notoginsenoside R1 in radix notoginseng by HPLC-ELSD].
PubMed:Bioactive saponins and glycosides. XIX. Notoginseng (3): immunological adjuvant activity of notoginsenosides and related saponins: structures of notoginsenosides-L, -M, and -N from the roots of Panax notoginseng (Burk.) F. H. Chen.
PubMed:Saponins of plants of Panax species collected in Central Nepal, and their chemotaxonomical significance. III.
PubMed:Effect of notoginsenoside R1 on the synthesis of components of the fibrinolytic system in cultured smooth muscle cells of human pulmonary artery.
PubMed:Notoginsenoside R1 counteracts endotoxin-induced activation of endothelial cells in vitro and endotoxin-induced lethality in mice in vivo.
PubMed:Effect of notoginsenoside R1 on the synthesis of tissue-type plasminogen activator and plasminogen activator inhibitor-1 in cultured human umbilical vein endothelial cells.
PubMed:[Protection of Chinese medicinal herb extracts against cerebral ischemia-reperfusion injury].
PubMed:[Preliminary studies of notoginsenoside R1-induced differentiation of HL-60 cell lines in vitro].
 
Notes:
Constit. of roots of Panax notoginseng (ginseng)
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