EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

protamine

Supplier Sponsors

CAS Number: 9012-00-4
ECHA EC Number:232-726-0
FDA UNII: 72G3UY6T4N
MDL:MFCD00132089
Category:preservatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Anhui Haibei
protamine free base grade iv
BOC Sciences
For experimental / research use only.
Protamine from salmon 95%
Sigma-Aldrich: Sigma
For experimental / research use only.
Protamine from salmon Grade IV, Histone, free (Millon test)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
preservatives
Recommendation for protamine usage levels up to:
 not for fragrance use.
 
Recommendation for protamine flavor usage levels up to:
 not for flavor use.
 
Safety References:
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0009012004
RTECS:UK9440000 for cas# 9012-00-4
 
References:
Pubchem (sid):135288846
 
Other Information:
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
 protamines
 

Articles:

PubMed:Interpreting sperm DNA damage in a diverse range of mammalian sperm by means of the two-tailed comet assay.
PubMed:Protamine requirements in cardiac surgery: effect of changes in the heparin reference standard.
PubMed:Modern analytics for naturally derived complex drug substances: NMR and MS tests for protamine sulfate from chum salmon.
PubMed:[Risk factors for adverse reactions after protamine administration in adult patients undergoing cardiac surgery- a case report and literature review].
PubMed:Identification of site-specific heterogeneity in peptide drugs using intact mass spectrometry with electron transfer dissociation.
PubMed:Dynamically analyte-responsive macrocyclic host-fluorophore systems.
PubMed:Effects of insulin detemir and NPH insulin on body weight and appetite-regulating brain regions in human type 1 diabetes: a randomized controlled trial.
PubMed:Novel intestinal-targeted Ca-alginate-based carrier for pH-responsive protection and release of lactic acid bacteria.
PubMed:Sperm protamine deficiency correlates with sperm DNA damage in Bos indicus bulls.
PubMed:Glycemic targets and medication limitations for type 2 diabetes mellitus in the older adult.
PubMed:Magnetic resonance imaging tracking of ferumoxytol-labeled human neural stem cells: studies leading to clinical use.
PubMed:A 1-year drug utilization evaluation of protamine in hospitalized patients to identify possible future roles of heparin and low molecular weight heparin reversal agents.
PubMed:Protamine nanoparticles with CpG-oligodeoxynucleotide prevent an allergen-induced Th2-response in BALB/c mice.
PubMed:Neutralizing the anticoagulant activity of ultra-low-molecular-weight heparins using N-acetylglucosamine 6-sulfatase.
PubMed:Characterization of currently marketed heparin products: adverse event relevant bioassays.
PubMed:The effect of ciprofloxacin on sperm DNA damage, fertility potential and early embryonic development in NMRI mice.
PubMed:Self-assembling nanocomplexes by combining ferumoxytol, heparin and protamine for cell tracking by magnetic resonance imaging.
PubMed:Epidural hematoma and intraoperative hemorrhage in a spine trauma patient on Pradaxa (dabigatran).
PubMed:Application of quality by design elements for the development and optimization of an analytical method for protamine sulfate.
PubMed:Insulin glargine: a reevaluation of rodent carcinogenicity findings.
PubMed:Discovery of salt taste enhancing arginyl dipeptides in protein digests and fermented fish sauces by means of a sensomics approach.
PubMed:Spectrophotometric determination of various polyanions with polymeric film optodes using microtiter plate reader.
PubMed:Effects of mealtime insulin aspart and bedtime NPH insulin on postprandial inflammation and endothelial cell function in patients with type 2 diabetes.
PubMed:Effect of dietary protamine on lipid metabolism in rats.
PubMed:Insulin detemir attenuates food intake, body weight gain and fat mass gain in diet-induced obese Sprague-Dawley rats.
PubMed:Newer agents for blood glucose control in type 2 diabetes: systematic review and economic evaluation.
PubMed:Effects of intracerebroventricular administration of the NPY-Y1 receptor antagonist, 1229U91, on hyperphagic and glycemic responses to acute and chronic intermediate insulin-induced hypoglycemia in female rats.
PubMed:Adaptation of feeding and counter-regulatory hormone responses to intermediate insulin-induced hypoglycaemia in the ovariectomised female rat: effects of oestradiol.
PubMed:An investigation of the action of Neutral Protamine Hagedorn human analogue insulin in dogs with naturally occurring diabetes mellitus.
PubMed:Inhibition of acrylamide toxicity in mice by three dietary constituents.
PubMed:Purification and characterisation of proteases A and D from Debaryomyces hansenii.
PubMed:[The discovery of hypoglycemic sulfonamides].
PubMed:Insulin lispro: a review of its use in the management of diabetes mellitus.
PubMed:Use of the Hemobag for modified ultrafiltration in a Jehovah's Witness patient undergoing cardiac surgery.
PubMed:In vivo comparison study of FDA-approved surface-modifying additives and poly-2-methoxyethylacrylate circuit surfaces coatings during cardiopulmonary bypass.
PubMed:Inhibition of foodborne bacteria by native and modified protamine: importance of electrostatic interactions.
PubMed:Protease B from Debaryomyces hansenii: purification and biochemical properties.
PubMed:Efficient magnetic cell labeling with protamine sulfate complexed to ferumoxides for cellular MRI.
PubMed:A K+ yptake protein, TrkA, is required for serum, protamine, and polymyxin B resistance in Vibrio vulnificus.
PubMed:The gastrointestinal tract as the portal of entry for foreign macromolecules: fate of DNA and proteins.
PubMed:Purification and properties of an arginyl aminopeptidase from Debaryomyces hansenii.
PubMed:[Successful management after cardiopulmonary bypass without administration of protamine in a patient with severe food allergy--beneficial result with the use of heparin-coated bypass circuit].
PubMed:Novel insulins: expanding options in diabetes management.
PubMed:Purification and characterisation of a glutaminase from Debaryomyces spp..
PubMed:Antibacterial activity of licochalcone A against spore-forming bacteria.
PubMed:Methods for determination of milt protein and epsilon-polylysine in food additive preparations and processed foods by capillary zone electrophoresis.
PubMed:Antibacterial effect of protamine in combination with EDTA and refrigeration.
PubMed:A review of clinical experience with the prandial glucose regulator, repaglinide, in the treatment of type 2 diabetes.
PubMed:Fatal anaphylactoid shock associated with protamine for heparin reversal during anesthesia.
PubMed:Solubility and antimicrobial efficacy of protamine on Listeria monocytogenes and Escherichia coli as influenced by pH.
PubMed:Low inducibility of CYP1A activity by polychlorinated biphenyls (PCBs) in flounder (Platichthys flesus): characterization of the Ah receptor and the role of CYP1A inhibition.
PubMed:Somatostatin administration modifies food intake, body weight, and gut motility in rat.
PubMed:Protamine-induced permeabilization of cell envelopes of gram-positive and gram-negative bacteria.
PubMed:Maternal hormonal manipulations in rats cause obesity and increase medial hypothalamic norepinephrine release in male offspring.
PubMed:Antibacterial effect of protamine assayed by impedimetry.
PubMed:Effects of food deprivation and restriction, and metabolic blockers on food hoarding in Siberian hamsters.
PubMed:[Historical review on chemical and medical studies of globefish toxin before World War II].
PubMed:Use of heparin-coated cardiopulmonary bypass.
PubMed:Pain and cyanosis associated with alpha 1-proteinase inhibitor.
PubMed:A nationwide investigation of a possible protamine drug-product defect.
PubMed:Insulin-induced anestrus in Syrian hamsters.
PubMed:Response to chronic insulin administration: effect of area postrema ablation.
PubMed:Lack of cross-reactivity between IgE to salmon and protamine sulfate.
PubMed:Evaluation of patients at risk for protamine reactions.
PubMed:Reversal of the toxic effects of cachectin by concurrent insulin administration.
PubMed:Protamine sulfate as an effective alternative to polybrene in retroviral-mediated gene-transfer: implications for human gene therapy.
PubMed:Loss of nitrogen from organs in rats induced by exogenous glucagon.
PubMed:Body composition changes in rats with experimental cancer cachexia: improvement with exogenous insulin.
PubMed:Impact of insulin on survival of cachectic tumor-bearing rats.
PubMed:Simplified purification method for Clostridium botulinum type E toxin.
PubMed:The effect of temperature on the electrochemical properties of copper-DNA membranes.
PubMed:Insulin counteracts the satiating effect of a fat meal in rats.
PubMed:Dynamic aspects of amino acid metabolism in alloxan-induced diabetes and insulin-treated rabbits: in vivo studies with 15N and gas chromatography-mass spectrometry.
PubMed:Partial purification and properties of the assimilatory nitrate reductase of the food yeast Candida utilis.
PubMed:Insulin reversal of cancer cachexia in rats.
PubMed:Protein turnover in insulin-treated, alloxan-diabetic lean and obese Zucker rats.
PubMed:Insulin increases body fat despite control of food intake and physical activity.
PubMed:Lipoprotein lipase is produced, regulated, and functional in rat brain.
PubMed:Failure of chronic experimental hyperinsulinism to alter insulin binding to hypothalamic receptors in the rat.
PubMed:Metabolic concomitants of hypophagia during recovery from insulin-induced obesity in rats.
PubMed:Reversible obesity and plasma fat metabolites.
PubMed:Obesity in Osborne-Mendel and S 5B/Pl rats: effects of sucrose solutions, castration, and treatment with estradiol or insulin.
PubMed:Effects of dopamine-depleting brain lesions on experimental hyperphagia in rats.
PubMed:An anaphylactic reaction to protamine in a patient allergic to fish.
PubMed:Effect of progesterone on lipid metabolism in the intact rat.
PubMed:Preparation of uridine diphosphate-N-acetylgalactosamine from uridine diphosphate-N-acetylglucosamine by using microbial enzymes.
PubMed:Insulin and glucagon as determinants of body weight set point and microregulation in rats.
PubMed:Feeding in response to insulin but not to 2-deoxy-D-glucose in the hamster.
PubMed:Insulin-induced hyperphagia in alloxan-diabetic rats fed a high-fat diet.
PubMed:Partial Purification and Some Properties of Tyrosine Phenol-Lyase from Aeromonas phenologenes ATCC 29063.
PubMed:Letter: Protamine sulfate and fish allergy.
PubMed:Death of Staphylococcus aureus in liquid whole egg near pH 8.
PubMed:Colchicine-induced inhibition of plasma lipoprotein lipase release in the intact rat.
 
Notes:
None found
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