EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

pramoxine hydrochloride
morpholine, 4-[3-(4-butoxyphenoxy)propyl]-, hydrochloride (1:1)

Supplier Sponsors

CAS Number: 637-58-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:211-293-1
FDA UNII: 88AYB867L5
MDL:MFCD00054323
Molecular Weight:329.86676000
Formula:C17 H28 Cl N O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 181.00 °C. @ 760.00 mm Hg (est)
Boiling Point: 427.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000000 mmHg @ 25.00 °C. (est)
Flash Point: 254.00 °F. TCC ( 123.50 °C. ) (est)
logP (o/w): 3.477 (est)
Soluble in:
 water, 190.6 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Pramoxine HCl >98%
Odor: characteristic
Use: Pramoxine is a topical local anesthetic that has been shown to have antipruritic properties.Like other local anesthetics, paramoxine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulse
Charkit Chemical
PRAMOXINE HCL
George Uhe Company
Pramoxine HCL
Penta International
PRAMOXINE HYDROCHLORIDE USP
Santa Cruz Biotechnology
For experimental / research use only.
Pramoxine Hydrochloride
Sigma-Aldrich
For experimental / research use only.
Pramoxine Hydrochloride ≥98%
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-guinea pig LDLo 109 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: CARDIAC OUTPUT LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Anesthesie, Analgesie, Reanimation. Vol. 14, Pg. 225, 1957.

intraperitoneal-mouse LD50 460 mg/kg
"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 99, 1969.

intravenous-mouse LD50 79500 ug/kg
Toxicology and Applied Pharmacology. Vol. 1, Pg. 454, 1959.

oral-mouse LD50 1050 mg/kg
"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 99, 1969.

intravenous-rabbit LD50 39 mg/kg
"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 99, 1969.

Dermal Toxicity:
subcutaneous-mouse LD50 1470 mg/kg
CARDIAC: CARDIAC OUTPUT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Anesthesie, Analgesie, Reanimation. Vol. 14, Pg. 225, 1957.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for pramoxine hydrochloride usage levels up to:
 not for fragrance use.
 
Recommendation for pramoxine hydrochloride flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :73957
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
4-[3-(4-butoxyphenoxy)propyl]morpholine;hydrochloride
Chemidplus:0000637581
RTECS:QD8750000 for cas# 637-58-1
 
References:
 4-[3-(4-butoxyphenoxy)propyl]morpholine;hydrochloride
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):73957
Pubchem (sid):135032174
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
KEGG (GenomeNet):D00739
HMDB (The Human Metabolome Database):Search
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
rectal or topical: aerosol, foam suspension: 1% proctofoamnon-steroid (with parabens), (schwarz); cream: 1% tronolane (with parabens), (ross). topical: 1% hemorrhoidal anesthetic cream, (clay-park), tronothane hydrochloride (with parabens), (ross); gell: 1% itch-x (with sd alcohol 40, benzyl alcohol 10%, parabens, and propylene glycol), (ascher), pramegel (with benzyl alcohol and menthol), (genderm); lotion: 1% prax lotion, (ferndale); pledgets (saturated with solution): 1% fleet pain-relief pads (with glycerin 12.5%), (fleet); solution: 1% itch-x spray (with benzyl alcohol 10%), (ascher).
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
4-(3-(p-butoxyphenoxy)propyl)morpholine hydrochloride
4-[3-(4-butoxyphenoxy)propyl]morpholine hydrochloride
4-[3-(p-butoxyphenoxy)propyl]morpholine hydrochloride
4-[3-(4-butoxyphenoxy)propyl]morpholine hydrochloride (1:1)
4-[3-(4-butoxyphenoxy)propyl]morpholine;hydrochloride
p-butoxyphenyl g-morpholinopropyl ether hydrochloride
 morpholine, 4-(3-(4-butoxyphenoxy)propyl)-, hydrochloride
 morpholine, 4-(3-(p-butoxyphenoxy)propyl)-, hydrochloride
 morpholine, 4-[3-(4-butoxyphenoxy)propyl]-, hydrochloride (1:1)
g-morpholinopropyl 4-N-butoxyphenyl ether hydrochloride
 pramocaine hydrochloride
 pramoxine HCl
 proctocream-HC
 proxazocain hydrochloride
 tronolane
 tronothane hydrochloride
 

Articles:

PubMed:[A case of prostate cancer presenting as extensive abdominal metastasis].
PubMed:Efficacy and onset of action of hydrocortisone acetate 2.5% and pramoxine hydrochloride 1% lotion for the management of pruritus: results of a pilot study.
PubMed:A pramoxine-based anti-itch lotion is more effective than a control lotion for the treatment of uremic pruritus in adult hemodialysis patients.
PubMed:An evaluation of the moisturizing and anti-itch effects of a lactic acid and pramoxine hydrochloride cream.
PubMed:Anorectal drug products for over-the-counter human use. Final rule.
PubMed:The safety of pramoxine hydrochloride when used as a topical (surface) anesthetic.
PubMed:Cost analysis of a mucoadhesive foam versus conventional treatment for postepisiotomy patients.
PubMed:Clinical evaluation of a topical anaesthetic preparation (pramoxine hydrochloride and hydrocortisone) in post-episiotomy pain relief.
PubMed:Rapid high-performance liquid chromatographic determination of pramoxine hydrochloride in topical cream and suppositories.
PubMed:Topical pramoxine and hydrocortisone foam versus placebo in relief of post partum episiotomy symptoms and wound healing.
PubMed:Allergic reactions to topical (surface) anesthetics with reference to the safety of tronothane (pramoxine hydrochloride).
PubMed:High-pressure liquid chromatographic analysis of pramoxine hydrochloride in high lipoid aerosol foam dosage form.
PubMed:[Local anesthetic activity of pramoxine hydrochloride (tronothane)].
PubMed:Tronothane hydrochloride (pramoxine hydrochloride) in the control of pruritus.
PubMed:The pharmacology of pramoxine hydrochloride: a new topical local anesthetic.
 
Notes:
None found
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