EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

lentinan
bromoduline

Supplier Sponsors

CAS Number: 37339-90-5Picture of molecule3D/inchi
FDA UNII: 6751655D1D
XlogP3-AA:-13.30 (est)
Molecular Weight:1153.00704000
Formula:C42 H72 O36
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point:1471.97 °C. @ 760.00 mm Hg (est)
Flash Point:1551.00 °F. TCC ( 844.00 °C. ) (est)
logP (o/w):-12.265 (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Lentinan 95%
Carbosynth
For experimental / research use only.
Lentinan
Changsha Organic Herb
Fu Ling Indian Bread Extract
Glentham Life Sciences
Lentinan
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-dog LD50 > 100 mg/kg
Drugs in Japan Vol. -, Pg. 1277, 1990.

intraperitoneal-mouse LD50 > 2500 mg/kg
Drugs in Japan Vol. -, Pg. 1277, 1990.

intravenous-mouse LD50 250 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 365, 1986.

intravenous-rabbit LD50 > 100 mg/kg
Drugs in Japan Vol. -, Pg. 1277, 1990.

intraperitoneal-rat LD50 > 2500 mg/kg
Drugs in Japan Vol. -, Pg. 1277, 1990.

intravenous-rat LD50 250 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 365, 1986.

Dermal Toxicity:
subcutaneous-mouse LD50 > 2500 mg/kg
Drugs in Japan Vol. -, Pg. 1277, 1990.

subcutaneous-rat LD50 > 2500 mg/kg
Drugs in Japan Vol. -, Pg. 1277, 1990.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for lentinan usage levels up to:
 not for fragrance use.
 
Recommendation for lentinan flavor usage levels up to:
 not for flavor use.
 
Safety References:
ClinicalTrials.gov:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :37723
National Institute of Allergy and Infectious Diseases:Data
Chemidplus:0037339905
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):37723
Pubchem (sid):134998498
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):C13156
HMDB (The Human Metabolome Database):HMDB29948
FooDB:FDB001229
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 lentinula edodes
Search PMC Picture
 
Synonyms:
 bromoduline
 

Articles:

PubMed:Lentinan degradation in the Lentinula edodes fruiting body during postharvest preservation is reduced by downregulation of the exo-β-1,3-glucanase EXG2.
PubMed:Shiitake dermatitis recorded by French Poison Control Centers - new case series with clinical observations.
PubMed:Inhibition of aflatoxin synthesis in Aspergillus flavus by three structurally modified lentinans.
PubMed:Characterization of polarized THP-1 macrophages and polarizing ability of LPS and food compounds.
PubMed:Shiitake dermatitis: a distinctive clinical entity.
PubMed:Clinical variability of shiitake dermatitis.
PubMed:Antitumor activity of mushroom polysaccharides: a review.
PubMed:Dynamic high pressure microfluidization-assisted extraction and antioxidant activities of lentinan.
PubMed:β-Glucans are involved in immune-modulation of THP-1 macrophages.
PubMed:[Pregnant woman with flagellate erythema].
PubMed:[Shiitake dermatitis now occurs in France].
PubMed:[Provision for adverse effect of S-1 containing chemotherapy in patients with advanced digestive cancer--combination with superfine dispersed lentinan].
PubMed:Effects of management factors on the concentration of a high molecular weight polysaccharide fraction from log-grown shiitake mushrooms (Lentinula edodes (Berk.) Pegler).
PubMed:Beta-glucans in higher fungi and their health effects.
PubMed:Different suppressive effects of fucoidan and lentinan on IL-8 mRNA expression in in vitro gut inflammation.
PubMed:Clinical efficacy of superfine dispersed lentinan (beta-1,3-glucan) in patients with hepatocellular carcinoma.
PubMed:Structural characterization, chain conformation, and morphology of a beta-(1-->3)-D-glucan isolated from the fruiting body of Dictyophora indusiata.
PubMed:[Effects of six polysaccharides extracted from plants on the immunological cells of mice].
PubMed:Immunological effects of yeast- and mushroom-derived beta-glucans.
PubMed:[Anti tumor activities of lentinan and micellapist in tumor-bearing mice].
PubMed:Lentinan from shiitake mushroom (Lentinus edodes) suppresses expression of cytochrome P450 1A subfamily in the mouse liver.
PubMed:1,3-beta-glucan quantification by a fluorescence microassay and analysis of its distribution in foods.
PubMed:Effects of management on the yield and high-molecular-weight polysaccharide content of shiitake (Lentinula edodes) mushrooms.
PubMed:Anti-tumor polysaccharides from mushrooms during storage.
PubMed:Autolysis of lentinan, an antitumor polysaccharide, during storage of Lentinus edodes, shiitake mushroom.
PubMed:Effects of lentinan on abnormal ingestive behaviors induced by tumor necrosis factor.
PubMed:Effect of a nitrofuran derivative (AF2) on the immune response of mice.
 
Notes:
polysaccharide isolated from the edible mushroom lentinula edodes. the exact composition is unknown. Elaborated by the fungus Lentinus edodes (shiitake) Lentinan is a beta-glucan with a glycosidic ?-1,3:?-1,6 linkage. It is an anti-tumor polysaccharide from the shiitake (Lentinula edodes) mushroom. Lentinan is a polysaccharide which is free of nitrogen, and has a molecular weight of approximently 500,000 Da.; Lentinan is one of the host-mediated anti-cancer drugs which has been shown to affect host defense immune systems.
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