|
Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 361.12 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 387.00 °F. TCC ( 197.30 °C. ) (est)
|
| logP (o/w): | -1.177 (est) |
| Soluble in: |
| | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 > 5000 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
SKIN AND APPENDAGES (SKIN): HAIR: OTHER
KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
International Journal of Toxicology. Vol. 16(Suppl
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for 1-deoxynojirimycin usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for 1-deoxynojirimycin flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
| | (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 29435 |
| Pubchem (sid): | 134993236 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| D-5- | amino-1,5-dideoxyglucopyranose | | 1,5- | deoxy-1,5-imino-D-mannitol | | 1- | deoxy-nojirimycin | | 1- | deoxymannojirimycin | | 1,5- | dideoxy-1,5-imino-D-glucitol | | | duvoglustat | | (2R,3R,4R,5S)-2- | hydroxymethyl-3,4,5-trihydroxypiperidine | | (2R,3R,4R,5S)-2- | hydroxymethyl-piperidine-3,4,5-triol | | [2R-(2a,3b,4a,5b)]-2-( | hydroxymethyl)-3,4,5-piperidinetriol | | (2R,3R,4R,5S)-2-( | hydroxymethyl)piperidine-3,4,5-triol | | | moranoline | | 3,4,5- | piperidinetriol, 2-(hydroxymethyl)-, (2R,3R,4R,5S)- |
Articles:
| PubMed:Central Administration of 1-Deoxynojirimycin Attenuates Hypothalamic Endoplasmic Reticulum Stress and Regulates Food Intake and Body Weight in Mice with High-Fat Diet-Induced Obesity. |
| PubMed:Intake of mulberry 1-deoxynojirimycin prevents colorectal cancer in mice. |
| PubMed:Metabolic Effect of 1-Deoxynojirimycin from Mulberry Leaves on db/db Diabetic Mice Using Liquid Chromatography-Mass Spectrometry Based Metabolomics. |
| PubMed:Fate of d-Fagomine after Oral Administration to Rats. |
| PubMed:Decreased formation of branched-chain short fatty acids in Bacillus amyloliquefaciens by metabolic engineering. |
| PubMed:Use of Bacillus amyloliquefaciens HZ-12 for High-Level Production of the Blood Glucose Lowering Compound, 1-Deoxynojirimycin (DNJ), and Nutraceutical Enriched Soybeans via Fermentation. |
| PubMed:Supplementation of a Fermented Soybean Extract Reduces Body Mass and Prevents Obesity in High Fat Diet-Induced C57BL/6J Obese Mice. |
| PubMed:A 28-Day Repeated Dose Toxicological Study of an Aqueous Extract of Morus Alba L. |
| PubMed:Effects of Applied Nitrogen Amounts on the Functional Components of Mulberry (Morus alba L.) Leaves. |
| PubMed:Concurrent Therapy with a Low-carbohydrate Diet and Miglitol Remarkably Improved the Postprandial Blood Glucose and Insulin Levels in a Patient with Reactive Hypoglycemia due to Late Dumping Syndrome. |
| PubMed:Prevention Effects and Possible Molecular Mechanism of Mulberry Leaf Extract and its Formulation on Rats with Insulin-Insensitivity. |
| PubMed:Pressurized liquid extraction of Aglaonema sp. iminosugars: Chemical composition, bioactivity, cell viability and thermal stability. |
| PubMed:Identification and Determination of the Polyhydroxylated Alkaloids Compounds with α-Glucosidase Inhibitor Activity in Mulberry Leaves of Different Origins. |
| PubMed:Effect of solar radiation on the functional components of mulberry (Morus alba L.) leaves. |
| PubMed:Chronic adjunction of 1-deoxynojirimycin protects from age-related behavioral and biochemical changes in the SAMP8 mice. |
| PubMed:Multiple Comparisons of Glucokinase Activation Mechanisms of Five Mulberry Bioactive Ingredients in Hepatocyte. |
| PubMed:Mulberry 1-Deoxynojirimycin Inhibits Adipogenesis by Repression of the ERK/PPARγ Signaling Pathway in Porcine Intramuscular Adipocytes. |
| PubMed:Inhibition of α-glucosidase activity by N-deoxynojirimycin analogs in several insect phloem sap feeders. |
| PubMed:Miglitol protects against age-dependent weight gain in mice: A potential role of increased UCP1 content in brown adipose tissue. |
| PubMed:1-deoxynojirimycin isolated from Bacillus subtilis improves hepatic lipid metabolism and mitochondrial function in high-fat-fed mice. |
| PubMed:Mulberry leaf extract improves postprandial glucose response in prediabetic subjects: a randomized, double-blind placebo-controlled trial. |
| PubMed:A Comparison of Food-grade Folium mori ( Sāng Yè) Extract and 1-Deoxynojirimycin for Glycemic Control and Renal Function in Streptozotocin-induced Diabetic Rats. |
| PubMed:Comparative evaluation of polysaccharides isolated from Astragalus, oyster mushroom, and yacon as inhibitors of α-glucosidase. |
| PubMed:1-Deoxynojirimycin attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells. |
| PubMed:Evaluation of general toxicity and genotoxicity of the silkworm extract powder. |
| PubMed:Cotreatment with the α-glucosidase inhibitor miglitol and DPP-4 inhibitor sitagliptin improves glycemic control and reduces the expressions of CVD risk factors in type 2 diabetic Japanese patients. |
| PubMed:Mulberry 1-deoxynojirimycin pleiotropically inhibits glucose-stimulated vascular smooth muscle cell migration by activation of AMPK/RhoB and down-regulation of FAK. |
| PubMed:Miglitol prevents diet-induced obesity by stimulating brown adipose tissue and energy expenditure independent of preventing the digestion of carbohydrates. |
| PubMed:Comparison of inhibitory activities and mechanisms of five mulberry plant bioactive components against α-glucosidase. |
| PubMed:Studies targeting α-glucosidase inhibition, antiangiogenic effects, and lipid modification regulation: background, evaluation, and challenges in the development of food ingredients for therapeutic purposes. |
| PubMed:1-Deoxynojirimycin isolated from a Bacillus subtilis stimulates adiponectin and GLUT4 expressions in 3T3-L1 adipocytes. |
| PubMed:Intake of mulberry 1-deoxynojirimycin prevents diet-induced obesity through increases in adiponectin in mice. |
| PubMed:Kinetic and thermodynamic analysis of the inhibitory effects of maltose, glucose, and related carbohydrates on wheat β-amylase. |
| PubMed:A novel gelatin crosslinking method retards release of mulberry 1-deoxynojirimycin providing a prolonged hypoglycaemic effect. |
| PubMed:Isolation of the putative biosynthetic gene cluster of 1-deoxynojirimycin by Bacillus amyloliquefaciens 140N, its production and application to the fermentation of soybean paste. |
| PubMed:Production of the α-glycosidase inhibitor 1-deoxynojirimycin from Bacillus species. |
| PubMed:Dysphagia as a risk factor for mortality in Niemann-Pick disease type C: systematic literature review and evidence from studies with miglustat. |
| PubMed:Anti-diabetic effect of a traditional Chinese medicine formula. |
| PubMed:Traditional medicinal herbs and food plants have the potential to inhibit key carbohydrate hydrolyzing enzymes in vitro and reduce postprandial blood glucose peaks in vivo. |
| PubMed:Effect of environmental conditions on the α-glucosidase inhibitory activity of mulberry leaves. |
| PubMed:[Report of attendance at the Parseghian Scientific Conference for Niemann-Pick Type C (NP-C) Research, South Bend, Indiana: in search of new therapeutic possibilities for a very rare illness]. |
| PubMed:Miglitol administered before breakfast increased plasma active glucagon-like peptide-1 (GLP-1) levels after lunch in patients with type 2 diabetes treated with sitagliptin. |
| PubMed:Treatment of genetically obese mice with the iminosugar N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin reduces body weight by decreasing food intake and increasing fat oxidation. |
| PubMed:Effect of mulberry leaf extract with enriched 1-deoxynojirimycin content on postprandial glycemic control in subjects with impaired glucose metabolism. |
| PubMed:Identification of the genes involved in 1-deoxynojirimycin synthesis in Bacillus subtilis MORI 3K-85. |
| PubMed:Comparison of 1-deoxynojirimycin and aqueous mulberry leaf extract with emphasis on postprandial hypoglycemic effects: in vivo and in vitro studies. |
| PubMed:1-Deoxynojirimycin inhibits metastasis of B16F10 melanoma cells by attenuating the activity and expression of matrix metalloproteinases-2 and -9 and altering cell surface glycosylation. |
| PubMed:Effects of pre-meal versus post-meal administration of miglitol on plasma glucagon-like peptide-1 and glucosedependent insulinotropic polypeptide levels in healthy men. |
| PubMed:Effects of miglitol, sitagliptin or their combination on plasma glucose, insulin and incretin levels in non-diabetic men. |
| PubMed:Simple, selective, and rapid quantification of 1-deoxynojirimycin in mulberry leaf products by high-performance anion-exchange chromatography with pulsed amperometric detection. |
| PubMed:Determination of iminosugars in mulberry leaves and silkworms using hydrophilic interaction chromatography-tandem mass spectrometry. |
| PubMed:Comparison of absorption of 1-deoxynojirimycin from mulberry water extract in rats. |
| PubMed:Purification and identification of 1-deoxynojirimycin (DNJ) in okara fermented by Bacillus subtilis B2 from Chinese traditional food (Meitaoza). |
| PubMed:Optimization of 1-deoxynojirimycin extraction from mulberry leaves by using response surface methodology. |
| PubMed:Intake of 1-deoxynojirimycin suppresses lipid accumulation through activation of the beta-oxidation system in rat liver. |
| PubMed:Phytochemical profiles of different mulberry (Morus sp.) species from China. |
| PubMed:Validation of an ion trap tandem mass spectrometric analysis of mulberry 1-deoxynojirimycin in human plasma: application to pharmacokinetic studies. |
| PubMed:Antioxidant constituents in the dayflower (Commelina communis L.) and their alpha-glucosidase-inhibitory activity. |
| PubMed:Antiobesity effects and improvement of insulin sensitivity by 1-deoxynojirimycin in animal models. |
| PubMed:N-butyldeoxynojirimycin causes weight loss as a result of appetite suppression in lean and obese mice. |
| PubMed:[In-vitro study of the drug interactions between Miglitol, an alpha-glucosidase inhibitor, and adsorbents]. |
| PubMed:Occurrence of orally administered mulberry 1-deoxynojirimycin in rat plasma. |
| PubMed:Influence of food intake on the pharmacokinetics of miglustat, an inhibitor of glucosylceramide synthase. |
| PubMed:Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. |
| PubMed:Effects of miglitol, an alpha-glucosidase inhibitor, on glycaemic status and histopathological changes in islets in non-obese, non-insulin-dependent diabetic Goto-Kakizaki rats. |
| PubMed:The sensitivity of murine spermiogenesis to miglustat is a quantitative trait: a pharmacogenetic study. |
| PubMed:Binding residues and catalytic domain of soluble Saccharomyces cerevisiae processing alpha-glucosidase I. |
| PubMed:Inhibitory effects of mulberry leaf extract on postprandial hyperglycemia in normal rats. |
| PubMed:Determination of 1-deoxynojirimycin in mulberry leaves using hydrophilic interaction chromatography with evaporative light scattering detection. |
| PubMed:An improved purification procedure for soluble processing alpha-glucosidase I from Saccharomyces cerevisiae overexpressing CWH41. |
| PubMed:Detailed kinetic analysis of a family 52 glycoside hydrolase: a beta-xylosidase from Geobacillus stearothermophilus. |
| PubMed:Purification and characterization of vanilla bean (Vanilla planifolia Andrews) beta-D-glucosidase. |
| PubMed:A novel method for the assay of alpha-glucosidase inhibitory activity using a multi-channel oxygen sensor. |
| PubMed:The effects of miglitol on glucagon-like peptide-1 secretion and appetite sensations in obese type 2 diabetics. |
| PubMed:Dose-dependent efficacy of miglitol, an alpha-glucosidase inhibitor, in type 2 diabetic patients on diet alone: results of a 24-week double-blind placebo-controlled study. |
| PubMed:Alpha-retaining glucosyl transfer catalysed by trehalose phosphorylase from Schizophyllum commune: mechanistic evidence obtained from steady-state kinetic studies with substrate analogues and inhibitors. |
| PubMed:Polyhydroxylated alkaloids isolated from mulberry trees (Morusalba L.) and silkworms (Bombyx mori L.). |
| PubMed:Glucosidase inhibitor from Umbilicaria esculenta. |
| PubMed:Glucose tolerance and insulin resistance in the JCR:LA-corpulent rat: effect of miglitol (Bay m1099). |
| PubMed:Miglitol (BAY m 1099) treatment of diabetic hypothalamic-dietary obese rats improves islet response to glucose. |
| PubMed:Advantages of alpha-glucosidase inhibition as monotherapy in elderly type 2 diabetic patients. |
| PubMed:Effect of miglitol administration to non-insulin-dependent diabetic rats. |
| PubMed:Differential scanning calorimetric studies on the domain structure of Aspergillus glucoamylase. |
| PubMed:Effects of Bay m 1099, an α-Glucosidase Inhibitor, on Starch Metabolism in Germinating Wheat Seeds. |
| PubMed:The effects of the intestinal glucosidase inhibitory BAY M 1099 (miglitol) on glycemic status of obese-diabetic rats. |
| PubMed:alpha-Glucosidase inhibition by miglitol in NIDDM patients. |
| PubMed:The effects of low-dose Bay-m-1099 (Miglitol) on serum lipids and liver enzyme activity of obese and obese-diabetic corpulent rats. |
| PubMed:Inhibition of intestinal alpha-glucosidase and postprandial hyperglycemia by N-substituted moranoline derivatives. |
| PubMed:The effect of two new alpha-glucosidase inhibitors on metabolic responses to a mixed meal in normal volunteers. |
| PubMed:Chronic effects of an alpha-glucosidase inhibitor (Bay o 1248) on intestinal disaccharidase activity in normal and diabetic mice. |
| PubMed:Influence of an absorbable alpha-glucosidase inhibitor (Bay o 1248) on the endocrine and exocrine pancreas of the rat. |
| PubMed:Effect of the alpha-glucosidase inhibitor Bay-O-1248 on the metabolic response of nondiabetic and diabetic rats to a high-carbohydrate diet. |
|
3D/inchi