EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

salinomycin
kokcisan

Supplier Sponsors

CAS Number: 53003-10-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:258-290-1
FDA UNII: 62UXS86T64
XlogP3-AA:5.70 (est)
Molecular Weight:751.01110000
Formula:C42 H70 O11
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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NCBI:Search
 
Physical Properties:
Appearance:white crystalline solid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 113.00 °C. @ 760.00 mm Hg
Boiling Point: 839.16 °C. @ 760.00 mm Hg (est)
Flash Point: 470.00 °F. TCC ( 243.20 °C. ) (est)
logP (o/w): 5.596 (est)
Soluble in:
 water, 2.079e-006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Salinomycin 0.98
Odor: characteristic
Use: Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. The mechanism of action by which salinomycin kills cancer stem cells specifically remains unknown, but is thought to be due to its action as a potassium ionophore.
EMD Millipore
For experimental / research use only.
Salinomycin
sds
Glentham Life Sciences
Salinomycin
OQEMA
Salinomycin
Santa Cruz Biotechnology
For experimental / research use only.
Salinomycin
Sigma-Aldrich: Sigma
For experimental / research use only.
Salinomycin from Streptomyces albus, ≥98% (HPLC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 7 mg/kg
Journal of Antibiotics. Vol. 31, Pg. 1, 1978.

oral-mouse LD50 50 mg/kg
"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 813, 1978.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for salinomycin usage levels up to:
 not for fragrance use.
 
Recommendation for salinomycin flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Review of substances/agents that have direct beneficial effect on the environment: mode of action and assessment of efficacy
View page or View pdf

EPI System: View
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :72370
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0053003104
RTECS:VO8620000 for cas# 53003-10-4
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):72370
Pubchem (sid):135029899
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
bio-cox; ovicox; sacox; salgain; salocin sodium salt
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 streptomyces albus
Search PMC Picture
 
Synonyms:
 bio-cox
 coxistac
 kokcisan
 salinomicina
 salinomycine
 salinomycinum
 

Articles:

PubMed:Sample treatment platform using nanoparticles to determine salinomycin in flesh and meat.
PubMed:Cloning and characterization of the polyether salinomycin biosynthesis gene cluster of Streptomyces albus XM211.
PubMed:Salinomycin, a polyether ionophoric antibiotic, inhibits adipogenesis.
PubMed:Comparison of the oral bioavailability and tissue disposition of monensin and salinomycin in chickens and turkeys.
PubMed:Dietary nisin modulates the gastrointestinal microbial ecology and enhances growth performance of the broiler chickens.
PubMed:Development of an ELISA for salinomycin and depletion kinetics of salinomycin residues in poultry.
PubMed:Effects of salinomycin on ruminal characteristics and performance of grazing beef steers.
PubMed:Effect of salinomycin level on nutrient digestibility and ruminal characteristics of sheep and feedlot performance of cattle.
PubMed:Rapid method for the simultaneous determination of six ionophores in feed by liquid chromatography/mass spectrometry.
PubMed:Impact of salinomycin on the intestinal microflora of broiler chickens.
PubMed:Effect of salinomycin on giardiasis and coccidiosis in growing lambs.
PubMed:Effects of orally administered chemotherapeutics (quinine, salinomycin) against Henneguya sp. Thelohán, 1892 (Myxozoa: Myxobolidae), a gill parasite in the tapir fish Gnathonemus petersii Günther, 1862 (Teleostei).
PubMed:Microwave extraction of incurred salinomycin from chicken tissues.
PubMed:Salinomycin poisoning in point-of-lay turkeys.
PubMed:Development and validation of a multiresidue liquid chromatography/tandem mass spectrometry method for 11 coccidiostats in feed.
PubMed:Residue control of coccidiostats in food of animal origin in Poland during 2007-2010.
PubMed:In vivo screening of four phytochemicals/extracts and a fungal immunomodulatory protein against an Eimeria acervulina infection in broilers.
PubMed:Concentrations of salinomycin in eggs and tissues of laying chickens fed medicated feed for 14 days followed by withdrawal for 3 days.
PubMed:Risk assessment of coccidostatics during feed cross-contamination: animal and human health aspects.
PubMed:Comparison of microwave assisted extraction with conventional (homogenization, vortexing) for the determination of incurred salinomycin in chicken eggs and tissues.
PubMed:Rapid time-resolved fluoroimmunoassay for the screening of narasin and salinomycin residues in poultry and eggs.
PubMed:Comparative effect of salinomycin and monensin on Streptococcus bovis strain ATCC 9809.
PubMed:Determination of the ionophoric coccidiostats narasin, monensin, lasalocid and salinomycin in eggs by liquid chromatography/tandem mass spectrometry.
PubMed:Susceptibility of Clostridium difficile toward antimicrobial agents used as feed additives for food animals.
PubMed:A case of salinomycin intoxication in turkeys.
PubMed:Salinomycin-induced polyneuropathy in cats: morphologic and epidemiologic data.
PubMed:The effect of flavophospholipol (Flavomycin) and salinomycin sodium (Sacox) on the excretion of Clostridium perfringens, Salmonella enteritidis, and Campylobacter jejuni in broilers after experimental infection.
PubMed:Trace level determination of polyether ionophores in feed.
PubMed:Salinomycin toxicosis in horses.
PubMed:The effects of halofuginone and salinomycin, alone and in combination, on live performance and skin characteristics of female broilers: influence of a high-proline diet supplemented with ascorbic acid and zinc.
PubMed:The effects of halofuginone and salinomycin, alone and in combination, on live performance and skin characteristics of broilers.
PubMed:[Tiamulin and salinomycin intolerance in swine].
PubMed:Comparison of virginiamycin and salinomycin as growth promoters in growing-fattening pigs.
PubMed:Determination of monensin, narasin, and salinomycin in mineral premixes, supplements, and animal feeds by liquid chromatography and post-column derivatization: collaborative study.
PubMed:Salinomycin poisoning in veal calves.
PubMed:Detection and quantitative analysis of 21 veterinary drugs in river water using high-pressure liquid chromatography coupled to tandem mass spectrometry.
PubMed:Single-laboratory validation of a multiplex flow cytometric immunoassay for the simultaneous detection of coccidiostats in eggs and feed.
PubMed:Can the use of coccidiostats in poultry breeding lead to residues in vegetables? An experimental study.
PubMed:Determination of ionophores in the tissues of food animals by liquid chromatography.
PubMed:Determination of 20 coccidiostats in milk, duck muscle and non-avian muscle tissue using UHPLC-MS/MS.
PubMed:Development of a five-plex flow cytometric immunoassay for the simultaneous detection of six coccidiostats in feed and eggs.
PubMed:The determination of six ionophore coccidiostats in feed by liquid chromatography with postcolumn derivatisation and spectrofotometric/fluorescence detection.
PubMed:Residues of veterinary medicinal products and coccidiostats in eggs--causes, control and results of surveillance program in Poland.
PubMed:Ionophores: their use as ruminant growth promotants and impact on food safety.
PubMed:Occurrence, selection and spread of resistance to antimicrobial agents used for growth promotion for food animals in Denmark.
PubMed:Fatty acid composition and oxidative stability of breast meat from broiler chickens supplemented with Moringa oleifera leaf meal over a period of refrigeration.
PubMed:The effect of commonly used anticoccidials and antibiotics in a subclinical necrotic enteritis model.
PubMed:Development and validation of an UPLC-MS/MS method for the determination of ionophoric and synthetic coccidiostats in vegetables.
PubMed:Antimicrobial susceptibilities of Listeria monocytogenes isolated in Japan.
PubMed:Multiple-antibiotic resistance of Enterococcus faecalis and Enterococcus faecium from cecal contents in broiler chicken and turkey flocks slaughtered in Canada and plasmid colocalization of tetO and ermB genes.
PubMed:Anticoccidial effects of coumestans from Eclipta alba for sustainable control of Eimeria tenella parasitosis in poultry production.
PubMed:Surveillance of antimicrobial resistance in bacteria isolated from food animals to antimicrobial growth promoters and related therapeutic agents in Denmark.
PubMed:Development and validation of a liquid chromatographic-tandem mass spectrometric method for determination of eleven coccidiostats in milk.
PubMed:Innovative approach for improvement of an antibiotic-overproducing industrial strain of Streptomyces albus.
PubMed:Monoclonal antibody production and immunochemical detection of polyether antibiotics.
PubMed:A new approach to the analysis of nicarbazin and ionophores in eggs by HPLC/MS/MS.
PubMed:Selection of single chain variable fragment (scFv) antibodies from a hyperimmunized phage display library for the detection of the antibiotic monensin.
PubMed:Determination of ionophore coccidiostats in feeding stuffs by liquid chromatography-tandem mass spectrometry. Part II. Application to cross-contamination levels and non-targeted feed.
PubMed:Effect of avoparcin interaction with anticoccidial compounds on the growth and carcase composition of broilers.
PubMed:Effect of ionophore antibiotics on experimentally induced lactic acidosis in cattle.
PubMed:Ionophore residues in eggs in Northern Ireland: incidence and cause.
PubMed:Development and validation of a multi-residue liquid chromatography-tandem mass spectrometry confirmatory method for eleven coccidiostats in eggs.
PubMed:Pilot survey of hen eggs consumed in the metropolitan area of Rio de Janeiro, Brazil, for polyether ionophores, macrolides and lincosamides residues.
PubMed:Effects of coccidiostats and dietary protein on performance and water consumption in broiler chickens.
PubMed:[Inhibitory effect of zinc on beta-hexosaminidase release from RBL-2H3 cells by synthetic chemicals].
PubMed:Incidence of residues of nine anticoccidials in eggs.
PubMed:Control of proliferative enteropathy in growing/fattening pigs using growth promoters.
PubMed:Evaluation of an improved floor pen model for severe coccidiosis.
PubMed:In vitro lactic acid inhibition and alterations in volatile fatty acid production by antimicrobial feed additives.
PubMed:Impact of feed supplementation with antimicrobial agents on growth performance of broiler chickens, Clostridium perfringens and enterococcus counts, and antibiotic resistance phenotypes and distribution of antimicrobial resistance determinants in Escherichia coli isolates.
PubMed:Simultaneous determination of four coccidiostats in eggs and broiler meat: validation of an LC-MS/MS method.
PubMed:Diversity and susceptibility of Enterococcus isolated from cattle before and after harvest.
PubMed:The effect of polyether, ionophorous anticoccidial drugs on feather growth in genetically slow-feathering broilers.
PubMed:LC/MS confirmation of ionophores in animal feeds.
PubMed:[Effects of veterinary drugs on beta-hexosaminidase release from rat basophilic leukemia cells (RBL-2H3)].
PubMed:Multi-residue method for detecting coccidiostats at carry-over level in feed by HPLC-MS/MS.
PubMed:Potentiometric determination of polyether ionophores growth promotors in animal feed preparations.
PubMed:Comparative efficacy of anticoccidials under the conditions of commercial broiler production and in battery trials.
PubMed:MALDI-TOF MS quantification of coccidiostats in poultry feeds.
PubMed:Efficacy of some anticoccidial drugs for treating coccidial enteritis of the common carp caused by Goussia carpelli (Apicomplexa: Eimeriidae).
PubMed:Associations between the use of antimicrobial agents for growth promotion and the occurrence of resistance among Enterococcus faecium from broilers and pigs in Denmark, Finland, and Norway.
PubMed:[Effect of anticoccidial preparations in the prevention of coccidiosis in turkeys caused by Eimeria adenoides].
PubMed:Prevalence and antimicrobial resistance of enterococci isolated from retail fruits, vegetables, and meats.
PubMed:Antimicrobial growth promoters used in animal feed: effects of less well known antibiotics on gram-positive bacteria.
PubMed:Liquid chromatographic determination of monensin in premix and animal feeds: collaborative study.
PubMed:Feed additives and contaminants as a cause of equine disease.
PubMed:[Preliminary results of antibiotic resistance monitoring in the Netherlands].
PubMed:Development of an ELISA for lasalocid and depletion kinetics of lasalocid residues in poultry.
PubMed:An unaddressed issue of agricultural terrorism: a case study on feed security.
PubMed:The influence of nutrient density of broiler rations on the effective dose of anticoccidial drugs.
PubMed:Ionophore toxicity in turkey breeders.
PubMed:[Growth stimulating effect of salinomycine in breeding and fattening of pigs (author's transl)].
PubMed:Chromatographic analysis of banned antibacterial growth promoters in animal feed.
PubMed:A new method for in vitro detection of microbially produced mitochondrial toxins.
PubMed:Efficient and sensitive screening and confirmation of residues of selected polyether ionophore antibiotics in liver and eggs by liquid chromatography-electrospray tandem mass spectrometry.
PubMed:Development of an ELISA for maduramicin and determination of the depletion kinetics of maduramicin residues in poultry.
PubMed:Improved agar diffusion method for detecting residual antimicrobial agents.
PubMed:Anticoccidials and turkeys.
PubMed:Mitigating the effects of halofuginone on skin strength by feeding L-proline to broiler chickens.
PubMed:Development of multiclass methods for drug residues in eggs: silica SPE cleanup and LC-MS/MS analysis of ionophore and macrolide residues.
PubMed:An integrated sample preparation to determine coccidiostats and emerging Fusarium-mycotoxins in various poultry tissues with LC-MS/MS.
PubMed:Microbial community composition of the ileum and cecum of broiler chickens as revealed by molecular and culture-based techniques.
PubMed:Antimicrobial susceptibilities of Staphylococcus aureus isolated from commercial broilers in northeastern Georgia.
 
Notes:
from streptomyces albus.
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