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Category:pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est)
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| logP (o/w): | -3.187 (est) |
| Soluble in: |
| | water, 3324 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 1036 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
intravenous-mouse LD50 732 mg/kg
Drugs in Japan Vol. 6, Pg. 910, 1982.
oral-mouse LD50 > 7000 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
intraperitoneal-rat LD50 1063 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
oral-rat LD50 > 8000 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | pharmaceuticals / chemical synthisis |
| Recommendation for leucovorin calcium usage levels up to: | | | not for fragrance use.
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| Recommendation for leucovorin calcium flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | calcium;2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 6099896 |
| Pubchem (sid): | 134981332 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | calcium (2S)-2-[(4-{[(2-amino-5-formyl-4-hydroxy-5,6,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)amino]pentanedioate | | | calcium (2S)-2-[(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl)methyl]amino}benzoyl)amino]pentanedioate | | (6S)- | calcium folinate | | | calcium leucovorin | | | calcium, [L-glutamato(2-)-kappaO1,kappaO5, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-]- | | | calcium;2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate | | | calciumlevofolinate | | (+)-L- | folinic acid calcium salt | | 5- | formlyl-5,6,7,8-tetrahydrofolic acid, calcium salt | | 5- | formyl-5,6,7,8-tetrahydrofolic acid calcium salt | | L- | glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1) | | | leucovorin calcium salt | | | wellcovorin |
Articles:
| PubMed:[A case of pathological complete response with neoadjuvant mFOLFOX6 chemotherapy for advanced lower rectal cancer]. |
| PubMed:Analysis of saliva samples from oncological patients treated with 5-fluorouracil and leucovorin calcium by scanning electron microscopy with energy dispersive system. |
| PubMed:Early ovarian pregnancy diagnosed by ultrasound and successfully treated with multidose methotrexate. A case report. |
| PubMed:A phase II randomized study of combined infusional leucovorin sodium and 5- FU versus the leucovorin calcium followed by 5-FU both in combination with irinotecan or oxaliplatin in patients with metastatic colorectal cancer. |
| PubMed:A clinical study on safety and efficacy of Aidi injection combined with chemotherapy. |
| PubMed:Cerebral folate receptor autoantibodies in autism spectrum disorder. |
| PubMed:Use of uridine triacetate for the management of fluorouracil overdose. |
| PubMed:Combination adjuvant chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin after liver transplantation for hepatocellular carcinoma: a preliminary open-label study. |
| PubMed:Clinical observation of Endostar® combined with chemotherapy in advanced colorectal cancer patients. |
| PubMed:Hyperbranched poly(amine-ester) based hydrogels for controlled multi-drug release in combination chemotherapy. |
| PubMed:Simultaneous determination of 6R-leucovorin, 6S-leucovorin and 5-methyltetrahydrofolate in human plasma using solid phase extraction and chiral liquid chromatography-tandem mass spectrometry. |
| PubMed:Oral signs of intravenous chemotherapy with 5-Fluorouracil and Leucovorin calcium in colon cancer treatment. |
| PubMed:[Efficacy of oxaliplatin plus 5-fluorouracil/leucovorin calcium combined with concurrent radiotherapy for local advanced gastric cancer]. |
| PubMed:Variation in the cost of medications for the treatment of colorectal cancer. |
| PubMed:Oxaliplatin-induced hypersensitivity reaction displaying marked elevation of immunoglobulin E. |
| PubMed:Reversible posterior leukoencephalopathy syndrome after bevacizumab/FOLFIRI regimen for metastatic colon cancer. |
| PubMed:Symptomatic venous thromboembolism in cancer patients treated with chemotherapy: an underestimated phenomenon. |
| PubMed:Leucovorin (calcium folinate) in "antifreeze" poisoning. |
| PubMed:Preoperative FLAC/granulocyte-colony-stimulating factor chemotherapy for stage II breast cancer: a prospective randomized trial. |
| PubMed:Cobalamin C disease presenting as hemolytic-uremic syndrome in the neonatal period. |
| PubMed:Phenytoin and fluorouracil interaction. |
| PubMed:UFT plus oral leucovorin calcium (Orzel) and radiation in combined modality therapy: a comprehensive review. |
| PubMed:High-dose methotrexate-doxycycline interaction. |
| PubMed:Phase II trial of intermediate dose methotrexate in combination with vinblastine, doxorubicin, and cisplatin in patients with unresectable or metastatic transitional cell carcinoma. |
| PubMed:Common vitamin B complex agents and folic acid: Part IV. Leucovorin calcium (citrovorum factor, folinic acid [wellcovorin]). |
| PubMed:5-Fluorouracil and d,l-leucovorin calcium are active to treat unresectable hepatocellular carcinoma patients: preliminary results of a phase II study. |
| PubMed:[Intra-arterial 5-FU/intra-venous MTX therapy for metastatic liver lesions]. |
| PubMed:Modulation of 5-fluorouracil with high-dose leucovorin calcium: activity in ovarian cancer and correlation with CA-125 levels. |
| PubMed:California: new drugs added to AIDS drug assistance program. |
| PubMed:Trimetrexate. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of Pneumocystis carinii pneumonia. |
| PubMed:Incompatibility of fluorouracil with leucovorin calcium or levoleucovorin calcium. |
| PubMed:Clinical pharmacokinetics and pharmacology of trimetrexate. |
| PubMed:Cisplatin, fluorouracil, and leucovorin. Increased toxicity without improved response in squamous cell head and neck cancer. |
| PubMed:Substitution of l-leucovorin for d,l-leucovorin in the rescue from high-dose methotrexate treatment in patients with osteosarcoma. |
| PubMed:A thin-layer chromatographic method to determine process impurities in leucovorin calcium. |
| PubMed:Phase II trial of 5-fluorouracil, high-dose leucovorin calcium, and dipyridamole in advanced prostate cancer. |
| PubMed:Drug treatment of colorectal cancer. Current status. |
| PubMed:Phase I clinical trial with floxuridine and high-dose continuous infusion of leucovorin calcium. |
| PubMed:Oral zidovudine, continuous-infusion fluorouracil, and oral leucovorin calcium: a phase I study. |
| PubMed:Clinical pharmacokinetics of high-dose leucovorin calcium after intravenous and oral administration. |
| PubMed:[The results of simultaneous radio-chemotherapy in advanced head and neck tumors]. |
| PubMed:Prospective randomized comparison of fluorouracil versus fluorouracil and high-dose continuous infusion leucovorin calcium for the treatment of advanced measurable colorectal cancer in patients previously unexposed to chemotherapy. |
| PubMed:Pulmonary carcinoid presenting as multiple subcutaneous nodules. |
| PubMed:Toxicity of vincristine overdose in a patient with invasive mole. |
| PubMed:Phase I trial of semustine plus weekly fluorouracil and high-dose leucovorin calcium in patients with advanced colorectal cancer. |
| PubMed:[Management of the administration of leucovorin calcium in high-dose methotrexate therapy]. |
| PubMed:Leucovorin calcium enhancement of mucositis after continuous infusion fluorouracil and short infusion cisplatin. |
| PubMed:Stability of floxuridine and leucovorin calcium admixtures for intraperitoneal administration. |
| PubMed:Cisplatin, fluorouracil with leucovorin calcium enhancement, and synchronous accelerated radiotherapy in the management of locally advanced head and neck cancer: a phase II study. |
| PubMed:Refractory metastatic breast cancer: salvage therapy with fluorouracil and high-dose continuous infusion leucovorin calcium. |
| PubMed:New vistas for leucovorin in cancer chemotherapy. |
| PubMed:Bioequivalence of two leucovorin calcium tablet formulations. |
| PubMed:Diminishing bioavailability of oral leucovorin calcium. |
| PubMed:Plasma and tumor tissue pharmacology of high-dose intravenous leucovorin calcium in combination with fluorouracil in patients with advanced colorectal carcinoma. |
| PubMed:Haziness in leucovorin calcium for injection. |
| PubMed:Pharmacokinetics of leucovorin calcium after intravenous, intramuscular, and oral administration. |
| PubMed:Treatment of advanced-stage colorectal adenocarcinoma with fluorouracil and high-dose leucovorin calcium: a pilot study. |
| PubMed:Acute bullous dermatosis and onycholysis due to high-dose methotrexate and leucovorin calcium. |
| PubMed:Absorption kinetics of orally administered leucovorin calcium. |
| PubMed:Primary chemotherapy for localized non-Hodgkin's lymphomas with diffuse histologic characteristics. Preliminary report of a prospective study. |
| PubMed:Surgical complications in patients with head and neck cancer receiving chemotherapy. |
| PubMed:Maintenance chemotherapy for high-risk patients. A preliminary report. |
| PubMed:Purity profiles of pteroylglutamate reference substances by high-performance liquid chromatography. |
| PubMed:Preparing cancer patients to administer medication. |
| PubMed:Stability and compatibility of antitumor agents in glass and plastic containers. |
| PubMed:Clinical and laboratory reevalution of dichloromethotrexate. |
| PubMed:High-dose methotrexate in combination chemotherapy for small cell lung cancer. |
| PubMed:Adjuvant methotrexate and leucovorin in head and neck squamous cancer. Two-year follow-up of a pilot project. |
| PubMed:Methotrexate-induced renal failure and ineffectiveness of peritoneal dialysis. |
| PubMed:Leucovorin calcium administration and preparation. |
| PubMed:Mycosis fungoides with pulmonary involvement. A complete remission. |
| PubMed:Primary osteogenic sarcoma: pathologic aspects in 20 patients after treatment with chemotherapy en bloc resection, and prosthetic bone replacement. |
| PubMed:T-cell rosette test in squamous cell carcinoma of the head and neck. |
| PubMed:Studies in bullous diseases. Treatment of pemphigus vulgaris with immunosuppressives (steroids and methotrexate) and leucovorin calcium. |
| PubMed:Acute toxoplasmosis. Effective treatment with pyrimethamine, sulfadiazine, leucovorin calcium, and yeast. |
| PubMed:LEUCOVORIN calcium. |
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3D/inchi