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astragaloside A
cyclosiversioside F

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CAS Number: 83207-58-3Picture of molecule3D/inchi
FDA UNII: 3A592W8XKE
XlogP3-AA:1.30 (est)
Molecular Weight:784.98176000
Formula:C41 H68 O14
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
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Physical Properties:
Appearance:yellow-brown or white powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 895.67 °C. @ 760.00 mm Hg (est)
Flash Point: 924.00 °F. TCC ( 495.50 °C. ) (est)
logP (o/w): 0.628 (est)
Soluble in:
 water, 14.59 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Astragaloside A >98%
Odor: characteristic
Use: Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases.
Carbosynth
For experimental / research use only.
Astragaloside IV
Santa Cruz Biotechnology
For experimental / research use only.
Astragaloside A
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for astragaloside A usage levels up to:
 not for fragrance use.
 
Recommendation for astragaloside A flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
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EPA ACToR:Toxicology Data
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Laboratory Chemical Safety Summary :122690
National Institute of Allergy and Infectious Diseases:Data
Chemidplus:0083207583
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):122690
Pubchem (sid):135079149
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 astragalus membranaceus
Search Trop Picture
 
Synonyms:
 astragaloside IV
 astragaloside-A
 cyclosiversioside F
 

Articles:

PubMed:Astragaloside IV stimulates angiogenesis and increases nitric oxide accumulation via JAK2/STAT3 and ERK1/2 pathway.
PubMed:Astragaloside IV attenuates experimental autoimmune encephalomyelitis of mice by counteracting oxidative stress at multiple levels.
PubMed:Astragalus injection protects cerebral ischemic injury by inhibiting neuronal apoptosis and the expression of JNK3 after cerebral ischemia reperfusion in rats.
PubMed:Identification of multiple ingredients for a Traditional Chinese Medicine preparation (bu-yang-huan-wu-tang) by liquid chromatography coupled with tandem mass spectrometry.
PubMed:Pharmacological effects of Astragaloside IV: a literature review.
PubMed:Pharmacokinetics and tolerance of toal astragalosides after intravenous infusion of astragalosides injection in healthy Chinese volunteers.
PubMed:Astragaloside IV reduces cerebral edema post-ischemia/reperfusion correlating the suppression of MMP-9 and AQP4.
PubMed:Can Hedysari Radix replace Astragali Radix in Danggui Buxue Tang, a Chinese herbal decoction for woman aliment?
PubMed:[Protective effect and mechanism of astragaloside IV on oxidative stress injury of mesangial cells].
PubMed:[Experimental studies on pharmacokinetics of three components in Buyanghuanwu injection on base of total quantum statistical moment].
PubMed:Synergistic promotion of blood vessel regeneration by astragaloside IV and ferulic acid from electrospun fibrous mats.
PubMed:Genetic and pharmacological inhibition of Rheb1-mTORC1 signaling exerts cardioprotection against adverse cardiac remodeling in mice.
PubMed:Effects of astragaloside IV on action potentials and ionic currents in guinea-pig ventricular myocytes.
PubMed:Astragaloside IV-loaded nanoparticle-enriched hydrogel induces wound healing and anti-scar activity through topical delivery.
PubMed:Astragaloside IV suppresses collagen production of activated hepatic stellate cells via oxidative stress-mediated p38 MAPK pathway.
PubMed:Astragaloside IV ameliorates renal injury in streptozotocin-induced diabetic rats through inhibiting NF-κB-mediated inflammatory genes expression.
PubMed:Astragaloside content in the periderm, cortex, and xylem of Astragalus membranaceus root.
PubMed:Astragaloside IV prevents acute kidney injury in two rodent models by inhibiting oxidative stress and apoptosis pathways.
PubMed:The experimental study of Astragalus membranaceus on meridian tropsim: the distribution study of astragaloside IV in rat tissues.
PubMed:Astragaloside IV inhibited the activity of CYP1A2 in liver microsomes and influenced theophylline pharmacokinetics in rats.
PubMed:[Protective effects of astragaloside IV on high-glucose-induced damage of retinal ganglion cells].
PubMed:Astragaloside IV inhibits oxidative stress-induced mitochondrial permeability transition pore opening by inactivating GSK-3β via nitric oxide in H9c2 cardiac cells.
PubMed:Astragaloside IV attenuates Toll-like receptor 4 expression via NF-κB pathway under high glucose condition in mesenchymal stem cells.
PubMed:Therapeutic effects of astragaloside IV on myocardial injuries: multi-target identification and network analysis.
PubMed:The effect of Astragaloside IV on immune function of regulatory T cell mediated by high mobility group box 1 protein in vitro.
PubMed:Tanshinone IIA and astragaloside IV promote the migration of mesenchymal stem cells by up-regulation of CXCR4.
PubMed:Astragaloside IV alleviates hypoxia/reoxygenation-induced neonatal rat cardiomyocyte injury via the protein kinase a pathway.
PubMed:Astragaloside IV, a novel antioxidant, prevents glucose-induced podocyte apoptosis in vitro and in vivo.
PubMed:[Inhibitory effects of astragaloside IV on cytochrome P450 enzyme of rat liver microsomes].
PubMed:Topical astragaloside IV-releasing hydrogel improves healing of skin wounds in vivo.
PubMed:Pharmacokinetic evidence on the contribution of intestinal bacterial conversion to beneficial effects of astragaloside IV, a marker compound of astragali radix, in traditional oral use of the herb.
PubMed:Effects of astragaloside IV on eosinophil activation induced by house dust mite allergen.
PubMed:Astragaloside IV regulates expression of ATP-sensitive potassium channel subunits after ischemia-reperfusion in rat ventricular cardiomyocytes.
PubMed:Astragaloside IV protects against focal cerebral ischemia/reperfusion injury correlating to suppression of neutrophils adhesion-related molecules.
PubMed:[Effects of astragaloside IV on the expressions of transforming growth factor-β1 and thymic stromal lymphopoietin in a murine model of asthma].
PubMed:Astragaloside IV prevents MPP⁺-induced SH-SY5Y cell death via the inhibition of Bax-mediated pathways and ROS production.
PubMed:Astragaloside IV inhibits apoptotic cell death in the guinea pig cochlea exposed to impulse noise.
PubMed:Determination of astragalin and astragaloside content in Radix Astragali using high-performance liquid chromatography coupled with pulsed amperometric detection.
PubMed:Synergistic protective effect of astragaloside IV-tetramethylpyrazine against cerebral ischemic-reperfusion injury induced by transient focal ischemia.
PubMed:Pro-angiogenic activity of astragaloside IV in HUVECs in vitro and zebrafish in vivo.
PubMed:[Immunoregulatory mechanisms of an optimal Chinese herbal monomer compound in mice with allergic rhinitis].
PubMed:The healing and anti-scar effects of astragaloside IV on the wound repair in vitro and in vivo.
PubMed:[Effect of ERK1/2 signaling pathway on astragaloside IV protects H9c2 cells against H2O2-induced oxidative injury].
PubMed:Astragaloside IV attenuates complement membranous attack complex induced podocyte injury through the MAPK pathway.
PubMed:Astragaloside IV and cycloastragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell types.
PubMed:[Determination of astragaloside IV of eight area in Astragali Radix is by HPLC-ELSD internal standard method].
PubMed:Protective effect of astragaloside IV against matrix metalloproteinase-1 expression in ultraviolet-irradiated human dermal fibroblasts.
PubMed:[Effects of astragaloside on IGF-1 and associated protein expression in mice with acute viral myocarditis].
PubMed:Ultrasonic-assisted liquid-liquid extraction and HILIC-ELSD analysis of ginsenoside Rb(1), astragaloside IV and dulcitol in sugar-free "Fufangfufangteng Heji".
PubMed:[Effect of astragaloside against the oxidative damage on endothelial cells].
PubMed:Effect comparison of different formulation of Dang-Gui-Bu-Xu-Tang on myelosuppression mouse.
PubMed:[Simultaneous determination of five glycosides in Aidi injection by RP-HPLC-ELSD].
PubMed:Astragaloside IV protects against ischemia reperfusion in a murine model of orthotopic liver transplantation.
PubMed:Chuanxiongzine-astragaloside IV decreases IL-1β and Caspase-3 gene expressions in rat brain damaged by cerebral ischemia/reperfusion: a study of real-time quantitative PCR assay.
PubMed:[Regulation of Vitreoscilla hemoglobin on biosynthesis of astragaloside IV].
PubMed:Astragaloside IV stimulates angiogenesis and increases hypoxia-inducible factor-1α accumulation via phosphatidylinositol 3-kinase/Akt pathway.
PubMed:Astragaloside IV improves metabolic syndrome and endothelium dysfunction in fructose-fed rats.
PubMed:Astragaloside IV attenuates impulse noise-induced trauma in guinea pig.
PubMed:Astragaloside IV inhibits adenovirus replication and apoptosis in A549 cells in vitro.
PubMed:Protective effects of astragaloside against ultraviolet A-induced photoaging in human fibroblasts.
PubMed:The osteogenetic effect of astragaloside IV with centrifugating pressure on the OCT-1 cells.
PubMed:Astragaloside IV attenuates myocardial fibrosis by inhibiting TGF-β1 signaling in coxsackievirus B3-induced cardiomyopathy.
PubMed:[Protective effect of astragalosides on anoxia/reoxygenation injury of hippocampal neuron].
PubMed:Astragaloside IV synergizes with ferulic acid to inhibit renal tubulointerstitial fibrosis in rats with obstructive nephropathy.
PubMed:The known immunologically active components of Astragalus account for only a small proportion of the immunological adjuvant activity when combined with conjugate vaccines.
PubMed:Comparative investigations on the protective effects of rhodioside, ciwujianoside-B and astragaloside IV on radiation injuries of the hematopoietic system in mice.
PubMed:Effects of astragaloside IV on IFN-gamma level and prolonged airway dysfunction in a murine model of chronic asthma.
PubMed:Effect of astragaloside IV on the general and peripartum reproductive toxicity in Sprague-Dawley rats.
PubMed:[Morphological investigation of the protective effect of astragaloside preconditioning against ischemia-reperfusion lung injury in rats].
PubMed:[Transformation of astragaloside IV in bidirectional solid fermenting of Astragalus membranaceus].
PubMed:Preparative enrichment and separation of astragalosides from Radix Astragali extracts using macroporous resins.
PubMed:[Study on preventative and curative effects of astragaloside (AST) on mice memory impairment and expression of amyloid precursor protein and beta secretase mRNA induced by dexamethasone].
PubMed:Protective effect of astragaloside on focal cerebral ischemia/reperfusion injury in rats.
PubMed:[Stem cell factor secretion by bone mesenchymal stem cells stimulated with astragaloside IV].
PubMed:Astragaloside IV improves homocysteine-induced acute phase endothelial dysfunction via antioxidation.
PubMed:[Inhibitory effect on activated renin-angiotensin system by astragaloside IV in rats with pressure-overload induced cardiac hypertrophy].
PubMed:Cigarette smoke enhances {beta}-defensin 2 expression in rat airways via nuclear factor-{kappa}B activation.
PubMed:Proteomic characterization of the cellular response to chemopreventive triterpenoid astragaloside IV in human hepatocellular carcinoma cell line HepG2.
PubMed:Effects of cycloartane saponins from hairy roots of Astragalus membranaceus Bge., on human tumor cell targets.
PubMed:Ligustilide suppresses the biological properties of Danggui Buxue Tang: a Chinese herbal decoction composed of radix astragali and radix angelica sinensis.
PubMed:Astragalosides isolated from the root of astragalus radix inhibit the formation of advanced glycation end products.
PubMed:Effect of astragaloside IV on hepatic glucose-regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin.
PubMed:Protective effects of astragaloside IV on porcine-serum-induced hepatic fibrosis in rats and in vitro effects on hepatic stellate cells.
PubMed:Neuroprotective effects of Astragaloside IV in 6-hydroxydopamine-treated primary nigral cell culture.
PubMed:[Study on the determination method of the astragaloside IV in health food].
PubMed:Astragaloside IV attenuates cerebral ischemia-reperfusion-induced increase in permeability of the blood-brain barrier in rats.
PubMed:Effect of astragaloside IV on the embryo-fetal development of Sprague-Dawley rats and New Zealand White rabbits.
PubMed:Anti-hepatitis B virus activities of astragaloside IV isolated from radix Astragali.
PubMed:Astragaloside IV attenuates hypoxia-induced cardiomyocyte damage in rats by upregulating superoxide dismutase-1 levels.
PubMed:Astragaloside IV attenuates lipolysis and improves insulin resistance induced by TNFalpha in 3T3-L1 adipocytes.
PubMed:[Study on absorption kinetics of astragaloside IV in rats intestines].
PubMed:Astragaloside IV improves high glucose-induced podocyte adhesion dysfunction via alpha3beta1 integrin upregulation and integrin-linked kinase inhibition.
PubMed:Inhibitory effects of astragaloside IV on ovalbumin-induced chronic experimental asthma.
PubMed:Astragaloside IV inhibits proliferation and promotes apoptosis in rat vascular smooth muscle cells under high glucose concentration in vitro.
PubMed:[Determination of the total content of astragaloside IV in Radix Astragali].
PubMed:[Amic solution hydrolysis for improving content of astragaloside IV in extract of Radix Astragali].
PubMed:Astragaloside IV improved intracellular calcium handling in hypoxia-reoxygenated cardiomyocytes via the sarcoplasmic reticulum Ca-ATPase.
PubMed:Simultaneous determination of calycosin-7-O-beta-D-glucoside, ononin, astragaloside IV, astragaloside I and ferulic acid in rat plasma after oral administration of Danggui Buxue Tang extract for their pharmacokinetic studies by liquid chromatography-mass spectrometry.
PubMed:[Effects of AST and ASI on metabolism of free radical in senescent rats treated by HC].
PubMed:Aqueous extract of Astragali Radix induces human natriuresis through enhancement of renal response to atrial natriuretic peptide.
PubMed:Astragaloside IV inhibits spontaneous synaptic transmission and synchronized Ca2+ oscillations on hippocampal neurons.
PubMed:[Astragalus polysaccharides and astragalosides regulate cytokine secretion in LX-2 cell line].
PubMed:[Investigation on one-pot extraction of active ingredient group from Yupingfeng powder by HPLC].
PubMed:[Protective effects of Astragaloside and Quercetin on rat myocardial cells after hypoxia].
PubMed:[Effect of astragaloside on myocardial fibrosis in chronic myocarditis].
PubMed:Pharmacokinetics of astragaloside iv in beagle dogs.
PubMed:Simultaneous characterization of isoflavonoids and astragalosides in two Astragalus species by high-performance liquid chromatography coupled with atmospheric pressure chemical ionization tandem mass spectrometry.
PubMed:Determination of seventeen main flavonoids and saponins in the medicinal plant Huang-qi (Radix astragali) by HPLC-DAD-ELSD.
PubMed:[Fundamentally study on mathematical kinetic model of component extraction from FTCM].
PubMed:Development of microwave assisted extraction for the simultaneous determination of isoflavonoids and saponins in radix astragali by high performance liquid chromatography.
PubMed:Modification of alterations in cardiac function and sarcoplasmic reticulum by astragaloside IV in myocardial injury in vivo.
PubMed:Effect of astragaloside on cardiomyocyte apoptosis in murine coxsackievirus B3 myocarditis.
PubMed:Mechanisms underlying vasorelaxant action of astragaloside IV in isolated rat aortic rings.
PubMed:Effects of Astragalus polysaccharides and astragalosides on the phagocytosis of Mycobacterium tuberculosis by macrophages.
PubMed:[The effect of icariin and astragalosid I on the proliferation and differentiation of bone marrow stromal cells].
PubMed:[Anti-apoptosis effect of astragaloside on adriamycin induced rat's cardiotoxicity].
PubMed:[Study on fingerprints of astragalosides injection by HPLC-ELSD].
PubMed:[Determination of three constituents in Radix Astragali by HPLC-MS].
PubMed:Simultaneous analysis of seven astragalosides in Radix Astragali and related preparations by liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry.
PubMed:Promotion of axonal maturation and prevention of memory loss in mice by extracts of Astragalus mongholicus.
PubMed:Inhibitory effects of astragaloside IV on diabetic peripheral neuropathy in rats.
PubMed:Astragaloside IV dilates aortic vessels from normal and spontaneously hypertensive rats through endothelium-dependent and endothelium-independent ways.
PubMed:Absorption enhancement study of astragaloside IV based on its transport mechanism in caco-2 cells.
PubMed:Astragaloside IV improved barrier dysfunction induced by acute high glucose in human umbilical vein endothelial cells.
PubMed:Chemical and biological assessment of a chinese herbal decoction containing Radix Astragali and Radix Angelicae Sinensis: Determination of drug ratio in having optimized properties.
PubMed:Preclinical pharmacokinetics and tissue distribution of a natural cardioprotective agent astragaloside IV in rats and dogs.
PubMed:Astragaloside IV exerts antiviral effects against coxsackievirus B3 by upregulating interferon-gamma.
PubMed:Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro.
PubMed:Pharmacokinetics of Astragaloside IV in rats by liquid chromatography coupled with tandem mass spectrometry.
PubMed:Effects of astragaloside IV on pathogenesis of metabolic syndrome in vitro.
PubMed:[Study on new extraction technology of astragaloside IV].
PubMed:The role of astragaloside in regeneration of the peripheral nerve system.
PubMed:Sensitive and selective liquid chromatography-electrospray ionisation-mass spectrometry analysis of astragaloside-IV in rat plasma.
PubMed:Gastroprotective effect of Astragaloside IV: role of prostaglandins, sulfhydryls and nitric oxide.
PubMed:Quantitation of astragaloside IV in rat plasma by liquid chromatography-tandem mass spectrometry.
PubMed:Quantitative determination of Astragaloside IV, a natural product with cardioprotective activity, in plasma, urine and other biological samples by HPLC coupled with tandem mass spectrometry.
PubMed:Separation of compounds interacting with liposome membrane in combined prescription of traditional Chinese medicines with immobilized liposome chromatography.
PubMed:Effect of astragalosides on intracellular calcium overload in cultured cardiac myocytes of neonatal rats.
PubMed:[Studies on chromatography fingerprint of huangqi by HPLC].
PubMed:Transport and bioavailability studies of astragaloside IV, an active ingredient in Radix Astragali.
PubMed:[Effect of astrgaloside IV on the long-term consequences of renal ischemia-reperfusion injury in rat].
PubMed:Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia.
PubMed:Determination of Astragaloside IV in rat plasma by liquid chromatography electrospray ionization mass spectrometry.
PubMed:Astragaloside IV and polysaccharide production by hairy roots of Astragalus membranaceus in bioreactors.
PubMed:Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-kappaB activation and adhesion molecule expression.
PubMed:Determination of serum astragaloside in rats fed with Buyanghuanwu dicoction using solidphase extraction, chemical derivatization and fluorospectrophotometry.
PubMed:[Scavenging effects of Astragalus and Gynostemma pentaphyllum with its product on O2-. and .OH].
PubMed:[Effects of components isolated from Astragalus membranaceus Bunge on cardiac function injured by myocardial ischemia reperfusion in rats].
PubMed:Effects of astragaloside IV on myocardial calcium transport and cardiac function in ischemic rats.
PubMed:[Determination of astragaloside IV in radix Astragali by HPLC with evaporative light scattering detector].
PubMed:Effect of astragaloside IV on T, B lymphocyte proliferation and peritoneal macrophage function in mice.
PubMed:Antinociceptive effect of astragalosides and its mechanism of action.
PubMed:Determination of astragaloside IV in Radix astragali (Astragalus membranaceus var. monghulicus) using high-performance liquid chromatography with evaporative light-scattering detection.
PubMed:[Experimental studies on the quality of ostracean powder].
PubMed:[A study on processing of the root of Astragalus membranaceus Bge. by HPLC].
PubMed:A precolumn derivatization high-performance liquid chromatographic method with improved sensitivity and specificity for the determination of astragaloside IV in Radix Astragali.
PubMed:Regulation of the fibrinolytic potential of cultured human umbilical vein endothelial cells: astragaloside IV downregulates plasminogen activator inhibitor-1 and upregulates tissue-type plasminogen activator expression.
PubMed:[Nuclear cardiology study on effective ingredients of Astragalus membranaceus in treating heart failure].
PubMed:[A new method for qualitative determination of astragaloside].
PubMed:[Comparative study of the effect of cycloartane and cardiac glycosides on various parameters of myocardial metabolism in animals].
PubMed:[Effects of astragalus (ASI, SK) on experimental liver injury].
PubMed:[Recent development of chemical studies on some medicinal plants of Astragalus spp].
PubMed:[Quantitative determination of astragaloside A in Astragalus membranaceus].
 
Notes:
isolated from astragalus membranaceus.
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